Hemorrhagic stroke and COVID-19 infection: coincidence or causality?

Detalhes bibliográficos
Autor(a) principal: Godeiro Junior, Clécio de Oliveira
Data de Publicação: 2020
Outros Autores: Freire, Mariana, Moreira Neto, Manuel, Fraiman, Pedro Henrique Almeida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/52862
Resumo: Amyloid Protein Precursor gene duplication is a rare cause of early-onset Alzheimer's disease that can be associated with Cerebral Amyloid Angiopathy. This condition predisposes cerebrovascular events, specifically, intracerebral hemorrhagic stroke. This report describes a case of first-time intracerebral hemorrhage in a patient with APP gene duplication during SARS-CoV-2 infection, a typically pro-thrombotic and pro-inflammatory condition, as a possible trigger for this condition.
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spelling Godeiro Junior, Clécio de OliveiraFreire, MarianaMoreira Neto, ManuelFraiman, Pedro Henrique Almeida0000-0002-4312-16332023-06-23T15:18:33Z2023-06-23T15:18:33Z2020-12GODEIRO JUNIOR, Clécio de Oliveira et al. Hemorrhagic stroke and COVID-19 infection: coincidence or causality?. Eneurologicalsci, [S.L.], v. 21, p. 100274, dez. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.ensci.2020.100274. Disponível em: https://www.sciencedirect.com/science/article/pii/S2405650220300538?via%3Dihub. Acesso em: 23 jun. 2023.https://repositorio.ufrn.br/handle/123456789/5286210.1016/j.ensci.2020.100274ElsevierAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCOVID-19early-onset alzheimer's diseasestrokeHemorrhagic stroke and COVID-19 infection: coincidence or causality?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAmyloid Protein Precursor gene duplication is a rare cause of early-onset Alzheimer's disease that can be associated with Cerebral Amyloid Angiopathy. This condition predisposes cerebrovascular events, specifically, intracerebral hemorrhagic stroke. This report describes a case of first-time intracerebral hemorrhage in a patient with APP gene duplication during SARS-CoV-2 infection, a typically pro-thrombotic and pro-inflammatory condition, as a possible trigger for this condition.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALHemorrhagicStrokeCOVID-19_GodeiroJunior_Etal_2020.pdfHemorrhagicStrokeCOVID-19_GodeiroJunior_Etal_2020.pdfapplication/pdf782349https://repositorio.ufrn.br/bitstream/123456789/52862/1/HemorrhagicStrokeCOVID-19_GodeiroJunior_Etal_2020.pdfccae7798cf8f8219830b05744c8cd3b9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/52862/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufrn.br/bitstream/123456789/52862/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52123456789/528622023-06-23 12:19:09.562oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-06-23T15:19:09Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
title Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
spellingShingle Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
Godeiro Junior, Clécio de Oliveira
COVID-19
early-onset alzheimer's disease
stroke
title_short Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
title_full Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
title_fullStr Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
title_full_unstemmed Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
title_sort Hemorrhagic stroke and COVID-19 infection: coincidence or causality?
author Godeiro Junior, Clécio de Oliveira
author_facet Godeiro Junior, Clécio de Oliveira
Freire, Mariana
Moreira Neto, Manuel
Fraiman, Pedro Henrique Almeida
author_role author
author2 Freire, Mariana
Moreira Neto, Manuel
Fraiman, Pedro Henrique Almeida
author2_role author
author
author
dc.contributor.authorID.pt_BR.fl_str_mv 0000-0002-4312-1633
dc.contributor.author.fl_str_mv Godeiro Junior, Clécio de Oliveira
Freire, Mariana
Moreira Neto, Manuel
Fraiman, Pedro Henrique Almeida
dc.subject.por.fl_str_mv COVID-19
early-onset alzheimer's disease
stroke
topic COVID-19
early-onset alzheimer's disease
stroke
description Amyloid Protein Precursor gene duplication is a rare cause of early-onset Alzheimer's disease that can be associated with Cerebral Amyloid Angiopathy. This condition predisposes cerebrovascular events, specifically, intracerebral hemorrhagic stroke. This report describes a case of first-time intracerebral hemorrhage in a patient with APP gene duplication during SARS-CoV-2 infection, a typically pro-thrombotic and pro-inflammatory condition, as a possible trigger for this condition.
publishDate 2020
dc.date.issued.fl_str_mv 2020-12
dc.date.accessioned.fl_str_mv 2023-06-23T15:18:33Z
dc.date.available.fl_str_mv 2023-06-23T15:18:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GODEIRO JUNIOR, Clécio de Oliveira et al. Hemorrhagic stroke and COVID-19 infection: coincidence or causality?. Eneurologicalsci, [S.L.], v. 21, p. 100274, dez. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.ensci.2020.100274. Disponível em: https://www.sciencedirect.com/science/article/pii/S2405650220300538?via%3Dihub. Acesso em: 23 jun. 2023.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/52862
dc.identifier.doi.none.fl_str_mv 10.1016/j.ensci.2020.100274
identifier_str_mv GODEIRO JUNIOR, Clécio de Oliveira et al. Hemorrhagic stroke and COVID-19 infection: coincidence or causality?. Eneurologicalsci, [S.L.], v. 21, p. 100274, dez. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.ensci.2020.100274. Disponível em: https://www.sciencedirect.com/science/article/pii/S2405650220300538?via%3Dihub. Acesso em: 23 jun. 2023.
10.1016/j.ensci.2020.100274
url https://repositorio.ufrn.br/handle/123456789/52862
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
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rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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