Whole organisms or pure compounds? entourage effect versus drug specificity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFRN |
| Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/25464 https://doi.org/10.1007/978-3-319-76720-8_8 |
Resumo: | 2019-07-30 |
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Ribeiro, Sidarta Tollendal Gomes2018-06-19T14:54:49Z2018-04-29RIBEIRO S. Whole organisms or pure compounds? entourage effect versus drug specificity. In: LABATE, B.; CAVNAR, C. (Eds). Plant medicines, healing and psychedelic science. Springer, Cham, 2018. p. 133-149.https://repositorio.ufrn.br/jspui/handle/123456789/25464https://doi.org/10.1007/978-3-319-76720-8_8engbanisteriopsisayahuascahallucinogenspsychedelicsWhole organisms or pure compounds? entourage effect versus drug specificityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2019-07-30As the therapeutic use of sacred plants and fungi becomes increasingly accepted by Western medicine, a tug of war has been taking place between those who advocate the traditional consumption of whole organisms and those who defend exclusively the utilization of purified compounds. The attempt to reduce organisms to single active principles is challenged by the sheer complexity of traditional medicine. Ayahuasca, for example, is a concoction of at least two plant species containing multiple psychoactive substances with complex interactions. Similarly, cannabis contains dozens of psychoactive substances whose specific combinations in different strains correspond to different types of therapeutic and cognitive effects. The “entourage effect” refers to the synergistic effects of the multiple compounds present in whole organisms, which may potentiate clinical efficacy while attenuating side effects. In opposition to this view, mainstream pharmacology is adamant about the need to use purified substances, presumably more specific and safe. In this chapter, I will review the evidence on both sides to discuss the scientific, economic, and political implications of this controversy. The evidence indicates that it is time to embrace the therapeutic complexity of psychedelics.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALSidartaRibeiro_ICe_Whole organisms_2018.pdfSidartaRibeiro_ICe_Whole organisms_2018.pdfSidartaRibeiro_ICe_Whole organisms_2018application/pdf323346https://repositorio.ufrn.br/bitstream/123456789/25464/1/SidartaRibeiro_ICe_Whole%20organisms_2018.pdfe563cd1b9d6708ca70e6ae8f7d0ef579MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25464/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTSidartaRibeiro_ICe_Whole organisms_2018.pdf.txtSidartaRibeiro_ICe_Whole organisms_2018.pdf.txtExtracted texttext/plain58351https://repositorio.ufrn.br/bitstream/123456789/25464/3/SidartaRibeiro_ICe_Whole%20organisms_2018.pdf.txt4a6898f037879048418bfb967dbfa8d7MD53THUMBNAILSidartaRibeiro_ICe_Whole organisms_2018.pdf.jpgSidartaRibeiro_ICe_Whole organisms_2018.pdf.jpgIM Thumbnailimage/jpeg7463https://repositorio.ufrn.br/bitstream/123456789/25464/4/SidartaRibeiro_ICe_Whole%20organisms_2018.pdf.jpgf04a474ad4ac80097ba2f776358b30acMD54123456789/254642024-03-19 01:04:54.887oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-03-19T04:04:54Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
| dc.title.pt_BR.fl_str_mv |
Whole organisms or pure compounds? entourage effect versus drug specificity |
| title |
Whole organisms or pure compounds? entourage effect versus drug specificity |
| spellingShingle |
Whole organisms or pure compounds? entourage effect versus drug specificity Ribeiro, Sidarta Tollendal Gomes banisteriopsis ayahuasca hallucinogens psychedelics |
| title_short |
Whole organisms or pure compounds? entourage effect versus drug specificity |
| title_full |
Whole organisms or pure compounds? entourage effect versus drug specificity |
| title_fullStr |
Whole organisms or pure compounds? entourage effect versus drug specificity |
| title_full_unstemmed |
Whole organisms or pure compounds? entourage effect versus drug specificity |
| title_sort |
Whole organisms or pure compounds? entourage effect versus drug specificity |
| author |
Ribeiro, Sidarta Tollendal Gomes |
| author_facet |
Ribeiro, Sidarta Tollendal Gomes |
| author_role |
author |
| dc.contributor.author.fl_str_mv |
Ribeiro, Sidarta Tollendal Gomes |
| dc.subject.por.fl_str_mv |
banisteriopsis ayahuasca hallucinogens psychedelics |
| topic |
banisteriopsis ayahuasca hallucinogens psychedelics |
| description |
2019-07-30 |
| publishDate |
2018 |
| dc.date.accessioned.fl_str_mv |
2018-06-19T14:54:49Z |
| dc.date.issued.fl_str_mv |
2018-04-29 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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RIBEIRO S. Whole organisms or pure compounds? entourage effect versus drug specificity. In: LABATE, B.; CAVNAR, C. (Eds). Plant medicines, healing and psychedelic science. Springer, Cham, 2018. p. 133-149. |
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https://repositorio.ufrn.br/jspui/handle/123456789/25464 |
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https://doi.org/10.1007/978-3-319-76720-8_8 |
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RIBEIRO S. Whole organisms or pure compounds? entourage effect versus drug specificity. In: LABATE, B.; CAVNAR, C. (Eds). Plant medicines, healing and psychedelic science. Springer, Cham, 2018. p. 133-149. |
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https://repositorio.ufrn.br/jspui/handle/123456789/25464 https://doi.org/10.1007/978-3-319-76720-8_8 |
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