Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54294 http://dx.doi.org/10.20960/nh.04024 |
Resumo: | Introduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels. Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/ mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies. |
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Medeiros, Paulo José deLima, Mabelle Alves Ferreira deSouza, Karla Simone Costa deAndrade, César Endrigo Silva deUrurahy, Marcela Abbott GalvãoAlmeida, José Bruno dePereira, Maurício GalvãoEvangelista, Karine Cavalcanti Maurício SenaRezende, Adriana Augusto de2023-07-31T15:26:24Z2023-07-31T15:26:24Z2023REZENDE, Adriana Augusto de; LIMA, Mabelle Alves Ferreira de; SOUZA, Karla Simone Costa de; ANDRADE, César Endrigo Silva de; URURAHY, Marcela Abbott Galvão; MEDEIROS, Paulo José de; PEREIRA, Maurício Galvão; ALMEIDA, José Bruno de; EVANGELISTA, Karine Cavalcanti Maurício Sena. Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study. Nutrición Hospitalaria, [S.L.], p. 1, 2023. ARAN Ediciones. http://dx.doi.org/10.20960/nh.04024. Disponível em: https://www.nutricionhospitalaria.org/articles/04024/show. Acesso em: 11 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54294http://dx.doi.org/10.20960/nh.04024Nutrición HospitalariaAttribution-NonCommercial-ShareAlike 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-sa/3.0/br/info:eu-repo/semantics/openAccesskidney transplantation25-Hydroxyvitamin Dhypovitaminosis Dalbuminuriaurinary albumin/creatinine ratioVitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal studyEstado de la vitamina D y biomarcadores de función del injerto renal después del trasplante de riñón: un estudio longitudinalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIntroduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels. Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/ mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALVitaminStatusBiomarkers_Medeiros_2023.pdfVitaminStatusBiomarkers_Medeiros_2023.pdfapplication/pdf1321828https://repositorio.ufrn.br/bitstream/123456789/54294/1/VitaminStatusBiomarkers_Medeiros_2023.pdf99ce9cb5690af4a22c0034544b5c7b17MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81037https://repositorio.ufrn.br/bitstream/123456789/54294/2/license_rdf996f8b5afe3136b76594f43bfda24c5eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54294/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/542942023-07-31 12:26:25.014oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-31T15:26:25Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
dc.title.alternative.pt_BR.fl_str_mv |
Estado de la vitamina D y biomarcadores de función del injerto renal después del trasplante de riñón: un estudio longitudinal |
title |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
spellingShingle |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study Medeiros, Paulo José de kidney transplantation 25-Hydroxyvitamin D hypovitaminosis D albuminuria urinary albumin/creatinine ratio |
title_short |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
title_full |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
title_fullStr |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
title_full_unstemmed |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
title_sort |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
author |
Medeiros, Paulo José de |
author_facet |
Medeiros, Paulo José de Lima, Mabelle Alves Ferreira de Souza, Karla Simone Costa de Andrade, César Endrigo Silva de Ururahy, Marcela Abbott Galvão Almeida, José Bruno de Pereira, Maurício Galvão Evangelista, Karine Cavalcanti Maurício Sena Rezende, Adriana Augusto de |
author_role |
author |
author2 |
Lima, Mabelle Alves Ferreira de Souza, Karla Simone Costa de Andrade, César Endrigo Silva de Ururahy, Marcela Abbott Galvão Almeida, José Bruno de Pereira, Maurício Galvão Evangelista, Karine Cavalcanti Maurício Sena Rezende, Adriana Augusto de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Medeiros, Paulo José de Lima, Mabelle Alves Ferreira de Souza, Karla Simone Costa de Andrade, César Endrigo Silva de Ururahy, Marcela Abbott Galvão Almeida, José Bruno de Pereira, Maurício Galvão Evangelista, Karine Cavalcanti Maurício Sena Rezende, Adriana Augusto de |
dc.subject.por.fl_str_mv |
kidney transplantation 25-Hydroxyvitamin D hypovitaminosis D albuminuria urinary albumin/creatinine ratio |
topic |
kidney transplantation 25-Hydroxyvitamin D hypovitaminosis D albuminuria urinary albumin/creatinine ratio |
description |
Introduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels. Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/ mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-07-31T15:26:24Z |
dc.date.available.fl_str_mv |
2023-07-31T15:26:24Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
REZENDE, Adriana Augusto de; LIMA, Mabelle Alves Ferreira de; SOUZA, Karla Simone Costa de; ANDRADE, César Endrigo Silva de; URURAHY, Marcela Abbott Galvão; MEDEIROS, Paulo José de; PEREIRA, Maurício Galvão; ALMEIDA, José Bruno de; EVANGELISTA, Karine Cavalcanti Maurício Sena. Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study. Nutrición Hospitalaria, [S.L.], p. 1, 2023. ARAN Ediciones. http://dx.doi.org/10.20960/nh.04024. Disponível em: https://www.nutricionhospitalaria.org/articles/04024/show. Acesso em: 11 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54294 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.20960/nh.04024 |
identifier_str_mv |
REZENDE, Adriana Augusto de; LIMA, Mabelle Alves Ferreira de; SOUZA, Karla Simone Costa de; ANDRADE, César Endrigo Silva de; URURAHY, Marcela Abbott Galvão; MEDEIROS, Paulo José de; PEREIRA, Maurício Galvão; ALMEIDA, José Bruno de; EVANGELISTA, Karine Cavalcanti Maurício Sena. Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study. Nutrición Hospitalaria, [S.L.], p. 1, 2023. ARAN Ediciones. http://dx.doi.org/10.20960/nh.04024. Disponível em: https://www.nutricionhospitalaria.org/articles/04024/show. Acesso em: 11 jul. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/54294 http://dx.doi.org/10.20960/nh.04024 |
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eng |
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eng |
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Attribution-NonCommercial-ShareAlike 3.0 Brazil http://creativecommons.org/licenses/by-nc-sa/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-ShareAlike 3.0 Brazil http://creativecommons.org/licenses/by-nc-sa/3.0/br/ |
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openAccess |
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Nutrición Hospitalaria |
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Nutrición Hospitalaria |
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