Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/31765 |
Resumo: | This study aimed to determine the effect of the co-administration of dexamethasone 8 mg and nimesulide 100 mg given 1 h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed (95% confidence interval, 80% test power, and 5% error), and a sample of 40 patients aged between 18 and 40 years was selected. The patients were randomized and divided into two groups: dexamethasone + placebo and dexamethasone + nimesulide. The following parameters were evaluated: pain (visual analogue scale), total number of rescue analgesics taken, time taken to first rescue analgesic consumption, oedema, trismus, and patient satisfaction. The paired t-test and the Wilcoxon test were used to compare means. Statistically significant differences were found between the groups in pain values at 2, 4, and 12 h postoperative, and in the total number of rescue analgesics and time taken to first rescue analgesic ingestion (P < 0.05), with results in favour of dexamethasone + nimesulide administration. Oedema and trismus were similar in the two treatment groups and decreased over time postoperatively. The coadministration of dexamethasone and nimesulide reduces pain intensity and the need for rescue medication after third molar surgery |
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Barbalho, J. C.Vasconcellos, R. J. H.Morais, Hecio Henrique Araujo deSantos, L. A. M.Almeida, R. de A. C.Rêbelo, H. L.Lucena, Eudes Euler de SouzaAraújo, S. Q. de2021-03-09T12:11:17Z2021-03-09T12:11:17Z2017-02BARBALHO, J. C.; VASCONCELLOS, R. J. H.; MORAIS, Hecio Henrique Araujo de; SANTOS, L. A. M.; ALMEIDA, R. A. C.; RÊBELO, H. l.; LUCENA, Eudes Euler de Souza; ARAÚJO, S. Q. Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. International Journal Of Oral And Maxillofacial Surgery, [s. l.], v. 46, n. 2, p. 236-242, fev. 2017. Elsevier BV. Disponível em: https://www.ijoms.com/article/S0901-5027(16)30284-3/fulltext#%20. Acesso em: 21 jul. 2020. http://dx.doi.org/10.1016/j.ijom.2016.10.0110901-5027 (print)1399-0020 (online)https://repositorio.ufrn.br/handle/123456789/3176510.1016/j.ijom.2016.10.011ElsevierThird molarPainOedemaTrismusAnti-inflammatory agentsEffects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThis study aimed to determine the effect of the co-administration of dexamethasone 8 mg and nimesulide 100 mg given 1 h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed (95% confidence interval, 80% test power, and 5% error), and a sample of 40 patients aged between 18 and 40 years was selected. The patients were randomized and divided into two groups: dexamethasone + placebo and dexamethasone + nimesulide. The following parameters were evaluated: pain (visual analogue scale), total number of rescue analgesics taken, time taken to first rescue analgesic consumption, oedema, trismus, and patient satisfaction. The paired t-test and the Wilcoxon test were used to compare means. Statistically significant differences were found between the groups in pain values at 2, 4, and 12 h postoperative, and in the total number of rescue analgesics and time taken to first rescue analgesic ingestion (P < 0.05), with results in favour of dexamethasone + nimesulide administration. Oedema and trismus were similar in the two treatment groups and decreased over time postoperatively. The coadministration of dexamethasone and nimesulide reduces pain intensity and the need for rescue medication after third molar surgeryengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/31765/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31765/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTEffectsDexamethasoneNimesulide_Lucena_2017.pdf.txtEffectsDexamethasoneNimesulide_Lucena_2017.pdf.txtExtracted texttext/plain39346https://repositorio.ufrn.br/bitstream/123456789/31765/4/EffectsDexamethasoneNimesulide_Lucena_2017.pdf.txt165cc067bf2da7b427a2f64d874b5acdMD54THUMBNAILEffectsDexamethasoneNimesulide_Lucena_2017.pdf.jpgEffectsDexamethasoneNimesulide_Lucena_2017.pdf.jpgGenerated Thumbnailimage/jpeg1664https://repositorio.ufrn.br/bitstream/123456789/31765/5/EffectsDexamethasoneNimesulide_Lucena_2017.pdf.jpg1b7eb5a1b7f0b4d0e2d776f8dcb53ccdMD55123456789/317652023-02-07 18:04:02.274oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-02-07T21:04:02Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial |
title |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial |
spellingShingle |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial Barbalho, J. C. Third molar Pain Oedema Trismus Anti-inflammatory agents |
title_short |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial |
title_full |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial |
title_fullStr |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial |
title_full_unstemmed |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial |
title_sort |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial |
author |
Barbalho, J. C. |
author_facet |
Barbalho, J. C. Vasconcellos, R. J. H. Morais, Hecio Henrique Araujo de Santos, L. A. M. Almeida, R. de A. C. Rêbelo, H. L. Lucena, Eudes Euler de Souza Araújo, S. Q. de |
author_role |
author |
author2 |
Vasconcellos, R. J. H. Morais, Hecio Henrique Araujo de Santos, L. A. M. Almeida, R. de A. C. Rêbelo, H. L. Lucena, Eudes Euler de Souza Araújo, S. Q. de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Barbalho, J. C. Vasconcellos, R. J. H. Morais, Hecio Henrique Araujo de Santos, L. A. M. Almeida, R. de A. C. Rêbelo, H. L. Lucena, Eudes Euler de Souza Araújo, S. Q. de |
dc.subject.por.fl_str_mv |
Third molar Pain Oedema Trismus Anti-inflammatory agents |
topic |
Third molar Pain Oedema Trismus Anti-inflammatory agents |
description |
This study aimed to determine the effect of the co-administration of dexamethasone 8 mg and nimesulide 100 mg given 1 h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed (95% confidence interval, 80% test power, and 5% error), and a sample of 40 patients aged between 18 and 40 years was selected. The patients were randomized and divided into two groups: dexamethasone + placebo and dexamethasone + nimesulide. The following parameters were evaluated: pain (visual analogue scale), total number of rescue analgesics taken, time taken to first rescue analgesic consumption, oedema, trismus, and patient satisfaction. The paired t-test and the Wilcoxon test were used to compare means. Statistically significant differences were found between the groups in pain values at 2, 4, and 12 h postoperative, and in the total number of rescue analgesics and time taken to first rescue analgesic ingestion (P < 0.05), with results in favour of dexamethasone + nimesulide administration. Oedema and trismus were similar in the two treatment groups and decreased over time postoperatively. The coadministration of dexamethasone and nimesulide reduces pain intensity and the need for rescue medication after third molar surgery |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-02 |
dc.date.accessioned.fl_str_mv |
2021-03-09T12:11:17Z |
dc.date.available.fl_str_mv |
2021-03-09T12:11:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARBALHO, J. C.; VASCONCELLOS, R. J. H.; MORAIS, Hecio Henrique Araujo de; SANTOS, L. A. M.; ALMEIDA, R. A. C.; RÊBELO, H. l.; LUCENA, Eudes Euler de Souza; ARAÚJO, S. Q. Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. International Journal Of Oral And Maxillofacial Surgery, [s. l.], v. 46, n. 2, p. 236-242, fev. 2017. Elsevier BV. Disponível em: https://www.ijoms.com/article/S0901-5027(16)30284-3/fulltext#%20. Acesso em: 21 jul. 2020. http://dx.doi.org/10.1016/j.ijom.2016.10.011 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/31765 |
dc.identifier.issn.none.fl_str_mv |
0901-5027 (print) 1399-0020 (online) |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.ijom.2016.10.011 |
identifier_str_mv |
BARBALHO, J. C.; VASCONCELLOS, R. J. H.; MORAIS, Hecio Henrique Araujo de; SANTOS, L. A. M.; ALMEIDA, R. A. C.; RÊBELO, H. l.; LUCENA, Eudes Euler de Souza; ARAÚJO, S. Q. Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. International Journal Of Oral And Maxillofacial Surgery, [s. l.], v. 46, n. 2, p. 236-242, fev. 2017. Elsevier BV. Disponível em: https://www.ijoms.com/article/S0901-5027(16)30284-3/fulltext#%20. Acesso em: 21 jul. 2020. http://dx.doi.org/10.1016/j.ijom.2016.10.011 0901-5027 (print) 1399-0020 (online) 10.1016/j.ijom.2016.10.011 |
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