Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Detalhes bibliográficos
Autor(a) principal: Osório, Flávia de L.
Data de Publicação: 2015
Outros Autores: Sanches, Rafael F., Macedo, Ligia R., Santos, Rafael G. dos, Maia-de-Oliveira, João P., Wichert-Ana, Lauro, Araújo, Dráulio Barros de, Riba, Jordi, Crippa, José A., Hallak, Jaime E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/23117
Resumo: Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.
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spelling Osório, Flávia de L.Sanches, Rafael F.Macedo, Ligia R.Santos, Rafael G. dosMaia-de-Oliveira, João P.Wichert-Ana, LauroAraújo, Dráulio Barros deRiba, JordiCrippa, José A.Hallak, Jaime E.2017-05-26T14:01:34Z2017-05-26T14:01:34Z2015OSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015.https://repositorio.ufrn.br/jspui/handle/123456789/2311710.1590/1516-4446-2014-1496engpsychedelic agentsdimethyltryptamineharminemonoamine oxidase inhibitorsmonoamine oxidase inhibitorstherapeutic useAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObjectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. 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dc.title.pt_BR.fl_str_mv Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
title Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
spellingShingle Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
Osório, Flávia de L.
psychedelic agents
dimethyltryptamine
harmine
monoamine oxidase inhibitors
monoamine oxidase inhibitors
therapeutic use
title_short Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
title_full Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
title_fullStr Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
title_full_unstemmed Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
title_sort Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
author Osório, Flávia de L.
author_facet Osório, Flávia de L.
Sanches, Rafael F.
Macedo, Ligia R.
Santos, Rafael G. dos
Maia-de-Oliveira, João P.
Wichert-Ana, Lauro
Araújo, Dráulio Barros de
Riba, Jordi
Crippa, José A.
Hallak, Jaime E.
author_role author
author2 Sanches, Rafael F.
Macedo, Ligia R.
Santos, Rafael G. dos
Maia-de-Oliveira, João P.
Wichert-Ana, Lauro
Araújo, Dráulio Barros de
Riba, Jordi
Crippa, José A.
Hallak, Jaime E.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Osório, Flávia de L.
Sanches, Rafael F.
Macedo, Ligia R.
Santos, Rafael G. dos
Maia-de-Oliveira, João P.
Wichert-Ana, Lauro
Araújo, Dráulio Barros de
Riba, Jordi
Crippa, José A.
Hallak, Jaime E.
dc.subject.por.fl_str_mv psychedelic agents
dimethyltryptamine
harmine
monoamine oxidase inhibitors
monoamine oxidase inhibitors
therapeutic use
topic psychedelic agents
dimethyltryptamine
harmine
monoamine oxidase inhibitors
monoamine oxidase inhibitors
therapeutic use
description Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-05-26T14:01:34Z
dc.date.available.fl_str_mv 2017-05-26T14:01:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv OSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/23117
dc.identifier.doi.none.fl_str_mv 10.1590/1516-4446-2014-1496
identifier_str_mv OSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015.
10.1590/1516-4446-2014-1496
url https://repositorio.ufrn.br/jspui/handle/123456789/23117
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