Behavioral and neurochemical effects of alpha lipoic acid associated with omega-3 in tardive dyskinesia induced by chronic haloperidol in rats

• Autor(a) principal: Araújo, Dayane Pessoa de
• Data de Publicação: 2017
• Outros Autores: Camboim, Thaisa Gracielle Martins, Silva, Ana Patrícia Magalhães, Silva, Caio da Fonseca, Sousa, Rebeca Canuto de, Barbosa, Mabson Delâno Alves, Oliveira, Lucidio Clebeson, Cavalcanti, José Rodolfo Lopes de Paiva, Lucena, Eudes Euler de Souza, Guzen, Fausto Pierdoná
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/31764
• topic: Lipoic acid; Omega-3; Tardive dyskinesia; Haloperidol; Oxidative stress; Acide lipoïque; Oméga 3; Dyskinésie tardive; Halopéridol; Stress oxydatif

Tardive dyskinesia (TD) is characterized by involuntary movements of the lower portion of the face being related to typical antipsychotic therapy. TD is associated with the oxidative imbalance in the basal ganglia. Lipoic acid (LA) and omega-3 (-3) are antioxidants acting as enzyme cofactors, regenerating antioxidant enzymes. This study aimed to investigate behavioral and neurochemical effects of supplementation with LA (100 mg/kg) and -3 (1 g/kg) in the treatment of TD induced by chronic use of haloperidol (HAL) (1 mg/kg) in rats. Wistar male rats were used, weighing between 180–200 g. The animals were treated chronically (31 days) with LA alone or associated with HAL or -3. Motor behavior was assessed by open-field test, the catalepsy test, and evaluation of orofacial dyskinesia. Oxidative stress was accessed by determination of lipid peroxidation and concentration of nitrite. LA and -3 alone or associated caused an improvement in motor performance by increasing locomotor activity in the open-field test and decreased the permanence time on the bar in the catalepsy test and decreased the orofacial dyskinesia. LA and -3 showed antioxidant effects, decreasing lipid peroxidation and nitrite levels. Thus, the use of LA associated with -3 reduced the extrapyramidal effects produced by chronic use of HAL