Dietary intake and zinc status in amyotrophic lateral sclerosis patients

Detalhes bibliográficos
Autor(a) principal: Dourado Junior, Mário Emílio Teixeira
Data de Publicação: 2017
Outros Autores: Silva, Heloisa Fernanda Lopes da, Brito, Acsa Nara de Araújo, Freitas, Erika Paula Silva de, Evangelista, Karine Cavalcanti Maurício de Sena, Lais, Lúcia Leite
Tipo de documento: Artigo
Idioma: spa
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/54241
http://dx.doi.org/10.20960/nh.1004
Resumo: Background: There is considerable evidence that abnormal zinc homeostasis is related to amyotrophic lateral sclerosis (ALS) pathogenesis, and malnutrition is an independent prognostic factor for worsened survival of ALS patients. Objective: To evaluate the dietary intake and zinc status in patients with ALS, treated in a specialized outpatient facility in Natal, Brazil. Methods: Twenty patients with ALS (case group) and 37 healthy subjects (control group) were included. Clinical and anthropometric assessments were carried out and dietary intake was obtained from two 24-hour recalls. Plasma and urinary zinc concentrations were determined by atomic absorption spectrophotometry. Results: Most of the participants were eutrophic. Mean energy, protein, carbohydrate and fat intake was significantly lower for the case group. There was greater prevalence of inadequate zinc intake in the case group (35%) compared to controls (27%). Mean plasma zinc was significantly lower in the case group than in controls (77.13 ± 22.21 vs 87.84 ± 17.44 µgZn/dl). Urinary zinc did not differ significantly between cases and controls. In the case group, plasma and urinary zinc concentrations were below reference values in 50.0% and 52.6% of patients, respectively. Conclusion: A large portion of patients with ALS exhibited poor dietary intake and changes in body zinc status. The zinc deficiency found in half of the ALS patients may contribute to a worsened prognosis and should be the target of nutritional intervention that aims to correct this deficiency.
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spelling Dourado Junior, Mário Emílio TeixeiraSilva, Heloisa Fernanda Lopes daBrito, Acsa Nara de AraújoFreitas, Erika Paula Silva deEvangelista, Karine Cavalcanti Maurício de SenaLais, Lúcia Leitehttps://orcid.org/0000-0002-9462-22942023-07-27T20:27:06Z2023-07-27T20:27:06Z2017DOURADO JUNIOR, Mário Emílio Teixeira, et al. Dietary intake and zinc status in amyotrophic lateral sclerosis. Nutricion Hospitalaria, v. 27, p. 1361-1367, 2017. Disponível em: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112017000900016. Acesso em: 25 jul. 2023https://repositorio.ufrn.br/handle/123456789/54241http://dx.doi.org/10.20960/nh.1004Background: There is considerable evidence that abnormal zinc homeostasis is related to amyotrophic lateral sclerosis (ALS) pathogenesis, and malnutrition is an independent prognostic factor for worsened survival of ALS patients. Objective: To evaluate the dietary intake and zinc status in patients with ALS, treated in a specialized outpatient facility in Natal, Brazil. Methods: Twenty patients with ALS (case group) and 37 healthy subjects (control group) were included. Clinical and anthropometric assessments were carried out and dietary intake was obtained from two 24-hour recalls. Plasma and urinary zinc concentrations were determined by atomic absorption spectrophotometry. Results: Most of the participants were eutrophic. Mean energy, protein, carbohydrate and fat intake was significantly lower for the case group. There was greater prevalence of inadequate zinc intake in the case group (35%) compared to controls (27%). Mean plasma zinc was significantly lower in the case group than in controls (77.13 ± 22.21 vs 87.84 ± 17.44 µgZn/dl). Urinary zinc did not differ significantly between cases and controls. In the case group, plasma and urinary zinc concentrations were below reference values in 50.0% and 52.6% of patients, respectively. Conclusion: A large portion of patients with ALS exhibited poor dietary intake and changes in body zinc status. The zinc deficiency found in half of the ALS patients may contribute to a worsened prognosis and should be the target of nutritional intervention that aims to correct this deficiency.Introducción: hay pruebas considerables de que los cambios en la homeostasis del zinc están relacionados con la patogénesis de la esclerosis lateral amiotrófica (ELA) y que la malnutrición es un factor pronóstico capaz de reducir la supervivencia de los pacientes con ELA. Objetivo: evaluar la ingesta dietética y el estado de zinc en pacientes con ELA, tratados en un centro de atención ambulatoria especializado en Natal, Brasil. Métodos: se incluyeron 20 pacientes con ELA (grupo de casos) y 37 sujetos sanos (grupo control). Se realizaron evaluaciones clínicas y antropométricas y se obtuvo la ingesta dietética en dos recordatorios de 24 horas. Las concentraciones plasmáticas y urinarias de zinc se determinaron por espectrofotometría de absorción atómica. Resultados: la mayoría de los participantes fueron eutróficos. El consumo medio de energía, proteínas, carbohidratos y grasas fue significativamente menor en el grupo de casos. Hubo una mayor prevalencia de ingesta inadecuada de zinc en el grupo de casos (35%) en comparación con los controles (27%). El zinc plasmático medio fue significativamente menor en el grupo de casos que en los controles (77,13 ± 22,21 frente a 87,84 ± 17,44 μgZn/dl). El zinc urinario no difirió significativamente entre los casos y los controles. En el grupo de casos, las concentraciones de zinc plasmático y urinario fueron inferiores a los valores de referencia en el 50,0% y 52,6% de los pacientes, respectivamente. Conclusión: gran parte de los pacientes con ELA exhibieron una ingesta dietética pobre y modificación en el estatus de zinc corporal. La deficiencia de zinc encontrada en la mitad de los pacientes con ELA puede contribuir a un empeoramiento del pronóstico y debe ser el objetivo de la intervención nutricional que apunta a corregir esta deficiencia.Nutrición HospitalariaAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessesclerosis lateral amiotróficaingesta dietéticaestado nutricionalamyotrophic lateral sclerosisdietary intake.zinc.nutritional status.Dietary intake and zinc status in amyotrophic lateral sclerosis patientsIngesta dietética y estado de zinc en pacientes con esclerosis lateral amiotróficainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlespareponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALIngestaDietética_DouradoJr_2017.pdfIngestaDietética_DouradoJr_2017.pdfapplication/pdf960876https://repositorio.ufrn.br/bitstream/123456789/54241/1/IngestaDiet%c3%a9tica_DouradoJr_2017.pdf325aa894a2a1619b3ba344a07dacdb55MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufrn.br/bitstream/123456789/54241/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54241/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/542412023-07-27 17:27:07.113oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-27T20:27:07Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Dietary intake and zinc status in amyotrophic lateral sclerosis patients
dc.title.alternative.pt_BR.fl_str_mv Ingesta dietética y estado de zinc en pacientes con esclerosis lateral amiotrófica
title Dietary intake and zinc status in amyotrophic lateral sclerosis patients
spellingShingle Dietary intake and zinc status in amyotrophic lateral sclerosis patients
Dourado Junior, Mário Emílio Teixeira
esclerosis lateral amiotrófica
ingesta dietética
estado nutricional
amyotrophic lateral sclerosis
dietary intake.
zinc.
nutritional status.
title_short Dietary intake and zinc status in amyotrophic lateral sclerosis patients
title_full Dietary intake and zinc status in amyotrophic lateral sclerosis patients
title_fullStr Dietary intake and zinc status in amyotrophic lateral sclerosis patients
title_full_unstemmed Dietary intake and zinc status in amyotrophic lateral sclerosis patients
title_sort Dietary intake and zinc status in amyotrophic lateral sclerosis patients
author Dourado Junior, Mário Emílio Teixeira
author_facet Dourado Junior, Mário Emílio Teixeira
Silva, Heloisa Fernanda Lopes da
Brito, Acsa Nara de Araújo
Freitas, Erika Paula Silva de
Evangelista, Karine Cavalcanti Maurício de Sena
Lais, Lúcia Leite
author_role author
author2 Silva, Heloisa Fernanda Lopes da
Brito, Acsa Nara de Araújo
Freitas, Erika Paula Silva de
Evangelista, Karine Cavalcanti Maurício de Sena
Lais, Lúcia Leite
author2_role author
author
author
author
author
dc.contributor.authorID.pt_BR.fl_str_mv https://orcid.org/0000-0002-9462-2294
dc.contributor.author.fl_str_mv Dourado Junior, Mário Emílio Teixeira
Silva, Heloisa Fernanda Lopes da
Brito, Acsa Nara de Araújo
Freitas, Erika Paula Silva de
Evangelista, Karine Cavalcanti Maurício de Sena
Lais, Lúcia Leite
dc.subject.por.fl_str_mv esclerosis lateral amiotrófica
ingesta dietética
estado nutricional
amyotrophic lateral sclerosis
dietary intake.
zinc.
nutritional status.
topic esclerosis lateral amiotrófica
ingesta dietética
estado nutricional
amyotrophic lateral sclerosis
dietary intake.
zinc.
nutritional status.
description Background: There is considerable evidence that abnormal zinc homeostasis is related to amyotrophic lateral sclerosis (ALS) pathogenesis, and malnutrition is an independent prognostic factor for worsened survival of ALS patients. Objective: To evaluate the dietary intake and zinc status in patients with ALS, treated in a specialized outpatient facility in Natal, Brazil. Methods: Twenty patients with ALS (case group) and 37 healthy subjects (control group) were included. Clinical and anthropometric assessments were carried out and dietary intake was obtained from two 24-hour recalls. Plasma and urinary zinc concentrations were determined by atomic absorption spectrophotometry. Results: Most of the participants were eutrophic. Mean energy, protein, carbohydrate and fat intake was significantly lower for the case group. There was greater prevalence of inadequate zinc intake in the case group (35%) compared to controls (27%). Mean plasma zinc was significantly lower in the case group than in controls (77.13 ± 22.21 vs 87.84 ± 17.44 µgZn/dl). Urinary zinc did not differ significantly between cases and controls. In the case group, plasma and urinary zinc concentrations were below reference values in 50.0% and 52.6% of patients, respectively. Conclusion: A large portion of patients with ALS exhibited poor dietary intake and changes in body zinc status. The zinc deficiency found in half of the ALS patients may contribute to a worsened prognosis and should be the target of nutritional intervention that aims to correct this deficiency.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2023-07-27T20:27:06Z
dc.date.available.fl_str_mv 2023-07-27T20:27:06Z
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dc.identifier.citation.fl_str_mv DOURADO JUNIOR, Mário Emílio Teixeira, et al. Dietary intake and zinc status in amyotrophic lateral sclerosis. Nutricion Hospitalaria, v. 27, p. 1361-1367, 2017. Disponível em: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112017000900016. Acesso em: 25 jul. 2023
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/54241
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.20960/nh.1004
identifier_str_mv DOURADO JUNIOR, Mário Emílio Teixeira, et al. Dietary intake and zinc status in amyotrophic lateral sclerosis. Nutricion Hospitalaria, v. 27, p. 1361-1367, 2017. Disponível em: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112017000900016. Acesso em: 25 jul. 2023
url https://repositorio.ufrn.br/handle/123456789/54241
http://dx.doi.org/10.20960/nh.1004
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http://creativecommons.org/licenses/by-nc-nd/3.0/br/
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dc.publisher.none.fl_str_mv Nutrición Hospitalaria
publisher.none.fl_str_mv Nutrición Hospitalaria
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