Common marmosets: a potential translational animal model of juvenile depression
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23985 |
Resumo: | Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression. The purpose was to validate this species and protocol as a translational model of juvenile depression, addressing all domain criteria of validation: etiologic, face, functional, predictive, inter-relational, evolutionary, and population. In both sexes and both protocols (IDS and DPT), we observed a significant reduction in cortisol levels in the last phase of social isolation, concomitant with increases in autogrooming, stereotyped and anxiety behaviors, and the presence of anhedonia. The alterations induced by chronic social isolation are characteristic of the depressive state in non-human primates and/or in humans, and were reversed in large part by treatment with an antidepressant drug (nortriptyline). Therefore, these results indicate C. jacchus as a potential translational model of juvenile depression by addressing all criteria of validation. |
id |
UFRN_f24e30d636958e5a156a39ddefb2ae0a |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/23985 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Galvão-Coelho, Nicole LeiteGalvão, Ana Cecília de MenezesSilva, Flávia Santos daSousa, Maria Bernardete Cordeiro de2017-10-05T16:29:30Z2017-10-05T16:29:30Z2017-09-21Galvão-Coelho NL, Galvão ACM, Silva FS, Sousa MBC (2017) Common marmosets: a potential translational animal model of juvenile depression. FrontIiers in Psychiatry 8:175.https://repositorio.ufrn.br/jspui/handle/123456789/2398510.3389/fpsyt.2017.00175engbehaviorscortisolchronic stressearly-age depressionnon-human primatetranslational animal modelCommon marmosets: a potential translational animal model of juvenile depressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMajor depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression. The purpose was to validate this species and protocol as a translational model of juvenile depression, addressing all domain criteria of validation: etiologic, face, functional, predictive, inter-relational, evolutionary, and population. In both sexes and both protocols (IDS and DPT), we observed a significant reduction in cortisol levels in the last phase of social isolation, concomitant with increases in autogrooming, stereotyped and anxiety behaviors, and the presence of anhedonia. The alterations induced by chronic social isolation are characteristic of the depressive state in non-human primates and/or in humans, and were reversed in large part by treatment with an antidepressant drug (nortriptyline). Therefore, these results indicate C. jacchus as a potential translational model of juvenile depression by addressing all criteria of validation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALBernardeteSousa_ICe_2017_Common marmosets.pdfBernardeteSousa_ICe_2017_Common marmosets.pdfBernardeteSousa_ICe_2017_Common marmosetsapplication/pdf2188143https://repositorio.ufrn.br/bitstream/123456789/23985/1/BernardeteSousa_ICe_2017_Common%20marmosets.pdf97c17a9859e6eca3349b40d449f86ec9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23985/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTBernardeteSousa_ICe_2017_Common marmosets.pdf.txtBernardeteSousa_ICe_2017_Common marmosets.pdf.txtExtracted texttext/plain90799https://repositorio.ufrn.br/bitstream/123456789/23985/5/BernardeteSousa_ICe_2017_Common%20marmosets.pdf.txt3b52fff4182a376731406cbcf9e75c70MD55THUMBNAILBernardeteSousa_ICe_2017_Common marmosets.pdf.jpgBernardeteSousa_ICe_2017_Common marmosets.pdf.jpgIM Thumbnailimage/jpeg11104https://repositorio.ufrn.br/bitstream/123456789/23985/6/BernardeteSousa_ICe_2017_Common%20marmosets.pdf.jpg33fa32b07efd11d6f4f212b63ed8e145MD56123456789/239852017-11-04 20:55:29.891oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2017-11-04T23:55:29Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Common marmosets: a potential translational animal model of juvenile depression |
title |
Common marmosets: a potential translational animal model of juvenile depression |
spellingShingle |
Common marmosets: a potential translational animal model of juvenile depression Galvão-Coelho, Nicole Leite behaviors cortisol chronic stress early-age depression non-human primate translational animal model |
title_short |
Common marmosets: a potential translational animal model of juvenile depression |
title_full |
Common marmosets: a potential translational animal model of juvenile depression |
title_fullStr |
Common marmosets: a potential translational animal model of juvenile depression |
title_full_unstemmed |
Common marmosets: a potential translational animal model of juvenile depression |
title_sort |
Common marmosets: a potential translational animal model of juvenile depression |
author |
Galvão-Coelho, Nicole Leite |
author_facet |
Galvão-Coelho, Nicole Leite Galvão, Ana Cecília de Menezes Silva, Flávia Santos da Sousa, Maria Bernardete Cordeiro de |
author_role |
author |
author2 |
Galvão, Ana Cecília de Menezes Silva, Flávia Santos da Sousa, Maria Bernardete Cordeiro de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Galvão-Coelho, Nicole Leite Galvão, Ana Cecília de Menezes Silva, Flávia Santos da Sousa, Maria Bernardete Cordeiro de |
dc.subject.por.fl_str_mv |
behaviors cortisol chronic stress early-age depression non-human primate translational animal model |
topic |
behaviors cortisol chronic stress early-age depression non-human primate translational animal model |
description |
Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression. The purpose was to validate this species and protocol as a translational model of juvenile depression, addressing all domain criteria of validation: etiologic, face, functional, predictive, inter-relational, evolutionary, and population. In both sexes and both protocols (IDS and DPT), we observed a significant reduction in cortisol levels in the last phase of social isolation, concomitant with increases in autogrooming, stereotyped and anxiety behaviors, and the presence of anhedonia. The alterations induced by chronic social isolation are characteristic of the depressive state in non-human primates and/or in humans, and were reversed in large part by treatment with an antidepressant drug (nortriptyline). Therefore, these results indicate C. jacchus as a potential translational model of juvenile depression by addressing all criteria of validation. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-10-05T16:29:30Z |
dc.date.available.fl_str_mv |
2017-10-05T16:29:30Z |
dc.date.issued.fl_str_mv |
2017-09-21 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Galvão-Coelho NL, Galvão ACM, Silva FS, Sousa MBC (2017) Common marmosets: a potential translational animal model of juvenile depression. FrontIiers in Psychiatry 8:175. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23985 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fpsyt.2017.00175 |
identifier_str_mv |
Galvão-Coelho NL, Galvão ACM, Silva FS, Sousa MBC (2017) Common marmosets: a potential translational animal model of juvenile depression. FrontIiers in Psychiatry 8:175. 10.3389/fpsyt.2017.00175 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23985 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/23985/1/BernardeteSousa_ICe_2017_Common%20marmosets.pdf https://repositorio.ufrn.br/bitstream/123456789/23985/2/license.txt https://repositorio.ufrn.br/bitstream/123456789/23985/5/BernardeteSousa_ICe_2017_Common%20marmosets.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/23985/6/BernardeteSousa_ICe_2017_Common%20marmosets.pdf.jpg |
bitstream.checksum.fl_str_mv |
97c17a9859e6eca3349b40d449f86ec9 8a4605be74aa9ea9d79846c1fba20a33 3b52fff4182a376731406cbcf9e75c70 33fa32b07efd11d6f4f212b63ed8e145 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117664541245440 |