Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/32110 |
Resumo: | Background: the preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. Material and Methods: the researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. Results: fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). Conclusions: the clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibular third molar removal was superior to ketorolac tromethamine’s |
id |
UFRN_81524f003d03c987985974f53c7cba9c |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/32110 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Martins-de-Barros, Allan ViníciusBarros, Ana Maria IpólitoSiqueira, Anna Karolline Cadengue deLucena, Eudes Euler de SouzaSette-de-Souza, Pedro HenriqueAraújo, Fábio Andrey da Costa2021-04-08T10:32:38Z2021-04-08T10:32:38Z2020MARTINS-DE-BARROS, Allan Vinícius; BARROS, Ana Maria Ipólito; SIQUEIRA, Anna Karolline Cadengue de; LUCENA, Eudes Euler de Souza; SETTE-DE-SOUZA, Pedro Henrique; ARAÚJO, Fábio Andrey da Costa. Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. Medicina Oral Patologia Oral y Cirugia Bucal, [s. l.], v. 28, p. 141-150, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33247572/#:~:text=Conclusions%3A%20The%20clinical%20performance%20of,was%20superior%20to%20ketorolac%20tromethamine's. Acesso em: 08 mar. 2021. http://dx.doi.org/10.4317/medoral.24088.1698-44471698-6946https://repositorio.ufrn.br/handle/123456789/3211010.4317/medoral.24088Medicina Oral S.LThird MolarAnti-inflammatory agentsDexamethasoneKetorolacIs Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground: the preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. Material and Methods: the researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. Results: fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). Conclusions: the clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibular third molar removal was superior to ketorolac tromethamine’sengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALDexamethasoneKetorolacPain_Lucena_2020.pdfDexamethasoneKetorolacPain_Lucena_2020.pdfapplication/pdf1680733https://repositorio.ufrn.br/bitstream/123456789/32110/1/DexamethasoneKetorolacPain_Lucena_2020.pdf74b813ffa5d1baad77b4c24b4278aca1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/32110/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52TEXTDexamethasoneKetorolacPain_Lucena_2020.pdf.txtDexamethasoneKetorolacPain_Lucena_2020.pdf.txtExtracted texttext/plain43928https://repositorio.ufrn.br/bitstream/123456789/32110/3/DexamethasoneKetorolacPain_Lucena_2020.pdf.txt5387f0f28fa7a493ed39c6575e68cab7MD53THUMBNAILDexamethasoneKetorolacPain_Lucena_2020.pdf.jpgDexamethasoneKetorolacPain_Lucena_2020.pdf.jpgGenerated Thumbnailimage/jpeg1562https://repositorio.ufrn.br/bitstream/123456789/32110/4/DexamethasoneKetorolacPain_Lucena_2020.pdf.jpged7978d9b0164521c9015697839716f2MD54123456789/321102021-04-11 06:06:29.786oai:https://repositorio.ufrn.br:123456789/32110Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKCkJ5IHNpZ25pbmcgYW5kIGRlbGl2ZXJpbmcgdGhpcyBsaWNlbnNlLCBNci4gKGF1dGhvciBvciBjb3B5cmlnaHQgaG9sZGVyKToKCgphKSBHcmFudHMgdGhlIFVuaXZlcnNpZGFkZSBGZWRlcmFsIFJpbyBHcmFuZGUgZG8gTm9ydGUgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgb2YKcmVwcm9kdWNlLCBjb252ZXJ0IChhcyBkZWZpbmVkIGJlbG93KSwgY29tbXVuaWNhdGUgYW5kIC8gb3IKZGlzdHJpYnV0ZSB0aGUgZGVsaXZlcmVkIGRvY3VtZW50IChpbmNsdWRpbmcgYWJzdHJhY3QgLyBhYnN0cmFjdCkgaW4KZGlnaXRhbCBvciBwcmludGVkIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bS4KCmIpIERlY2xhcmVzIHRoYXQgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBpdHMgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQKeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gRGVjbGFyZXMKdGhhdCB0aGUgZGVsaXZlcnkgb2YgdGhlIGRvY3VtZW50IGRvZXMgbm90IGluZnJpbmdlLCBhcyBmYXIgYXMgaXQgaXMKdGhlIHJpZ2h0cyBvZiBhbnkgb3RoZXIgcGVyc29uIG9yIGVudGl0eS4KCmMpIElmIHRoZSBkb2N1bWVudCBkZWxpdmVyZWQgY29udGFpbnMgbWF0ZXJpYWwgd2hpY2ggZG9lcyBub3QKcmlnaHRzLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBvYnRhaW5lZCBhdXRob3JpemF0aW9uIGZyb20gdGhlIGhvbGRlciBvZiB0aGUKY29weXJpZ2h0IHRvIGdyYW50IHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdCB0aGlzIG1hdGVyaWFsIHdob3NlIHJpZ2h0cyBhcmUgb2YKdGhpcmQgcGFydGllcyBpcyBjbGVhcmx5IGlkZW50aWZpZWQgYW5kIHJlY29nbml6ZWQgaW4gdGhlIHRleHQgb3IKY29udGVudCBvZiB0aGUgZG9jdW1lbnQgZGVsaXZlcmVkLgoKSWYgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBiYXNlZCBvbiBmdW5kZWQgb3Igc3VwcG9ydGVkIHdvcmsKYnkgYW5vdGhlciBpbnN0aXR1dGlvbiBvdGhlciB0aGFuIHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBmdWxmaWxsZWQgYW55IG9ibGlnYXRpb25zIHJlcXVpcmVkIGJ5IHRoZSByZXNwZWN0aXZlIGFncmVlbWVudCBvciBhZ3JlZW1lbnQuCgpUaGUgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBOb3J0ZSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgaXRzIG5hbWUgKHMpIGFzIHRoZSBhdXRob3IgKHMpIG9yIGhvbGRlciAocykgb2YgdGhlIGRvY3VtZW50J3MgcmlnaHRzCmRlbGl2ZXJlZCwgYW5kIHdpbGwgbm90IG1ha2UgYW55IGNoYW5nZXMsIG90aGVyIHRoYW4gdGhvc2UgcGVybWl0dGVkIGJ5CnRoaXMgbGljZW5zZQo=Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-04-11T09:06:29Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial |
title |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial |
spellingShingle |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial Martins-de-Barros, Allan Vinícius Third Molar Anti-inflammatory agents Dexamethasone Ketorolac |
title_short |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial |
title_full |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial |
title_fullStr |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial |
title_full_unstemmed |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial |
title_sort |
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial |
author |
Martins-de-Barros, Allan Vinícius |
author_facet |
Martins-de-Barros, Allan Vinícius Barros, Ana Maria Ipólito Siqueira, Anna Karolline Cadengue de Lucena, Eudes Euler de Souza Sette-de-Souza, Pedro Henrique Araújo, Fábio Andrey da Costa |
author_role |
author |
author2 |
Barros, Ana Maria Ipólito Siqueira, Anna Karolline Cadengue de Lucena, Eudes Euler de Souza Sette-de-Souza, Pedro Henrique Araújo, Fábio Andrey da Costa |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Martins-de-Barros, Allan Vinícius Barros, Ana Maria Ipólito Siqueira, Anna Karolline Cadengue de Lucena, Eudes Euler de Souza Sette-de-Souza, Pedro Henrique Araújo, Fábio Andrey da Costa |
dc.subject.por.fl_str_mv |
Third Molar Anti-inflammatory agents Dexamethasone Ketorolac |
topic |
Third Molar Anti-inflammatory agents Dexamethasone Ketorolac |
description |
Background: the preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. Material and Methods: the researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. Results: fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). Conclusions: the clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibular third molar removal was superior to ketorolac tromethamine’s |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-04-08T10:32:38Z |
dc.date.available.fl_str_mv |
2021-04-08T10:32:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MARTINS-DE-BARROS, Allan Vinícius; BARROS, Ana Maria Ipólito; SIQUEIRA, Anna Karolline Cadengue de; LUCENA, Eudes Euler de Souza; SETTE-DE-SOUZA, Pedro Henrique; ARAÚJO, Fábio Andrey da Costa. Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. Medicina Oral Patologia Oral y Cirugia Bucal, [s. l.], v. 28, p. 141-150, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33247572/#:~:text=Conclusions%3A%20The%20clinical%20performance%20of,was%20superior%20to%20ketorolac%20tromethamine's. Acesso em: 08 mar. 2021. http://dx.doi.org/10.4317/medoral.24088. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/32110 |
dc.identifier.issn.none.fl_str_mv |
1698-4447 1698-6946 |
dc.identifier.doi.none.fl_str_mv |
10.4317/medoral.24088 |
identifier_str_mv |
MARTINS-DE-BARROS, Allan Vinícius; BARROS, Ana Maria Ipólito; SIQUEIRA, Anna Karolline Cadengue de; LUCENA, Eudes Euler de Souza; SETTE-DE-SOUZA, Pedro Henrique; ARAÚJO, Fábio Andrey da Costa. Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. Medicina Oral Patologia Oral y Cirugia Bucal, [s. l.], v. 28, p. 141-150, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33247572/#:~:text=Conclusions%3A%20The%20clinical%20performance%20of,was%20superior%20to%20ketorolac%20tromethamine's. Acesso em: 08 mar. 2021. http://dx.doi.org/10.4317/medoral.24088. 1698-4447 1698-6946 10.4317/medoral.24088 |
url |
https://repositorio.ufrn.br/handle/123456789/32110 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Medicina Oral S.L |
publisher.none.fl_str_mv |
Medicina Oral S.L |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/32110/1/DexamethasoneKetorolacPain_Lucena_2020.pdf https://repositorio.ufrn.br/bitstream/123456789/32110/2/license.txt https://repositorio.ufrn.br/bitstream/123456789/32110/3/DexamethasoneKetorolacPain_Lucena_2020.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/32110/4/DexamethasoneKetorolacPain_Lucena_2020.pdf.jpg |
bitstream.checksum.fl_str_mv |
74b813ffa5d1baad77b4c24b4278aca1 e9597aa2854d128fd968be5edc8a28d9 5387f0f28fa7a493ed39c6575e68cab7 ed7978d9b0164521c9015697839716f2 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117908336214016 |