Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/25432 http://dx.doi.org/10.1590/1516-4446-2015-1895 |
Resumo: | Objective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors’ research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined. Results: The EPM and ETM tests evoke anxiety/fear-related defensive responses that are pharmacologically validated, whereas the confrontation between rodents and snakes in polygonal arenas with or without shelters or in the complex labyrinth offers ethological conditions for studying more complex defensive behaviors and the effects of anxiolytic and panicolytic drugs. Prey vs. predator paradigms also allow discrimination between non-oriented and oriented escape behavior. Conclusions: Both EPM and ETM simple labyrinths are excellent apparatuses for the study of anxiety- and instinctive fear-related responses, respectively. The confrontation between rodents and snakes in polygonal arenas, however, offers a more ethological environment for addressing both unconditioned and conditioned fear-induced behaviors and the effects of anxiolytic and panicolytic drugs. |
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Soares, Bruno LobãoCoimbra, Norberto C.Paschoalin-Maurin, TatianaBassi, Gabriel S.Kanashiro, AlexandreBiagioni, Audrey F.Felippotti, Tatiana T.Elias-Filho, Daoud H.Mendes-Gomes, JoyceCysne-Coimbra, Jade P.Almada, Rafael C.2018-06-16T14:33:36Z2018-06-16T14:33:36Z2017-02-26SOARES, Bruno Lobão et al. Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests. Revista Brasileira de Psiquiatria, v. 39, p. 72-83, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000100072&lng=en&tlng=en>. Acesso em: 27 mar. 2018.1809-452Xhttps://repositorio.ufrn.br/jspui/handle/123456789/25432http://dx.doi.org/10.1590/1516-4446-2015-1895engAssociação Brasileira de PsiquiatriaInnate fearPanic attacksPrey versus snakes paradigmsPolygonal arenas for snakesElevated plus-maze testElevated T-maze testCritical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral testsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObjective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors’ research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined. Results: The EPM and ETM tests evoke anxiety/fear-related defensive responses that are pharmacologically validated, whereas the confrontation between rodents and snakes in polygonal arenas with or without shelters or in the complex labyrinth offers ethological conditions for studying more complex defensive behaviors and the effects of anxiolytic and panicolytic drugs. Prey vs. predator paradigms also allow discrimination between non-oriented and oriented escape behavior. Conclusions: Both EPM and ETM simple labyrinths are excellent apparatuses for the study of anxiety- and instinctive fear-related responses, respectively. The confrontation between rodents and snakes in polygonal arenas, however, offers a more ethological environment for addressing both unconditioned and conditioned fear-induced behaviors and the effects of anxiolytic and panicolytic drugs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNTEXTCritical neuropsychobiological analysis_2017.pdf.txtCritical neuropsychobiological analysis_2017.pdf.txtExtracted texttext/plain70856https://repositorio.ufrn.br/bitstream/123456789/25432/3/Critical%20neuropsychobiological%20analysis_2017.pdf.txt63c1c556a6f954f2b8fa81801ea1f91aMD53THUMBNAILCritical neuropsychobiological analysis_2017.pdf.jpgCritical neuropsychobiological analysis_2017.pdf.jpgIM Thumbnailimage/jpeg12543https://repositorio.ufrn.br/bitstream/123456789/25432/4/Critical%20neuropsychobiological%20analysis_2017.pdf.jpga2471aaf2d192c703bcfa3cad323ff1eMD54TEXTCritical neuropsychobiological analysis_2017.pdf.txtCritical neuropsychobiological analysis_2017.pdf.txtExtracted texttext/plain70856https://repositorio.ufrn.br/bitstream/123456789/25432/3/Critical%20neuropsychobiological%20analysis_2017.pdf.txt63c1c556a6f954f2b8fa81801ea1f91aMD53THUMBNAILCritical neuropsychobiological analysis_2017.pdf.jpgCritical neuropsychobiological analysis_2017.pdf.jpgIM Thumbnailimage/jpeg12543https://repositorio.ufrn.br/bitstream/123456789/25432/4/Critical%20neuropsychobiological%20analysis_2017.pdf.jpga2471aaf2d192c703bcfa3cad323ff1eMD54ORIGINALCriticalNeuropsychobiologicalAnalysis_Soares_2017.pdfCriticalNeuropsychobiologicalAnalysis_Soares_2017.pdfapplication/pdf1481416https://repositorio.ufrn.br/bitstream/123456789/25432/1/CriticalNeuropsychobiologicalAnalysis_Soares_2017.pdfef65c4e50954466afad35a03eb11246cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25432/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/254322021-11-11 15:13:10.042oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-11T18:13:10Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests |
title |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests |
spellingShingle |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests Soares, Bruno Lobão Innate fear Panic attacks Prey versus snakes paradigms Polygonal arenas for snakes Elevated plus-maze test Elevated T-maze test |
title_short |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests |
title_full |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests |
title_fullStr |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests |
title_full_unstemmed |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests |
title_sort |
Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests |
author |
Soares, Bruno Lobão |
author_facet |
Soares, Bruno Lobão Coimbra, Norberto C. Paschoalin-Maurin, Tatiana Bassi, Gabriel S. Kanashiro, Alexandre Biagioni, Audrey F. Felippotti, Tatiana T. Elias-Filho, Daoud H. Mendes-Gomes, Joyce Cysne-Coimbra, Jade P. Almada, Rafael C. |
author_role |
author |
author2 |
Coimbra, Norberto C. Paschoalin-Maurin, Tatiana Bassi, Gabriel S. Kanashiro, Alexandre Biagioni, Audrey F. Felippotti, Tatiana T. Elias-Filho, Daoud H. Mendes-Gomes, Joyce Cysne-Coimbra, Jade P. Almada, Rafael C. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Soares, Bruno Lobão Coimbra, Norberto C. Paschoalin-Maurin, Tatiana Bassi, Gabriel S. Kanashiro, Alexandre Biagioni, Audrey F. Felippotti, Tatiana T. Elias-Filho, Daoud H. Mendes-Gomes, Joyce Cysne-Coimbra, Jade P. Almada, Rafael C. |
dc.subject.por.fl_str_mv |
Innate fear Panic attacks Prey versus snakes paradigms Polygonal arenas for snakes Elevated plus-maze test Elevated T-maze test |
topic |
Innate fear Panic attacks Prey versus snakes paradigms Polygonal arenas for snakes Elevated plus-maze test Elevated T-maze test |
description |
Objective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors’ research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined. Results: The EPM and ETM tests evoke anxiety/fear-related defensive responses that are pharmacologically validated, whereas the confrontation between rodents and snakes in polygonal arenas with or without shelters or in the complex labyrinth offers ethological conditions for studying more complex defensive behaviors and the effects of anxiolytic and panicolytic drugs. Prey vs. predator paradigms also allow discrimination between non-oriented and oriented escape behavior. Conclusions: Both EPM and ETM simple labyrinths are excellent apparatuses for the study of anxiety- and instinctive fear-related responses, respectively. The confrontation between rodents and snakes in polygonal arenas, however, offers a more ethological environment for addressing both unconditioned and conditioned fear-induced behaviors and the effects of anxiolytic and panicolytic drugs. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-02-26 |
dc.date.accessioned.fl_str_mv |
2018-06-16T14:33:36Z |
dc.date.available.fl_str_mv |
2018-06-16T14:33:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOARES, Bruno Lobão et al. Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests. Revista Brasileira de Psiquiatria, v. 39, p. 72-83, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000100072&lng=en&tlng=en>. Acesso em: 27 mar. 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/25432 |
dc.identifier.issn.none.fl_str_mv |
1809-452X |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/1516-4446-2015-1895 |
identifier_str_mv |
SOARES, Bruno Lobão et al. Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests. Revista Brasileira de Psiquiatria, v. 39, p. 72-83, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000100072&lng=en&tlng=en>. Acesso em: 27 mar. 2018. 1809-452X |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/25432 http://dx.doi.org/10.1590/1516-4446-2015-1895 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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Repositório Institucional da UFRN |
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