Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23117 |
Resumo: | Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder. |
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Osório, Flávia de L.Sanches, Rafael F.Macedo, Ligia R.Santos, Rafael G. dosMaia-de-Oliveira, João P.Wichert-Ana, LauroAraújo, Dráulio Barros deRiba, JordiCrippa, José A.Hallak, Jaime E.2017-05-26T14:01:34Z2017-05-26T14:01:34Z2015OSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015.https://repositorio.ufrn.br/jspui/handle/123456789/2311710.1590/1516-4446-2014-1496engpsychedelic agentsdimethyltryptamineharminemonoamine oxidase inhibitorsmonoamine oxidase inhibitorstherapeutic useAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObjectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdfAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdfDraulioAraujo_ICe_Antidepressant effects_2015application/pdf198924https://repositorio.ufrn.br/bitstream/123456789/23117/1/Antidepressant%20effects%20of%20a%20single%20dose%20of%20ayahuasca%20in%20patients%20with%20recurrent%20depression.pdf78be9a07f93943a72e16e8b3e1495786MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23117/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdf.txtAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdf.txtExtracted texttext/plain36245https://repositorio.ufrn.br/bitstream/123456789/23117/5/Antidepressant%20effects%20of%20a%20single%20dose%20of%20ayahuasca%20in%20patients%20with%20recurrent%20depression.pdf.txtc8aca2cc1e3a0131530cc8064583668dMD55THUMBNAILAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdf.jpgAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdf.jpgIM Thumbnailimage/jpeg8274https://repositorio.ufrn.br/bitstream/123456789/23117/6/Antidepressant%20effects%20of%20a%20single%20dose%20of%20ayahuasca%20in%20patients%20with%20recurrent%20depression.pdf.jpg77fbd32e6b0c152451fc23b66c96e485MD56123456789/231172021-07-08 15:40:30.345oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T18:40:30Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report |
title |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report |
spellingShingle |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report Osório, Flávia de L. psychedelic agents dimethyltryptamine harmine monoamine oxidase inhibitors monoamine oxidase inhibitors therapeutic use |
title_short |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report |
title_full |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report |
title_fullStr |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report |
title_full_unstemmed |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report |
title_sort |
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report |
author |
Osório, Flávia de L. |
author_facet |
Osório, Flávia de L. Sanches, Rafael F. Macedo, Ligia R. Santos, Rafael G. dos Maia-de-Oliveira, João P. Wichert-Ana, Lauro Araújo, Dráulio Barros de Riba, Jordi Crippa, José A. Hallak, Jaime E. |
author_role |
author |
author2 |
Sanches, Rafael F. Macedo, Ligia R. Santos, Rafael G. dos Maia-de-Oliveira, João P. Wichert-Ana, Lauro Araújo, Dráulio Barros de Riba, Jordi Crippa, José A. Hallak, Jaime E. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Osório, Flávia de L. Sanches, Rafael F. Macedo, Ligia R. Santos, Rafael G. dos Maia-de-Oliveira, João P. Wichert-Ana, Lauro Araújo, Dráulio Barros de Riba, Jordi Crippa, José A. Hallak, Jaime E. |
dc.subject.por.fl_str_mv |
psychedelic agents dimethyltryptamine harmine monoamine oxidase inhibitors monoamine oxidase inhibitors therapeutic use |
topic |
psychedelic agents dimethyltryptamine harmine monoamine oxidase inhibitors monoamine oxidase inhibitors therapeutic use |
description |
Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-05-26T14:01:34Z |
dc.date.available.fl_str_mv |
2017-05-26T14:01:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23117 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1516-4446-2014-1496 |
identifier_str_mv |
OSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015. 10.1590/1516-4446-2014-1496 |
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https://repositorio.ufrn.br/jspui/handle/123456789/23117 |
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eng |
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eng |
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openAccess |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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