Herdabilidade de preditores do risco cardiovascular

Detalhes bibliográficos
Autor(a) principal: Oliveira, Michelle Vasconcelos de
Data de Publicação: 2013
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/14620
Resumo: genetic and environmental factors contribute to the development of cardiovascular risk and that influence can be differentiated by factors characteristic of each population, age and sex. Aim: To investigate the heritability of anthropometric and biochemical markers as predictors of cardiovascular risk in men and women of different age groups, using the method of twins. Methods: A sample of 88 subjects and of these 52 children and adolescents (08-17 years old) 32 monozygotic (20 female and 12 male) and 20 dizygotic (12 female and 08 male) and 36 adults (18-28 years age) 24 monozygotic (08 female and 16 male) and 12 dizygotic (06 female and 06 male), living in the metropolitan region of Natal / RN, Brazil. Anthropometric measures were taken as the height, body mass, waist circumference (WC), sum of skinfolds (ΣDC), fat percentage CUN-BAE, BMI and conicity. Biochemical markers analyzed were: fasting glucose (GLU), total cholesterol (COL), HDL-C, LDL-C and triglycerides (TG). After processing the data the index of heritability (h2) = (S ² MZ) / S ² DZ (DZ S ²) X100 was applied disaggregated by sex and age. Results: The variables showed differential heritability of behavior for men and women, depending on age. The variables with the highest heritability values were ΣDC, GLU, HDL, TG, in men and BMI, WC, ΣDC, GLU, HDL-C and TG in women. And more influenced by the environment variables were: body mass, BMI, Chol, LDL-C in men; body mass and LDL-C in women. Conclusion: Differences index of heritability by gender for cardiovascular risk predictors may assist in planning specific intervention strategies according to gender and stage of life of that individual. It is from the level of environmental influence that can run interventions for changes of components related to cardiovascular risk
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spelling Oliveira, Michelle Vasconcelos dehttp://lattes.cnpq.br/5402923122245427http://lattes.cnpq.br/4311626091295357Dantas, Paulo Moreira Silvahttp://lattes.cnpq.br/0392766010188739Cabral, Breno Guilherme de Araújo Tinôcohttp://lattes.cnpq.br/8399135324397066Santos, Luciano Alonso Valente doshttp://lattes.cnpq.br/9017927437502071Lemos, Telma Maria Araujo Moura2014-12-17T14:44:18Z2014-06-112014-12-17T14:44:18Z2013-12-11OLIVEIRA, Michelle Vasconcelos de. Herdabilidade de preditores do risco cardiovascular. 2013. 130 f. Dissertação (Mestrado em Movimento Humano, Cultura e Educação, Saúde e Desempenho) - Universidade Federal do Rio Grande do Norte, Natal, 2013.https://repositorio.ufrn.br/jspui/handle/123456789/14620genetic and environmental factors contribute to the development of cardiovascular risk and that influence can be differentiated by factors characteristic of each population, age and sex. Aim: To investigate the heritability of anthropometric and biochemical markers as predictors of cardiovascular risk in men and women of different age groups, using the method of twins. Methods: A sample of 88 subjects and of these 52 children and adolescents (08-17 years old) 32 monozygotic (20 female and 12 male) and 20 dizygotic (12 female and 08 male) and 36 adults (18-28 years age) 24 monozygotic (08 female and 16 male) and 12 dizygotic (06 female and 06 male), living in the metropolitan region of Natal / RN, Brazil. Anthropometric measures were taken as the height, body mass, waist circumference (WC), sum of skinfolds (ΣDC), fat percentage CUN-BAE, BMI and conicity. Biochemical markers analyzed were: fasting glucose (GLU), total cholesterol (COL), HDL-C, LDL-C and triglycerides (TG). After processing the data the index of heritability (h2) = (S ² MZ) / S ² DZ (DZ S ²) X100 was applied disaggregated by sex and age. Results: The variables showed differential heritability of behavior for men and women, depending on age. The variables with the highest heritability values were ΣDC, GLU, HDL, TG, in men and BMI, WC, ΣDC, GLU, HDL-C and TG in women. And more influenced by the environment variables were: body mass, BMI, Chol, LDL-C in men; body mass and LDL-C in women. Conclusion: Differences index of heritability by gender for cardiovascular risk predictors may assist in planning specific intervention strategies according to gender and stage of life of that individual. It is from the level of environmental influence that can run interventions for changes of components related to cardiovascular riskOs fatores genéticos e ambientais contribuem para o desenvolvimento do risco cardiovascular e essa influência pode ser diferenciada por fatores característicos de cada população, idade e sexo. Objetivo: investigar a herdabilidade de variáveis antropométricas e marcadores bioquímicos como preditores do risco cardiovascular em homens e mulheres de diferentes faixas etárias, utilizando o método de gêmeos. Métodos: Amostra composta por 130 gêmeos, sendo do sexo feminino 42 monozigotos e 32 dizigotos e do sexo masculino 28 monozigotos e 28 dizigotos, residentes na região metropolitana de Natal/RN, Brasil. Como medidas antropométricas foram aferidas a estatura, massa corporal, circunferência da cintura (CC), somatório de dobras cutâneas (∑DC), percentual de gordura CUN-BAE, IMC e índice de conicidade. Os marcadores bioquímicos analisados foram: glicemia de jejum (GLI), colesterol total (COL), HDL-C, LDL-C e triglicerídeos (TG). Após o tratamento dos dados foi aplicado o índice de herdabilidade (h2) = ((S² DZ S² MZ) / S² DZ) x 100; separado por sexo e idade. Resultados: As variáveis apresentaram comportamento de hereditariedade diferenciado para homens e mulheres, dependendo da idade. As variáveis com maior herdabilidade foram: ∑DC, GLI, HDL, TG, nos homens; e IMC, CC, ∑DC, GLI, HDL-C e TG nas mulheres. E as variáveis mais influenciadas pelo ambiente foram: Massa, IMC, COL, LDL-C, nos homens; massa e LDL-C nas mulheres. Conclusão: As diferenças por sexo do índice de herdabilidade para os preditores do risco cardiovascular podem auxiliar no planejamento de estratégias de intervenção específicas de acordo com o sexo e estágio da vida desse indivíduo. É a partir do nível de influência ambiental que poderá correr as intervenções para modificações dos componentes relacionados ao risco cardiovascularapplication/pdfporUniversidade Federal do Rio Grande do NortePrograma de Pós-Graduação em Educação FísicaUFRNBRMovimento Humano, Cultura e Educação, Saúde e DesempenhoGêmeos. Obesidade. Herança genética. Antropometria. Fatores bioquímicosTwins. Obesity. Genetic inheritance. Anthropometry. Biochemical factorsCNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICAHerdabilidade de preditores do risco cardiovascularinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALMicheleVO_DISSERT.pdfapplication/pdf9305862https://repositorio.ufrn.br/bitstream/123456789/14620/1/MicheleVO_DISSERT.pdf2d47288223836ac6ba52c9de6822c77fMD51TEXTMicheleVO_DISSERT.pdf.txtMicheleVO_DISSERT.pdf.txtExtracted texttext/plain132607https://repositorio.ufrn.br/bitstream/123456789/14620/6/MicheleVO_DISSERT.pdf.txt61d042e211b83b1b56b3f076a39c3a6eMD56THUMBNAILMicheleVO_DISSERT.pdf.jpgMicheleVO_DISSERT.pdf.jpgIM Thumbnailimage/jpeg2653https://repositorio.ufrn.br/bitstream/123456789/14620/7/MicheleVO_DISSERT.pdf.jpg63f639597b51d456103790e9d8616b3dMD57123456789/146202017-10-31 15:45:02.876oai:https://repositorio.ufrn.br:123456789/14620Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2017-10-31T18:45:02Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.por.fl_str_mv Herdabilidade de preditores do risco cardiovascular
title Herdabilidade de preditores do risco cardiovascular
spellingShingle Herdabilidade de preditores do risco cardiovascular
Oliveira, Michelle Vasconcelos de
Gêmeos. Obesidade. Herança genética. Antropometria. Fatores bioquímicos
Twins. Obesity. Genetic inheritance. Anthropometry. Biochemical factors
CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
title_short Herdabilidade de preditores do risco cardiovascular
title_full Herdabilidade de preditores do risco cardiovascular
title_fullStr Herdabilidade de preditores do risco cardiovascular
title_full_unstemmed Herdabilidade de preditores do risco cardiovascular
title_sort Herdabilidade de preditores do risco cardiovascular
author Oliveira, Michelle Vasconcelos de
author_facet Oliveira, Michelle Vasconcelos de
author_role author
dc.contributor.authorID.por.fl_str_mv
dc.contributor.authorLattes.por.fl_str_mv http://lattes.cnpq.br/5402923122245427
dc.contributor.advisorID.por.fl_str_mv
dc.contributor.advisorLattes.por.fl_str_mv http://lattes.cnpq.br/4311626091295357
dc.contributor.referees1.pt_BR.fl_str_mv Dantas, Paulo Moreira Silva
dc.contributor.referees1ID.por.fl_str_mv
dc.contributor.referees1Lattes.por.fl_str_mv http://lattes.cnpq.br/0392766010188739
dc.contributor.referees2.pt_BR.fl_str_mv Cabral, Breno Guilherme de Araújo Tinôco
dc.contributor.referees2ID.por.fl_str_mv
dc.contributor.referees2Lattes.por.fl_str_mv http://lattes.cnpq.br/8399135324397066
dc.contributor.referees3.pt_BR.fl_str_mv Santos, Luciano Alonso Valente dos
dc.contributor.referees3ID.por.fl_str_mv
dc.contributor.referees3Lattes.por.fl_str_mv http://lattes.cnpq.br/9017927437502071
dc.contributor.author.fl_str_mv Oliveira, Michelle Vasconcelos de
dc.contributor.advisor1.fl_str_mv Lemos, Telma Maria Araujo Moura
contributor_str_mv Lemos, Telma Maria Araujo Moura
dc.subject.por.fl_str_mv Gêmeos. Obesidade. Herança genética. Antropometria. Fatores bioquímicos
topic Gêmeos. Obesidade. Herança genética. Antropometria. Fatores bioquímicos
Twins. Obesity. Genetic inheritance. Anthropometry. Biochemical factors
CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
dc.subject.eng.fl_str_mv Twins. Obesity. Genetic inheritance. Anthropometry. Biochemical factors
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
description genetic and environmental factors contribute to the development of cardiovascular risk and that influence can be differentiated by factors characteristic of each population, age and sex. Aim: To investigate the heritability of anthropometric and biochemical markers as predictors of cardiovascular risk in men and women of different age groups, using the method of twins. Methods: A sample of 88 subjects and of these 52 children and adolescents (08-17 years old) 32 monozygotic (20 female and 12 male) and 20 dizygotic (12 female and 08 male) and 36 adults (18-28 years age) 24 monozygotic (08 female and 16 male) and 12 dizygotic (06 female and 06 male), living in the metropolitan region of Natal / RN, Brazil. Anthropometric measures were taken as the height, body mass, waist circumference (WC), sum of skinfolds (ΣDC), fat percentage CUN-BAE, BMI and conicity. Biochemical markers analyzed were: fasting glucose (GLU), total cholesterol (COL), HDL-C, LDL-C and triglycerides (TG). After processing the data the index of heritability (h2) = (S ² MZ) / S ² DZ (DZ S ²) X100 was applied disaggregated by sex and age. Results: The variables showed differential heritability of behavior for men and women, depending on age. The variables with the highest heritability values were ΣDC, GLU, HDL, TG, in men and BMI, WC, ΣDC, GLU, HDL-C and TG in women. And more influenced by the environment variables were: body mass, BMI, Chol, LDL-C in men; body mass and LDL-C in women. Conclusion: Differences index of heritability by gender for cardiovascular risk predictors may assist in planning specific intervention strategies according to gender and stage of life of that individual. It is from the level of environmental influence that can run interventions for changes of components related to cardiovascular risk
publishDate 2013
dc.date.issued.fl_str_mv 2013-12-11
dc.date.accessioned.fl_str_mv 2014-12-17T14:44:18Z
dc.date.available.fl_str_mv 2014-06-11
2014-12-17T14:44:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv OLIVEIRA, Michelle Vasconcelos de. Herdabilidade de preditores do risco cardiovascular. 2013. 130 f. Dissertação (Mestrado em Movimento Humano, Cultura e Educação, Saúde e Desempenho) - Universidade Federal do Rio Grande do Norte, Natal, 2013.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/14620
identifier_str_mv OLIVEIRA, Michelle Vasconcelos de. Herdabilidade de preditores do risco cardiovascular. 2013. 130 f. Dissertação (Mestrado em Movimento Humano, Cultura e Educação, Saúde e Desempenho) - Universidade Federal do Rio Grande do Norte, Natal, 2013.
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dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Educação Física
dc.publisher.initials.fl_str_mv UFRN
dc.publisher.country.fl_str_mv BR
dc.publisher.department.fl_str_mv Movimento Humano, Cultura e Educação, Saúde e Desempenho
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
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