Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias

• Autor(a) principal: Carvalho, Marianne de Vasconcelos
• Data de Publicação: 2010
• Outros Autores: Pereira, Joabe dos Santos, Costa, Antonio de Lisboa Lopes, Souza, Lelia Batista de, Freitas, Roseana de Almeida, Miguel, Marcia Cristina da Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/21793
• topic: Oral epithelial dysplasia; Claudin-1; Tight junctions; Immunohistochemical; Potentially malignant lesion

Claudins are transmembrane proteins that play a role in cell proliferation and adhesion and tumourigenesis. This study evaluated the immunoexpression of claudin-1 in the oral epithelial dysplasia (OED) (19 mild, 26 moderate, 3 severe). Diffuse staining predominated in mild (89.4%) and moderate (80.8%) OEDs. Immunoexpression in the middle and upper third was observed in all mild cases, whereas in moderate/severe dysplasias staining was observed in the upper third in 41.4% of cases, in the upper and middle third in 41.4%, and in the upper, middle and lower third in 17.2% (P<0.05). All mild OEDs and 73.1% of moderate cases presented only membrane staining, whereas membrane/cytoplasmic staining was observed in severe cases. Staining intensity was weak in 60% of parakeratinized OEDs and moderate/strong in orthokeratinized OEDs (60.8%) (P>0.05). The differences in the immunoexpression of claudin-1 between different grades of OEDs suggest the involvement of this protein in the progression of dysplasias.