Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23263 |
Resumo: | Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express a-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local a-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, a-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations. |
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Velho, Tarciso André FerreiraLu, KaiRibeiro, Sidarta Tollendal GomesPinaud, RaphaelVicario, DavidMello, Claudio V.2017-05-31T12:40:09Z2017-05-31T12:40:09Z2012-05-041932-6203https://repositorio.ufrn.br/jspui/handle/123456789/23263engNoradrenergic ControlGene ExpressionVocalizationsSongbirdsNoradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirdsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNorepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express a-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local a-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, a-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23263/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALNoradrenergic Control of Gene Expression and LongTerm.pdfNoradrenergic Control of Gene Expression and LongTerm.pdfArtigo completoapplication/pdf4496022https://repositorio.ufrn.br/bitstream/123456789/23263/1/Noradrenergic%20Control%20of%20Gene%20Expression%20and%20LongTerm.pdf76503fa841b0b77ba261712dd0f26f13MD51TEXTNoradrenergic Control of Gene Expression and LongTerm.pdf.txtNoradrenergic Control of Gene Expression and LongTerm.pdf.txtExtracted texttext/plain74676https://repositorio.ufrn.br/bitstream/123456789/23263/5/Noradrenergic%20Control%20of%20Gene%20Expression%20and%20LongTerm.pdf.txt8bd54bcd6598e0d7bb96a00a591ec13fMD55THUMBNAILNoradrenergic Control of Gene Expression and LongTerm.pdf.jpgNoradrenergic Control of Gene Expression and LongTerm.pdf.jpgIM Thumbnailimage/jpeg12914https://repositorio.ufrn.br/bitstream/123456789/23263/6/Noradrenergic%20Control%20of%20Gene%20Expression%20and%20LongTerm.pdf.jpg8d75fd26964730e02681482cd8bf9224MD56123456789/232632021-07-12 15:42:40.091oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-12T18:42:40Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds |
title |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds |
spellingShingle |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds Velho, Tarciso André Ferreira Noradrenergic Control Gene Expression Vocalizations Songbirds |
title_short |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds |
title_full |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds |
title_fullStr |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds |
title_full_unstemmed |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds |
title_sort |
Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds |
author |
Velho, Tarciso André Ferreira |
author_facet |
Velho, Tarciso André Ferreira Lu, Kai Ribeiro, Sidarta Tollendal Gomes Pinaud, Raphael Vicario, David Mello, Claudio V. |
author_role |
author |
author2 |
Lu, Kai Ribeiro, Sidarta Tollendal Gomes Pinaud, Raphael Vicario, David Mello, Claudio V. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Velho, Tarciso André Ferreira Lu, Kai Ribeiro, Sidarta Tollendal Gomes Pinaud, Raphael Vicario, David Mello, Claudio V. |
dc.subject.por.fl_str_mv |
Noradrenergic Control Gene Expression Vocalizations Songbirds |
topic |
Noradrenergic Control Gene Expression Vocalizations Songbirds |
description |
Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express a-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local a-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, a-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-05-04 |
dc.date.accessioned.fl_str_mv |
2017-05-31T12:40:09Z |
dc.date.available.fl_str_mv |
2017-05-31T12:40:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23263 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
identifier_str_mv |
1932-6203 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23263 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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