Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54239 https://doi.org/10.3389/fneur.2018.00306 |
Resumo: | The relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these parameters were investigated non-invasively through nasal inspiratory sniff pressure test (SNIP) in 39 middle stage spinal onset ALS subjects and compared with 39 healthy controls. ALS patients were also divided into three subgroups according to a decline in their percentage of predicted forced vital capacity (FVC%pred) as well as a decline in the ALS functional rating scale score and its respiratory subscore (R-subscore) in order to determine the best parameter linked to early respiratory muscle weakness. When compared with healthy subjects, middle stage ALS subjects exhibited a significantly lower (p < 0.0001) maximum relaxation rate and maximum rate of pressure development (MRPD), as well as a significantly higher (p < 0.0001) tau (τ), contraction time, and half-relaxation time. The results from receiver operating characteristic curves showed that MRPD (AUC 0.735, p < 0.001) and FVC%pred (AUC 0.749, p = 0.009) were the best discriminator parameters between ALS patients with ≤30 and >30 points in the ALS functional rating scale. In addition, 1/2RT (AUC 0.720, p = 0.01), FVC%pred (AUC 0.700, p = 0.03), τ (AUC 0.824, p < 0.0001), and MRPD (AUC 0.721, p = 0.01) were the parameters more sensitive in detecting a fall of three points in the R-subscore. On the other hand, MRPD (AUC 0.781, p < 0.001), τ (AUC 0.794, p = 0.0001), and percentage of predicted of SNIP (AUC 0.769, p = 0.002) were the parameters able to detect a fall in 30% of the FVC%pred in middle stage ALS patients. The contractile properties and relaxation rates of the diaphragm are altered in middle stage spinal onset ALS when compared with healthy subjects. These parameters are able to discriminate between those middle stage ALS subjects with early decline in inspiratory muscle function and those who not. |
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Dourado Junior, Mário Emílio TeixeiraSarmento, AntonioAliverti, AndreaMarques, LayanaPennati, FrancescaFregonezi, GuilhermeFregonezi, Vanessa Regiane Resquetihttps://orcid.org/0000-0002-9462-22942023-07-27T20:03:11Z2023-07-27T20:03:11Z2018-05-02DOURADO JÚNIOR, Mário Emílio Teixeira, et al. Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis. Frontiers in Neurology, v. 9, p. 10.3389. DOI: 10.3389/fneur.2018.00306 Disponível em: https://www.frontiersin.org/articles/10.3389/fneur.2018.00306/full Acesso em: 19 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54239https://doi.org/10.3389/fneur.2018.00306Frontiers in NeurologyAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessamyotrophic lateral sclerosisforced vital capacityinspiratory muscle weaknessrelaxation ratesrespiratory subscoresniff nasal inspiratory pressureMultiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these parameters were investigated non-invasively through nasal inspiratory sniff pressure test (SNIP) in 39 middle stage spinal onset ALS subjects and compared with 39 healthy controls. ALS patients were also divided into three subgroups according to a decline in their percentage of predicted forced vital capacity (FVC%pred) as well as a decline in the ALS functional rating scale score and its respiratory subscore (R-subscore) in order to determine the best parameter linked to early respiratory muscle weakness. When compared with healthy subjects, middle stage ALS subjects exhibited a significantly lower (p < 0.0001) maximum relaxation rate and maximum rate of pressure development (MRPD), as well as a significantly higher (p < 0.0001) tau (τ), contraction time, and half-relaxation time. The results from receiver operating characteristic curves showed that MRPD (AUC 0.735, p < 0.001) and FVC%pred (AUC 0.749, p = 0.009) were the best discriminator parameters between ALS patients with ≤30 and >30 points in the ALS functional rating scale. In addition, 1/2RT (AUC 0.720, p = 0.01), FVC%pred (AUC 0.700, p = 0.03), τ (AUC 0.824, p < 0.0001), and MRPD (AUC 0.721, p = 0.01) were the parameters more sensitive in detecting a fall of three points in the R-subscore. On the other hand, MRPD (AUC 0.781, p < 0.001), τ (AUC 0.794, p = 0.0001), and percentage of predicted of SNIP (AUC 0.769, p = 0.002) were the parameters able to detect a fall in 30% of the FVC%pred in middle stage ALS patients. The contractile properties and relaxation rates of the diaphragm are altered in middle stage spinal onset ALS when compared with healthy subjects. These parameters are able to discriminate between those middle stage ALS subjects with early decline in inspiratory muscle function and those who not.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/54239/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54239/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALMultiparametricAnalysisSniff_Douradojr_2018.pdfMultiparametricAnalysisSniff_Douradojr_2018.pdfapplication/pdf737437https://repositorio.ufrn.br/bitstream/123456789/54239/1/MultiparametricAnalysisSniff_Douradojr_2018.pdf02b522cfcc483f96f5aea5853329ba53MD51123456789/542392023-07-27 17:03:11.522oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-27T20:03:11Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis |
title |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis |
spellingShingle |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis Dourado Junior, Mário Emílio Teixeira amyotrophic lateral sclerosis forced vital capacity inspiratory muscle weakness relaxation rates respiratory subscore sniff nasal inspiratory pressure |
title_short |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis |
title_full |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis |
title_fullStr |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis |
title_full_unstemmed |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis |
title_sort |
Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis |
author |
Dourado Junior, Mário Emílio Teixeira |
author_facet |
Dourado Junior, Mário Emílio Teixeira Sarmento, Antonio Aliverti, Andrea Marques, Layana Pennati, Francesca Fregonezi, Guilherme Fregonezi, Vanessa Regiane Resqueti |
author_role |
author |
author2 |
Sarmento, Antonio Aliverti, Andrea Marques, Layana Pennati, Francesca Fregonezi, Guilherme Fregonezi, Vanessa Regiane Resqueti |
author2_role |
author author author author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-9462-2294 |
dc.contributor.author.fl_str_mv |
Dourado Junior, Mário Emílio Teixeira Sarmento, Antonio Aliverti, Andrea Marques, Layana Pennati, Francesca Fregonezi, Guilherme Fregonezi, Vanessa Regiane Resqueti |
dc.subject.por.fl_str_mv |
amyotrophic lateral sclerosis forced vital capacity inspiratory muscle weakness relaxation rates respiratory subscore sniff nasal inspiratory pressure |
topic |
amyotrophic lateral sclerosis forced vital capacity inspiratory muscle weakness relaxation rates respiratory subscore sniff nasal inspiratory pressure |
description |
The relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these parameters were investigated non-invasively through nasal inspiratory sniff pressure test (SNIP) in 39 middle stage spinal onset ALS subjects and compared with 39 healthy controls. ALS patients were also divided into three subgroups according to a decline in their percentage of predicted forced vital capacity (FVC%pred) as well as a decline in the ALS functional rating scale score and its respiratory subscore (R-subscore) in order to determine the best parameter linked to early respiratory muscle weakness. When compared with healthy subjects, middle stage ALS subjects exhibited a significantly lower (p < 0.0001) maximum relaxation rate and maximum rate of pressure development (MRPD), as well as a significantly higher (p < 0.0001) tau (τ), contraction time, and half-relaxation time. The results from receiver operating characteristic curves showed that MRPD (AUC 0.735, p < 0.001) and FVC%pred (AUC 0.749, p = 0.009) were the best discriminator parameters between ALS patients with ≤30 and >30 points in the ALS functional rating scale. In addition, 1/2RT (AUC 0.720, p = 0.01), FVC%pred (AUC 0.700, p = 0.03), τ (AUC 0.824, p < 0.0001), and MRPD (AUC 0.721, p = 0.01) were the parameters more sensitive in detecting a fall of three points in the R-subscore. On the other hand, MRPD (AUC 0.781, p < 0.001), τ (AUC 0.794, p = 0.0001), and percentage of predicted of SNIP (AUC 0.769, p = 0.002) were the parameters able to detect a fall in 30% of the FVC%pred in middle stage ALS patients. The contractile properties and relaxation rates of the diaphragm are altered in middle stage spinal onset ALS when compared with healthy subjects. These parameters are able to discriminate between those middle stage ALS subjects with early decline in inspiratory muscle function and those who not. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-05-02 |
dc.date.accessioned.fl_str_mv |
2023-07-27T20:03:11Z |
dc.date.available.fl_str_mv |
2023-07-27T20:03:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DOURADO JÚNIOR, Mário Emílio Teixeira, et al. Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis. Frontiers in Neurology, v. 9, p. 10.3389. DOI: 10.3389/fneur.2018.00306 Disponível em: https://www.frontiersin.org/articles/10.3389/fneur.2018.00306/full Acesso em: 19 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54239 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3389/fneur.2018.00306 |
identifier_str_mv |
DOURADO JÚNIOR, Mário Emílio Teixeira, et al. Multiparametric analysis of sniff nasal inspiratory pressure test in middle stage amyotrophic lateral sclerosis. Frontiers in Neurology, v. 9, p. 10.3389. DOI: 10.3389/fneur.2018.00306 Disponível em: https://www.frontiersin.org/articles/10.3389/fneur.2018.00306/full Acesso em: 19 jul. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/54239 https://doi.org/10.3389/fneur.2018.00306 |
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eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Frontiers in Neurology |
publisher.none.fl_str_mv |
Frontiers in Neurology |
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