Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame

Detalhes bibliográficos
Autor(a) principal: Parreira, Fabiana Trocades
Data de Publicação: 2017
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/4450
Resumo: Overweight in women of childbearing age and during pregnancy has consequences of fetal and adult life of offspring. This fact has been demonstrated through studies with experimental models of maternal obesity. Previous data from our group showed that maternal consumption of a high fat diet (HF) induced, at weaning, increase body mass of offspring, adiposity and hyperleptinemia. Cardiac function at 30 days of life showed lower systolic function (decreased ejection fraction and increased final systolic volume). These data demonstrate that the maternal consumption of the high fat diet promotes early changes in the cardiac function of rats regardless of sex of the offspring. This study aimed to investigate if maternal consumption of HF diet can alters cardiac structure or metabolism in male and female at weaning. For this purpose, Wistar female rats consumed control (9% lipids, C group) or HF diet (29% lipids, HF group) for 7 consecutive weeks before mating and during pregnancy and lactation. At weaning, 21 days-old, puppies were weighted and euthanized by cardiac puncture. Heart and white adipose tissues (retroperitoneal, inguinal and perigonadal) were weighted. Histological (Hematoxilin-Eosin) and biochemical (TLC and HPLC) analysis were performed using LV samples. The ventricular expression of Ir? and PI3K receptors were analysed by Western blotting (Protocol IBCCF- 114, UFRJ). HF offspring had higher body weight, adiposity and cardiac hypertrophy. Among the neutral lipids measured (monoacylglycerol, cholesterol, esterified cholesterol, triacylglycerol, fatty acids and phospholipids) the cholesterol was decreased in male HF offspring (13%), whereas the esterified cholesterol was decreased in male (52%) and female (29%) HF offspring. The triacylglycerol content was increased in both sexes of the HF offspring (52% in male and 48% in female). The quantification of the organic acids (oxaloacetic, lactic and succinic acid) did not show any alteration between C and HF offspring. There were no difference in the cardiac expression of the Ir? and PI3K receptors. These results suggest that the maternal consumption of high fat diet changes the morphology of LV cardiomyocytes and the cardiac metabolism in rats regardless of the sex of the offspring, which can explain the decreased systolic function observed in juvenile rats
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spelling Almeida, Norma Aparecida dos Santos07234019774http://lattes.cnpq.br/8601494649709728Almeida, Norma Aparecida dos SantosCosta, Patr?cia Cristina dos SantosRocha, F?bio Fagundes da08803743724http://lattes.cnpq.br/6044902011339772Parreira, Fabiana Trocades2021-03-16T11:52:10Z2017-08-01PARREIRA, Fabiana Trocades. Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame. 2017. 86 f. Disserta??o (Mestrado em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ, 2017.https://tede.ufrrj.br/jspui/handle/jspui/4450Overweight in women of childbearing age and during pregnancy has consequences of fetal and adult life of offspring. This fact has been demonstrated through studies with experimental models of maternal obesity. Previous data from our group showed that maternal consumption of a high fat diet (HF) induced, at weaning, increase body mass of offspring, adiposity and hyperleptinemia. Cardiac function at 30 days of life showed lower systolic function (decreased ejection fraction and increased final systolic volume). These data demonstrate that the maternal consumption of the high fat diet promotes early changes in the cardiac function of rats regardless of sex of the offspring. This study aimed to investigate if maternal consumption of HF diet can alters cardiac structure or metabolism in male and female at weaning. For this purpose, Wistar female rats consumed control (9% lipids, C group) or HF diet (29% lipids, HF group) for 7 consecutive weeks before mating and during pregnancy and lactation. At weaning, 21 days-old, puppies were weighted and euthanized by cardiac puncture. Heart and white adipose tissues (retroperitoneal, inguinal and perigonadal) were weighted. Histological (Hematoxilin-Eosin) and biochemical (TLC and HPLC) analysis were performed using LV samples. The ventricular expression of Ir? and PI3K receptors were analysed by Western blotting (Protocol IBCCF- 114, UFRJ). HF offspring had higher body weight, adiposity and cardiac hypertrophy. Among the neutral lipids measured (monoacylglycerol, cholesterol, esterified cholesterol, triacylglycerol, fatty acids and phospholipids) the cholesterol was decreased in male HF offspring (13%), whereas the esterified cholesterol was decreased in male (52%) and female (29%) HF offspring. The triacylglycerol content was increased in both sexes of the HF offspring (52% in male and 48% in female). The quantification of the organic acids (oxaloacetic, lactic and succinic acid) did not show any alteration between C and HF offspring. There were no difference in the cardiac expression of the Ir? and PI3K receptors. These results suggest that the maternal consumption of high fat diet changes the morphology of LV cardiomyocytes and the cardiac metabolism in rats regardless of the sex of the offspring, which can explain the decreased systolic function observed in juvenile ratsO sobrepeso em mulheres em idade f?rtil e durante a gesta??o tem consequ?ncias perniciosas na vida fetal e adulta da prole. Isto tem sido demonstrado atrav?s de estudos com modelos experimentais de obesidade materna. Dados anteriores do nosso grupo demonstraram que o consumo materno de dieta hiperlip?dica (DH) induziu, ao desmame, aumento de massa corporal da prole, adiposidade e hiperleptinemia. A fun??o card?aca aos 30 dias de vida demonstrou preju?zo na fun??o sist?lica (diminui??o da fra??o de eje??o e aumento do volume sist?lico final). Estes resultados demonstram que o consumo materno de dieta hiperlip?dica promove altera??es precoces na fun??o card?aca de ratos independentemente do sexo do filhote. Este estudo teve como objetivo verificar se o consumo materno de dieta hiperlip?dica pode alterar a morfologia e o metabolismo dos cardiomi?citos de animais machos e f?meas da prole ao desmame. Para isso, ratas Wistar consumiram dieta controle (9% lip?deos, grupo C) ou hiperlip?dica (29% lip?deos, grupo DH) durante 7 semanas antes do acasalamento, e durante a gesta??o e lacta??o. Ao desmame, 21 dias de vida, as proles foram pesadas e eutanasiadas por pun??o card?aca. O cora??o e os tecidos adiposos branco (retroperitoneal, inguinal e perigonadal) foram pesados. An?lises histol?gicas (cortes corados com HE) e bioqu?micas (TLC e HPLC) foram realizadas utilizando amostras do ventr?culo esquerdo (VE) e a express?o card?aca dos receptores Ir? e PI3K foi avaliada atrav?s da t?cnica de Western Blotting (Protocolo IBCCF- 114, UFRJ). A prole DH apresentou maior peso corporal e hipertrofia card?aca. Dentre os lip?deos neutros mensurados (monoacilglicerol, colesterol, colesterol esterificado, triacilglicerol, ?cidos graxos e fosfolip?deos) o colesterol apresentou-se diminu?do nos machos (13%) da prole DH, enquanto o colesterol esterificado estava diminu?do nos machos (52%) e f?meas (29%) da prole DH. O conte?do de triacilglicerol estava aumentado em ambos os sexos da prole DH (52% nos machos e 48% nas f?meas). A quantifica??o de ?cidos org?nicos (?cido oxaloac?tico, l?tico e succ?nico) n?o demonstrou nenhuma varia??o entre as prole C e DH. N?o houve altera??o na express?o card?aca dos recptores Ir? e PI3K. Estes resultados sugerem que o consumo materno de dieta hiperlip?dica altera a morfologia dos cardiomi?citos do VE e o metabolismo card?aco de ratos indepentedente do sexo da prole, o que pode explicar a diminui??o da fun??o sist?lica observada em ratos juvenis.Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2021-03-16T11:52:10Z No. of bitstreams: 1 2017 - Fabiana Trocades Parreira.pdf: 1357917 bytes, checksum: 79aca3266e3a8a2d9f9cf030936fc1b4 (MD5)Made available in DSpace on 2021-03-16T11:52:10Z (GMT). No. of bitstreams: 1 2017 - Fabiana Trocades Parreira.pdf: 1357917 bytes, checksum: 79aca3266e3a8a2d9f9cf030936fc1b4 (MD5) Previous issue date: 2017-08-01Funda??o de Amparo ? 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V. 87, p. 303- 316, 1992.Dieta hiperlip?dicahipertrofia card?acametabolismo card?acoHigh fat dietcardiac hypertrophycardiac metabolismFisiologiaEfeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmameEffect of maternal consumption of high fat diet on remodeling and metabolism of the left ventricle in rat offspring at weaninginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL2017 - Fabiana Trocades Parreira.pdf.jpg2017 - Fabiana Trocades Parreira.pdf.jpgimage/jpeg3460http://localhost:8080/tede/bitstream/jspui/4450/4/2017+-+Fabiana+Trocades+Parreira.pdf.jpgdc1b303af2d98d4635e28b7224892c4eMD54TEXT2017 - Fabiana Trocades Parreira.pdf.txt2017 - Fabiana Trocades Parreira.pdf.txttext/plain198596http://localhost:8080/tede/bitstream/jspui/4450/3/2017+-+Fabiana+Trocades+Parreira.pdf.txtea340f20c4b24172e1fddb220f6f6bcbMD53ORIGINAL2017 - Fabiana Trocades Parreira.pdf2017 - Fabiana Trocades Parreira.pdfapplication/pdf1357917http://localhost:8080/tede/bitstream/jspui/4450/2/2017+-+Fabiana+Trocades+Parreira.pdf79aca3266e3a8a2d9f9cf030936fc1b4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/jspui/4450/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51jspui/44502021-08-11 14:26:02.069oai:localhost:jspui/4450Tk9UQTogQ09MT1FVRSBBUVVJIEEgU1VBIFBSP1BSSUEgTElDRU4/QQpFc3RhIGxpY2VuP2EgZGUgZXhlbXBsbyA/IGZvcm5lY2lkYSBhcGVuYXMgcGFyYSBmaW5zIGluZm9ybWF0aXZvcy4KCkxJQ0VOP0EgREUgRElTVFJJQlVJPz9PIE4/Ty1FWENMVVNJVkEKCkNvbSBhIGFwcmVzZW50YT8/byBkZXN0YSBsaWNlbj9hLCB2b2M/IChvIGF1dG9yIChlcykgb3UgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBkZSBhdXRvcikgY29uY2VkZSA/IFVuaXZlcnNpZGFkZSAKWFhYIChTaWdsYSBkYSBVbml2ZXJzaWRhZGUpIG8gZGlyZWl0byBuP28tZXhjbHVzaXZvIGRlIHJlcHJvZHV6aXIsICB0cmFkdXppciAoY29uZm9ybWUgZGVmaW5pZG8gYWJhaXhvKSwgZS9vdSAKZGlzdHJpYnVpciBhIHN1YSB0ZXNlIG91IGRpc3NlcnRhPz9vIChpbmNsdWluZG8gbyByZXN1bW8pIHBvciB0b2RvIG8gbXVuZG8gbm8gZm9ybWF0byBpbXByZXNzbyBlIGVsZXRyP25pY28gZSAKZW0gcXVhbHF1ZXIgbWVpbywgaW5jbHVpbmRvIG9zIGZvcm1hdG9zID91ZGlvIG91IHY/ZGVvLgoKVm9jPyBjb25jb3JkYSBxdWUgYSBTaWdsYSBkZSBVbml2ZXJzaWRhZGUgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250ZT9kbywgdHJhbnNwb3IgYSBzdWEgdGVzZSBvdSBkaXNzZXJ0YT8/byAKcGFyYSBxdWFscXVlciBtZWlvIG91IGZvcm1hdG8gcGFyYSBmaW5zIGRlIHByZXNlcnZhPz9vLgoKVm9jPyB0YW1iP20gY29uY29yZGEgcXVlIGEgU2lnbGEgZGUgVW5pdmVyc2lkYWRlIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGM/cGlhIGEgc3VhIHRlc2Ugb3UgCmRpc3NlcnRhPz9vIHBhcmEgZmlucyBkZSBzZWd1cmFuP2EsIGJhY2stdXAgZSBwcmVzZXJ2YT8/by4KClZvYz8gZGVjbGFyYSBxdWUgYSBzdWEgdGVzZSBvdSBkaXNzZXJ0YT8/byA/IG9yaWdpbmFsIGUgcXVlIHZvYz8gdGVtIG8gcG9kZXIgZGUgY29uY2VkZXIgb3MgZGlyZWl0b3MgY29udGlkb3MgCm5lc3RhIGxpY2VuP2EuIFZvYz8gdGFtYj9tIGRlY2xhcmEgcXVlIG8gZGVwP3NpdG8gZGEgc3VhIHRlc2Ugb3UgZGlzc2VydGE/P28gbj9vLCBxdWUgc2VqYSBkZSBzZXUgCmNvbmhlY2ltZW50bywgaW5mcmluZ2UgZGlyZWl0b3MgYXV0b3JhaXMgZGUgbmluZ3U/bS4KCkNhc28gYSBzdWEgdGVzZSBvdSBkaXNzZXJ0YT8/byBjb250ZW5oYSBtYXRlcmlhbCBxdWUgdm9jPyBuP28gcG9zc3VpIGEgdGl0dWxhcmlkYWRlIGRvcyBkaXJlaXRvcyBhdXRvcmFpcywgdm9jPyAKZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzcz9vIGlycmVzdHJpdGEgZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIHBhcmEgY29uY2VkZXIgPyBTaWdsYSBkZSBVbml2ZXJzaWRhZGUgCm9zIGRpcmVpdG9zIGFwcmVzZW50YWRvcyBuZXN0YSBsaWNlbj9hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Q/IGNsYXJhbWVudGUgCmlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIG5vIHRleHRvIG91IG5vIGNvbnRlP2RvIGRhIHRlc2Ugb3UgZGlzc2VydGE/P28gb3JhIGRlcG9zaXRhZGEuCgpDQVNPIEEgVEVTRSBPVSBESVNTRVJUQT8/TyBPUkEgREVQT1NJVEFEQSBURU5IQSBTSURPIFJFU1VMVEFETyBERSBVTSBQQVRST0M/TklPIE9VIApBUE9JTyBERSBVTUEgQUc/TkNJQSBERSBGT01FTlRPIE9VIE9VVFJPIE9SR0FOSVNNTyBRVUUgTj9PIFNFSkEgQSBTSUdMQSBERSAKVU5JVkVSU0lEQURFLCBWT0M/IERFQ0xBUkEgUVVFIFJFU1BFSVRPVSBUT0RPUyBFIFFVQUlTUVVFUiBESVJFSVRPUyBERSBSRVZJUz9PIENPTU8gClRBTUI/TSBBUyBERU1BSVMgT0JSSUdBPz9FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKQSBTaWdsYSBkZSBVbml2ZXJzaWRhZGUgc2UgY29tcHJvbWV0ZSBhIGlkZW50aWZpY2FyIGNsYXJhbWVudGUgbyBzZXUgbm9tZSAocykgb3UgbyhzKSBub21lKHMpIGRvKHMpIApkZXRlbnRvcihlcykgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIGRhIHRlc2Ugb3UgZGlzc2VydGE/P28sIGUgbj9vIGZhcj8gcXVhbHF1ZXIgYWx0ZXJhPz9vLCBhbD9tIGRhcXVlbGFzIApjb25jZWRpZGFzIHBvciBlc3RhIGxpY2VuP2EuCg==Biblioteca Digital de Teses e Dissertaçõeshttps://tede.ufrrj.br/PUBhttps://tede.ufrrj.br/oai/requestbibliot@ufrrj.br||bibliot@ufrrj.bropendoar:2021-08-11T17:26:02Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)false
dc.title.por.fl_str_mv Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
dc.title.alternative.eng.fl_str_mv Effect of maternal consumption of high fat diet on remodeling and metabolism of the left ventricle in rat offspring at weaning
title Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
spellingShingle Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
Parreira, Fabiana Trocades
Dieta hiperlip?dica
hipertrofia card?aca
metabolismo card?aco
High fat diet
cardiac hypertrophy
cardiac metabolism
Fisiologia
title_short Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
title_full Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
title_fullStr Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
title_full_unstemmed Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
title_sort Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame
author Parreira, Fabiana Trocades
author_facet Parreira, Fabiana Trocades
author_role author
dc.contributor.advisor1.fl_str_mv Almeida, Norma Aparecida dos Santos
dc.contributor.advisor1ID.fl_str_mv 07234019774
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/8601494649709728
dc.contributor.referee1.fl_str_mv Almeida, Norma Aparecida dos Santos
dc.contributor.referee2.fl_str_mv Costa, Patr?cia Cristina dos Santos
dc.contributor.referee3.fl_str_mv Rocha, F?bio Fagundes da
dc.contributor.authorID.fl_str_mv 08803743724
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6044902011339772
dc.contributor.author.fl_str_mv Parreira, Fabiana Trocades
contributor_str_mv Almeida, Norma Aparecida dos Santos
Almeida, Norma Aparecida dos Santos
Costa, Patr?cia Cristina dos Santos
Rocha, F?bio Fagundes da
dc.subject.por.fl_str_mv Dieta hiperlip?dica
hipertrofia card?aca
metabolismo card?aco
topic Dieta hiperlip?dica
hipertrofia card?aca
metabolismo card?aco
High fat diet
cardiac hypertrophy
cardiac metabolism
Fisiologia
dc.subject.eng.fl_str_mv High fat diet
cardiac hypertrophy
cardiac metabolism
dc.subject.cnpq.fl_str_mv Fisiologia
description Overweight in women of childbearing age and during pregnancy has consequences of fetal and adult life of offspring. This fact has been demonstrated through studies with experimental models of maternal obesity. Previous data from our group showed that maternal consumption of a high fat diet (HF) induced, at weaning, increase body mass of offspring, adiposity and hyperleptinemia. Cardiac function at 30 days of life showed lower systolic function (decreased ejection fraction and increased final systolic volume). These data demonstrate that the maternal consumption of the high fat diet promotes early changes in the cardiac function of rats regardless of sex of the offspring. This study aimed to investigate if maternal consumption of HF diet can alters cardiac structure or metabolism in male and female at weaning. For this purpose, Wistar female rats consumed control (9% lipids, C group) or HF diet (29% lipids, HF group) for 7 consecutive weeks before mating and during pregnancy and lactation. At weaning, 21 days-old, puppies were weighted and euthanized by cardiac puncture. Heart and white adipose tissues (retroperitoneal, inguinal and perigonadal) were weighted. Histological (Hematoxilin-Eosin) and biochemical (TLC and HPLC) analysis were performed using LV samples. The ventricular expression of Ir? and PI3K receptors were analysed by Western blotting (Protocol IBCCF- 114, UFRJ). HF offspring had higher body weight, adiposity and cardiac hypertrophy. Among the neutral lipids measured (monoacylglycerol, cholesterol, esterified cholesterol, triacylglycerol, fatty acids and phospholipids) the cholesterol was decreased in male HF offspring (13%), whereas the esterified cholesterol was decreased in male (52%) and female (29%) HF offspring. The triacylglycerol content was increased in both sexes of the HF offspring (52% in male and 48% in female). The quantification of the organic acids (oxaloacetic, lactic and succinic acid) did not show any alteration between C and HF offspring. There were no difference in the cardiac expression of the Ir? and PI3K receptors. These results suggest that the maternal consumption of high fat diet changes the morphology of LV cardiomyocytes and the cardiac metabolism in rats regardless of the sex of the offspring, which can explain the decreased systolic function observed in juvenile rats
publishDate 2017
dc.date.issued.fl_str_mv 2017-08-01
dc.date.accessioned.fl_str_mv 2021-03-16T11:52:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv PARREIRA, Fabiana Trocades. Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame. 2017. 86 f. Disserta??o (Mestrado em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ, 2017.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/4450
identifier_str_mv PARREIRA, Fabiana Trocades. Efeito do consumo materno de dieta hiperlip?dica sobre o remodelamento e metabolismo do ventr?culo esquerdo na prole de ratos ao desmame. 2017. 86 f. Disserta??o (Mestrado em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ, 2017.
url https://tede.ufrrj.br/jspui/handle/jspui/4450
dc.language.iso.fl_str_mv por
language por
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repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)
repository.mail.fl_str_mv bibliot@ufrrj.br||bibliot@ufrrj.br
_version_ 1800313521723932672

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