Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23859 |
Resumo: | The expression of integrins α2β1, α3β1, and α5β1 in 30 ameloblastomas (20 solid and 10 unicystic tumors), 12 adenomatoid odontogenic tumors (AOTs), and 5 human tooth germs in different stages of odontogenesis was analyzed. The distribution, location, pattern, and intensity of immunohistochemical expression were evaluated. Intensity was analyzed using scores (0 = absence, 1 = weak staining, and 2 = strong staining). No difference in the immunoexpression of the integrins was observed between solid and unicystic ameloblastomas. When these two ameloblastoma types were pooled into a single group, the following significant differences were found: immunoexpression of integrin α2β1 was stronger in ameloblastomas than in AOTs and tooth germs, and the expression of integrin α5β1 was stronger in ameloblastomas than in AOTs. The lack of detection of integrin α3β1 in tooth germs and its detection in the odontogenic tumors studied suggest that this integrin might be used as a marker of neoplastic transformation in odontogenic tissues. |
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Andrade, Emanuel Sávio de SouzaMiguel, Márcia Cristina da CostaFreitas, Roseana de AlmeidaPinto, Leão PereiraSouza, Lélia Batista de2017-09-13T15:24:29Z2017-09-13T15:24:29Z2008ANDRADE, Emanuel Sávio de Souza et al . Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor and human tooth germs. International Journal of Surgical Pathology, v. 16, n. 3, p. 277-285, 2008.10668969https://repositorio.ufrn.br/jspui/handle/123456789/23859engAmeloblastomaAdenomatoid odontogenic tumorHuman tooth germsIntegrinsImmunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe expression of integrins α2β1, α3β1, and α5β1 in 30 ameloblastomas (20 solid and 10 unicystic tumors), 12 adenomatoid odontogenic tumors (AOTs), and 5 human tooth germs in different stages of odontogenesis was analyzed. The distribution, location, pattern, and intensity of immunohistochemical expression were evaluated. Intensity was analyzed using scores (0 = absence, 1 = weak staining, and 2 = strong staining). No difference in the immunoexpression of the integrins was observed between solid and unicystic ameloblastomas. When these two ameloblastoma types were pooled into a single group, the following significant differences were found: immunoexpression of integrin α2β1 was stronger in ameloblastomas than in AOTs and tooth germs, and the expression of integrin α5β1 was stronger in ameloblastomas than in AOTs. The lack of detection of integrin α3β1 in tooth germs and its detection in the odontogenic tumors studied suggest that this integrin might be used as a marker of neoplastic transformation in odontogenic tissues.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALImmunoexpressionIntegrinsAmeloblastoma_Andrade_2008.pdfImmunoexpressionIntegrinsAmeloblastoma_Andrade_2008.pdfhttp://journals.sagepub.com/doi/abs/10.1177/1066896907306084?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&application/pdf1645944https://repositorio.ufrn.br/bitstream/123456789/23859/1/ImmunoexpressionIntegrinsAmeloblastoma_Andrade_2008.pdf9af66ce2adf8fb6e266843beb5d863d4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23859/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTImmunoexpression of Integrins.pdf.txtImmunoexpression of Integrins.pdf.txtExtracted texttext/plain35323https://repositorio.ufrn.br/bitstream/123456789/23859/5/Immunoexpression%20of%20Integrins.pdf.txtd41cef21a093ab44414c1d9027d48e82MD55THUMBNAILImmunoexpression of Integrins.pdf.jpgImmunoexpression of Integrins.pdf.jpgIM Thumbnailimage/jpeg12457https://repositorio.ufrn.br/bitstream/123456789/23859/6/Immunoexpression%20of%20Integrins.pdf.jpg7a51384f11b7c4152014ae87e7d895cfMD56123456789/238592021-12-09 13:17:57.345oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-12-09T16:17:57Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs |
title |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs |
spellingShingle |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs Andrade, Emanuel Sávio de Souza Ameloblastoma Adenomatoid odontogenic tumor Human tooth germs Integrins |
title_short |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs |
title_full |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs |
title_fullStr |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs |
title_full_unstemmed |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs |
title_sort |
Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs |
author |
Andrade, Emanuel Sávio de Souza |
author_facet |
Andrade, Emanuel Sávio de Souza Miguel, Márcia Cristina da Costa Freitas, Roseana de Almeida Pinto, Leão Pereira Souza, Lélia Batista de |
author_role |
author |
author2 |
Miguel, Márcia Cristina da Costa Freitas, Roseana de Almeida Pinto, Leão Pereira Souza, Lélia Batista de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Emanuel Sávio de Souza Miguel, Márcia Cristina da Costa Freitas, Roseana de Almeida Pinto, Leão Pereira Souza, Lélia Batista de |
dc.subject.por.fl_str_mv |
Ameloblastoma Adenomatoid odontogenic tumor Human tooth germs Integrins |
topic |
Ameloblastoma Adenomatoid odontogenic tumor Human tooth germs Integrins |
description |
The expression of integrins α2β1, α3β1, and α5β1 in 30 ameloblastomas (20 solid and 10 unicystic tumors), 12 adenomatoid odontogenic tumors (AOTs), and 5 human tooth germs in different stages of odontogenesis was analyzed. The distribution, location, pattern, and intensity of immunohistochemical expression were evaluated. Intensity was analyzed using scores (0 = absence, 1 = weak staining, and 2 = strong staining). No difference in the immunoexpression of the integrins was observed between solid and unicystic ameloblastomas. When these two ameloblastoma types were pooled into a single group, the following significant differences were found: immunoexpression of integrin α2β1 was stronger in ameloblastomas than in AOTs and tooth germs, and the expression of integrin α5β1 was stronger in ameloblastomas than in AOTs. The lack of detection of integrin α3β1 in tooth germs and its detection in the odontogenic tumors studied suggest that this integrin might be used as a marker of neoplastic transformation in odontogenic tissues. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2017-09-13T15:24:29Z |
dc.date.available.fl_str_mv |
2017-09-13T15:24:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, Emanuel Sávio de Souza et al . Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor and human tooth germs. International Journal of Surgical Pathology, v. 16, n. 3, p. 277-285, 2008. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23859 |
dc.identifier.issn.none.fl_str_mv |
10668969 |
identifier_str_mv |
ANDRADE, Emanuel Sávio de Souza et al . Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor and human tooth germs. International Journal of Surgical Pathology, v. 16, n. 3, p. 277-285, 2008. 10668969 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23859 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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