Medical and surgical management of advanced Parkinson's disease
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/52940 https://doi.org/10.1002/mds.27340 |
Resumo: | Advanced Parkinson's disease is characterized by the presence of motor fluctuations, various degree of dyskinesia, and disability with functional impact on activities of daily living and independence. Therapeutic management aims to extend levodopa benefit while minimizing motor complications and includes, in selected cases, the implementation of drug infusion and surgical techniques. In milder forms of motor complications, these can often be controlled with manipulation of levodopa dose and the introduction of supplemental therapies such as catechol-O-methyl transferase inhibitors, monoamine oxidase B inhibitors, and dopamine agonists including apomorphine. Clinical experience and evidence from published studies indicate that when these agents cannot satisfactorily control motor complications, patients should be assessed and considered for device-aided therapies. This review article summarizes some of the newer available therapeutic opportunities such as use of enzyme inhibitors like opicapone and safinamide, adenosine A2A receptor antagonists, apomorphine and levodopa/carbidopa intestinal gel infusion, deep brain stimulation including the role of closed-loop and adaptive stimulation, and MRI-guided focused ultrasound. © 2018 International Parkinson and Movement Disorder Society |
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Godeiro Junior, Clécio de OliveiraAntonini, AngeloMoro, ElenaReichmann, Heinz0000-0002-4312-16332023-06-30T17:37:42Z2023-06-30T17:37:42Z2018-03-23GODEIRO JUNIOR, Clécio de Oliveira; MORO, Elena; ANTONINI, Angelo; REICHMANN, Heinz. Medical and surgical management of advanced Parkinson's disease. Movement Disorders, [S.L.], v. 33, n. 6, p. 900-908, 23 mar. 2018. Wiley. http://dx.doi.org/10.1002/mds.27340. Disponível em: https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.27340. Acesso em: 30 jun. 2023.https://repositorio.ufrn.br/handle/123456789/52940https://doi.org/10.1002/mds.27340Movement DisordersParkinson's diseasetherapeutic managementlevodopa benefitMedical and surgical management of advanced Parkinson's diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAdvanced Parkinson's disease is characterized by the presence of motor fluctuations, various degree of dyskinesia, and disability with functional impact on activities of daily living and independence. Therapeutic management aims to extend levodopa benefit while minimizing motor complications and includes, in selected cases, the implementation of drug infusion and surgical techniques. In milder forms of motor complications, these can often be controlled with manipulation of levodopa dose and the introduction of supplemental therapies such as catechol-O-methyl transferase inhibitors, monoamine oxidase B inhibitors, and dopamine agonists including apomorphine. Clinical experience and evidence from published studies indicate that when these agents cannot satisfactorily control motor complications, patients should be assessed and considered for device-aided therapies. This review article summarizes some of the newer available therapeutic opportunities such as use of enzyme inhibitors like opicapone and safinamide, adenosine A2A receptor antagonists, apomorphine and levodopa/carbidopa intestinal gel infusion, deep brain stimulation including the role of closed-loop and adaptive stimulation, and MRI-guided focused ultrasound. © 2018 International Parkinson and Movement Disorder Societyengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/52940/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/529402023-06-30 14:37:57.634oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-06-30T17:37:57Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Medical and surgical management of advanced Parkinson's disease |
title |
Medical and surgical management of advanced Parkinson's disease |
spellingShingle |
Medical and surgical management of advanced Parkinson's disease Godeiro Junior, Clécio de Oliveira Parkinson's disease therapeutic management levodopa benefit |
title_short |
Medical and surgical management of advanced Parkinson's disease |
title_full |
Medical and surgical management of advanced Parkinson's disease |
title_fullStr |
Medical and surgical management of advanced Parkinson's disease |
title_full_unstemmed |
Medical and surgical management of advanced Parkinson's disease |
title_sort |
Medical and surgical management of advanced Parkinson's disease |
author |
Godeiro Junior, Clécio de Oliveira |
author_facet |
Godeiro Junior, Clécio de Oliveira Antonini, Angelo Moro, Elena Reichmann, Heinz |
author_role |
author |
author2 |
Antonini, Angelo Moro, Elena Reichmann, Heinz |
author2_role |
author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
0000-0002-4312-1633 |
dc.contributor.author.fl_str_mv |
Godeiro Junior, Clécio de Oliveira Antonini, Angelo Moro, Elena Reichmann, Heinz |
dc.subject.por.fl_str_mv |
Parkinson's disease therapeutic management levodopa benefit |
topic |
Parkinson's disease therapeutic management levodopa benefit |
description |
Advanced Parkinson's disease is characterized by the presence of motor fluctuations, various degree of dyskinesia, and disability with functional impact on activities of daily living and independence. Therapeutic management aims to extend levodopa benefit while minimizing motor complications and includes, in selected cases, the implementation of drug infusion and surgical techniques. In milder forms of motor complications, these can often be controlled with manipulation of levodopa dose and the introduction of supplemental therapies such as catechol-O-methyl transferase inhibitors, monoamine oxidase B inhibitors, and dopamine agonists including apomorphine. Clinical experience and evidence from published studies indicate that when these agents cannot satisfactorily control motor complications, patients should be assessed and considered for device-aided therapies. This review article summarizes some of the newer available therapeutic opportunities such as use of enzyme inhibitors like opicapone and safinamide, adenosine A2A receptor antagonists, apomorphine and levodopa/carbidopa intestinal gel infusion, deep brain stimulation including the role of closed-loop and adaptive stimulation, and MRI-guided focused ultrasound. © 2018 International Parkinson and Movement Disorder Society |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-03-23 |
dc.date.accessioned.fl_str_mv |
2023-06-30T17:37:42Z |
dc.date.available.fl_str_mv |
2023-06-30T17:37:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GODEIRO JUNIOR, Clécio de Oliveira; MORO, Elena; ANTONINI, Angelo; REICHMANN, Heinz. Medical and surgical management of advanced Parkinson's disease. Movement Disorders, [S.L.], v. 33, n. 6, p. 900-908, 23 mar. 2018. Wiley. http://dx.doi.org/10.1002/mds.27340. Disponível em: https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.27340. Acesso em: 30 jun. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/52940 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1002/mds.27340 |
identifier_str_mv |
GODEIRO JUNIOR, Clécio de Oliveira; MORO, Elena; ANTONINI, Angelo; REICHMANN, Heinz. Medical and surgical management of advanced Parkinson's disease. Movement Disorders, [S.L.], v. 33, n. 6, p. 900-908, 23 mar. 2018. Wiley. http://dx.doi.org/10.1002/mds.27340. Disponível em: https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.27340. Acesso em: 30 jun. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/52940 https://doi.org/10.1002/mds.27340 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Movement Disorders |
publisher.none.fl_str_mv |
Movement Disorders |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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