Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores

Detalhes bibliográficos
Autor(a) principal: Silva, Antonio Kerverson Batista da
Data de Publicação: 2022
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/50286
Resumo: The cytochrome P450 consists of a superfamily of hemoproteins, present in different domains of life such as plants, bacteria and mammals. These monooxygenases are mainly present in the liver, and are considered versatile biocatalysts. They are responsible for participating in primary metabolism and biosynthesis of various secondary metabolites. Knowing their importance, chemistry catalysts were used for mimicking their enzymatic activity. Metaloporphyrins and Salen complexes can contribute to the products’ characterization and help to elucidate biotransformation processes, which are investigated during pre-clinical trials. These catalysts also aid in discovery of biological active compounds and get better yields of products of industrial interest. The aim of this review is to investigate which natural products classes are being investigated by biomimetic chemical models and the functionalities applied in use of these catalysts. A very limited number of studies were observed, with terpenes and alkaloids being the most investigated natural product classes. The research also revealed that Metalloporphyrins are still the most popular in the studies, and the identity and yield of the products obtained were shown to depend on the reaction system conditions.
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spelling Silva, Antonio Kerverson Batista dahttps://orcid.org/0000-0003-2676-0879?lang=enhttps://lattes.cnpq.br/3987659330558487https://orcid.org/0000-0002-8408-5886http://lattes.cnpq.br/6622861873027635Oliveira, Artur de Santanahttps://orcid.org/0000-0001-7243-8309http://lattes.cnpq.br/1464163858130396Lima, Waldenice de Alencar Moraishttp://lattes.cnpq.br/2575667613995470Ferreira, Leandro De Santis2022-12-19T21:11:50Z2022-12-19T21:11:50Z2022-12-28SILVA, Antônio Batista Kerverson da. Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores. 2022. 27f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2022.https://repositorio.ufrn.br/handle/123456789/50286Universidade Federal do Rio Grande do NorteFarmáciaUFRNBrasilDepartamento de FarmáciaAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCNPQ::CIENCIAS DA SAUDEBiomimetic oxidationBioinspired modelNatural productsMetalloporphyrinsSalen complexesMetabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadoresSpecialized metabolites in biomimetic reactions using metalloporfirins and Salen complexes as catalystinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisThe cytochrome P450 consists of a superfamily of hemoproteins, present in different domains of life such as plants, bacteria and mammals. These monooxygenases are mainly present in the liver, and are considered versatile biocatalysts. They are responsible for participating in primary metabolism and biosynthesis of various secondary metabolites. Knowing their importance, chemistry catalysts were used for mimicking their enzymatic activity. Metaloporphyrins and Salen complexes can contribute to the products’ characterization and help to elucidate biotransformation processes, which are investigated during pre-clinical trials. These catalysts also aid in discovery of biological active compounds and get better yields of products of industrial interest. The aim of this review is to investigate which natural products classes are being investigated by biomimetic chemical models and the functionalities applied in use of these catalysts. A very limited number of studies were observed, with terpenes and alkaloids being the most investigated natural product classes. The research also revealed that Metalloporphyrins are still the most popular in the studies, and the identity and yield of the products obtained were shown to depend on the reaction system conditions.porreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufrn.br/bitstream/123456789/50286/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/50286/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALMetabolitosespecializados_Silva_2022.pdfMetabolitosespecializados_Silva_2022.pdfapplication/pdf1253724https://repositorio.ufrn.br/bitstream/123456789/50286/1/Metabolitosespecializados_Silva_2022.pdf63e8aeac49b488cdc59dacc36b802d53MD51123456789/502862022-12-19 18:11:50.803oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-12-19T21:11:50Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
dc.title.alternative.pt_BR.fl_str_mv Specialized metabolites in biomimetic reactions using metalloporfirins and Salen complexes as catalyst
title Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
spellingShingle Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
Silva, Antonio Kerverson Batista da
CNPQ::CIENCIAS DA SAUDE
Biomimetic oxidation
Bioinspired model
Natural products
Metalloporphyrins
Salen complexes
title_short Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
title_full Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
title_fullStr Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
title_full_unstemmed Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
title_sort Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores
author Silva, Antonio Kerverson Batista da
author_facet Silva, Antonio Kerverson Batista da
author_role author
dc.contributor.authorID.pt_BR.fl_str_mv https://orcid.org/0000-0003-2676-0879?lang=en
dc.contributor.authorLattes.pt_BR.fl_str_mv https://lattes.cnpq.br/3987659330558487
dc.contributor.advisorID.pt_BR.fl_str_mv https://orcid.org/0000-0002-8408-5886
dc.contributor.advisorLattes.pt_BR.fl_str_mv http://lattes.cnpq.br/6622861873027635
dc.contributor.referees1.none.fl_str_mv Oliveira, Artur de Santana
dc.contributor.referees1ID.pt_BR.fl_str_mv https://orcid.org/0000-0001-7243-8309
dc.contributor.referees1Lattes.pt_BR.fl_str_mv http://lattes.cnpq.br/1464163858130396
dc.contributor.referees2.none.fl_str_mv Lima, Waldenice de Alencar Morais
dc.contributor.referees2Lattes.pt_BR.fl_str_mv http://lattes.cnpq.br/2575667613995470
dc.contributor.author.fl_str_mv Silva, Antonio Kerverson Batista da
dc.contributor.advisor1.fl_str_mv Ferreira, Leandro De Santis
contributor_str_mv Ferreira, Leandro De Santis
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE
topic CNPQ::CIENCIAS DA SAUDE
Biomimetic oxidation
Bioinspired model
Natural products
Metalloporphyrins
Salen complexes
dc.subject.por.fl_str_mv Biomimetic oxidation
Bioinspired model
Natural products
Metalloporphyrins
Salen complexes
description The cytochrome P450 consists of a superfamily of hemoproteins, present in different domains of life such as plants, bacteria and mammals. These monooxygenases are mainly present in the liver, and are considered versatile biocatalysts. They are responsible for participating in primary metabolism and biosynthesis of various secondary metabolites. Knowing their importance, chemistry catalysts were used for mimicking their enzymatic activity. Metaloporphyrins and Salen complexes can contribute to the products’ characterization and help to elucidate biotransformation processes, which are investigated during pre-clinical trials. These catalysts also aid in discovery of biological active compounds and get better yields of products of industrial interest. The aim of this review is to investigate which natural products classes are being investigated by biomimetic chemical models and the functionalities applied in use of these catalysts. A very limited number of studies were observed, with terpenes and alkaloids being the most investigated natural product classes. The research also revealed that Metalloporphyrins are still the most popular in the studies, and the identity and yield of the products obtained were shown to depend on the reaction system conditions.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-19T21:11:50Z
dc.date.available.fl_str_mv 2022-12-19T21:11:50Z
dc.date.issued.fl_str_mv 2022-12-28
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.citation.fl_str_mv SILVA, Antônio Batista Kerverson da. Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores. 2022. 27f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2022.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/50286
identifier_str_mv SILVA, Antônio Batista Kerverson da. Metabólitos especializados em reações biomiméticas usando metaloporfirinas e complexos de Salen como catalisadores. 2022. 27f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2022.
url https://repositorio.ufrn.br/handle/123456789/50286
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rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
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dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.publisher.program.fl_str_mv Farmácia
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dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Departamento de Farmácia
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
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