Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer

Detalhes bibliográficos
Autor(a) principal: Rodrigues, P. R. S.
Data de Publicação: 2015
Outros Autores: Maia, L. L., Santos, Marcelo dos, Peterle, G. T., Alves, L. U., Takamori, J. T., Souza, R. P., Barbosa, W. M., Mercante, A. M. C., Nunes, F. D., Carvalho, M. B., Tajara, E. H., Louro, I. D., Silva-Conforti, A. M. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/31434
Resumo: The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies
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spelling Rodrigues, P. R. S.Maia, L. L.Santos, Marcelo dosPeterle, G. T.Alves, L. U.Takamori, J. T.Souza, R. P.Barbosa, W. M.Mercante, A. M. C.Nunes, F. D.Carvalho, M. B.Tajara, E. H.Louro, I. D.Silva-Conforti, A. M. A.2021-02-09T17:33:14Z2021-02-09T17:33:14Z2015-11-24RODRIGUES, P. R. S. et al. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 14979-14988, 2015. Disponível em: http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.november.24.51676-5680 (print)https://repositorio.ufrn.br/handle/123456789/3143410.4238/2015.november.24.5Fundação de Pesquisas de Ribeirão PretoAttribution-NonCommercial-ShareAlike 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-sa/3.0/br/info:eu-repo/semantics/openAccessLEPR expressionGln223ArgPrognostic markerHead and neck cancerLeptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapiesengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81037https://repositorio.ufrn.br/bitstream/123456789/31434/2/license_rdf996f8b5afe3136b76594f43bfda24c5eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31434/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALLeptinReceptorExpression_Santos_2015.pdfLeptinReceptorExpression_Santos_2015.pdfapplication/pdf789127https://repositorio.ufrn.br/bitstream/123456789/31434/1/LeptinReceptorExpression_Santos_2015.pdf165627d5737e4702d8a14a9047c11b58MD51TEXTLeptinReceptorExpression_Santos_2015.pdf.txtLeptinReceptorExpression_Santos_2015.pdf.txtExtracted texttext/plain30734https://repositorio.ufrn.br/bitstream/123456789/31434/4/LeptinReceptorExpression_Santos_2015.pdf.txt3e2b1806392c124a15136111931ac849MD54THUMBNAILLeptinReceptorExpression_Santos_2015.pdf.jpgLeptinReceptorExpression_Santos_2015.pdf.jpgGenerated Thumbnailimage/jpeg1557https://repositorio.ufrn.br/bitstream/123456789/31434/5/LeptinReceptorExpression_Santos_2015.pdf.jpg4d149ed648700ad3956413d3f9bd73c9MD55123456789/314342022-04-11 16:18:40.542oai:https://repositorio.ufrn.br:123456789/31434Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKCkJ5IHNpZ25pbmcgYW5kIGRlbGl2ZXJpbmcgdGhpcyBsaWNlbnNlLCBNci4gKGF1dGhvciBvciBjb3B5cmlnaHQgaG9sZGVyKToKCgphKSBHcmFudHMgdGhlIFVuaXZlcnNpZGFkZSBGZWRlcmFsIFJpbyBHcmFuZGUgZG8gTm9ydGUgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgb2YKcmVwcm9kdWNlLCBjb252ZXJ0IChhcyBkZWZpbmVkIGJlbG93KSwgY29tbXVuaWNhdGUgYW5kIC8gb3IKZGlzdHJpYnV0ZSB0aGUgZGVsaXZlcmVkIGRvY3VtZW50IChpbmNsdWRpbmcgYWJzdHJhY3QgLyBhYnN0cmFjdCkgaW4KZGlnaXRhbCBvciBwcmludGVkIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bS4KCmIpIERlY2xhcmVzIHRoYXQgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBpdHMgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQKeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gRGVjbGFyZXMKdGhhdCB0aGUgZGVsaXZlcnkgb2YgdGhlIGRvY3VtZW50IGRvZXMgbm90IGluZnJpbmdlLCBhcyBmYXIgYXMgaXQgaXMKdGhlIHJpZ2h0cyBvZiBhbnkgb3RoZXIgcGVyc29uIG9yIGVudGl0eS4KCmMpIElmIHRoZSBkb2N1bWVudCBkZWxpdmVyZWQgY29udGFpbnMgbWF0ZXJpYWwgd2hpY2ggZG9lcyBub3QKcmlnaHRzLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBvYnRhaW5lZCBhdXRob3JpemF0aW9uIGZyb20gdGhlIGhvbGRlciBvZiB0aGUKY29weXJpZ2h0IHRvIGdyYW50IHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdCB0aGlzIG1hdGVyaWFsIHdob3NlIHJpZ2h0cyBhcmUgb2YKdGhpcmQgcGFydGllcyBpcyBjbGVhcmx5IGlkZW50aWZpZWQgYW5kIHJlY29nbml6ZWQgaW4gdGhlIHRleHQgb3IKY29udGVudCBvZiB0aGUgZG9jdW1lbnQgZGVsaXZlcmVkLgoKSWYgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBiYXNlZCBvbiBmdW5kZWQgb3Igc3VwcG9ydGVkIHdvcmsKYnkgYW5vdGhlciBpbnN0aXR1dGlvbiBvdGhlciB0aGFuIHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBmdWxmaWxsZWQgYW55IG9ibGlnYXRpb25zIHJlcXVpcmVkIGJ5IHRoZSByZXNwZWN0aXZlIGFncmVlbWVudCBvciBhZ3JlZW1lbnQuCgpUaGUgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBOb3J0ZSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgaXRzIG5hbWUgKHMpIGFzIHRoZSBhdXRob3IgKHMpIG9yIGhvbGRlciAocykgb2YgdGhlIGRvY3VtZW50J3MgcmlnaHRzCmRlbGl2ZXJlZCwgYW5kIHdpbGwgbm90IG1ha2UgYW55IGNoYW5nZXMsIG90aGVyIHRoYW4gdGhvc2UgcGVybWl0dGVkIGJ5CnRoaXMgbGljZW5zZQo=Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-04-11T19:18:40Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
title Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
spellingShingle Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
Rodrigues, P. R. S.
LEPR expression
Gln223Arg
Prognostic marker
Head and neck cancer
title_short Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
title_full Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
title_fullStr Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
title_full_unstemmed Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
title_sort Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
author Rodrigues, P. R. S.
author_facet Rodrigues, P. R. S.
Maia, L. L.
Santos, Marcelo dos
Peterle, G. T.
Alves, L. U.
Takamori, J. T.
Souza, R. P.
Barbosa, W. M.
Mercante, A. M. C.
Nunes, F. D.
Carvalho, M. B.
Tajara, E. H.
Louro, I. D.
Silva-Conforti, A. M. A.
author_role author
author2 Maia, L. L.
Santos, Marcelo dos
Peterle, G. T.
Alves, L. U.
Takamori, J. T.
Souza, R. P.
Barbosa, W. M.
Mercante, A. M. C.
Nunes, F. D.
Carvalho, M. B.
Tajara, E. H.
Louro, I. D.
Silva-Conforti, A. M. A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, P. R. S.
Maia, L. L.
Santos, Marcelo dos
Peterle, G. T.
Alves, L. U.
Takamori, J. T.
Souza, R. P.
Barbosa, W. M.
Mercante, A. M. C.
Nunes, F. D.
Carvalho, M. B.
Tajara, E. H.
Louro, I. D.
Silva-Conforti, A. M. A.
dc.subject.por.fl_str_mv LEPR expression
Gln223Arg
Prognostic marker
Head and neck cancer
topic LEPR expression
Gln223Arg
Prognostic marker
Head and neck cancer
description The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies
publishDate 2015
dc.date.issued.fl_str_mv 2015-11-24
dc.date.accessioned.fl_str_mv 2021-02-09T17:33:14Z
dc.date.available.fl_str_mv 2021-02-09T17:33:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv RODRIGUES, P. R. S. et al. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 14979-14988, 2015. Disponível em: http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.november.24.5
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/31434
dc.identifier.issn.none.fl_str_mv 1676-5680 (print)
dc.identifier.doi.none.fl_str_mv 10.4238/2015.november.24.5
identifier_str_mv RODRIGUES, P. R. S. et al. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 14979-14988, 2015. Disponível em: http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.november.24.5
1676-5680 (print)
10.4238/2015.november.24.5
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