Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54318 |
Resumo: | The diagnosis of liver cirrhosis in patients with chronic hepatitis C has not always been easy, since the gold standard method is the liver biopsy, which is an invasive procedure with interobserver accuracy problems and there have been reports of complications including records of deaths due to hemoperitoneum. Cirrhosis changes the prognosis of the subject with hepatitis C and requires a different clinical management. This study aimed to identify clinical and laboratory variables associated with the diagnosis of cirrhosis in the ultrasonography of patients infected with hepatitis C. In a case-control study, we evaluated 70 cirrhotic patients with chronic hepatitis C compared to a control group of 70 non-cirrhotic people with positive HCV. The results showed, through logistic regression analysis, that the variables blood donor and professional athlete, adjusted for alcohol consumption, showed OR 0.24 and 0.18, with p values of 0.044 and 0.035, respectively. We conclude that the diagnosis of cirrhosis in patients with chronic hepatitis C remains challenging, but the patients with the condition of blood donor or professional athlete prove to be less likely to cirrhosis in ultrasonography in the initial consultation. |
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Oliveira, Lucila Samara Dantas deSousa, Gilmar Amorim deCosta, Iris do Céu ClaraSouza, Dyego Leandro Bezerra deAndrade, Fabia Barbosa deCelani, Lívia Medeiros SoaresPessoa, Ranna SantosSouza Filho, Marlon César deOliveira, Daniel Fernandes Mello deMedeiros, Luana Lopes deMonteiro, Maria Flávia2023-08-01T16:53:39Z2023-08-01T16:53:39Z2015OLIVEIRA, Lucila Samara Dantas de: SOUSA, Gilmar Amorim de; COSTA, Iris do Céu Clara; SOUZA, Dyego Leandro Bezerra de; ANDRADE, Fabia Barbosa de; CELANI, Lívia Medeiros Soares; PESSOA, Ranna Santos; SOUZA FILHO, Marlon César de; OLIVEIRA, Daniel Fernandes Mello de; MEDEIROS, Luana Lopes de. Variables Associated with Cirrhosis Diagnosis in Patients with Chronic Hepatitis C: a case-control study. Health, [S.L.], v. 07, n. 12, p. 1634-1641, 2015. Scientific Research Publishing, Inc.. http://dx.doi.org/10.4236/health.2015.712176. Disponível em: https://www.scirp.org/journal/paperinformation.aspx?paperid=61789. Acesso em: 25 jul. 2023.https://repositorio.ufrn.br/handle/123456789/5431810.4236/health.2015.712176HealthAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccesscirrhosisbiomakersfibrosishepatitis c virusclinical diagnosisbiopsyultrasonographyVariables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe diagnosis of liver cirrhosis in patients with chronic hepatitis C has not always been easy, since the gold standard method is the liver biopsy, which is an invasive procedure with interobserver accuracy problems and there have been reports of complications including records of deaths due to hemoperitoneum. Cirrhosis changes the prognosis of the subject with hepatitis C and requires a different clinical management. This study aimed to identify clinical and laboratory variables associated with the diagnosis of cirrhosis in the ultrasonography of patients infected with hepatitis C. In a case-control study, we evaluated 70 cirrhotic patients with chronic hepatitis C compared to a control group of 70 non-cirrhotic people with positive HCV. The results showed, through logistic regression analysis, that the variables blood donor and professional athlete, adjusted for alcohol consumption, showed OR 0.24 and 0.18, with p values of 0.044 and 0.035, respectively. We conclude that the diagnosis of cirrhosis in patients with chronic hepatitis C remains challenging, but the patients with the condition of blood donor or professional athlete prove to be less likely to cirrhosis in ultrasonography in the initial consultation.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALVariablesAssociatedCirrhosis_Oliveira_2015.pdfVariablesAssociatedCirrhosis_Oliveira_2015.pdfapplication/pdf310107https://repositorio.ufrn.br/bitstream/123456789/54318/1/VariablesAssociatedCirrhosis_Oliveira_2015.pdf1b8407a1fec4c17785ba6e34e20c65eaMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54318/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/54318/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52123456789/543182023-08-01 13:53:40.259oai:https://repositorio.ufrn.br:123456789/54318Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKCkJ5IHNpZ25pbmcgYW5kIGRlbGl2ZXJpbmcgdGhpcyBsaWNlbnNlLCBNci4gKGF1dGhvciBvciBjb3B5cmlnaHQgaG9sZGVyKToKCgphKSBHcmFudHMgdGhlIFVuaXZlcnNpZGFkZSBGZWRlcmFsIFJpbyBHcmFuZGUgZG8gTm9ydGUgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgb2YKcmVwcm9kdWNlLCBjb252ZXJ0IChhcyBkZWZpbmVkIGJlbG93KSwgY29tbXVuaWNhdGUgYW5kIC8gb3IKZGlzdHJpYnV0ZSB0aGUgZGVsaXZlcmVkIGRvY3VtZW50IChpbmNsdWRpbmcgYWJzdHJhY3QgLyBhYnN0cmFjdCkgaW4KZGlnaXRhbCBvciBwcmludGVkIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bS4KCmIpIERlY2xhcmVzIHRoYXQgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBpdHMgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQKeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gRGVjbGFyZXMKdGhhdCB0aGUgZGVsaXZlcnkgb2YgdGhlIGRvY3VtZW50IGRvZXMgbm90IGluZnJpbmdlLCBhcyBmYXIgYXMgaXQgaXMKdGhlIHJpZ2h0cyBvZiBhbnkgb3RoZXIgcGVyc29uIG9yIGVudGl0eS4KCmMpIElmIHRoZSBkb2N1bWVudCBkZWxpdmVyZWQgY29udGFpbnMgbWF0ZXJpYWwgd2hpY2ggZG9lcyBub3QKcmlnaHRzLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBvYnRhaW5lZCBhdXRob3JpemF0aW9uIGZyb20gdGhlIGhvbGRlciBvZiB0aGUKY29weXJpZ2h0IHRvIGdyYW50IHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdCB0aGlzIG1hdGVyaWFsIHdob3NlIHJpZ2h0cyBhcmUgb2YKdGhpcmQgcGFydGllcyBpcyBjbGVhcmx5IGlkZW50aWZpZWQgYW5kIHJlY29nbml6ZWQgaW4gdGhlIHRleHQgb3IKY29udGVudCBvZiB0aGUgZG9jdW1lbnQgZGVsaXZlcmVkLgoKSWYgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBiYXNlZCBvbiBmdW5kZWQgb3Igc3VwcG9ydGVkIHdvcmsKYnkgYW5vdGhlciBpbnN0aXR1dGlvbiBvdGhlciB0aGFuIHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBmdWxmaWxsZWQgYW55IG9ibGlnYXRpb25zIHJlcXVpcmVkIGJ5IHRoZSByZXNwZWN0aXZlIGFncmVlbWVudCBvciBhZ3JlZW1lbnQuCgpUaGUgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBOb3J0ZSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgaXRzIG5hbWUgKHMpIGFzIHRoZSBhdXRob3IgKHMpIG9yIGhvbGRlciAocykgb2YgdGhlIGRvY3VtZW50J3MgcmlnaHRzCmRlbGl2ZXJlZCwgYW5kIHdpbGwgbm90IG1ha2UgYW55IGNoYW5nZXMsIG90aGVyIHRoYW4gdGhvc2UgcGVybWl0dGVkIGJ5CnRoaXMgbGljZW5zZQo=Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-08-01T16:53:40Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study |
title |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study |
spellingShingle |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study Oliveira, Lucila Samara Dantas de cirrhosis biomakers fibrosis hepatitis c virus clinical diagnosis biopsy ultrasonography |
title_short |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study |
title_full |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study |
title_fullStr |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study |
title_full_unstemmed |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study |
title_sort |
Variables associated with cirrhosis diagnosis in patients with chronic hepatitis C: a case-control study |
author |
Oliveira, Lucila Samara Dantas de |
author_facet |
Oliveira, Lucila Samara Dantas de Sousa, Gilmar Amorim de Costa, Iris do Céu Clara Souza, Dyego Leandro Bezerra de Andrade, Fabia Barbosa de Celani, Lívia Medeiros Soares Pessoa, Ranna Santos Souza Filho, Marlon César de Oliveira, Daniel Fernandes Mello de Medeiros, Luana Lopes de Monteiro, Maria Flávia |
author_role |
author |
author2 |
Sousa, Gilmar Amorim de Costa, Iris do Céu Clara Souza, Dyego Leandro Bezerra de Andrade, Fabia Barbosa de Celani, Lívia Medeiros Soares Pessoa, Ranna Santos Souza Filho, Marlon César de Oliveira, Daniel Fernandes Mello de Medeiros, Luana Lopes de Monteiro, Maria Flávia |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Lucila Samara Dantas de Sousa, Gilmar Amorim de Costa, Iris do Céu Clara Souza, Dyego Leandro Bezerra de Andrade, Fabia Barbosa de Celani, Lívia Medeiros Soares Pessoa, Ranna Santos Souza Filho, Marlon César de Oliveira, Daniel Fernandes Mello de Medeiros, Luana Lopes de Monteiro, Maria Flávia |
dc.subject.por.fl_str_mv |
cirrhosis biomakers fibrosis hepatitis c virus clinical diagnosis biopsy ultrasonography |
topic |
cirrhosis biomakers fibrosis hepatitis c virus clinical diagnosis biopsy ultrasonography |
description |
The diagnosis of liver cirrhosis in patients with chronic hepatitis C has not always been easy, since the gold standard method is the liver biopsy, which is an invasive procedure with interobserver accuracy problems and there have been reports of complications including records of deaths due to hemoperitoneum. Cirrhosis changes the prognosis of the subject with hepatitis C and requires a different clinical management. This study aimed to identify clinical and laboratory variables associated with the diagnosis of cirrhosis in the ultrasonography of patients infected with hepatitis C. In a case-control study, we evaluated 70 cirrhotic patients with chronic hepatitis C compared to a control group of 70 non-cirrhotic people with positive HCV. The results showed, through logistic regression analysis, that the variables blood donor and professional athlete, adjusted for alcohol consumption, showed OR 0.24 and 0.18, with p values of 0.044 and 0.035, respectively. We conclude that the diagnosis of cirrhosis in patients with chronic hepatitis C remains challenging, but the patients with the condition of blood donor or professional athlete prove to be less likely to cirrhosis in ultrasonography in the initial consultation. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2023-08-01T16:53:39Z |
dc.date.available.fl_str_mv |
2023-08-01T16:53:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Lucila Samara Dantas de: SOUSA, Gilmar Amorim de; COSTA, Iris do Céu Clara; SOUZA, Dyego Leandro Bezerra de; ANDRADE, Fabia Barbosa de; CELANI, Lívia Medeiros Soares; PESSOA, Ranna Santos; SOUZA FILHO, Marlon César de; OLIVEIRA, Daniel Fernandes Mello de; MEDEIROS, Luana Lopes de. Variables Associated with Cirrhosis Diagnosis in Patients with Chronic Hepatitis C: a case-control study. Health, [S.L.], v. 07, n. 12, p. 1634-1641, 2015. Scientific Research Publishing, Inc.. http://dx.doi.org/10.4236/health.2015.712176. Disponível em: https://www.scirp.org/journal/paperinformation.aspx?paperid=61789. Acesso em: 25 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54318 |
dc.identifier.doi.none.fl_str_mv |
10.4236/health.2015.712176 |
identifier_str_mv |
OLIVEIRA, Lucila Samara Dantas de: SOUSA, Gilmar Amorim de; COSTA, Iris do Céu Clara; SOUZA, Dyego Leandro Bezerra de; ANDRADE, Fabia Barbosa de; CELANI, Lívia Medeiros Soares; PESSOA, Ranna Santos; SOUZA FILHO, Marlon César de; OLIVEIRA, Daniel Fernandes Mello de; MEDEIROS, Luana Lopes de. Variables Associated with Cirrhosis Diagnosis in Patients with Chronic Hepatitis C: a case-control study. Health, [S.L.], v. 07, n. 12, p. 1634-1641, 2015. Scientific Research Publishing, Inc.. http://dx.doi.org/10.4236/health.2015.712176. Disponível em: https://www.scirp.org/journal/paperinformation.aspx?paperid=61789. Acesso em: 25 jul. 2023. 10.4236/health.2015.712176 |
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https://repositorio.ufrn.br/handle/123456789/54318 |
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eng |
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Health |
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Health |
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