Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus
| Autor(a) principal: | |
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| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFRN |
| Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23832 |
Resumo: | 2018-03-10 |
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Radiske, AndressaGonzalez, Maria CarolinaConde-Ocaziones, SergioFeitosa, AnatildesKöhler, Cristiano A.Bevilaqua, Lia Rejane MüllerCammarota, Martín Pablo2017-09-11T17:32:56Z2017-09-08https://repositorio.ufrn.br/jspui/handle/123456789/2383210.1523/JNEUROSCI.1372-17.2017engmemorylearningpost-traumatic stress disordergamma oscillationsthetacross-frequency couplingPrior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-03-10Reactivated memories can be modified during reconsolidation, making this process a potential therapeutic target for post-traumatic stress disorder (PTSD), a mental illness characterized by the recurring avoidance of situations that evoke trauma-related fears. However, avoidance memory reconsolidation depends on a set of still loosely defined boundary conditions, limiting the translational value of basic research. In particular, the involvement of the hippocampus in fear-motivated avoidance memory reconsolidation remains controversial. Combining behavioral and electrophysiological analyses in male Wistar rats, we found that previous learning of relevant non-aversive information is essential to elicit the participation of the hippocampus in avoidance memory reconsolidation, which is associated with an increase in theta and gamma oscillations power and cross-frequency coupling in dorsal CA1 during reactivation of the avoidance response. Our results indicate that the hippocampus is involved in memory reconsolidation only when reactivation results in contradictory representations regarding the consequences of avoidance, and suggest that robust nesting of hippocampal theta-gamma rhythms at the time of retrieval is a specific reconsolidation marker.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALMartínCammarota_ICe_2017_Prior learning.pdfMartínCammarota_ICe_2017_Prior learning.pdfMartínCammarota_ICe_2017_Prior learningapplication/pdf2632576https://repositorio.ufrn.br/bitstream/123456789/23832/1/Mart%c3%adnCammarota_ICe_2017_Prior%20learning.pdf42d144f42d62a332c5097dd08b2b2e03MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23832/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTMartínCammarota_ICe_2017_Prior learning.pdf.txtMartínCammarota_ICe_2017_Prior learning.pdf.txtExtracted texttext/plain75455https://repositorio.ufrn.br/bitstream/123456789/23832/5/Mart%c3%adnCammarota_ICe_2017_Prior%20learning.pdf.txtc79fa4e9c34655213f25624fd5057cf3MD55THUMBNAILMartínCammarota_ICe_2017_Prior learning.pdf.jpgMartínCammarota_ICe_2017_Prior learning.pdf.jpgIM Thumbnailimage/jpeg9174https://repositorio.ufrn.br/bitstream/123456789/23832/6/Mart%c3%adnCammarota_ICe_2017_Prior%20learning.pdf.jpg1edab415af29674e76b5232034d97c5aMD56123456789/238322024-03-19 01:04:53.96oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-03-19T04:04:53Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
| dc.title.pt_BR.fl_str_mv |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus |
| title |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus |
| spellingShingle |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus Radiske, Andressa memory learning post-traumatic stress disorder gamma oscillations theta cross-frequency coupling |
| title_short |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus |
| title_full |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus |
| title_fullStr |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus |
| title_full_unstemmed |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus |
| title_sort |
Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus |
| author |
Radiske, Andressa |
| author_facet |
Radiske, Andressa Gonzalez, Maria Carolina Conde-Ocaziones, Sergio Feitosa, Anatildes Köhler, Cristiano A. Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo |
| author_role |
author |
| author2 |
Gonzalez, Maria Carolina Conde-Ocaziones, Sergio Feitosa, Anatildes Köhler, Cristiano A. Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Radiske, Andressa Gonzalez, Maria Carolina Conde-Ocaziones, Sergio Feitosa, Anatildes Köhler, Cristiano A. Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo |
| dc.subject.por.fl_str_mv |
memory learning post-traumatic stress disorder gamma oscillations theta cross-frequency coupling |
| topic |
memory learning post-traumatic stress disorder gamma oscillations theta cross-frequency coupling |
| description |
2018-03-10 |
| publishDate |
2017 |
| dc.date.accessioned.fl_str_mv |
2017-09-11T17:32:56Z |
| dc.date.issued.fl_str_mv |
2017-09-08 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://repositorio.ufrn.br/jspui/handle/123456789/23832 |
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10.1523/JNEUROSCI.1372-17.2017 |
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https://repositorio.ufrn.br/jspui/handle/123456789/23832 |
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10.1523/JNEUROSCI.1372-17.2017 |
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eng |
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