Global slowing of network oscillations in mouse neocortex by diazepam

Detalhes bibliográficos
Autor(a) principal: Scheffzük, Claudia
Data de Publicação: 2013
Outros Autores: Kukushka, Valeriy I., Vyssotski, Alexei L., Draguhn, Andreas, Tort, Adriano Bretanha Lopes, Branka, Jurij
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/1/6201
Resumo: SCHEFFZUK, C. , KUKUSHKA, V. , VYSSOTSKI, A. L. , DRAGUHN, A. , TORT, A. B. L. , BRANKACK, J. . Global slowing of network oscillations in mouse neocortex by diazepam. Neuropharmacology , v. 65, p. 123-133, 2013.
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spelling Scheffzük, ClaudiaKukushka, Valeriy I.Vyssotski, Alexei L.Draguhn, AndreasTort, Adriano Bretanha LopesBranka, Jurij2013-02-25T14:36:31Z2013-02-25T14:36:31Z2013SCHEFFZUK, C. ; KUKUSHKA, V. ; VYSSOTSKI, A. L. ; DRAGUHN, A. ; TORT, A. B. L. ; BRANKACK, J. ( 2013)https://repositorio.ufrn.br/jspui/handle/1/6201SCHEFFZUK, C. , KUKUSHKA, V. , VYSSOTSKI, A. L. , DRAGUHN, A. , TORT, A. B. L. , BRANKACK, J. . Global slowing of network oscillations in mouse neocortex by diazepam. Neuropharmacology , v. 65, p. 123-133, 2013.Benzodiazepines have a broad spectrum of clinical applications including sedation, anti-anxiety, and anticonvulsive therapy. At the cellular level, benzodiazepines are allosteric modulators of GABAA receptors; they increase the efficacy of inhibition in neuronal networks by prolonging the duration of inhibitory postsynaptic potentials. This mechanism of action predicts that benzodiazepines reduce the frequency of inhibition-driven network oscillations, consistent with observations from human and animal EEG. However, most of existing data are restricted to frequency bands beloww30 Hz. Recent data suggest that faster cortical network rhythms are critically involved in several behavioral and cognitive tasks. We therefore analyzed diazepam effects on a large range of cortical network oscillations in freely moving mice, including theta (4e12 Hz), gamma (40e100 Hz) and fast gamma (120e160 Hz) oscillations. We also investigated diazepam effects over the coupling between theta phase and the amplitude fast oscillations. We report that diazepam causes a global slowing of oscillatory activity in all frequency domains. Oscillation power was changed differently for each frequency domain, with characteristic differences between active wakefulness, slow-wave sleep and REM sleep. Cross-frequency coupling strength, in contrast, was mostly unaffected by diazepam. Such state- and frequency-dependent actions of benzodiazepines on cortical network oscillations may be relevant for their specific cognitive effects. They also underline the strong interaction between local network oscillations and global brain statesengIn vivo electrophysiologyLocal field potentialNeuronal oscillationsBrain rhythmsSleep-wake cycleCross-frequency couplingGlobal slowing of network oscillations in mouse neocortex by diazepaminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALAdrianoBLTort_ICE_Global slowing2013.pdfAdrianoBLTort_ICE_Global slowing2013.pdfapplication/pdf1823447https://repositorio.ufrn.br/bitstream/1/6201/1/AdrianoBLTort_ICE_Global%20slowing2013.pdf5939aec49f3284aff5230f2bbc40c482MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/1/6201/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAdrianoBLTort_ICE_Global slowing2013.pdf.txtAdrianoBLTort_ICE_Global slowing2013.pdf.txtExtracted texttext/plain51821https://repositorio.ufrn.br/bitstream/1/6201/7/AdrianoBLTort_ICE_Global%20slowing2013.pdf.txteeab36bad63514fcab42a78cb0d6c0caMD57THUMBNAILAdrianoBLTort_ICE_Global slowing2013.pdf.jpgAdrianoBLTort_ICE_Global slowing2013.pdf.jpgIM Thumbnailimage/jpeg8916https://repositorio.ufrn.br/bitstream/1/6201/8/AdrianoBLTort_ICE_Global%20slowing2013.pdf.jpg4cd1abfd119913f18b0d1274b3f34f2bMD581/62012021-07-08 11:25:41.07oai:https://repositorio.ufrn.br:1/6201Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T14:25:41Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Global slowing of network oscillations in mouse neocortex by diazepam
title Global slowing of network oscillations in mouse neocortex by diazepam
spellingShingle Global slowing of network oscillations in mouse neocortex by diazepam
Scheffzük, Claudia
In vivo electrophysiology
Local field potential
Neuronal oscillations
Brain rhythms
Sleep-wake cycle
Cross-frequency coupling
title_short Global slowing of network oscillations in mouse neocortex by diazepam
title_full Global slowing of network oscillations in mouse neocortex by diazepam
title_fullStr Global slowing of network oscillations in mouse neocortex by diazepam
title_full_unstemmed Global slowing of network oscillations in mouse neocortex by diazepam
title_sort Global slowing of network oscillations in mouse neocortex by diazepam
author Scheffzük, Claudia
author_facet Scheffzük, Claudia
Kukushka, Valeriy I.
Vyssotski, Alexei L.
Draguhn, Andreas
Tort, Adriano Bretanha Lopes
Branka, Jurij
author_role author
author2 Kukushka, Valeriy I.
Vyssotski, Alexei L.
Draguhn, Andreas
Tort, Adriano Bretanha Lopes
Branka, Jurij
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Scheffzük, Claudia
Kukushka, Valeriy I.
Vyssotski, Alexei L.
Draguhn, Andreas
Tort, Adriano Bretanha Lopes
Branka, Jurij
dc.subject.por.fl_str_mv In vivo electrophysiology
Local field potential
Neuronal oscillations
Brain rhythms
Sleep-wake cycle
Cross-frequency coupling
topic In vivo electrophysiology
Local field potential
Neuronal oscillations
Brain rhythms
Sleep-wake cycle
Cross-frequency coupling
description SCHEFFZUK, C. , KUKUSHKA, V. , VYSSOTSKI, A. L. , DRAGUHN, A. , TORT, A. B. L. , BRANKACK, J. . Global slowing of network oscillations in mouse neocortex by diazepam. Neuropharmacology , v. 65, p. 123-133, 2013.
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-02-25T14:36:31Z
dc.date.available.fl_str_mv 2013-02-25T14:36:31Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHEFFZUK, C. ; KUKUSHKA, V. ; VYSSOTSKI, A. L. ; DRAGUHN, A. ; TORT, A. B. L. ; BRANKACK, J. ( 2013)
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/1/6201
identifier_str_mv SCHEFFZUK, C. ; KUKUSHKA, V. ; VYSSOTSKI, A. L. ; DRAGUHN, A. ; TORT, A. B. L. ; BRANKACK, J. ( 2013)
url https://repositorio.ufrn.br/jspui/handle/1/6201
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
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instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
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