Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems

Detalhes bibliográficos
Autor(a) principal: Soares, Bruno Lobão
Data de Publicação: 2014
Outros Autores: Maia-de-Oliveira, Joao Paulo, Baker, Glen B., Hallak, Jaime E.C., Dursun, Serdar M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/25459
https://doi.org/10.1016/j.schres.2014.08.020
Resumo: “Schizophrenia is arguably the worst disease affecting mankind, even AIDS not excepted”. Since this statement in 1988 (Editors, 1988), schizophrenia still remains a major challenge to medicine, with up to 60% of patients not responding adequately to treatment despite the relatively large arsenal of antipsychotics currently available. By modulating the nitric oxide (NO) pathway, a new paradigm for schizophrenia treatment apparently involving modulation of nitric oxide (NO) has been proposed (Oliveira et al., 2011).
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spelling Soares, Bruno LobãoMaia-de-Oliveira, Joao PauloBaker, Glen B.Hallak, Jaime E.C.Dursun, Serdar M.2018-06-19T13:56:39Z2018-06-19T13:56:39Z2014-11SOARES, Bruno Lobão et al. Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems. Schizophrenia Research, v. 14, p. 456-456, 2014. Disponível em: <http://www.schres-journal.com/article/S0920-9964(14)00456-3/abstract>. Acesso em: 27 mar. 2018.0920-9964https://repositorio.ufrn.br/jspui/handle/123456789/25459https://doi.org/10.1016/j.schres.2014.08.020engElsevierSodium nitroprussideSodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systemsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article“Schizophrenia is arguably the worst disease affecting mankind, even AIDS not excepted”. Since this statement in 1988 (Editors, 1988), schizophrenia still remains a major challenge to medicine, with up to 60% of patients not responding adequately to treatment despite the relatively large arsenal of antipsychotics currently available. By modulating the nitric oxide (NO) pathway, a new paradigm for schizophrenia treatment apparently involving modulation of nitric oxide (NO) has been proposed (Oliveira et al., 2011).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNTEXTSodium nitroprusside, a nitric oxide donor_2014.pdf.txtSodium nitroprusside, a nitric oxide donor_2014.pdf.txtExtracted texttext/plain10570https://repositorio.ufrn.br/bitstream/123456789/25459/3/Sodium%20nitroprusside%2c%20a%20nitric%20oxide%20donor_2014.pdf.txt7c634cb94485c2691e5d948c9cb3538eMD53THUMBNAILSodium nitroprusside, a nitric oxide donor_2014.pdf.jpgSodium nitroprusside, a nitric oxide donor_2014.pdf.jpgIM Thumbnailimage/jpeg12808https://repositorio.ufrn.br/bitstream/123456789/25459/4/Sodium%20nitroprusside%2c%20a%20nitric%20oxide%20donor_2014.pdf.jpgffd8377fd0daa3085317b3f9dda9a0c7MD54ORIGINALSodiumNitroprussideNitricOxide_Soares_2014.pdfSodiumNitroprussideNitricOxide_Soares_2014.pdfapplication/pdf292861https://repositorio.ufrn.br/bitstream/123456789/25459/1/SodiumNitroprussideNitricOxide_Soares_2014.pdf617f77033641906a0f4065f54e7bb1caMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25459/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/254592021-11-11 16:09:08.677oai:https://repositorio.ufrn.br:123456789/25459Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-11T19:09:08Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
title Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
spellingShingle Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
Soares, Bruno Lobão
Sodium nitroprusside
title_short Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
title_full Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
title_fullStr Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
title_full_unstemmed Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
title_sort Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
author Soares, Bruno Lobão
author_facet Soares, Bruno Lobão
Maia-de-Oliveira, Joao Paulo
Baker, Glen B.
Hallak, Jaime E.C.
Dursun, Serdar M.
author_role author
author2 Maia-de-Oliveira, Joao Paulo
Baker, Glen B.
Hallak, Jaime E.C.
Dursun, Serdar M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Soares, Bruno Lobão
Maia-de-Oliveira, Joao Paulo
Baker, Glen B.
Hallak, Jaime E.C.
Dursun, Serdar M.
dc.subject.por.fl_str_mv Sodium nitroprusside
topic Sodium nitroprusside
description “Schizophrenia is arguably the worst disease affecting mankind, even AIDS not excepted”. Since this statement in 1988 (Editors, 1988), schizophrenia still remains a major challenge to medicine, with up to 60% of patients not responding adequately to treatment despite the relatively large arsenal of antipsychotics currently available. By modulating the nitric oxide (NO) pathway, a new paradigm for schizophrenia treatment apparently involving modulation of nitric oxide (NO) has been proposed (Oliveira et al., 2011).
publishDate 2014
dc.date.issued.fl_str_mv 2014-11
dc.date.accessioned.fl_str_mv 2018-06-19T13:56:39Z
dc.date.available.fl_str_mv 2018-06-19T13:56:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Bruno Lobão et al. Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems. Schizophrenia Research, v. 14, p. 456-456, 2014. Disponível em: <http://www.schres-journal.com/article/S0920-9964(14)00456-3/abstract>. Acesso em: 27 mar. 2018.
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dc.identifier.issn.none.fl_str_mv 0920-9964
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.schres.2014.08.020
identifier_str_mv SOARES, Bruno Lobão et al. Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems. Schizophrenia Research, v. 14, p. 456-456, 2014. Disponível em: <http://www.schres-journal.com/article/S0920-9964(14)00456-3/abstract>. Acesso em: 27 mar. 2018.
0920-9964
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https://doi.org/10.1016/j.schres.2014.08.020
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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