Effect of chronic stress during adolescence in prefrontal cortex structure and function
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23356 |
Resumo: | Critical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent’s rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions. |
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Folha, Otávio Augusto de Araújo CostaBahia, Carlomagno PachecoAguiar, Gisele Priscila Soares deHerculano, Anderson ManoelCoelho, Nicole Leite GalvãoSousa, Maria Bernardete Cordeiro deShiramizu, Victor Kenji MedeirosGalvão, Ana Cecília de MenezesCarvalho, Walther Augusto dePereira, Antonio2017-06-01T19:44:56Z2017-06-01T19:44:56Z20170166-4328https://repositorio.ufrn.br/jspui/handle/123456789/23356engPre-frontal cortexChronic stressPerineuronal netsCritical periodPlasticityEffect of chronic stress during adolescence in prefrontal cortex structure and functioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCritical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent’s rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23356/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTEffect of Chronic Stress during Adolescence in Prefrontal Cortex Structure and Function.pdf.txtEffect of Chronic Stress during Adolescence in Prefrontal Cortex Structure and Function.pdf.txtExtracted texttext/plain42486https://repositorio.ufrn.br/bitstream/123456789/23356/5/Effect%20of%20Chronic%20Stress%20during%20Adolescence%20in%20Prefrontal%20Cortex%20Structure%20and%20Function.pdf.txta6e1418e4e67c0fad3347429e0b7a6d6MD55THUMBNAILEffect of Chronic Stress during Adolescence in Prefrontal Cortex Structure and Function.pdf.jpgEffect of Chronic Stress during Adolescence in Prefrontal Cortex Structure and Function.pdf.jpgIM Thumbnailimage/jpeg7901https://repositorio.ufrn.br/bitstream/123456789/23356/6/Effect%20of%20Chronic%20Stress%20during%20Adolescence%20in%20Prefrontal%20Cortex%20Structure%20and%20Function.pdf.jpg711b67c0f77f2c2cf9892661c7a208a8MD56123456789/233562022-12-15 20:48:08.766oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-12-15T23:48:08Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Effect of chronic stress during adolescence in prefrontal cortex structure and function |
title |
Effect of chronic stress during adolescence in prefrontal cortex structure and function |
spellingShingle |
Effect of chronic stress during adolescence in prefrontal cortex structure and function Folha, Otávio Augusto de Araújo Costa Pre-frontal cortex Chronic stress Perineuronal nets Critical period Plasticity |
title_short |
Effect of chronic stress during adolescence in prefrontal cortex structure and function |
title_full |
Effect of chronic stress during adolescence in prefrontal cortex structure and function |
title_fullStr |
Effect of chronic stress during adolescence in prefrontal cortex structure and function |
title_full_unstemmed |
Effect of chronic stress during adolescence in prefrontal cortex structure and function |
title_sort |
Effect of chronic stress during adolescence in prefrontal cortex structure and function |
author |
Folha, Otávio Augusto de Araújo Costa |
author_facet |
Folha, Otávio Augusto de Araújo Costa Bahia, Carlomagno Pacheco Aguiar, Gisele Priscila Soares de Herculano, Anderson Manoel Coelho, Nicole Leite Galvão Sousa, Maria Bernardete Cordeiro de Shiramizu, Victor Kenji Medeiros Galvão, Ana Cecília de Menezes Carvalho, Walther Augusto de Pereira, Antonio |
author_role |
author |
author2 |
Bahia, Carlomagno Pacheco Aguiar, Gisele Priscila Soares de Herculano, Anderson Manoel Coelho, Nicole Leite Galvão Sousa, Maria Bernardete Cordeiro de Shiramizu, Victor Kenji Medeiros Galvão, Ana Cecília de Menezes Carvalho, Walther Augusto de Pereira, Antonio |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Folha, Otávio Augusto de Araújo Costa Bahia, Carlomagno Pacheco Aguiar, Gisele Priscila Soares de Herculano, Anderson Manoel Coelho, Nicole Leite Galvão Sousa, Maria Bernardete Cordeiro de Shiramizu, Victor Kenji Medeiros Galvão, Ana Cecília de Menezes Carvalho, Walther Augusto de Pereira, Antonio |
dc.subject.por.fl_str_mv |
Pre-frontal cortex Chronic stress Perineuronal nets Critical period Plasticity |
topic |
Pre-frontal cortex Chronic stress Perineuronal nets Critical period Plasticity |
description |
Critical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent’s rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-06-01T19:44:56Z |
dc.date.available.fl_str_mv |
2017-06-01T19:44:56Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23356 |
dc.identifier.issn.none.fl_str_mv |
0166-4328 |
identifier_str_mv |
0166-4328 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23356 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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