Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/25440 |
Resumo: | Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C). Subjects received a single dose of ayahuasca or placebo (dosing session), and both plasma and awakening salivary cortisol response were measured at baseline (before dosing session) and 48 h after the dosing session. Baseline assessment (D0) showed blunted awakening salivary cortisol response and hypocortisolemia in patients, with respect to healthy controls. Salivary cortisol was also measured during dosing session, and we observed higher increases for both C and MD that ingested ayahuasca than placebo. After 48 h from the dosing session with ayahuasca, patients' awakening salivary cortisol response is similar to the ones detected in controls. No significant changes in plasma cortisol levels were observed 48 h after the sessions. Therefore, these findings point to new evidence on the modulation of salivary cortisol levels as a result of an ayahuasca session, both in healthy and depressive volunteers. Considering that cortisol acts in regulation of distinct physiological pathways, emotional and cognitive processes, it is assumed to be critically involved to the etiology of depression and its regulation seems to be important for the treatment and remission of major depression, ayahuasca use as antidepressant should be further investigated. Moreover, this study highlights the importance of psychedelics in the treatment of human mental disorders. |
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Galvão, Ana C. de MenezesAlmeida, Raíssa N. deSilva, Erick A. dos SantosFreire, Fúlvio A. M.Palhano-Fontes, FernandaOnias, HeloisaArcoverde, EmersonMaia-de-Oliveira, João P.Araújo, Dráulio Barros deLobão-Soares, BrunoGalvão-Coelho, Nicole L.2018-06-18T16:43:59Z2018-06-18T16:43:59Z2018-05-08GALVÃO, A.C.M. et al. Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls. Front. Psychiatry v. 9, n.185, maio/2018. DOI: 10.3389/fpsyt.2018.0018510.3389/fpsyt.2018.00185https://repositorio.ufrn.br/jspui/handle/123456789/25440engayahuascaawakening salivary cortisolplasma cortisoltreatment-resistant depressionhypocortisolemiaCortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controlsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMajor depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C). Subjects received a single dose of ayahuasca or placebo (dosing session), and both plasma and awakening salivary cortisol response were measured at baseline (before dosing session) and 48 h after the dosing session. Baseline assessment (D0) showed blunted awakening salivary cortisol response and hypocortisolemia in patients, with respect to healthy controls. Salivary cortisol was also measured during dosing session, and we observed higher increases for both C and MD that ingested ayahuasca than placebo. After 48 h from the dosing session with ayahuasca, patients' awakening salivary cortisol response is similar to the ones detected in controls. No significant changes in plasma cortisol levels were observed 48 h after the sessions. Therefore, these findings point to new evidence on the modulation of salivary cortisol levels as a result of an ayahuasca session, both in healthy and depressive volunteers. Considering that cortisol acts in regulation of distinct physiological pathways, emotional and cognitive processes, it is assumed to be critically involved to the etiology of depression and its regulation seems to be important for the treatment and remission of major depression, ayahuasca use as antidepressant should be further investigated. Moreover, this study highlights the importance of psychedelics in the treatment of human mental disorders.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALDraulioAraujo_ICe_Cortisol modulation_2018.pdfDraulioAraujo_ICe_Cortisol modulation_2018.pdfDraulioAraujo_ICe_Cortisol modulation_2018application/pdf891956https://repositorio.ufrn.br/bitstream/123456789/25440/1/DraulioAraujo_ICe_Cortisol%20modulation_2018.pdfda807f12083380bca1ce540b495aa487MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25440/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTDraulioAraujo_ICe_Cortisol modulation_2018.pdf.txtDraulioAraujo_ICe_Cortisol modulation_2018.pdf.txtExtracted texttext/plain61029https://repositorio.ufrn.br/bitstream/123456789/25440/3/DraulioAraujo_ICe_Cortisol%20modulation_2018.pdf.txt82149d5a5fb5e094d78d86a42088b993MD53THUMBNAILDraulioAraujo_ICe_Cortisol modulation_2018.pdf.jpgDraulioAraujo_ICe_Cortisol modulation_2018.pdf.jpgIM Thumbnailimage/jpeg11204https://repositorio.ufrn.br/bitstream/123456789/25440/4/DraulioAraujo_ICe_Cortisol%20modulation_2018.pdf.jpg964bbda47eeb9c2053ba4bdb0a52511eMD54123456789/254402021-07-08 15:22:38.357oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T18:22:38Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls |
title |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls |
spellingShingle |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls Galvão, Ana C. de Menezes ayahuasca awakening salivary cortisol plasma cortisol treatment-resistant depression hypocortisolemia |
title_short |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls |
title_full |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls |
title_fullStr |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls |
title_full_unstemmed |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls |
title_sort |
Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls |
author |
Galvão, Ana C. de Menezes |
author_facet |
Galvão, Ana C. de Menezes Almeida, Raíssa N. de Silva, Erick A. dos Santos Freire, Fúlvio A. M. Palhano-Fontes, Fernanda Onias, Heloisa Arcoverde, Emerson Maia-de-Oliveira, João P. Araújo, Dráulio Barros de Lobão-Soares, Bruno Galvão-Coelho, Nicole L. |
author_role |
author |
author2 |
Almeida, Raíssa N. de Silva, Erick A. dos Santos Freire, Fúlvio A. M. Palhano-Fontes, Fernanda Onias, Heloisa Arcoverde, Emerson Maia-de-Oliveira, João P. Araújo, Dráulio Barros de Lobão-Soares, Bruno Galvão-Coelho, Nicole L. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Galvão, Ana C. de Menezes Almeida, Raíssa N. de Silva, Erick A. dos Santos Freire, Fúlvio A. M. Palhano-Fontes, Fernanda Onias, Heloisa Arcoverde, Emerson Maia-de-Oliveira, João P. Araújo, Dráulio Barros de Lobão-Soares, Bruno Galvão-Coelho, Nicole L. |
dc.subject.por.fl_str_mv |
ayahuasca awakening salivary cortisol plasma cortisol treatment-resistant depression hypocortisolemia |
topic |
ayahuasca awakening salivary cortisol plasma cortisol treatment-resistant depression hypocortisolemia |
description |
Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C). Subjects received a single dose of ayahuasca or placebo (dosing session), and both plasma and awakening salivary cortisol response were measured at baseline (before dosing session) and 48 h after the dosing session. Baseline assessment (D0) showed blunted awakening salivary cortisol response and hypocortisolemia in patients, with respect to healthy controls. Salivary cortisol was also measured during dosing session, and we observed higher increases for both C and MD that ingested ayahuasca than placebo. After 48 h from the dosing session with ayahuasca, patients' awakening salivary cortisol response is similar to the ones detected in controls. No significant changes in plasma cortisol levels were observed 48 h after the sessions. Therefore, these findings point to new evidence on the modulation of salivary cortisol levels as a result of an ayahuasca session, both in healthy and depressive volunteers. Considering that cortisol acts in regulation of distinct physiological pathways, emotional and cognitive processes, it is assumed to be critically involved to the etiology of depression and its regulation seems to be important for the treatment and remission of major depression, ayahuasca use as antidepressant should be further investigated. Moreover, this study highlights the importance of psychedelics in the treatment of human mental disorders. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-06-18T16:43:59Z |
dc.date.available.fl_str_mv |
2018-06-18T16:43:59Z |
dc.date.issued.fl_str_mv |
2018-05-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GALVÃO, A.C.M. et al. Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls. Front. Psychiatry v. 9, n.185, maio/2018. DOI: 10.3389/fpsyt.2018.00185 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/25440 |
dc.identifier.issn.none.fl_str_mv |
10.3389/fpsyt.2018.00185 |
identifier_str_mv |
GALVÃO, A.C.M. et al. Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls. Front. Psychiatry v. 9, n.185, maio/2018. DOI: 10.3389/fpsyt.2018.00185 10.3389/fpsyt.2018.00185 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/25440 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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