Immunoexpression of transforming growth factor beta and interferon gamma in radicular and dentigerous cysts

• Autor(a) principal: Moraes, Maiara de
• Data de Publicação: 2014
• Outros Autores: Rocha-Neto, Pedro Carlos da, Matos, Felipe Rodrigues de, Lopes, Maria Luiza Diniz de Sousa, Azevedo, Paulo Roberto Medeiros de, Costa, Antonio de Lisboa Lopes
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/51950; https://doi.org/10.1016/j.joen.2014.01.010
• topic: Dentigerous cyst; Immunohistochemistry; Interferon gamma; Radicular cyst; Transforming growth factors

Introduction: The aim of this study was to evaluate and compare the immunohistochemical expression of transforming growing factor beta (TGF-b) and interferon gamma (IFN-g) between radicular cysts (RCs) and dentigerous cysts (DCs). Methods: Twenty RCs and DCs were selected for analysis of the immunoexpression of TGF-b and IFN-g in the epithelium and capsule. Results: The cell reactivity of TGF-b and IFN-g in the lining epithelium and capsule of RCs showed no significant differences when compared with DCs (P > .05). There was a tendency of a higher expression of TGF-b in the capsule of DCs. Conclusions: Our results showed the presence of TGF-b and IFN-g in RCs and DCs, supporting the hypothesis that both participate in the development of these lesions, where IFN-g usually plays a role in bone resorption, which is counterbalanced by the osteoprotective activity performed by TGF-b.