Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/49631 https://doi.org/10.1016/j.neulet.2016.06.044 |
Resumo: | Manic bipolar is diagnosed by psychomotor agitation, increased goal-directed activity, insomnia, grandiosity, excessive speech, and risky behavior. Animal studies aimed to modeling mania are commonly based in psychostimulants-induced hyperlocomotion. The exploration of other behaviors related with mania is mandatory to investigate this phase of bipolar disorder in animals. In this study, the hole board apparatus was suggested for evaluating mania-like behaviors induced by the psychostimulant methylphenidate. The treatment with methylphenidate (10 mg/kg, ip) increased locomotion in the open field test. The pretreatment with lithium (50 mg/kg, ip) and valproate (400 mg/kg, ip) significantly prevented the hyperlocomotion. In the hole-board test, methylphenidate increased interactions with the central and peripheral holes and the exploration of central areas. Lithium was more effective than valproate in preventing all the behavioral manifestations induced by the psychostimulant. These findings were discussed based on the ability of methylphenidate-treated mice mimicking two symptoms of mania in the hole board test: goal-directed action and risk-taking behavior. In conclusion, the results point to a new approach to study mania through the hole board apparatus. The hole board test appears to be a sensitive assay to detect the efficacy of antimanic drugs. |
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Souza, L.S.Soares, Bruno LobãoSilva, E.F.Santos, W.B.Asth, L.Soares-Rachetti, V.P.Medeiros, I.U.Gavioli, E.C.2022-10-25T23:29:36Z2022-10-25T23:29:36Z2016-08-26SOUZA, L. S. et al. Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test. Neuroscience Letters (Print), v. 629, p. 143-148, 2016. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304394016304530?via%3Dihub>. Acesso em: 26 mar. 2018.0304-3940https://repositorio.ufrn.br/handle/123456789/49631https://doi.org/10.1016/j.neulet.2016.06.044ElsevierManiaPsychostimulantAnimal modelMouseLithiumValproateLithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board testinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleManic bipolar is diagnosed by psychomotor agitation, increased goal-directed activity, insomnia, grandiosity, excessive speech, and risky behavior. Animal studies aimed to modeling mania are commonly based in psychostimulants-induced hyperlocomotion. The exploration of other behaviors related with mania is mandatory to investigate this phase of bipolar disorder in animals. In this study, the hole board apparatus was suggested for evaluating mania-like behaviors induced by the psychostimulant methylphenidate. The treatment with methylphenidate (10 mg/kg, ip) increased locomotion in the open field test. The pretreatment with lithium (50 mg/kg, ip) and valproate (400 mg/kg, ip) significantly prevented the hyperlocomotion. In the hole-board test, methylphenidate increased interactions with the central and peripheral holes and the exploration of central areas. Lithium was more effective than valproate in preventing all the behavioral manifestations induced by the psychostimulant. These findings were discussed based on the ability of methylphenidate-treated mice mimicking two symptoms of mania in the hole board test: goal-directed action and risk-taking behavior. In conclusion, the results point to a new approach to study mania through the hole board apparatus. The hole board test appears to be a sensitive assay to detect the efficacy of antimanic drugs.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALLithium and valproate prevent methylphenidate-induced_2016.pdfLithium and valproate prevent methylphenidate-induced_2016.pdfapplication/pdf519378https://repositorio.ufrn.br/bitstream/123456789/49631/1/Lithium%20and%20valproate%20prevent%20methylphenidate-induced_2016.pdf90a15d4aae3b7e99c270c446965e3bf1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/49631/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/496312022-10-25 20:29:38.556oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-10-25T23:29:38Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test |
title |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test |
spellingShingle |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test Souza, L.S. Mania Psychostimulant Animal model Mouse Lithium Valproate |
title_short |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test |
title_full |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test |
title_fullStr |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test |
title_full_unstemmed |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test |
title_sort |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test |
author |
Souza, L.S. |
author_facet |
Souza, L.S. Soares, Bruno Lobão Silva, E.F. Santos, W.B. Asth, L. Soares-Rachetti, V.P. Medeiros, I.U. Gavioli, E.C. |
author_role |
author |
author2 |
Soares, Bruno Lobão Silva, E.F. Santos, W.B. Asth, L. Soares-Rachetti, V.P. Medeiros, I.U. Gavioli, E.C. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, L.S. Soares, Bruno Lobão Silva, E.F. Santos, W.B. Asth, L. Soares-Rachetti, V.P. Medeiros, I.U. Gavioli, E.C. |
dc.subject.por.fl_str_mv |
Mania Psychostimulant Animal model Mouse Lithium Valproate |
topic |
Mania Psychostimulant Animal model Mouse Lithium Valproate |
description |
Manic bipolar is diagnosed by psychomotor agitation, increased goal-directed activity, insomnia, grandiosity, excessive speech, and risky behavior. Animal studies aimed to modeling mania are commonly based in psychostimulants-induced hyperlocomotion. The exploration of other behaviors related with mania is mandatory to investigate this phase of bipolar disorder in animals. In this study, the hole board apparatus was suggested for evaluating mania-like behaviors induced by the psychostimulant methylphenidate. The treatment with methylphenidate (10 mg/kg, ip) increased locomotion in the open field test. The pretreatment with lithium (50 mg/kg, ip) and valproate (400 mg/kg, ip) significantly prevented the hyperlocomotion. In the hole-board test, methylphenidate increased interactions with the central and peripheral holes and the exploration of central areas. Lithium was more effective than valproate in preventing all the behavioral manifestations induced by the psychostimulant. These findings were discussed based on the ability of methylphenidate-treated mice mimicking two symptoms of mania in the hole board test: goal-directed action and risk-taking behavior. In conclusion, the results point to a new approach to study mania through the hole board apparatus. The hole board test appears to be a sensitive assay to detect the efficacy of antimanic drugs. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-08-26 |
dc.date.accessioned.fl_str_mv |
2022-10-25T23:29:36Z |
dc.date.available.fl_str_mv |
2022-10-25T23:29:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, L. S. et al. Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test. Neuroscience Letters (Print), v. 629, p. 143-148, 2016. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304394016304530?via%3Dihub>. Acesso em: 26 mar. 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/49631 |
dc.identifier.issn.none.fl_str_mv |
0304-3940 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.neulet.2016.06.044 |
identifier_str_mv |
SOUZA, L. S. et al. Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test. Neuroscience Letters (Print), v. 629, p. 143-148, 2016. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304394016304530?via%3Dihub>. Acesso em: 26 mar. 2018. 0304-3940 |
url |
https://repositorio.ufrn.br/handle/123456789/49631 https://doi.org/10.1016/j.neulet.2016.06.044 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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