Hippocampal functional organization: a microstructure of the place cell network encoding space
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/26963 |
Resumo: | A clue to hippocampal function has been the discovery of place cells, leading to the ‘spatial map’ theory. Although the firing attributes of place cells are well documented, little is known about the organization of the spatial map. Unit recording studies, thus far, have reported a low coherence between neighboring cells and geometric space, leading to the prevalent view that the spatial map is not topographically organized. However, the number of simultaneously recorded units is severely limited, rendering construction of the spatial map nearly impossible. To visualize the functional organization of place cells, we used the activity-dependent immediate-early gene Zif268 in combination with behavioral, pharmacological and electrophysiological methods, in mice and rats exploring an environment. Here, we show that in animals confined to a small part of a maze, principal cells in the CA1/CA3 subfields of the dorsal hippocampus immunoreactive (IR) for Zif268 adhere to a ‘cluster-type’ organization. Unit recordings confirmed that the Zif268 IR clusters correspond to active place cells, while blockade of NMDAR (which alters place fields) disrupted the Zif268 IR clusters. Contrary to the prevalent view that the spatial map consists of a non-topographic neural network, our results provide evidence for a ‘cluster-type’ functional organization of hippocampal neurons encoding for space. |
id |
UFRN_f9b914757b54722a5f916bc3803909c5 |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/26963 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Pavlides, ConstantineDonishi, TomohiroRibeiro, Sidarta Tollendal GomesMello, Claudio V.Blanco, WilfredoOgawa, Sonoko2019-04-23T17:13:50Z2019-04-23T17:13:50Z2019-04-06PAVLIDES, C. et al. Hippocampal functional organization: a microstructure of the place cell network encoding space. Neurobiology of Learning and Memory, v. 161, p. 122-134, maio 2019. doi: 10.1016/j.nlm.2019.03.010https://repositorio.ufrn.br/jspui/handle/123456789/2696310.1016/j.nlm.2019.03.010hippocampusplace cellsspatial mapcluster-type organizationimmediate early genesZif268Hippocampal functional organization: a microstructure of the place cell network encoding spaceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleA clue to hippocampal function has been the discovery of place cells, leading to the ‘spatial map’ theory. Although the firing attributes of place cells are well documented, little is known about the organization of the spatial map. Unit recording studies, thus far, have reported a low coherence between neighboring cells and geometric space, leading to the prevalent view that the spatial map is not topographically organized. However, the number of simultaneously recorded units is severely limited, rendering construction of the spatial map nearly impossible. To visualize the functional organization of place cells, we used the activity-dependent immediate-early gene Zif268 in combination with behavioral, pharmacological and electrophysiological methods, in mice and rats exploring an environment. Here, we show that in animals confined to a small part of a maze, principal cells in the CA1/CA3 subfields of the dorsal hippocampus immunoreactive (IR) for Zif268 adhere to a ‘cluster-type’ organization. Unit recordings confirmed that the Zif268 IR clusters correspond to active place cells, while blockade of NMDAR (which alters place fields) disrupted the Zif268 IR clusters. Contrary to the prevalent view that the spatial map consists of a non-topographic neural network, our results provide evidence for a ‘cluster-type’ functional organization of hippocampal neurons encoding for space.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessTEXTSidartaRibeiro_ICe_2019_Hippocampal functional.pdf.txtSidartaRibeiro_ICe_2019_Hippocampal functional.pdf.txtExtracted texttext/plain77635https://repositorio.ufrn.br/bitstream/123456789/26963/3/SidartaRibeiro_ICe_2019_Hippocampal%20functional.pdf.txtc5c41f0dc3b60afd726938e5bf3b1751MD53THUMBNAILSidartaRibeiro_ICe_2019_Hippocampal functional.pdf.jpgSidartaRibeiro_ICe_2019_Hippocampal functional.pdf.jpgGenerated Thumbnailimage/jpeg1708https://repositorio.ufrn.br/bitstream/123456789/26963/4/SidartaRibeiro_ICe_2019_Hippocampal%20functional.pdf.jpgdd1ee7038ee3ec261866260b4b09dca7MD54ORIGINALSidartaRibeiro_ICe_2019_Hippocampal functional.pdfSidartaRibeiro_ICe_2019_Hippocampal functional.pdfSidartaRibeiro_ICe_2019_Hippocampal functionalapplication/pdf3076106https://repositorio.ufrn.br/bitstream/123456789/26963/1/SidartaRibeiro_ICe_2019_Hippocampal%20functional.pdfb789fdc7e4d1130766d3ec27f104da66MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/26963/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/269632021-07-10 18:41:00.221oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-10T21:41Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Hippocampal functional organization: a microstructure of the place cell network encoding space |
title |
Hippocampal functional organization: a microstructure of the place cell network encoding space |
spellingShingle |
Hippocampal functional organization: a microstructure of the place cell network encoding space Pavlides, Constantine hippocampus place cells spatial map cluster-type organization immediate early genes Zif268 |
title_short |
Hippocampal functional organization: a microstructure of the place cell network encoding space |
title_full |
Hippocampal functional organization: a microstructure of the place cell network encoding space |
title_fullStr |
Hippocampal functional organization: a microstructure of the place cell network encoding space |
title_full_unstemmed |
Hippocampal functional organization: a microstructure of the place cell network encoding space |
title_sort |
Hippocampal functional organization: a microstructure of the place cell network encoding space |
author |
Pavlides, Constantine |
author_facet |
Pavlides, Constantine Donishi, Tomohiro Ribeiro, Sidarta Tollendal Gomes Mello, Claudio V. Blanco, Wilfredo Ogawa, Sonoko |
author_role |
author |
author2 |
Donishi, Tomohiro Ribeiro, Sidarta Tollendal Gomes Mello, Claudio V. Blanco, Wilfredo Ogawa, Sonoko |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pavlides, Constantine Donishi, Tomohiro Ribeiro, Sidarta Tollendal Gomes Mello, Claudio V. Blanco, Wilfredo Ogawa, Sonoko |
dc.subject.por.fl_str_mv |
hippocampus place cells spatial map cluster-type organization immediate early genes Zif268 |
topic |
hippocampus place cells spatial map cluster-type organization immediate early genes Zif268 |
description |
A clue to hippocampal function has been the discovery of place cells, leading to the ‘spatial map’ theory. Although the firing attributes of place cells are well documented, little is known about the organization of the spatial map. Unit recording studies, thus far, have reported a low coherence between neighboring cells and geometric space, leading to the prevalent view that the spatial map is not topographically organized. However, the number of simultaneously recorded units is severely limited, rendering construction of the spatial map nearly impossible. To visualize the functional organization of place cells, we used the activity-dependent immediate-early gene Zif268 in combination with behavioral, pharmacological and electrophysiological methods, in mice and rats exploring an environment. Here, we show that in animals confined to a small part of a maze, principal cells in the CA1/CA3 subfields of the dorsal hippocampus immunoreactive (IR) for Zif268 adhere to a ‘cluster-type’ organization. Unit recordings confirmed that the Zif268 IR clusters correspond to active place cells, while blockade of NMDAR (which alters place fields) disrupted the Zif268 IR clusters. Contrary to the prevalent view that the spatial map consists of a non-topographic neural network, our results provide evidence for a ‘cluster-type’ functional organization of hippocampal neurons encoding for space. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-04-23T17:13:50Z |
dc.date.available.fl_str_mv |
2019-04-23T17:13:50Z |
dc.date.issued.fl_str_mv |
2019-04-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PAVLIDES, C. et al. Hippocampal functional organization: a microstructure of the place cell network encoding space. Neurobiology of Learning and Memory, v. 161, p. 122-134, maio 2019. doi: 10.1016/j.nlm.2019.03.010 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/26963 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.nlm.2019.03.010 |
identifier_str_mv |
PAVLIDES, C. et al. Hippocampal functional organization: a microstructure of the place cell network encoding space. Neurobiology of Learning and Memory, v. 161, p. 122-134, maio 2019. doi: 10.1016/j.nlm.2019.03.010 10.1016/j.nlm.2019.03.010 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/26963 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/26963/3/SidartaRibeiro_ICe_2019_Hippocampal%20functional.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/26963/4/SidartaRibeiro_ICe_2019_Hippocampal%20functional.pdf.jpg https://repositorio.ufrn.br/bitstream/123456789/26963/1/SidartaRibeiro_ICe_2019_Hippocampal%20functional.pdf https://repositorio.ufrn.br/bitstream/123456789/26963/2/license.txt |
bitstream.checksum.fl_str_mv |
c5c41f0dc3b60afd726938e5bf3b1751 dd1ee7038ee3ec261866260b4b09dca7 b789fdc7e4d1130766d3ec27f104da66 e9597aa2854d128fd968be5edc8a28d9 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117739286888448 |