Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/24631 |
Resumo: | The present study tested the effects of alcohol on seeking behavior and memory in the Siamese fighting fish Betta splendens. We tested behavior using 5 alcohol concentrations: .00%, .10%, .25%, 1.00%, and 1.50% (vol/vol%). Drug seeking was tested using a conditioned place preference (CPP) paradigm, with a single 20-min exposure to alcohol. The effect of alcohol on memory was tested using a T-maze protocol with acute (20 min/day for 5 days) and chronic (20 min/day for 20 days) alcohol exposure and after alcohol withdrawal (20 min/day alcohol exposure for 15 days water exposure). In the CPP test, the higher acute alcohol doses (1.00 and 1.50%) induced seeking behavior, but the lower (.10%) and medium (.25%) doses did not. When the fish were tested after 37 days of alcohol exposure, the higher-dose groups still exhibited seeking behavior, indicating that these doses may have caused drug addiction. In the memory test, we observed a dose-dependent pattern with both the acute and chronic treatments. High alcohol doses (1.00 and 1.50%) impaired memory, and low alcohol doses (.10%) caused an anticipatory response. The withdrawal group did not exhibit differences in memory, suggesting some capacity for recovery. The low alcohol doses did not impair memory or cause drug seeking, whereas the high doses affected memory and caused prolonged seeking behavior. Therefore, a dual effect of alcohol was corroborated by our data, and Betta splendens may be an adequate animal model for high-throughput screening with alcohol |
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Luchiari, Ana CarolinaChacon, Diana M.Oliveira, Jéssica J.2018-01-22T19:20:35Z2018-01-22T19:20:35Z2015LUCHIARI, Ana Carolina; CHACON, Diana M.; OLIVEIRA, Jéssica J. Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens. Psychology and Neuroscience, v. 8, p. 143-154, 2015. Disponível em:<http://doi.apa.org/fulltext/2015-12673-007.html>. Acesso em: 17 out. 2017.1984-3054https://repositorio.ufrn.br/jspui/handle/123456789/2463110.1037/h0101024engAmerican Psychological AssociationAbstinenceSeeking behaviorToleranceBetta splendensDose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe present study tested the effects of alcohol on seeking behavior and memory in the Siamese fighting fish Betta splendens. We tested behavior using 5 alcohol concentrations: .00%, .10%, .25%, 1.00%, and 1.50% (vol/vol%). Drug seeking was tested using a conditioned place preference (CPP) paradigm, with a single 20-min exposure to alcohol. The effect of alcohol on memory was tested using a T-maze protocol with acute (20 min/day for 5 days) and chronic (20 min/day for 20 days) alcohol exposure and after alcohol withdrawal (20 min/day alcohol exposure for 15 days water exposure). In the CPP test, the higher acute alcohol doses (1.00 and 1.50%) induced seeking behavior, but the lower (.10%) and medium (.25%) doses did not. When the fish were tested after 37 days of alcohol exposure, the higher-dose groups still exhibited seeking behavior, indicating that these doses may have caused drug addiction. In the memory test, we observed a dose-dependent pattern with both the acute and chronic treatments. High alcohol doses (1.00 and 1.50%) impaired memory, and low alcohol doses (.10%) caused an anticipatory response. The withdrawal group did not exhibit differences in memory, suggesting some capacity for recovery. The low alcohol doses did not impair memory or cause drug seeking, whereas the high doses affected memory and caused prolonged seeking behavior. Therefore, a dual effect of alcohol was corroborated by our data, and Betta splendens may be an adequate animal model for high-throughput screening with alcoholinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNTEXTDoseDependentEffects_2015.pdf.txtDoseDependentEffects_2015.pdf.txtExtracted texttext/plain54409https://repositorio.ufrn.br/bitstream/123456789/24631/3/DoseDependentEffects_2015.pdf.txt877fa344c09a8651b67ba8e3da059c7eMD53THUMBNAILDoseDependentEffects_2015.pdf.jpgDoseDependentEffects_2015.pdf.jpgIM Thumbnailimage/jpeg11370https://repositorio.ufrn.br/bitstream/123456789/24631/4/DoseDependentEffects_2015.pdf.jpg97699f32bbe179d5c552e0b537e8df6bMD54ORIGINALDoseDependentEffects_Luchiari_2015.pdfDoseDependentEffects_Luchiari_2015.pdfapplication/pdf201796https://repositorio.ufrn.br/bitstream/123456789/24631/1/DoseDependentEffects_Luchiari_2015.pdfedd1796b72e4dfba681e07b19e36aa8bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/24631/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/246312021-11-08 17:27:47.861oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-08T20:27:47Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens |
title |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens |
spellingShingle |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens Luchiari, Ana Carolina Abstinence Seeking behavior Tolerance Betta splendens |
title_short |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens |
title_full |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens |
title_fullStr |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens |
title_full_unstemmed |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens |
title_sort |
Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens |
author |
Luchiari, Ana Carolina |
author_facet |
Luchiari, Ana Carolina Chacon, Diana M. Oliveira, Jéssica J. |
author_role |
author |
author2 |
Chacon, Diana M. Oliveira, Jéssica J. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Luchiari, Ana Carolina Chacon, Diana M. Oliveira, Jéssica J. |
dc.subject.por.fl_str_mv |
Abstinence Seeking behavior Tolerance Betta splendens |
topic |
Abstinence Seeking behavior Tolerance Betta splendens |
description |
The present study tested the effects of alcohol on seeking behavior and memory in the Siamese fighting fish Betta splendens. We tested behavior using 5 alcohol concentrations: .00%, .10%, .25%, 1.00%, and 1.50% (vol/vol%). Drug seeking was tested using a conditioned place preference (CPP) paradigm, with a single 20-min exposure to alcohol. The effect of alcohol on memory was tested using a T-maze protocol with acute (20 min/day for 5 days) and chronic (20 min/day for 20 days) alcohol exposure and after alcohol withdrawal (20 min/day alcohol exposure for 15 days water exposure). In the CPP test, the higher acute alcohol doses (1.00 and 1.50%) induced seeking behavior, but the lower (.10%) and medium (.25%) doses did not. When the fish were tested after 37 days of alcohol exposure, the higher-dose groups still exhibited seeking behavior, indicating that these doses may have caused drug addiction. In the memory test, we observed a dose-dependent pattern with both the acute and chronic treatments. High alcohol doses (1.00 and 1.50%) impaired memory, and low alcohol doses (.10%) caused an anticipatory response. The withdrawal group did not exhibit differences in memory, suggesting some capacity for recovery. The low alcohol doses did not impair memory or cause drug seeking, whereas the high doses affected memory and caused prolonged seeking behavior. Therefore, a dual effect of alcohol was corroborated by our data, and Betta splendens may be an adequate animal model for high-throughput screening with alcohol |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2018-01-22T19:20:35Z |
dc.date.available.fl_str_mv |
2018-01-22T19:20:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LUCHIARI, Ana Carolina; CHACON, Diana M.; OLIVEIRA, Jéssica J. Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens. Psychology and Neuroscience, v. 8, p. 143-154, 2015. Disponível em:<http://doi.apa.org/fulltext/2015-12673-007.html>. Acesso em: 17 out. 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/24631 |
dc.identifier.issn.none.fl_str_mv |
1984-3054 |
dc.identifier.doi.none.fl_str_mv |
10.1037/h0101024 |
identifier_str_mv |
LUCHIARI, Ana Carolina; CHACON, Diana M.; OLIVEIRA, Jéssica J. Dose-dependent effects of alcohol on seeking behavior and memory in the fish betta splendens. Psychology and Neuroscience, v. 8, p. 143-154, 2015. Disponível em:<http://doi.apa.org/fulltext/2015-12673-007.html>. Acesso em: 17 out. 2017. 1984-3054 10.1037/h0101024 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/24631 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Psychological Association |
publisher.none.fl_str_mv |
American Psychological Association |
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