Blendas de PVA – polímeros naturais carregados com mel de manuka
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| Data de Publicação: | 2019 |
| Tipo de documento: | Dissertação |
| Idioma: | por |
| Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRRJ |
| Texto Completo: | https://rima.ufrrj.br/jspui/handle/20.500.14407/13470 |
Resumo: | Blendas de PVA combinados com polímeros naturais carregados com mel de Manuka foram desenvolvidos com intuito de tratamento de úlceras de pressão, visto que a maioria dos curativos voltados para esse tratamento são hidrogéis. O amido, carboximetil cellulose sódica (NaCMC) e a gelatina são atóxicos, biocompatíveis, biodegradavéis e apresentam baixo custo, estes por sua vez podem alterar as propriedades do PVA quando formam blendas. O mel de Manuka foi usado pois ele apresenta atividade antibacteriana e acelera a cicatrização do ferimento. Os hidrogéis deste trabalho foram desenvolvidos pelo método de casting, e caracterizados via FTIR, DSC, grau de intumescimento, cinética de liberação de mel e ensaio microbiológico. As análises de FTIR mostraram que houve interação física entre os polímeros em todas as blendas analisadas. Os maiores graus de intumescimento (GI) foram encontrados nas amostras de PVA/NaCMC e PVA/NaCMC/Mel e os menores nas amostras PVA/Amido e PVA/Mel. A diferença no GI pode ser correlacionada à formação de cristalitos, bem como à presença de mel, os quais podem atuar como impedimento à entrada de fluido. As amostras PVA/Amido e PVA/Gel/Mel apresentaram os maiores valores de fração gel e os menores valores de perda de massa. As análises de DSC mostraram que nas amostras com mel, o mel pode não só interferir no movimento das cadeias amorfas, como também no empacotamento das cadeias de PVA. Na análise de liberação de mel, observou-se que há o máximo de liberação em 48 h. No modelo cinético, observou-se expoente de difusão n<1, atestando que a reticulação física foi favorável, onde o desvio relativo médio (DRM) estava entre 2,5 % e 17,65 %. Os géis não apresentaram atividade contra S. aureus, porém o mel puro apresentou atividade antibacteriana e diluições de mel superiores à 25 % mel apresentaram atividade bacteriostática. |
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Santos, Antonia Mônica NeresOliveira, Renata NunesCPF: 055.175.607-17http://lattes.cnpq.br/9026953896544145Mendes, Marisa FernandesCPF: 023.918.187-50http://lattes.cnpq.br/3233683706295801Oliveira, Renata NunesCPF: 055.175.607-17http://lattes.cnpq.br/9026953896544145Mendes, Marisa FernandesCPF: 023.918.187-50http://lattes.cnpq.br/3233683706295801Balbino, Tiago Albertinihttp://lattes.cnpq.br/7922519072204589Machado Júnior, Hélio Fernandeshttp://lattes.cnpq.br/3462534255321209Moreira, Ana Paula Duartehttp://lattes.cnpq.br/3095636219911661CPF: 035.301.143-67http://lattes.cnpq.br/45147252081305832023-12-22T02:47:07Z2023-12-22T02:47:07Z2019-01-23SANTOS, Antonia Mônica Neres. Blendas de PVA – polímeros naturais carregados com mel de manuka. 2019. 51 f. Dissertação (Mestrado em Engenharia Química) - Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019.https://rima.ufrrj.br/jspui/handle/20.500.14407/13470Blendas de PVA combinados com polímeros naturais carregados com mel de Manuka foram desenvolvidos com intuito de tratamento de úlceras de pressão, visto que a maioria dos curativos voltados para esse tratamento são hidrogéis. O amido, carboximetil cellulose sódica (NaCMC) e a gelatina são atóxicos, biocompatíveis, biodegradavéis e apresentam baixo custo, estes por sua vez podem alterar as propriedades do PVA quando formam blendas. O mel de Manuka foi usado pois ele apresenta atividade antibacteriana e acelera a cicatrização do ferimento. Os hidrogéis deste trabalho foram desenvolvidos pelo método de casting, e caracterizados via FTIR, DSC, grau de intumescimento, cinética de liberação de mel e ensaio microbiológico. As análises de FTIR mostraram que houve interação física entre os polímeros em todas as blendas analisadas. Os maiores graus de intumescimento (GI) foram encontrados nas amostras de PVA/NaCMC e PVA/NaCMC/Mel e os menores nas amostras PVA/Amido e PVA/Mel. A diferença no GI pode ser correlacionada à formação de cristalitos, bem como à presença de mel, os quais podem atuar como impedimento à entrada de fluido. As amostras PVA/Amido e PVA/Gel/Mel apresentaram os maiores valores de fração gel e os menores valores de perda de massa. As análises de DSC mostraram que nas amostras com mel, o mel pode não só interferir no movimento das cadeias amorfas, como também no empacotamento das cadeias de PVA. Na análise de liberação de mel, observou-se que há o máximo de liberação em 48 h. No modelo cinético, observou-se expoente de difusão n<1, atestando que a reticulação física foi favorável, onde o desvio relativo médio (DRM) estava entre 2,5 % e 17,65 %. Os géis não apresentaram atividade contra S. aureus, porém o mel puro apresentou atividade antibacteriana e diluições de mel superiores à 25 % mel apresentaram atividade bacteriostática.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorPVA blends with natural polymers loaded with Manuka honey were developed for the treatment of pressure ulcers/bed sores, since most bandages used for this treatment are hydrogels. Starch and sodium Carboxymethyl cellulose (NaCMC) and gelatin are non-toxic, biocompatible, biodegradable polymers that have low cost and they can alter the properties of PVA, when mixed to it. Manuka honey was used because it presents antibacterial activity and it accelerates the wound healing. The hydrogels were manufactured by the casting method and they were characterized by FTIR, DSC, swelling degree, honey release kinetics analysis, and microbiological analysis. The FTIR analysis showed that physical interaction occurred between the blends’ materials. The highest swelling rates were found in PVA/NaCMC and PVA/NaCMC/Honey samples and the lowest in PVA/Starch and PVA/Honey samples. The difference of the swelling degree can be related to the crystallites’ formation as well as to the presence of honey, both acting as barrier to fluid entrance. The PVA/Starch and PVA/Gel/Honey samples presented the highest values of gel fraction and the lowest values of weight loss. DSC analysis showed that in samples containing honey, the honey can not only interfere with the movement of amorphous chains, but also in the packaging of PVA chains. In honey release analysis, it was observed that there is a maximum release in 48 h. It was observed a diffusion exponent n<1 in the kinetic model, showing that physical cross-linking occurred, and the average relative deviation was between 2.5 % and 17.65 %. 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| dc.title.por.fl_str_mv |
Blendas de PVA – polímeros naturais carregados com mel de manuka |
| dc.title.alternative.eng.fl_str_mv |
PVA blends – natural polymers loaded with manuka honey |
| title |
Blendas de PVA – polímeros naturais carregados com mel de manuka |
| spellingShingle |
Blendas de PVA – polímeros naturais carregados com mel de manuka Santos, Antonia Mônica Neres Hidrogéis Mel de Manuka PVA Gelatina NaCMC Amido Hydrogels Manuka honey Poly (vinyl alcohol) Gelatin NaCMC Starch Engenharia Química |
| title_short |
Blendas de PVA – polímeros naturais carregados com mel de manuka |
| title_full |
Blendas de PVA – polímeros naturais carregados com mel de manuka |
| title_fullStr |
Blendas de PVA – polímeros naturais carregados com mel de manuka |
| title_full_unstemmed |
Blendas de PVA – polímeros naturais carregados com mel de manuka |
| title_sort |
Blendas de PVA – polímeros naturais carregados com mel de manuka |
| author |
Santos, Antonia Mônica Neres |
| author_facet |
Santos, Antonia Mônica Neres |
| author_role |
author |
| dc.contributor.author.fl_str_mv |
Santos, Antonia Mônica Neres |
| dc.contributor.advisor1.fl_str_mv |
Oliveira, Renata Nunes |
| dc.contributor.advisor1ID.fl_str_mv |
CPF: 055.175.607-17 |
| dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9026953896544145 |
| dc.contributor.advisor-co1.fl_str_mv |
Mendes, Marisa Fernandes |
| dc.contributor.advisor-co1ID.fl_str_mv |
CPF: 023.918.187-50 |
| dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/3233683706295801 |
| dc.contributor.referee1.fl_str_mv |
Oliveira, Renata Nunes |
| dc.contributor.referee1ID.fl_str_mv |
CPF: 055.175.607-17 |
| dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9026953896544145 |
| dc.contributor.referee2.fl_str_mv |
Mendes, Marisa Fernandes |
| dc.contributor.referee2ID.fl_str_mv |
CPF: 023.918.187-50 |
| dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/3233683706295801 |
| dc.contributor.referee3.fl_str_mv |
Balbino, Tiago Albertini |
| dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/7922519072204589 |
| dc.contributor.referee4.fl_str_mv |
Machado Júnior, Hélio Fernandes |
| dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/3462534255321209 |
| dc.contributor.referee5.fl_str_mv |
Moreira, Ana Paula Duarte |
| dc.contributor.referee5Lattes.fl_str_mv |
http://lattes.cnpq.br/3095636219911661 |
| dc.contributor.authorID.fl_str_mv |
CPF: 035.301.143-67 |
| dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4514725208130583 |
| contributor_str_mv |
Oliveira, Renata Nunes Mendes, Marisa Fernandes Oliveira, Renata Nunes Mendes, Marisa Fernandes Balbino, Tiago Albertini Machado Júnior, Hélio Fernandes Moreira, Ana Paula Duarte |
| dc.subject.por.fl_str_mv |
Hidrogéis Mel de Manuka PVA Gelatina NaCMC Amido |
| topic |
Hidrogéis Mel de Manuka PVA Gelatina NaCMC Amido Hydrogels Manuka honey Poly (vinyl alcohol) Gelatin NaCMC Starch Engenharia Química |
| dc.subject.eng.fl_str_mv |
Hydrogels Manuka honey Poly (vinyl alcohol) Gelatin NaCMC Starch |
| dc.subject.cnpq.fl_str_mv |
Engenharia Química |
| description |
Blendas de PVA combinados com polímeros naturais carregados com mel de Manuka foram desenvolvidos com intuito de tratamento de úlceras de pressão, visto que a maioria dos curativos voltados para esse tratamento são hidrogéis. O amido, carboximetil cellulose sódica (NaCMC) e a gelatina são atóxicos, biocompatíveis, biodegradavéis e apresentam baixo custo, estes por sua vez podem alterar as propriedades do PVA quando formam blendas. O mel de Manuka foi usado pois ele apresenta atividade antibacteriana e acelera a cicatrização do ferimento. Os hidrogéis deste trabalho foram desenvolvidos pelo método de casting, e caracterizados via FTIR, DSC, grau de intumescimento, cinética de liberação de mel e ensaio microbiológico. As análises de FTIR mostraram que houve interação física entre os polímeros em todas as blendas analisadas. Os maiores graus de intumescimento (GI) foram encontrados nas amostras de PVA/NaCMC e PVA/NaCMC/Mel e os menores nas amostras PVA/Amido e PVA/Mel. A diferença no GI pode ser correlacionada à formação de cristalitos, bem como à presença de mel, os quais podem atuar como impedimento à entrada de fluido. As amostras PVA/Amido e PVA/Gel/Mel apresentaram os maiores valores de fração gel e os menores valores de perda de massa. As análises de DSC mostraram que nas amostras com mel, o mel pode não só interferir no movimento das cadeias amorfas, como também no empacotamento das cadeias de PVA. Na análise de liberação de mel, observou-se que há o máximo de liberação em 48 h. No modelo cinético, observou-se expoente de difusão n<1, atestando que a reticulação física foi favorável, onde o desvio relativo médio (DRM) estava entre 2,5 % e 17,65 %. Os géis não apresentaram atividade contra S. aureus, porém o mel puro apresentou atividade antibacteriana e diluições de mel superiores à 25 % mel apresentaram atividade bacteriostática. |
| publishDate |
2019 |
| dc.date.issued.fl_str_mv |
2019-01-23 |
| dc.date.accessioned.fl_str_mv |
2023-12-22T02:47:07Z |
| dc.date.available.fl_str_mv |
2023-12-22T02:47:07Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| format |
masterThesis |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
SANTOS, Antonia Mônica Neres. Blendas de PVA – polímeros naturais carregados com mel de manuka. 2019. 51 f. Dissertação (Mestrado em Engenharia Química) - Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019. |
| dc.identifier.uri.fl_str_mv |
https://rima.ufrrj.br/jspui/handle/20.500.14407/13470 |
| identifier_str_mv |
SANTOS, Antonia Mônica Neres. Blendas de PVA – polímeros naturais carregados com mel de manuka. 2019. 51 f. Dissertação (Mestrado em Engenharia Química) - Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019. |
| url |
https://rima.ufrrj.br/jspui/handle/20.500.14407/13470 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.references.por.fl_str_mv |
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