Chitosan-based copaiba oil carrier polymeric systems: obtaining, characterization and antifungal activity in vitro

• Autor(a) principal: Bezerra, Gabriela Suassuna
• Data de Publicação: 2020
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/35823
• topic: Copaiba oil; Microemulsioned system; Chitosan

Copaifera multijuga Hayne is a typical Brazilian species known for producing copaíba oil-resin and its wide use by popular medicine due to its various pharmacological properties, however, its lipophilic character makes its use in new pharmaceutical systems difficult. Chitosan is a polymer of great interest in the pharmaceutical area due to its biocompatibility, filmogenic and bioadhesive properties, which allows its use by topic. To obtain chitosan polymeric systems with copaiba oil, two methods of obtaining films were used, the direct incorporation of the oil in the polymeric matrix and a microemulsioned carrier system. The interactions between the oil and the polymeric network were analyzed by infrared spectroscopy, thermogravimetry and X-ray diffraction techniques, as well as the characterization of the microemulsioned system used. The microemulsion obtained was effective in the formation of a copaiba oil carrier film, causing changes in the physical-chemical pattern that prove an adequate incorporation and increase in the diffusion of the oil in the culture medium, and may become a therapeutic alternative for skin injury treatments, since growth inhibition halos were observed in strains of Candida spp.