Medial prefrontal cortex dopamine controls the persistent storage of aversive memories
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/19075 |
Resumo: | Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task and the hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists and antagonists we found that persistence but not formation of long-term aversive memories requires dopamine D1/D5 receptors activation in mPFC immediately after training and, depending on the task, between 6 and 12 h later. Our results indicate that besides its well-known participation in retrieval and early consolidation, mPFC also modulates the endurance of long-lasting aversive memories regardless of whether formation of the aversive mnemonic trace requires the participation of the hippocampus. |
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Gonzalez, María C.Kramar, Cecilia P.Tomaiuolo, MicolKatche, CynthiaWeisstaub, NoeliaCammarota, Martín PabloMedina, Jorge H.2015-06-10T19:41:19Z2015-06-10T19:41:19Z2014-11-26Gonzalez MC, Kramar CP, Tomaiuolo M, Katche C, Weisstaub N, Cammarota M and Medina JH (2014) Medial prefrontal cortex dopamine controls the persistent storage of aversive memories. Front. Behav. Neurosci. 8:408. doi: 10.3389/ fnbeh.2014.004081662-5153https://repositorio.ufrn.br/jspui/handle/123456789/19075Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task and the hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists and antagonists we found that persistence but not formation of long-term aversive memories requires dopamine D1/D5 receptors activation in mPFC immediately after training and, depending on the task, between 6 and 12 h later. Our results indicate that besides its well-known participation in retrieval and early consolidation, mPFC also modulates the endurance of long-lasting aversive memories regardless of whether formation of the aversive mnemonic trace requires the participation of the hippocampus.Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, Argentina) to Jorge H. Medina; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil) and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Norte (FAPERN, Brazil) to Martín Cammarota; and International Brain Research Organization (IBRO) to Jorge H. Medina and Martín Cammarota.inhibitory avoidanceconditioned taste aversionD1/D5 receptorVTAsystem consolidationMedial prefrontal cortex dopamine controls the persistent storage of aversive memoriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/19075/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52ORIGINALMariaGonzalez_ICE_Medial_prefrontal_2014.pdfMariaGonzalez_ICE_Medial_prefrontal_2014.pdfArtigo completoapplication/pdf1005637https://repositorio.ufrn.br/bitstream/123456789/19075/1/MariaGonzalez_ICE_Medial_prefrontal_2014.pdff34ed2df3e088ff68a611579da41fe13MD51TEXTMariaGonzalez_ICE_Medial_prefrontal_2014.pdf.txtMariaGonzalez_ICE_Medial_prefrontal_2014.pdf.txtExtracted texttext/plain39089https://repositorio.ufrn.br/bitstream/123456789/19075/7/MariaGonzalez_ICE_Medial_prefrontal_2014.pdf.txte48e2c71692f998f716c7239a620d17cMD57THUMBNAILMariaGonzalez_ICE_Medial_prefrontal_2014.pdf.jpgMariaGonzalez_ICE_Medial_prefrontal_2014.pdf.jpgIM Thumbnailimage/jpeg10012https://repositorio.ufrn.br/bitstream/123456789/19075/8/MariaGonzalez_ICE_Medial_prefrontal_2014.pdf.jpg245bd37cd6d3c17f728b8ccc0abaa98bMD58123456789/190752021-07-09 18:04:49.293oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T21:04:49Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
spellingShingle |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories Gonzalez, María C. inhibitory avoidance conditioned taste aversion D1/D5 receptor VTA system consolidation |
title_short |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_full |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_fullStr |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_full_unstemmed |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_sort |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
author |
Gonzalez, María C. |
author_facet |
Gonzalez, María C. Kramar, Cecilia P. Tomaiuolo, Micol Katche, Cynthia Weisstaub, Noelia Cammarota, Martín Pablo Medina, Jorge H. |
author_role |
author |
author2 |
Kramar, Cecilia P. Tomaiuolo, Micol Katche, Cynthia Weisstaub, Noelia Cammarota, Martín Pablo Medina, Jorge H. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Gonzalez, María C. Kramar, Cecilia P. Tomaiuolo, Micol Katche, Cynthia Weisstaub, Noelia Cammarota, Martín Pablo Medina, Jorge H. |
dc.subject.por.fl_str_mv |
inhibitory avoidance conditioned taste aversion D1/D5 receptor VTA system consolidation |
topic |
inhibitory avoidance conditioned taste aversion D1/D5 receptor VTA system consolidation |
description |
Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task and the hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists and antagonists we found that persistence but not formation of long-term aversive memories requires dopamine D1/D5 receptors activation in mPFC immediately after training and, depending on the task, between 6 and 12 h later. Our results indicate that besides its well-known participation in retrieval and early consolidation, mPFC also modulates the endurance of long-lasting aversive memories regardless of whether formation of the aversive mnemonic trace requires the participation of the hippocampus. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-11-26 |
dc.date.accessioned.fl_str_mv |
2015-06-10T19:41:19Z |
dc.date.available.fl_str_mv |
2015-06-10T19:41:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Gonzalez MC, Kramar CP, Tomaiuolo M, Katche C, Weisstaub N, Cammarota M and Medina JH (2014) Medial prefrontal cortex dopamine controls the persistent storage of aversive memories. Front. Behav. Neurosci. 8:408. doi: 10.3389/ fnbeh.2014.00408 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/19075 |
dc.identifier.issn.none.fl_str_mv |
1662-5153 |
identifier_str_mv |
Gonzalez MC, Kramar CP, Tomaiuolo M, Katche C, Weisstaub N, Cammarota M and Medina JH (2014) Medial prefrontal cortex dopamine controls the persistent storage of aversive memories. Front. Behav. Neurosci. 8:408. doi: 10.3389/ fnbeh.2014.00408 1662-5153 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/19075 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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