Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study

• Autor(a) principal: Fayh, Ana Paula Trussardi
• Data de Publicação: 2023
• Outros Autores: Sousa, Iasmin Matias
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/55765; http://dx.doi.org/10.1007/s00520-023-07845-w
• topic: Sarcopenia; mortality; nutritional assessment; performance status; cancer

Purpose Sarcopenia is a muscle dysfunction that increases negative outcomes in patients with cancer. However, its diagnosis remains uncommon in clinical practice. The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is a questionnaire to assess the functional status, but it is unknown if is comparable with sarcopenia. We aimed at comparing ECOG-PS with sarcopenia to predict 12-month mortality in patients with cancer. Methods Cohort study including older adult patients with cancer in treatment (any stage of the disease or treatment) at a reference hospital for oncological care. Socio-demographic, clinical, and anthropometric data, muscle mass, and physical function variables (handgrip strength [HGS] and gait speed [GS]) were collected. Skeletal muscle quantity and quality were assessed by computed tomography at the L3. Sarcopenia was diagnosed according to the EWGSP2. ECOG-PS and all-cause mortality were evaluated. The Cox proportional hazards model was calculated. Results We evaluated 159 patients (69 years old, 55% males). Low performance (ECOG-PS≥2) was found in 23.3%, 35.8% presented sarcopenia, and 22.0% severe sarcopenia. ECOG-PS≥2 was not an independent predictor of mortality. Sarcopenia, severe sarcopenia, and probable sarcopenia has increased by 3.25 (confdence interval, CI 95% 1.55–6.80), 2.64 (CI 95% 1.23–5.67), and 2.81 (CI 95% 1.30–6.07) times the risk of mortality, respectively. Conclusion Sarcopenia, but not ECOG-PS, was a predictor of mortality. Therefore, ECOG-PS was not similar to sarcopenia to predict mortality in patients with cancer