Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54206 |
Resumo: | Background:Little information is available regarding the incidence and clinical outcome of the SARS-CoV2 infection in patients with multiple sclerosis (pwMS). Objective:To determine the incidence, clinical outcome, and impact of COVID-19 on pwMS. Methods:This observational study was prospectively performed on a cohort of pwMS (N = 11,560) followed up by 47 out of 51 Brazilian MS referral centers that registered pwMS with COVID-19 at the REDONE platform from 13 March to 4 June 2020. Results:The incidence of COVID-19 for pwMS patients was 27.7/10,000 patients and for the general population was 29.2/10,000 inhabitants. A total of 94 (77 women) pwMS patients, aged 40 ± 10.25 years, presenting 9.9 ± 8.6 years of MS disease duration, developed the COVID-19, most of them (87%) exhibited the mild form of the disease. Eighty (96%) patients maintained the use of MS disease-modifying treatment (DMT) during COVID-19 pandemic and 14 patients were not in use of DMTs. Conclusion:Incidence of COVID-19 in Brazilian pwMS was not different from those observed for the general Brazilian population. Most pwMS exhibited mild COVID-19, despite the maintenance of the underlying MS treatment. |
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Dourado Junior, Mário Emílio TeixeiraFerreira, Lis CamposSousa, Nise Alessandra de Carvalhohttps://orcid.org/0000-0002-9462-22942023-07-26T18:18:43Z2023-07-26T18:18:43Z2021DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Lis Campos; SOUSA, Nise Alessandra de Carvalho; FERREIRA, Maria Lucia Brito; DIAS-CARNEIRO, Rafael Paternò Castello; MENDES, Maria Fernanda; PICCOLO, Ana Claudia; THOMAZ, Rodrigo Barbosa; VASCONCELOS, Claudia Cristina Ferreira; ALVES-LEON, Soniza Vieira. Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 Brazilian patients with multiple sclerosis. Multiple Sclerosis Journal, [S.L.], v. 27, n. 10, p. 1615-1619, 2 fev. 2021. SAGE Publications. http://dx.doi.org/10.1177/1352458520978354. Disponível em: https://journals.sagepub.com/doi/10.1177/1352458520978354. Acesso em: 14 jul. 2023.https://repositorio.ufrn.br/handle/123456789/5420610.1177/1352458520978354Multiple Sclerosis Journalmultiple sclerosiscovid-19virus infection sars-cov2Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground:Little information is available regarding the incidence and clinical outcome of the SARS-CoV2 infection in patients with multiple sclerosis (pwMS). Objective:To determine the incidence, clinical outcome, and impact of COVID-19 on pwMS. Methods:This observational study was prospectively performed on a cohort of pwMS (N = 11,560) followed up by 47 out of 51 Brazilian MS referral centers that registered pwMS with COVID-19 at the REDONE platform from 13 March to 4 June 2020. Results:The incidence of COVID-19 for pwMS patients was 27.7/10,000 patients and for the general population was 29.2/10,000 inhabitants. A total of 94 (77 women) pwMS patients, aged 40 ± 10.25 years, presenting 9.9 ± 8.6 years of MS disease duration, developed the COVID-19, most of them (87%) exhibited the mild form of the disease. Eighty (96%) patients maintained the use of MS disease-modifying treatment (DMT) during COVID-19 pandemic and 14 patients were not in use of DMTs. Conclusion:Incidence of COVID-19 in Brazilian pwMS was not different from those observed for the general Brazilian population. Most pwMS exhibited mild COVID-19, despite the maintenance of the underlying MS treatment.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALIncidenceClinicalOutcome_DouradoJr_2021.pdfIncidenceClinicalOutcome_DouradoJr_2021.pdfapplication/pdf321973https://repositorio.ufrn.br/bitstream/123456789/54206/1/IncidenceClinicalOutcome_DouradoJr_2021.pdf9394bf73d7632099122d47c1c261613cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54206/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/542062023-07-26 15:18:43.723oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-26T18:18:43Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis |
title |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis |
spellingShingle |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis Dourado Junior, Mário Emílio Teixeira multiple sclerosis covid-19 virus infection sars-cov2 |
title_short |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis |
title_full |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis |
title_fullStr |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis |
title_full_unstemmed |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis |
title_sort |
Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis |
author |
Dourado Junior, Mário Emílio Teixeira |
author_facet |
Dourado Junior, Mário Emílio Teixeira Ferreira, Lis Campos Sousa, Nise Alessandra de Carvalho |
author_role |
author |
author2 |
Ferreira, Lis Campos Sousa, Nise Alessandra de Carvalho |
author2_role |
author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-9462-2294 |
dc.contributor.author.fl_str_mv |
Dourado Junior, Mário Emílio Teixeira Ferreira, Lis Campos Sousa, Nise Alessandra de Carvalho |
dc.subject.por.fl_str_mv |
multiple sclerosis covid-19 virus infection sars-cov2 |
topic |
multiple sclerosis covid-19 virus infection sars-cov2 |
description |
Background:Little information is available regarding the incidence and clinical outcome of the SARS-CoV2 infection in patients with multiple sclerosis (pwMS). Objective:To determine the incidence, clinical outcome, and impact of COVID-19 on pwMS. Methods:This observational study was prospectively performed on a cohort of pwMS (N = 11,560) followed up by 47 out of 51 Brazilian MS referral centers that registered pwMS with COVID-19 at the REDONE platform from 13 March to 4 June 2020. Results:The incidence of COVID-19 for pwMS patients was 27.7/10,000 patients and for the general population was 29.2/10,000 inhabitants. A total of 94 (77 women) pwMS patients, aged 40 ± 10.25 years, presenting 9.9 ± 8.6 years of MS disease duration, developed the COVID-19, most of them (87%) exhibited the mild form of the disease. Eighty (96%) patients maintained the use of MS disease-modifying treatment (DMT) during COVID-19 pandemic and 14 patients were not in use of DMTs. Conclusion:Incidence of COVID-19 in Brazilian pwMS was not different from those observed for the general Brazilian population. Most pwMS exhibited mild COVID-19, despite the maintenance of the underlying MS treatment. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-07-26T18:18:43Z |
dc.date.available.fl_str_mv |
2023-07-26T18:18:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Lis Campos; SOUSA, Nise Alessandra de Carvalho; FERREIRA, Maria Lucia Brito; DIAS-CARNEIRO, Rafael Paternò Castello; MENDES, Maria Fernanda; PICCOLO, Ana Claudia; THOMAZ, Rodrigo Barbosa; VASCONCELOS, Claudia Cristina Ferreira; ALVES-LEON, Soniza Vieira. Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 Brazilian patients with multiple sclerosis. Multiple Sclerosis Journal, [S.L.], v. 27, n. 10, p. 1615-1619, 2 fev. 2021. SAGE Publications. http://dx.doi.org/10.1177/1352458520978354. Disponível em: https://journals.sagepub.com/doi/10.1177/1352458520978354. Acesso em: 14 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54206 |
dc.identifier.doi.none.fl_str_mv |
10.1177/1352458520978354 |
identifier_str_mv |
DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Lis Campos; SOUSA, Nise Alessandra de Carvalho; FERREIRA, Maria Lucia Brito; DIAS-CARNEIRO, Rafael Paternò Castello; MENDES, Maria Fernanda; PICCOLO, Ana Claudia; THOMAZ, Rodrigo Barbosa; VASCONCELOS, Claudia Cristina Ferreira; ALVES-LEON, Soniza Vieira. Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 Brazilian patients with multiple sclerosis. Multiple Sclerosis Journal, [S.L.], v. 27, n. 10, p. 1615-1619, 2 fev. 2021. SAGE Publications. http://dx.doi.org/10.1177/1352458520978354. Disponível em: https://journals.sagepub.com/doi/10.1177/1352458520978354. Acesso em: 14 jul. 2023. 10.1177/1352458520978354 |
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https://repositorio.ufrn.br/handle/123456789/54206 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Multiple Sclerosis Journal |
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Multiple Sclerosis Journal |
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