Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)

Detalhes bibliográficos
Autor(a) principal: Marchesini, Paula Barroso Cruz
Data de Publicação: 2020
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/6317
Resumo: Compounds of plant origin have been identified as promising in the control of ticks. Thus, a study was carried out on the phytochemical characterization of essential oils (EOs) of the bark of Cinnamomum zeylanicum (cinnamon) and of the stem of Eremanthus erythropappus (candeia) and evaluation of the tick activity of these OEs and the major compounds on engorged larvae and females of Rhipicephalus microplus. In addition, the tick activity of an acetylated compound, produced from (E)-cinnamaldehyde, which was the predominant compound in cinnamon OE, was also evaluated. The bioassays with the non-fed larvae were performed using the larval pack test at concentrations from 0.31 to 10.0 mg / mL. For the EOs of cinnamon, candeia, and for the isolated substances, (E)-cinnamaldehyde, ?-bisabolol and cinamyl acetate, mortality of over 90% was observed from the concentrations of 2.0; 2.0; 2.5; 5.0; 5.0 mg / ml, respectively. For engorged females, the immersion test was performed at concentrations of 2.5 to 60.0 mg / mL, and it was observed that only cinnamyl acetate showed low activity. A control percentage above 95% was observed for cinnamon and cinnamon EOs, and for substances (E)-cinnamaldehyde and ?-bisabolol, at concentrations of 20.0; 60.0; 20.0 and 20.0 mg / mL respectively. Based on these results, the activity of (E)-cinnamaldehyde and ?-bisabolol was investigated on fifty-one populations of R. microplus, with different profiles of resistance to different commercial ticks. For the characterization of resistance, carrapaticides based on deltamethrin (Pyrethroid - Butox?), amitraz (Amidine - Triatox?) and chlorfenvinphos (Organophosphate - Supokill?) were used in their commercial concentration in the female immersion test. For the calculation of the LC50 of the larvae translated with the pure compounds, the larval pack test was performed at concentrations from 0.31 to 10.0 mg / mL. In this stage, tests were also performed with the Porto Alegre strain (POA), a sensitive strain for reference in the calculation of the Resistance Ratio (RR). Based on the results generated, it was not possible to infer a correlation between the efficiency of ticks and the LC50 values of the pure compounds tested, thus not observing cross resistance, indicating that the different results found may be related to existing phenotypic variations between populations. Finally, the lipid profile of the fatty body and eggs of R. microplus engorged females exposed to a concentration of 10.0 mg / mL of (E)-cinnamaldehyde and ?-bisabolol were evaluated. To characterize the lipid profile, the techniques of thin layer chromatography and gas chromatography coupled to a mass spectrometer were applied. In addition, an in silico study was carried out in order to know the possible molecular targets of these plant compounds. The results demonstrated changes in the profile of lipids present in the fatty body and eggs of females treated with (E)-cinnamaldehyde and ?-bisabolol, showing a possible mechanism of action of these compounds.
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spelling Bittencourt, V?nia Rita Elias Pinheiro505.198.676-53http://lattes.cnpq.br/3888832724995864Monteiro, Caio M?rcio de Oliveira058.965.206-03http://lattes.cnpq.br/2496419306394657Angelo, Isabele da Costa090.347.797-18Lopes, Welber Daniel ZanettiMonteiro, Caio M?rcio de OliveiraReck, Jos?Fabri, Rodrigo LuizCamargo, Mariana Guedes087.158.016-08http://lattes.cnpq.br/2159998919091266Marchesini, Paula Barroso Cruz2023-02-07T15:46:35Z2020-09-30MARCHESINI, Paula Barroso Cruz. Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae). 2020. 155 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2020.https://tede.ufrrj.br/jspui/handle/jspui/6317Compounds of plant origin have been identified as promising in the control of ticks. Thus, a study was carried out on the phytochemical characterization of essential oils (EOs) of the bark of Cinnamomum zeylanicum (cinnamon) and of the stem of Eremanthus erythropappus (candeia) and evaluation of the tick activity of these OEs and the major compounds on engorged larvae and females of Rhipicephalus microplus. In addition, the tick activity of an acetylated compound, produced from (E)-cinnamaldehyde, which was the predominant compound in cinnamon OE, was also evaluated. The bioassays with the non-fed larvae were performed using the larval pack test at concentrations from 0.31 to 10.0 mg / mL. For the EOs of cinnamon, candeia, and for the isolated substances, (E)-cinnamaldehyde, ?-bisabolol and cinamyl acetate, mortality of over 90% was observed from the concentrations of 2.0; 2.0; 2.5; 5.0; 5.0 mg / ml, respectively. For engorged females, the immersion test was performed at concentrations of 2.5 to 60.0 mg / mL, and it was observed that only cinnamyl acetate showed low activity. A control percentage above 95% was observed for cinnamon and cinnamon EOs, and for substances (E)-cinnamaldehyde and ?-bisabolol, at concentrations of 20.0; 60.0; 20.0 and 20.0 mg / mL respectively. Based on these results, the activity of (E)-cinnamaldehyde and ?-bisabolol was investigated on fifty-one populations of R. microplus, with different profiles of resistance to different commercial ticks. For the characterization of resistance, carrapaticides based on deltamethrin (Pyrethroid - Butox?), amitraz (Amidine - Triatox?) and chlorfenvinphos (Organophosphate - Supokill?) were used in their commercial concentration in the female immersion test. For the calculation of the LC50 of the larvae translated with the pure compounds, the larval pack test was performed at concentrations from 0.31 to 10.0 mg / mL. In this stage, tests were also performed with the Porto Alegre strain (POA), a sensitive strain for reference in the calculation of the Resistance Ratio (RR). Based on the results generated, it was not possible to infer a correlation between the efficiency of ticks and the LC50 values of the pure compounds tested, thus not observing cross resistance, indicating that the different results found may be related to existing phenotypic variations between populations. Finally, the lipid profile of the fatty body and eggs of R. microplus engorged females exposed to a concentration of 10.0 mg / mL of (E)-cinnamaldehyde and ?-bisabolol were evaluated. To characterize the lipid profile, the techniques of thin layer chromatography and gas chromatography coupled to a mass spectrometer were applied. In addition, an in silico study was carried out in order to know the possible molecular targets of these plant compounds. The results demonstrated changes in the profile of lipids present in the fatty body and eggs of females treated with (E)-cinnamaldehyde and ?-bisabolol, showing a possible mechanism of action of these compounds.Compostos de origem vegetal t?m sido apontados como promissores no controle de carrapatos. Dessa forma, foi realizado um estudo de caracteriza??o fitoqu?mica dos ?leos essenciais (OEs) da casca de Cinnamomum zeylanicum (canela) e do caule de Eremanthus erythropappus (candeia) e avalia??o da atividade carrapaticida desses OEs e dos compostos majorit?rios sobre larvas e f?meas ingurgitadas de Rhipicephalus microplus. Al?m disso, tamb?m foi avaliado a atividade carrapaticida de um composto acetilado, produzido a partir do (E)-cinamalde?do, que foi o composto predominte no OE de canela. Os bioensaios com as larvas n?o alimentadas foram realizados atrav?s do teste de pacote de larvas nas concentra??es de 0,31 a 10,0 mg/mL. Para os OEs de canela, candeia, e para as subst?ncias isoladas, (E)-cinamalde?do, ?-bisabolol e acetato de cinamila, foram observadas mortalidade superior a 90% a partir das concentra??es de 2,0; 2,0; 2,5; 5,0; 5.0 mg/mL, respectivamente. Para f?meas ingurgitadas foi realizado o teste de imers?o nas concentra??es de 2,5 a 60,0 mg/mL, sendo observado que apenas o acetato de cinamila apresentou baixa atividade. Um percentual de controle acima de 95% foi observado para os OEs de canela e candeia, e para as subst?ncias (E)-cinamalde?do e ?-bisabolol, nas concentra??es de 20,0; 60,0; 20,0 e 20,0 mg/mL respectivamente. Com base nesses resultados, foi investigado a atividade do (E)-cinamalde?do e ?-bisabolol sobre cinquenta e uma popula??es de R. microplus, com diferentes perfis de resist?ncia a diferentes carrapaticidas comerciais. Para caracteriza??o de resist?ncia, foram utilizados os carrapaticidas a base de deltametrina (Piretroide ? Butox?), amitraz (Amid?nico ? Triatox?) e clorfenvinf?s (Organofosforado ? Supokill?) em sua concentra??o comercial no teste de imers?o de f?meas. J? para o c?lculo da CL50 das larvas tradadas com os compostos puros, foi realizado o teste de pacote de larvas nas concentra??es de 0,31 a 10,0 mg/mL. Nessa etapa tamb?m foram realizados testes com a cepa Porto Alegre (POA), uma cepa sens?vel para refer?ncia do c?lculo da Raz?o de Resist?ncia (RR). Com base nos resultados gerados, n?o foi poss?vel inferir uma correla??o entre a efici?ncia dos carrapaticidas e os valores de CL50 dos compostos puros testados, n?o sendo observado, dessa forma, resist?ncia cruzada, indicando que os diferentes resultados encontrados podem estar relacionados com varia??es fenot?picas existentes entre as popula??es. Por fim, foi avaliado o perfil lip?dico do corpo gorduroso e ovos de f?meas ingurgitadas de R. microplus expostas a concentra??o de 10,0 mg/mL do (E)-cinamaldeido e do ?-bisabolol. Para caracteriza??o do perfil de lip?dios, foram aplicadas as t?cnicas de cromatografia em camada delgada e cromatografia gasosa acoplada a um espectr?metro de massa. Al?m disso, foi realizado um estudo in silico com o intuito de se conhecer os poss?veis alvos moleculares desses compostos vegetais. Os resultados demonstraram altera??es no perfil de lip?dios presentes no corpo gorduroso e ovos de f?meas tratadas com (E)-cinamaldeido e ?-bisabolol, evidenciando um poss?vel mecanismo de a??o desses compostos.Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2023-02-07T15:46:35Z No. of bitstreams: 1 2020 - Paula Barroso Cruz Marchesini.pdf: 3054492 bytes, checksum: 5a186c0b683afc5c2c09f7eef43628b2 (MD5)Made available in DSpace on 2023-02-07T15:46:35Z (GMT). No. of bitstreams: 1 2020 - Paula Barroso Cruz Marchesini.pdf: 3054492 bytes, checksum: 5a186c0b683afc5c2c09f7eef43628b2 (MD5) Previous issue date: 2020-09-30CAPES - Coordena??o de Aperfei?oamento de Pessoal de N?vel SuperiorCNPq - Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gicoapplication/pdfhttps://tede.ufrrj.br/retrieve/72136/2020%20-%20Paula%20Barroso%20Cruz%20Marchesini.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Ci?ncias Veterin?riasUFRRJBrasilInstituto de Veterin?riaABBAS, R.Z.; ZAMAN, M.A.; COLWELL, D.D.; GILLEARD, J.; IQBAL, Z. Acaricide resistance in cattle ticks and approaches to its management: the state of play. Veterinary Parasitology, v. 203, p. 6-20, 2014. ANGELO, I.C.; G?LO, P.S.; PERINOTTO, W.M.S.; CAMARGO, M.G.; QUINELATO, S.; S?, F.A.; PONTES, E.G. 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The FEBS Journal, v. 276, n. 23, p. 6826-6843, 2009. XAVIER, M.A.; TIRLONI, L.; PINTO, A.F.M.; DIEDRICH, J.K.; YATES, J.R.; GONZALES, S.; FARBER, M.; VAZ, I.D.; TERMIGNONI, C. Tick Gene?s organ engagement in lipid metabolism revealed by a combined transcriptomic and proteomic approach. Ticks and Tick-borne Diseases, v. 10, p. 787-797, 2019. YILMAZ, B. GC-MS and HPLC Methods for Determination of Estriol Hormone in Pharmaceutical Preparations. 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dc.title.por.fl_str_mv Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
dc.title.alternative.eng.fl_str_mv Potential of the essential oils of Eremanthus erythropappus and Cinnamomum zeylanicum and compounds isolated ?-bisabolol and (E)-cinnamaldehyde for the control of the Rhipicephalus microplus (Acari: Ixodidae)
title Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
spellingShingle Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
Marchesini, Paula Barroso Cruz
Carrapato dos bovinos
carrapaticidas bot?nicos
sesquiterpeno
fenilpropano?de
metabolismo energ?tico
Cattle tick
botanical acaricide
sesquiterpene
phenylpropanoid
energy metabolism.
Medicina Veterin?ria
title_short Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
title_full Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
title_fullStr Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
title_full_unstemmed Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
title_sort Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae)
author Marchesini, Paula Barroso Cruz
author_facet Marchesini, Paula Barroso Cruz
author_role author
dc.contributor.advisor1.fl_str_mv Bittencourt, V?nia Rita Elias Pinheiro
dc.contributor.advisor1ID.fl_str_mv 505.198.676-53
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3888832724995864
dc.contributor.advisor-co1.fl_str_mv Monteiro, Caio M?rcio de Oliveira
dc.contributor.advisor-co1ID.fl_str_mv 058.965.206-03
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/2496419306394657
dc.contributor.advisor-co2.fl_str_mv Angelo, Isabele da Costa
dc.contributor.advisor-co2ID.fl_str_mv 090.347.797-18
dc.contributor.referee1.fl_str_mv Lopes, Welber Daniel Zanetti
dc.contributor.referee2.fl_str_mv Monteiro, Caio M?rcio de Oliveira
dc.contributor.referee3.fl_str_mv Reck, Jos?
dc.contributor.referee4.fl_str_mv Fabri, Rodrigo Luiz
dc.contributor.referee5.fl_str_mv Camargo, Mariana Guedes
dc.contributor.authorID.fl_str_mv 087.158.016-08
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2159998919091266
dc.contributor.author.fl_str_mv Marchesini, Paula Barroso Cruz
contributor_str_mv Bittencourt, V?nia Rita Elias Pinheiro
Monteiro, Caio M?rcio de Oliveira
Angelo, Isabele da Costa
Lopes, Welber Daniel Zanetti
Monteiro, Caio M?rcio de Oliveira
Reck, Jos?
Fabri, Rodrigo Luiz
Camargo, Mariana Guedes
dc.subject.por.fl_str_mv Carrapato dos bovinos
carrapaticidas bot?nicos
sesquiterpeno
fenilpropano?de
metabolismo energ?tico
topic Carrapato dos bovinos
carrapaticidas bot?nicos
sesquiterpeno
fenilpropano?de
metabolismo energ?tico
Cattle tick
botanical acaricide
sesquiterpene
phenylpropanoid
energy metabolism.
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Cattle tick
botanical acaricide
sesquiterpene
phenylpropanoid
energy metabolism.
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Compounds of plant origin have been identified as promising in the control of ticks. Thus, a study was carried out on the phytochemical characterization of essential oils (EOs) of the bark of Cinnamomum zeylanicum (cinnamon) and of the stem of Eremanthus erythropappus (candeia) and evaluation of the tick activity of these OEs and the major compounds on engorged larvae and females of Rhipicephalus microplus. In addition, the tick activity of an acetylated compound, produced from (E)-cinnamaldehyde, which was the predominant compound in cinnamon OE, was also evaluated. The bioassays with the non-fed larvae were performed using the larval pack test at concentrations from 0.31 to 10.0 mg / mL. For the EOs of cinnamon, candeia, and for the isolated substances, (E)-cinnamaldehyde, ?-bisabolol and cinamyl acetate, mortality of over 90% was observed from the concentrations of 2.0; 2.0; 2.5; 5.0; 5.0 mg / ml, respectively. For engorged females, the immersion test was performed at concentrations of 2.5 to 60.0 mg / mL, and it was observed that only cinnamyl acetate showed low activity. A control percentage above 95% was observed for cinnamon and cinnamon EOs, and for substances (E)-cinnamaldehyde and ?-bisabolol, at concentrations of 20.0; 60.0; 20.0 and 20.0 mg / mL respectively. Based on these results, the activity of (E)-cinnamaldehyde and ?-bisabolol was investigated on fifty-one populations of R. microplus, with different profiles of resistance to different commercial ticks. For the characterization of resistance, carrapaticides based on deltamethrin (Pyrethroid - Butox?), amitraz (Amidine - Triatox?) and chlorfenvinphos (Organophosphate - Supokill?) were used in their commercial concentration in the female immersion test. For the calculation of the LC50 of the larvae translated with the pure compounds, the larval pack test was performed at concentrations from 0.31 to 10.0 mg / mL. In this stage, tests were also performed with the Porto Alegre strain (POA), a sensitive strain for reference in the calculation of the Resistance Ratio (RR). Based on the results generated, it was not possible to infer a correlation between the efficiency of ticks and the LC50 values of the pure compounds tested, thus not observing cross resistance, indicating that the different results found may be related to existing phenotypic variations between populations. Finally, the lipid profile of the fatty body and eggs of R. microplus engorged females exposed to a concentration of 10.0 mg / mL of (E)-cinnamaldehyde and ?-bisabolol were evaluated. To characterize the lipid profile, the techniques of thin layer chromatography and gas chromatography coupled to a mass spectrometer were applied. In addition, an in silico study was carried out in order to know the possible molecular targets of these plant compounds. The results demonstrated changes in the profile of lipids present in the fatty body and eggs of females treated with (E)-cinnamaldehyde and ?-bisabolol, showing a possible mechanism of action of these compounds.
publishDate 2020
dc.date.issued.fl_str_mv 2020-09-30
dc.date.accessioned.fl_str_mv 2023-02-07T15:46:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARCHESINI, Paula Barroso Cruz. Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae). 2020. 155 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2020.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/6317
identifier_str_mv MARCHESINI, Paula Barroso Cruz. Potencial dos ?leos essenciais de Eremanthus erythropappus e Cinnamomum zeylanicum e compostos isolados ?-bisabolol e (E)-cinamalde?do para o controle de Rhipicephalus microplus (Acari: Ixodidae). 2020. 155 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2020.
url https://tede.ufrrj.br/jspui/handle/jspui/6317
dc.language.iso.fl_str_mv por
language por
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