Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/31434 |
Resumo: | The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies |
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Rodrigues, P. R. S.Maia, L. L.Santos, Marcelo dosPeterle, G. T.Alves, L. U.Takamori, J. T.Souza, R. P.Barbosa, W. M.Mercante, A. M. C.Nunes, F. D.Carvalho, M. B.Tajara, E. H.Louro, I. D.Silva-Conforti, A. M. A.2021-02-09T17:33:14Z2021-02-09T17:33:14Z2015-11-24RODRIGUES, P. R. S. et al. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 14979-14988, 2015. Disponível em: http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.november.24.51676-5680 (print)https://repositorio.ufrn.br/handle/123456789/3143410.4238/2015.november.24.5Fundação de Pesquisas de Ribeirão PretoAttribution-NonCommercial-ShareAlike 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-sa/3.0/br/info:eu-repo/semantics/openAccessLEPR expressionGln223ArgPrognostic markerHead and neck cancerLeptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapiesengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81037https://repositorio.ufrn.br/bitstream/123456789/31434/2/license_rdf996f8b5afe3136b76594f43bfda24c5eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31434/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALLeptinReceptorExpression_Santos_2015.pdfLeptinReceptorExpression_Santos_2015.pdfapplication/pdf789127https://repositorio.ufrn.br/bitstream/123456789/31434/1/LeptinReceptorExpression_Santos_2015.pdf165627d5737e4702d8a14a9047c11b58MD51TEXTLeptinReceptorExpression_Santos_2015.pdf.txtLeptinReceptorExpression_Santos_2015.pdf.txtExtracted texttext/plain30734https://repositorio.ufrn.br/bitstream/123456789/31434/4/LeptinReceptorExpression_Santos_2015.pdf.txt3e2b1806392c124a15136111931ac849MD54THUMBNAILLeptinReceptorExpression_Santos_2015.pdf.jpgLeptinReceptorExpression_Santos_2015.pdf.jpgGenerated Thumbnailimage/jpeg1557https://repositorio.ufrn.br/bitstream/123456789/31434/5/LeptinReceptorExpression_Santos_2015.pdf.jpg4d149ed648700ad3956413d3f9bd73c9MD55123456789/314342022-04-11 16:18:40.542oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-04-11T19:18:40Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer |
title |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer |
spellingShingle |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer Rodrigues, P. R. S. LEPR expression Gln223Arg Prognostic marker Head and neck cancer |
title_short |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer |
title_full |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer |
title_fullStr |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer |
title_full_unstemmed |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer |
title_sort |
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer |
author |
Rodrigues, P. R. S. |
author_facet |
Rodrigues, P. R. S. Maia, L. L. Santos, Marcelo dos Peterle, G. T. Alves, L. U. Takamori, J. T. Souza, R. P. Barbosa, W. M. Mercante, A. M. C. Nunes, F. D. Carvalho, M. B. Tajara, E. H. Louro, I. D. Silva-Conforti, A. M. A. |
author_role |
author |
author2 |
Maia, L. L. Santos, Marcelo dos Peterle, G. T. Alves, L. U. Takamori, J. T. Souza, R. P. Barbosa, W. M. Mercante, A. M. C. Nunes, F. D. Carvalho, M. B. Tajara, E. H. Louro, I. D. Silva-Conforti, A. M. A. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, P. R. S. Maia, L. L. Santos, Marcelo dos Peterle, G. T. Alves, L. U. Takamori, J. T. Souza, R. P. Barbosa, W. M. Mercante, A. M. C. Nunes, F. D. Carvalho, M. B. Tajara, E. H. Louro, I. D. Silva-Conforti, A. M. A. |
dc.subject.por.fl_str_mv |
LEPR expression Gln223Arg Prognostic marker Head and neck cancer |
topic |
LEPR expression Gln223Arg Prognostic marker Head and neck cancer |
description |
The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-11-24 |
dc.date.accessioned.fl_str_mv |
2021-02-09T17:33:14Z |
dc.date.available.fl_str_mv |
2021-02-09T17:33:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RODRIGUES, P. R. S. et al. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 14979-14988, 2015. Disponível em: http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.november.24.5 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/31434 |
dc.identifier.issn.none.fl_str_mv |
1676-5680 (print) |
dc.identifier.doi.none.fl_str_mv |
10.4238/2015.november.24.5 |
identifier_str_mv |
RODRIGUES, P. R. S. et al. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 14979-14988, 2015. Disponível em: http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.november.24.5 1676-5680 (print) 10.4238/2015.november.24.5 |
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https://repositorio.ufrn.br/handle/123456789/31434 |
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eng |
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eng |
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Attribution-NonCommercial-ShareAlike 3.0 Brazil http://creativecommons.org/licenses/by-nc-sa/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-ShareAlike 3.0 Brazil http://creativecommons.org/licenses/by-nc-sa/3.0/br/ |
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openAccess |
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Fundação de Pesquisas de Ribeirão Preto |
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Fundação de Pesquisas de Ribeirão Preto |
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