S?ntese, caracteriza??o, estudo de complexa??o e avalia??o da atividade t?xica de novos bisfosfonatos sim?tricos

• Autor(a) principal: Rodrigues, Jana?na Marques
• Data de Publicação: 2000
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
• Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/4205
• topic: Qu?mica; Qu?mica

Organophosphorus compounds are well known chelating agents, among which can be found the N,N-dialkylcarbamylmethylenephosphonates (3) which work as powerful extracting agents for IA and IIA metal cations and also transition metais, through the phosphoryl and carbonyl groups. lt is believed that a modification in this structure, increasing the coordination sites, might improve the extracting properties of these compounds. Based on this idea seven novel bisphosphonates were prepared. AII of them were characterized by IR, 1H-NMR, 13C-NMR, 31P-NMR and mass spectroscopy. The preliminary study of potential chelation power of these compounds was performed in solution, by condutometric and spectrometric (Ultraviolet) titration. The analysis by ultraviolet spectroscopy did not produce conclusive data, because lhe absorptions were superimposed and approached 200 nm, where there is strong interference of air in the instrument. The condutometric analysis has pointed out the tendency of these possible ligands to form complexes with Ni++, Zn++, Cu++, Co++ and Mn++ cat1ons. Since organophosphorus compounds are known by their wide applicability as pesticides, tests on Artemia salina Leach were done in order to evaluate the toxicity of the bisphosphonates synthesized. Among them, only compound 29 showed a LDso within the range of the concentration studied, under the total of 5,25x10-4 M; the other compounds showed LO50 values higher than the approximated concentration of 8,0x104 M.