Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/17103 |
Resumo: | The giant cell fibroma is a benign neoplasm characterized by the presence of mono, bi or multinucleate cells, which can have a connection to the presence of mast cells. This research aims to analyze, descriptively and comparatively, the immunohystochemistry expression of the tryptase in mast cells of the giant cell f ibroma, f ibrous hyperplasia and samples of the normal oral mucosa. Thirty cases of giant cell fibroma, ten cases of fibrous hyperplasia and ten cases of normal oral mucosa were selected for the analysis of the immunohistochemistry expression, determination of the number of present mast cells, as well as their location and shape. It could be stated that there was a statistically signif icant difference (p<0,001) in relation to the quantity of mast cells among other samples analyzed where the giant cell f ibroma presented lesser quantity of mast cell and the hyperplasia showed higher concentration of this cellular type. Although the oral mucosa has presented a higher quantity of mast cells when compared to the giant cells fibroma, these were found in usual locations in the connective tissue in normal tissues. There could be noticed a statistically significant difference in relation to the number of non-granulated mast cells (p<0,001). On the areas of fibrosis, we could observe a statistically signif icant difference (p<0,006) among the samples. In relation to the present mast cells in perivascular location, no statistically signif icant difference was found. On the morphological analysis there was a predominance of oval mast cells. It was concluded that despite of the fact there was a lesser quantity of mast cells present in cases of giant cell f ibroma, they appeared to have a stronger relation to the present giant fibroblasts in this lesions, around 59,62%, being also evidenced a strong relation between these cells and the fibrosis areas in both cases of giant cell f ibroma and f ibrous hyperplasias and samples of normal oral mucosa, used as control group in our study, confirming, this way, the role of the mast cells as fibrinogenous inductor |
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Santos, Pedro Paulo de Andradehttp://lattes.cnpq.br/2878739335493429http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787927Z7&dataRevisao=nullAndrade, Emanuel Savio de Souzahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4763194A9&dataRevisao=nullCosta, Antônio de Lisboa Lopeshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786083Z7&dataRevisao=nullSouza, Lélia Batista de2014-12-17T15:32:16Z2009-06-022014-12-17T15:32:16Z2008-02-27SANTOS, Pedro Paulo de Andrade. Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral. 2008. 147 f. Dissertação (Mestrado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2008.https://repositorio.ufrn.br/jspui/handle/123456789/17103The giant cell fibroma is a benign neoplasm characterized by the presence of mono, bi or multinucleate cells, which can have a connection to the presence of mast cells. This research aims to analyze, descriptively and comparatively, the immunohystochemistry expression of the tryptase in mast cells of the giant cell f ibroma, f ibrous hyperplasia and samples of the normal oral mucosa. Thirty cases of giant cell fibroma, ten cases of fibrous hyperplasia and ten cases of normal oral mucosa were selected for the analysis of the immunohistochemistry expression, determination of the number of present mast cells, as well as their location and shape. It could be stated that there was a statistically signif icant difference (p<0,001) in relation to the quantity of mast cells among other samples analyzed where the giant cell f ibroma presented lesser quantity of mast cell and the hyperplasia showed higher concentration of this cellular type. Although the oral mucosa has presented a higher quantity of mast cells when compared to the giant cells fibroma, these were found in usual locations in the connective tissue in normal tissues. There could be noticed a statistically significant difference in relation to the number of non-granulated mast cells (p<0,001). On the areas of fibrosis, we could observe a statistically signif icant difference (p<0,006) among the samples. In relation to the present mast cells in perivascular location, no statistically signif icant difference was found. On the morphological analysis there was a predominance of oval mast cells. It was concluded that despite of the fact there was a lesser quantity of mast cells present in cases of giant cell f ibroma, they appeared to have a stronger relation to the present giant fibroblasts in this lesions, around 59,62%, being also evidenced a strong relation between these cells and the fibrosis areas in both cases of giant cell f ibroma and f ibrous hyperplasias and samples of normal oral mucosa, used as control group in our study, confirming, this way, the role of the mast cells as fibrinogenous inductorO fibroma de células gigantes constitui-se de uma neoplasia benigna, caracterizada pela presença de células gigantes, mono, bi ou multinucleadas, células estas que podem guardar relação com a presença de mastócitos. O propósito desta pesquisa consistiu em analisar descritiva e comparativamente a expressão imuno-histoquímica da triptase em mastócitos de fibroma de células gigantes, hiperplasia fibrosa e espécimes de mucosa oral normal. Foram selecionados 30 casos de fibroma de células gigantes, 10 casos de hiperplasia fibrosa e 10 casos de mucosa oral normal, para a análise da expressão imuno-histoquímica, determinação do número de mastócitos presentes, bem como a sua forma e localização. Constatou-se diferença estatisticamente significativa (p<0,001) em relação a quantidade de mastócitos entre os espécimes analisados, onde o fibroma de células gigantes apresentou a menor quantidade de mastócitos e a hiperplasia exibiu a maior concentração deste tipo celular. Embora a mucosa oral tenha apresentado uma maior quantidade de mastócitos quando comparado com os casos de f ibroma de células gigantes, estes se encontravam em localizações usuais no tecido conjuntivo em tecidos normais. Verif icou-se, diferença estatisticamente significativa, no que diz respeito ao número de mastócitos não degranulados (p<0,001). Nas áreas de fibrose, observamos diferença estatisticamente signif icativa (p<0,006) entre os espécimes. Com relação aos mastócitos presentes em localização perivascular não se observou diferença estatisticamente significativa. Na análise morfológica verif icou-se uma predominância de mastócitos ovais. Concluiu-se que embora uma menor quantidade de mastócitos estivesse presente nos casos de fibroma de células gigantes, estes exibiam maior relação com os fibroblastos gigantes presentes nestas lesões em torno de 59,62%, sendo evidenciada também uma forte relação entre estas células e áreas de fibrose tanto nos casos de fibroma de células gigantes como de hiperplasias fibrosas e espécimes de mucosa oral normal, utilizados como controle em nosso estudo, confirmando desta forma, o papel dos mastócitos como indutor fibrinogênicoConselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal do Rio Grande do NortePrograma de Pós-Graduação em Patologia OralUFRNBROdontologiaMastócitosTriptaseFibroma de células gigantesHiperplasia fibrosaImuno-histoquímicaMast cellsTryptaseGiant Cell FibromaFibrousHyperplasiaImmunohistochemistryCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAExpressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oralinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALPedroPAS.pdfapplication/pdf6126862https://repositorio.ufrn.br/bitstream/123456789/17103/1/PedroPAS.pdf3ae3ec2483d9e09d3a05fcd73782e862MD51TEXTPedroPAS.pdf.txtPedroPAS.pdf.txtExtracted texttext/plain178761https://repositorio.ufrn.br/bitstream/123456789/17103/6/PedroPAS.pdf.txt35040c371770a685aa7d7da64c9598e1MD56THUMBNAILPedroPAS.pdf.jpgPedroPAS.pdf.jpgIM Thumbnailimage/jpeg2537https://repositorio.ufrn.br/bitstream/123456789/17103/7/PedroPAS.pdf.jpgfc8fb5b664f11a99482f86dcc17b121cMD57123456789/171032017-11-04 13:20:20.949oai:https://repositorio.ufrn.br:123456789/17103Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2017-11-04T16:20:20Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.por.fl_str_mv |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral |
title |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral |
spellingShingle |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral Santos, Pedro Paulo de Andrade Mastócitos Triptase Fibroma de células gigantes Hiperplasia fibrosa Imuno-histoquímica Mast cells Tryptase Giant Cell Fibroma Fibrous Hyperplasia Immunohistochemistry CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral |
title_full |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral |
title_fullStr |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral |
title_full_unstemmed |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral |
title_sort |
Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral |
author |
Santos, Pedro Paulo de Andrade |
author_facet |
Santos, Pedro Paulo de Andrade |
author_role |
author |
dc.contributor.authorID.por.fl_str_mv |
|
dc.contributor.authorLattes.por.fl_str_mv |
http://lattes.cnpq.br/2878739335493429 |
dc.contributor.advisorLattes.por.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787927Z7&dataRevisao=null |
dc.contributor.referees1.pt_BR.fl_str_mv |
Andrade, Emanuel Savio de Souza |
dc.contributor.referees1ID.por.fl_str_mv |
|
dc.contributor.referees1Lattes.por.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4763194A9&dataRevisao=null |
dc.contributor.referees2.pt_BR.fl_str_mv |
Costa, Antônio de Lisboa Lopes |
dc.contributor.referees2ID.por.fl_str_mv |
|
dc.contributor.referees2Lattes.por.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786083Z7&dataRevisao=null |
dc.contributor.author.fl_str_mv |
Santos, Pedro Paulo de Andrade |
dc.contributor.advisor1.fl_str_mv |
Souza, Lélia Batista de |
contributor_str_mv |
Souza, Lélia Batista de |
dc.subject.por.fl_str_mv |
Mastócitos Triptase Fibroma de células gigantes Hiperplasia fibrosa Imuno-histoquímica |
topic |
Mastócitos Triptase Fibroma de células gigantes Hiperplasia fibrosa Imuno-histoquímica Mast cells Tryptase Giant Cell Fibroma Fibrous Hyperplasia Immunohistochemistry CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Mast cells Tryptase Giant Cell Fibroma Fibrous Hyperplasia Immunohistochemistry |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
The giant cell fibroma is a benign neoplasm characterized by the presence of mono, bi or multinucleate cells, which can have a connection to the presence of mast cells. This research aims to analyze, descriptively and comparatively, the immunohystochemistry expression of the tryptase in mast cells of the giant cell f ibroma, f ibrous hyperplasia and samples of the normal oral mucosa. Thirty cases of giant cell fibroma, ten cases of fibrous hyperplasia and ten cases of normal oral mucosa were selected for the analysis of the immunohistochemistry expression, determination of the number of present mast cells, as well as their location and shape. It could be stated that there was a statistically signif icant difference (p<0,001) in relation to the quantity of mast cells among other samples analyzed where the giant cell f ibroma presented lesser quantity of mast cell and the hyperplasia showed higher concentration of this cellular type. Although the oral mucosa has presented a higher quantity of mast cells when compared to the giant cells fibroma, these were found in usual locations in the connective tissue in normal tissues. There could be noticed a statistically significant difference in relation to the number of non-granulated mast cells (p<0,001). On the areas of fibrosis, we could observe a statistically signif icant difference (p<0,006) among the samples. In relation to the present mast cells in perivascular location, no statistically signif icant difference was found. On the morphological analysis there was a predominance of oval mast cells. It was concluded that despite of the fact there was a lesser quantity of mast cells present in cases of giant cell f ibroma, they appeared to have a stronger relation to the present giant fibroblasts in this lesions, around 59,62%, being also evidenced a strong relation between these cells and the fibrosis areas in both cases of giant cell f ibroma and f ibrous hyperplasias and samples of normal oral mucosa, used as control group in our study, confirming, this way, the role of the mast cells as fibrinogenous inductor |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-02-27 |
dc.date.available.fl_str_mv |
2009-06-02 2014-12-17T15:32:16Z |
dc.date.accessioned.fl_str_mv |
2014-12-17T15:32:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Pedro Paulo de Andrade. Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral. 2008. 147 f. Dissertação (Mestrado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2008. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/17103 |
identifier_str_mv |
SANTOS, Pedro Paulo de Andrade. Expressão imuno-histoquímica da triptase em mastócitos nos fibromas de células gigantes e hiperplasias fibrosas de mucosa oral. 2008. 147 f. Dissertação (Mestrado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2008. |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/17103 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal do Rio Grande do Norte |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Patologia Oral |
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UFRN |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Odontologia |
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Universidade Federal do Rio Grande do Norte |
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