Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/53506 https://doi.org/10.1590/0004-282X-ANP-2020-0464 |
Resumo: | Background: Guillain-Barré syndrome (GBS) is currently the most common cause of acute flaccid paralysis worldwide. Risk factors for GBS include previous viral or bacterial infections or vaccination. Recently, an outbreak of Zika virus led to an outbreak of GBS in Latin America, mostly in Brazil, concomitant to continuous circulation of dengue virus serotypes. However, there is no study about cytomegalovirus (CMV) infection as a risk for GBS in Brazil. Objectives: In this study, we report a series of cases of GBS with the aim of determining the prevalence of CMV and the characteristics associated with the infection. Methods: A cohort of 111 GBS cases diagnosed between 2011 and 2017 in Natal, northeastern Brazil, was studied. Presence of CMV IgM antibodies was determined by means of electrochemiluminescence. The analysis was performed considering CMV infection status and the clinical outcome. Results: We found seroprevalence of 15.3% (n = 17) for CMV. CMV patients were younger (26 vs. 40; p = 0.016), with no apparent gastrointestinal (p = 0.762) or upper respiratory infections (p = 0.779) or sensory loss (p = 0.03). They presented more often with a classic GBS sensorimotor variant (p = 0.02) and with a demyelinating pattern in electrophysiological studies (p < 0.001). Conclusion: In Brazil, the clinical-epidemiological profile of GBS associated with CMV infection is similar to that described in other countries. Better understanding of the relationship between infectious processes and GBS is a key component of the research agenda and assistance strategy for global health initiatives relating to peripheral neuropathic conditions. |
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Dourado Junior, Mário Emílio TeixeiraSousa, Bruno Fernandes deCosta, Nathaly M. Coelho daJeronimo, Selma Maria Bezerrahttps://orcid.org/0000-0002-9462-22942023-07-17T17:12:22Z2023-07-17T17:12:22Z2021DOURADO JUNIOR, Mario Emilio Teixeira; SOUSA, Bruno Fernandes de; COSTA, Nathaly M. Coelho da; JERONIMO, Selma Maria Bezerra. Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in brazil. Arquivos de Neuro-Psiquiatria, [S.L.], v. 79, n. 7, p. 607-611, jul. 2021. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/0004-282x-anp-2020-0464. Disponível em: https://www.scielo.br/j/anp/a/W7FvKWchXgVCxkvysVVZ4Gb/?lang=en#. Acesso em: 17 jul. 2023.https://repositorio.ufrn.br/handle/123456789/53506https://doi.org/10.1590/0004-282X-ANP-2020-0464Background: Guillain-Barré syndrome (GBS) is currently the most common cause of acute flaccid paralysis worldwide. Risk factors for GBS include previous viral or bacterial infections or vaccination. Recently, an outbreak of Zika virus led to an outbreak of GBS in Latin America, mostly in Brazil, concomitant to continuous circulation of dengue virus serotypes. However, there is no study about cytomegalovirus (CMV) infection as a risk for GBS in Brazil. Objectives: In this study, we report a series of cases of GBS with the aim of determining the prevalence of CMV and the characteristics associated with the infection. Methods: A cohort of 111 GBS cases diagnosed between 2011 and 2017 in Natal, northeastern Brazil, was studied. Presence of CMV IgM antibodies was determined by means of electrochemiluminescence. The analysis was performed considering CMV infection status and the clinical outcome. Results: We found seroprevalence of 15.3% (n = 17) for CMV. CMV patients were younger (26 vs. 40; p = 0.016), with no apparent gastrointestinal (p = 0.762) or upper respiratory infections (p = 0.779) or sensory loss (p = 0.03). They presented more often with a classic GBS sensorimotor variant (p = 0.02) and with a demyelinating pattern in electrophysiological studies (p < 0.001). Conclusion: In Brazil, the clinical-epidemiological profile of GBS associated with CMV infection is similar to that described in other countries. Better understanding of the relationship between infectious processes and GBS is a key component of the research agenda and assistance strategy for global health initiatives relating to peripheral neuropathic conditions.Introdução: Aproximadamente 2/3 dos pacientes com a Síndrome de Guillain-Barré (SGB) apresentam alguma doença infecciosa precedente. Recentemente, uma epidemia de infecção por o vírus Zika resultou em surto de SGB na América Latina, principalmente no Brasil, concomitante à circulação contínua de sorotipos do vírus da Dengue. No entanto, não há estudo sobre a infecção por citomegalovírus (CMV) como fator de risco para SGB no Brasil. Objetivos: Neste estudo, relatamos uma série de casos de SGB com o intuito de determinar a prevalência de CMV e as características associadas à infecção. Métodos: Foi estudada uma coorte de 111 casos de SGB diagnosticados entre 2011 e 2017 na cidade de Natal, capital do estudo do Rio Grande do Norte, nordeste do Brasil. A presença de anticorpos IgM CMV foi determinada por eletroquimiluminescência. A análise foi realizada considerando o status de infecção por CMV e os achados clínicos. Resultados: Foi observada uma soroprevalência de 15,3% (n = 17) para o CMV. Os casos de CMV eram mais jovens (26 vs. 40, p = 0,016), sem história de infecção gastrointestinal (p = 0,762) ou respiratória superior (0,779) ou perda sensorial (p = 0,03). Apresentaram-se mais frequentemente como uma variante sensitiva-motora clássica da SGB (p = 0,02) e subtipo desmielinizante nos estudos eletrofisiológicos (p <0,001). Conclusão: No Brasil, o perfil clínico-epidemiológico do SGB associado à infecção por CMV é semelhante ao descrito em outros países. O melhor entendimento das relações entre processos infecciosos e SGB é um componente-chave de uma agenda de pesquisa e estratégia de assistência para iniciativas globais de saúde em neuropatia periféricaArquivos de Neuro-PsiquiatriaAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccesscytomegalovirus infectionsguillain-barré syndromeepidemiologybrazilCytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in BrazilInfecção por citomegalovirus na Síndrome de Guillain-Barré: um estudo retrospectivo no Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/53506/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/53506/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALCytomegalovirusInfection_DouradoJr_2021.pdfCytomegalovirusInfection_DouradoJr_2021.pdfapplication/pdf113184https://repositorio.ufrn.br/bitstream/123456789/53506/4/CytomegalovirusInfection_DouradoJr_2021.pdfb2f3781eb641f14eaf527d461bda3336MD54123456789/535062023-07-17 14:13:12.488oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-17T17:13:12Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Infecção por citomegalovirus na Síndrome de Guillain-Barré: um estudo retrospectivo no Brasil |
title |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil |
spellingShingle |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil Dourado Junior, Mário Emílio Teixeira cytomegalovirus infections guillain-barré syndrome epidemiology brazil |
title_short |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil |
title_full |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil |
title_fullStr |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil |
title_full_unstemmed |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil |
title_sort |
Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in Brazil |
author |
Dourado Junior, Mário Emílio Teixeira |
author_facet |
Dourado Junior, Mário Emílio Teixeira Sousa, Bruno Fernandes de Costa, Nathaly M. Coelho da Jeronimo, Selma Maria Bezerra |
author_role |
author |
author2 |
Sousa, Bruno Fernandes de Costa, Nathaly M. Coelho da Jeronimo, Selma Maria Bezerra |
author2_role |
author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-9462-2294 |
dc.contributor.author.fl_str_mv |
Dourado Junior, Mário Emílio Teixeira Sousa, Bruno Fernandes de Costa, Nathaly M. Coelho da Jeronimo, Selma Maria Bezerra |
dc.subject.por.fl_str_mv |
cytomegalovirus infections guillain-barré syndrome epidemiology brazil |
topic |
cytomegalovirus infections guillain-barré syndrome epidemiology brazil |
description |
Background: Guillain-Barré syndrome (GBS) is currently the most common cause of acute flaccid paralysis worldwide. Risk factors for GBS include previous viral or bacterial infections or vaccination. Recently, an outbreak of Zika virus led to an outbreak of GBS in Latin America, mostly in Brazil, concomitant to continuous circulation of dengue virus serotypes. However, there is no study about cytomegalovirus (CMV) infection as a risk for GBS in Brazil. Objectives: In this study, we report a series of cases of GBS with the aim of determining the prevalence of CMV and the characteristics associated with the infection. Methods: A cohort of 111 GBS cases diagnosed between 2011 and 2017 in Natal, northeastern Brazil, was studied. Presence of CMV IgM antibodies was determined by means of electrochemiluminescence. The analysis was performed considering CMV infection status and the clinical outcome. Results: We found seroprevalence of 15.3% (n = 17) for CMV. CMV patients were younger (26 vs. 40; p = 0.016), with no apparent gastrointestinal (p = 0.762) or upper respiratory infections (p = 0.779) or sensory loss (p = 0.03). They presented more often with a classic GBS sensorimotor variant (p = 0.02) and with a demyelinating pattern in electrophysiological studies (p < 0.001). Conclusion: In Brazil, the clinical-epidemiological profile of GBS associated with CMV infection is similar to that described in other countries. Better understanding of the relationship between infectious processes and GBS is a key component of the research agenda and assistance strategy for global health initiatives relating to peripheral neuropathic conditions. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-07-17T17:12:22Z |
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2023-07-17T17:12:22Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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DOURADO JUNIOR, Mario Emilio Teixeira; SOUSA, Bruno Fernandes de; COSTA, Nathaly M. Coelho da; JERONIMO, Selma Maria Bezerra. Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in brazil. Arquivos de Neuro-Psiquiatria, [S.L.], v. 79, n. 7, p. 607-611, jul. 2021. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/0004-282x-anp-2020-0464. Disponível em: https://www.scielo.br/j/anp/a/W7FvKWchXgVCxkvysVVZ4Gb/?lang=en#. Acesso em: 17 jul. 2023. |
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https://repositorio.ufrn.br/handle/123456789/53506 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1590/0004-282X-ANP-2020-0464 |
identifier_str_mv |
DOURADO JUNIOR, Mario Emilio Teixeira; SOUSA, Bruno Fernandes de; COSTA, Nathaly M. Coelho da; JERONIMO, Selma Maria Bezerra. Cytomegalovirus infection in Guillain-Barré syndrome: a retrospective study in brazil. Arquivos de Neuro-Psiquiatria, [S.L.], v. 79, n. 7, p. 607-611, jul. 2021. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/0004-282x-anp-2020-0464. Disponível em: https://www.scielo.br/j/anp/a/W7FvKWchXgVCxkvysVVZ4Gb/?lang=en#. Acesso em: 17 jul. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/53506 https://doi.org/10.1590/0004-282X-ANP-2020-0464 |
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eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Arquivos de Neuro-Psiquiatria |
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Arquivos de Neuro-Psiquiatria |
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