Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23058 |
Resumo: | In rodents, repeated exposure to unavoidable aggression followed by sustained sensory treat can lead to prolonged social aversion. The chronic social defeat stress model explores that phenomenon and it has been used as an animal model for human depression. However, some authors have questioned whether confounding effects may arise as the model also boosts anxiety-related behaviors. Despite its wide acceptance, most studies extract limited information from the behavior of the defeated animal. Often, the normalized occupancy around the social stimulus, the interaction zone, is taken as an index of depression. We hypothesized that this parameter is insufficient to fully characterize the behavioral consequences of this form of stress. Using an ethological approach, we showed that repeated social defeat delayed the expression of social investigation in long (10 min) sessions of social interaction. Also, the incidence of defensive behaviors, including stretched-attend posture and high speed retreats, was significantly higher in defeated mice in comparison to controls. Interestingly, a subpopulation of defeated mice showed recurrent and non-habituating stretched-attend posture and persistent flights during the entire session. Two indexes were created based on defensive behaviors to show that only recurrent flights correlates with sucrose intake. Together, the present study corroborates the idea that this model of social stress can precipitate a myriad of behaviors not readily disentangled. We propose that long sessions (>150 s) and detailed ethological evaluation during social interaction tests are necessary to provide enough information to correctly classify defeated animals in terms of resilience and susceptibility to social defeat stress. |
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Henriques-Alves, Aron M.Queiroz, Claudio Marcos Teixeira de2017-05-24T12:46:10Z2017-05-24T12:46:10Z2016-02-03https://repositorio.ufrn.br/jspui/handle/123456789/2305810.3389/fnbeh.2015.00364engresident–intruder paradigmsocial defeat stressstretch-attend postureflightdefensive behaviorssucrose preference testphenotypingEthological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratioinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIn rodents, repeated exposure to unavoidable aggression followed by sustained sensory treat can lead to prolonged social aversion. The chronic social defeat stress model explores that phenomenon and it has been used as an animal model for human depression. However, some authors have questioned whether confounding effects may arise as the model also boosts anxiety-related behaviors. Despite its wide acceptance, most studies extract limited information from the behavior of the defeated animal. Often, the normalized occupancy around the social stimulus, the interaction zone, is taken as an index of depression. We hypothesized that this parameter is insufficient to fully characterize the behavioral consequences of this form of stress. Using an ethological approach, we showed that repeated social defeat delayed the expression of social investigation in long (10 min) sessions of social interaction. Also, the incidence of defensive behaviors, including stretched-attend posture and high speed retreats, was significantly higher in defeated mice in comparison to controls. Interestingly, a subpopulation of defeated mice showed recurrent and non-habituating stretched-attend posture and persistent flights during the entire session. Two indexes were created based on defensive behaviors to show that only recurrent flights correlates with sucrose intake. Together, the present study corroborates the idea that this model of social stress can precipitate a myriad of behaviors not readily disentangled. We propose that long sessions (>150 s) and detailed ethological evaluation during social interaction tests are necessary to provide enough information to correctly classify defeated animals in terms of resilience and susceptibility to social defeat stress.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23058/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALEthological Evaluation of the Effects of Social Defeat Stress in Mice_Beyond the Social Interaction Ratio.pdfEthological Evaluation of the Effects of Social Defeat Stress in Mice_Beyond the Social Interaction Ratio.pdfClaudioQueiroz_ICe_Ethological Evaluation_2016application/pdf3987016https://repositorio.ufrn.br/bitstream/123456789/23058/1/Ethological%20Evaluation%20of%20the%20Effects%20of%20Social%20Defeat%20Stress%20in%20Mice_Beyond%20the%20Social%20Interaction%20Ratio.pdfc80de785929f07912d60964b2c1effd3MD51TEXTEthological Evaluation of the Effects of Social Defeat Stress in Mice_Beyond the Social Interaction Ratio.pdf.txtEthological Evaluation of the Effects of Social Defeat Stress in Mice_Beyond the Social Interaction Ratio.pdf.txtExtracted texttext/plain71465https://repositorio.ufrn.br/bitstream/123456789/23058/5/Ethological%20Evaluation%20of%20the%20Effects%20of%20Social%20Defeat%20Stress%20in%20Mice_Beyond%20the%20Social%20Interaction%20Ratio.pdf.txta7f41953d656363b94bc7448c58b2bf6MD55THUMBNAILEthological Evaluation of the Effects of Social Defeat Stress in Mice_Beyond the Social Interaction Ratio.pdf.jpgEthological Evaluation of the Effects of Social Defeat Stress in Mice_Beyond the Social Interaction Ratio.pdf.jpgIM Thumbnailimage/jpeg7927https://repositorio.ufrn.br/bitstream/123456789/23058/6/Ethological%20Evaluation%20of%20the%20Effects%20of%20Social%20Defeat%20Stress%20in%20Mice_Beyond%20the%20Social%20Interaction%20Ratio.pdf.jpg962eaf08fc34f1f2b719e75145b87df3MD56123456789/230582021-07-08 12:32:47.059oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T15:32:47Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio |
title |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio |
spellingShingle |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio Henriques-Alves, Aron M. resident–intruder paradigm social defeat stress stretch-attend posture flight defensive behaviors sucrose preference test phenotyping |
title_short |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio |
title_full |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio |
title_fullStr |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio |
title_full_unstemmed |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio |
title_sort |
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio |
author |
Henriques-Alves, Aron M. |
author_facet |
Henriques-Alves, Aron M. Queiroz, Claudio Marcos Teixeira de |
author_role |
author |
author2 |
Queiroz, Claudio Marcos Teixeira de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Henriques-Alves, Aron M. Queiroz, Claudio Marcos Teixeira de |
dc.subject.por.fl_str_mv |
resident–intruder paradigm social defeat stress stretch-attend posture flight defensive behaviors sucrose preference test phenotyping |
topic |
resident–intruder paradigm social defeat stress stretch-attend posture flight defensive behaviors sucrose preference test phenotyping |
description |
In rodents, repeated exposure to unavoidable aggression followed by sustained sensory treat can lead to prolonged social aversion. The chronic social defeat stress model explores that phenomenon and it has been used as an animal model for human depression. However, some authors have questioned whether confounding effects may arise as the model also boosts anxiety-related behaviors. Despite its wide acceptance, most studies extract limited information from the behavior of the defeated animal. Often, the normalized occupancy around the social stimulus, the interaction zone, is taken as an index of depression. We hypothesized that this parameter is insufficient to fully characterize the behavioral consequences of this form of stress. Using an ethological approach, we showed that repeated social defeat delayed the expression of social investigation in long (10 min) sessions of social interaction. Also, the incidence of defensive behaviors, including stretched-attend posture and high speed retreats, was significantly higher in defeated mice in comparison to controls. Interestingly, a subpopulation of defeated mice showed recurrent and non-habituating stretched-attend posture and persistent flights during the entire session. Two indexes were created based on defensive behaviors to show that only recurrent flights correlates with sucrose intake. Together, the present study corroborates the idea that this model of social stress can precipitate a myriad of behaviors not readily disentangled. We propose that long sessions (>150 s) and detailed ethological evaluation during social interaction tests are necessary to provide enough information to correctly classify defeated animals in terms of resilience and susceptibility to social defeat stress. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-02-03 |
dc.date.accessioned.fl_str_mv |
2017-05-24T12:46:10Z |
dc.date.available.fl_str_mv |
2017-05-24T12:46:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23058 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fnbeh.2015.00364 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23058 |
identifier_str_mv |
10.3389/fnbeh.2015.00364 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Repositório Institucional da UFRN |
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