Association of BDNF Val66MET polymorphism with parkinson’s disease and depression and anxiety symptoms

• Autor(a) principal: Godeiro Junior, Clécio de Oliveira
• Data de Publicação: 2016
• Outros Autores: Cagni, Fernanda Carvalho, Campêlo, Clarissa Loureiro das Chagas, Coimbra, Daniel Gomes, Barbosa, Mayara Rodrigues, Oliveira Júnior, Luiz Gonzaga, Silva Neto, Antônio Braz, Ribeiro, Alessandra Mussi, Andrade, Tiago Gomes de, Silva, Regina Helena
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• DOI: https://doi.org/10.1176/appi.neuropsych.16040062
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/53060; https://doi.org/10.1176/appi.neuropsych.16040062
• topic: parkinson’s disease; genetics; depression; anxiety disorders (neuropsychiatric aspects)

Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects mainly dopaminergic neurons of the substantia nigra pars compacta (SNpc), leading to motor symptoms (tremor, bradykinesia, rigidity, and postural instability). PD also presents nonmotor symptoms, such as cognitive impairments and emotional disturbances (depression and anxiety). Although the direct cause is unknown, PD is a multifactorial disease influenced by environmental and genetic factors, with aging being the core predisposing factor.