Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol

Detalhes bibliográficos
Autor(a) principal: Maciel, Bruna Leal Lima
Data de Publicação: 2021
Outros Autores: Bona, Mariana Duarte, Torres, Carlos Henrique de Medeiros, Lima, Severina Carla Vieira Cunha, Lima, Aldo Angelo Moreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/57451
http://dx.doi.org/10.1136/bmjopen-2020-043959
Resumo: Introduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentations
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spelling Maciel, Bruna Leal LimaBona, Mariana DuarteTorres, Carlos Henrique de MedeirosLima, Severina Carla Vieira CunhaLima, Aldo Angelo Moreira2024-01-30T13:43:29Z2024-01-30T13:43:29Z2021-05BONA, Mariana Duarte; TORRES, Carlos Henrique de Medeiros; LIMA, Severina Carla Vieira Cunha; LIMA, Aldo Angelo Moreira; MACIEL, Bruna Leal Lima. Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol. Bmj Open, [S.l.], v. 11, n. 5, p. 1-5, mai. 2021. DOI: 10.1136/bmjopen-2020-043959. Disponível em: https://bmjopen.bmj.com/content/11/5/e043959. Acesso em: 26 jan. 2024.https://repositorio.ufrn.br/handle/123456789/57451http://dx.doi.org/10.1136/bmjopen-2020-043959BMJ OpenAttribution-NonCommercial 3.0 Brazilhttp://creativecommons.org/licenses/by-nc/3.0/br/info:eu-repo/semantics/openAccessIntestinal barrierObesityMetabolic syndromeIntestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIntroduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentationsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALIntestinalBarrier_Bona_2021.pdfIntestinalBarrier_Bona_2021.pdfapplication/pdf255994https://repositorio.ufrn.br/bitstream/123456789/57451/1/IntestinalBarrier_Bona_2021.pdf486c1e0066d271fae274489f1131ab47MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8920https://repositorio.ufrn.br/bitstream/123456789/57451/2/license_rdf728dfda2fa81b274c619d08d1dfc1a03MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/57451/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/574512024-01-30 10:43:29.528oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-01-30T13:43:29Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
title Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
spellingShingle Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
Maciel, Bruna Leal Lima
Intestinal barrier
Obesity
Metabolic syndrome
title_short Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
title_full Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
title_fullStr Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
title_full_unstemmed Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
title_sort Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
author Maciel, Bruna Leal Lima
author_facet Maciel, Bruna Leal Lima
Bona, Mariana Duarte
Torres, Carlos Henrique de Medeiros
Lima, Severina Carla Vieira Cunha
Lima, Aldo Angelo Moreira
author_role author
author2 Bona, Mariana Duarte
Torres, Carlos Henrique de Medeiros
Lima, Severina Carla Vieira Cunha
Lima, Aldo Angelo Moreira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Maciel, Bruna Leal Lima
Bona, Mariana Duarte
Torres, Carlos Henrique de Medeiros
Lima, Severina Carla Vieira Cunha
Lima, Aldo Angelo Moreira
dc.subject.por.fl_str_mv Intestinal barrier
Obesity
Metabolic syndrome
topic Intestinal barrier
Obesity
Metabolic syndrome
description Introduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentations
publishDate 2021
dc.date.issued.fl_str_mv 2021-05
dc.date.accessioned.fl_str_mv 2024-01-30T13:43:29Z
dc.date.available.fl_str_mv 2024-01-30T13:43:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv BONA, Mariana Duarte; TORRES, Carlos Henrique de Medeiros; LIMA, Severina Carla Vieira Cunha; LIMA, Aldo Angelo Moreira; MACIEL, Bruna Leal Lima. Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol. Bmj Open, [S.l.], v. 11, n. 5, p. 1-5, mai. 2021. DOI: 10.1136/bmjopen-2020-043959. Disponível em: https://bmjopen.bmj.com/content/11/5/e043959. Acesso em: 26 jan. 2024.
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dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1136/bmjopen-2020-043959
identifier_str_mv BONA, Mariana Duarte; TORRES, Carlos Henrique de Medeiros; LIMA, Severina Carla Vieira Cunha; LIMA, Aldo Angelo Moreira; MACIEL, Bruna Leal Lima. Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol. Bmj Open, [S.l.], v. 11, n. 5, p. 1-5, mai. 2021. DOI: 10.1136/bmjopen-2020-043959. Disponível em: https://bmjopen.bmj.com/content/11/5/e043959. Acesso em: 26 jan. 2024.
url https://repositorio.ufrn.br/handle/123456789/57451
http://dx.doi.org/10.1136/bmjopen-2020-043959
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