Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/57451 http://dx.doi.org/10.1136/bmjopen-2020-043959 |
Resumo: | Introduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentations |
id |
UFRN_ae9ea1f9ae7f46d5bf58f7d901c12923 |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/57451 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Maciel, Bruna Leal LimaBona, Mariana DuarteTorres, Carlos Henrique de MedeirosLima, Severina Carla Vieira CunhaLima, Aldo Angelo Moreira2024-01-30T13:43:29Z2024-01-30T13:43:29Z2021-05BONA, Mariana Duarte; TORRES, Carlos Henrique de Medeiros; LIMA, Severina Carla Vieira Cunha; LIMA, Aldo Angelo Moreira; MACIEL, Bruna Leal Lima. Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol. Bmj Open, [S.l.], v. 11, n. 5, p. 1-5, mai. 2021. DOI: 10.1136/bmjopen-2020-043959. Disponível em: https://bmjopen.bmj.com/content/11/5/e043959. Acesso em: 26 jan. 2024.https://repositorio.ufrn.br/handle/123456789/57451http://dx.doi.org/10.1136/bmjopen-2020-043959BMJ OpenAttribution-NonCommercial 3.0 Brazilhttp://creativecommons.org/licenses/by-nc/3.0/br/info:eu-repo/semantics/openAccessIntestinal barrierObesityMetabolic syndromeIntestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIntroduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentationsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALIntestinalBarrier_Bona_2021.pdfIntestinalBarrier_Bona_2021.pdfapplication/pdf255994https://repositorio.ufrn.br/bitstream/123456789/57451/1/IntestinalBarrier_Bona_2021.pdf486c1e0066d271fae274489f1131ab47MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8920https://repositorio.ufrn.br/bitstream/123456789/57451/2/license_rdf728dfda2fa81b274c619d08d1dfc1a03MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/57451/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/574512024-01-30 10:43:29.528oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-01-30T13:43:29Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol |
title |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol |
spellingShingle |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol Maciel, Bruna Leal Lima Intestinal barrier Obesity Metabolic syndrome |
title_short |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol |
title_full |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol |
title_fullStr |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol |
title_full_unstemmed |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol |
title_sort |
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol |
author |
Maciel, Bruna Leal Lima |
author_facet |
Maciel, Bruna Leal Lima Bona, Mariana Duarte Torres, Carlos Henrique de Medeiros Lima, Severina Carla Vieira Cunha Lima, Aldo Angelo Moreira |
author_role |
author |
author2 |
Bona, Mariana Duarte Torres, Carlos Henrique de Medeiros Lima, Severina Carla Vieira Cunha Lima, Aldo Angelo Moreira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Maciel, Bruna Leal Lima Bona, Mariana Duarte Torres, Carlos Henrique de Medeiros Lima, Severina Carla Vieira Cunha Lima, Aldo Angelo Moreira |
dc.subject.por.fl_str_mv |
Intestinal barrier Obesity Metabolic syndrome |
topic |
Intestinal barrier Obesity Metabolic syndrome |
description |
Introduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentations |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-05 |
dc.date.accessioned.fl_str_mv |
2024-01-30T13:43:29Z |
dc.date.available.fl_str_mv |
2024-01-30T13:43:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BONA, Mariana Duarte; TORRES, Carlos Henrique de Medeiros; LIMA, Severina Carla Vieira Cunha; LIMA, Aldo Angelo Moreira; MACIEL, Bruna Leal Lima. Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol. Bmj Open, [S.l.], v. 11, n. 5, p. 1-5, mai. 2021. DOI: 10.1136/bmjopen-2020-043959. Disponível em: https://bmjopen.bmj.com/content/11/5/e043959. Acesso em: 26 jan. 2024. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/57451 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1136/bmjopen-2020-043959 |
identifier_str_mv |
BONA, Mariana Duarte; TORRES, Carlos Henrique de Medeiros; LIMA, Severina Carla Vieira Cunha; LIMA, Aldo Angelo Moreira; MACIEL, Bruna Leal Lima. Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol. Bmj Open, [S.l.], v. 11, n. 5, p. 1-5, mai. 2021. DOI: 10.1136/bmjopen-2020-043959. Disponível em: https://bmjopen.bmj.com/content/11/5/e043959. Acesso em: 26 jan. 2024. |
url |
https://repositorio.ufrn.br/handle/123456789/57451 http://dx.doi.org/10.1136/bmjopen-2020-043959 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial 3.0 Brazil http://creativecommons.org/licenses/by-nc/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial 3.0 Brazil http://creativecommons.org/licenses/by-nc/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
BMJ Open |
publisher.none.fl_str_mv |
BMJ Open |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/57451/1/IntestinalBarrier_Bona_2021.pdf https://repositorio.ufrn.br/bitstream/123456789/57451/2/license_rdf https://repositorio.ufrn.br/bitstream/123456789/57451/3/license.txt |
bitstream.checksum.fl_str_mv |
486c1e0066d271fae274489f1131ab47 728dfda2fa81b274c619d08d1dfc1a03 e9597aa2854d128fd968be5edc8a28d9 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1814833004907855872 |