Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae)
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| Data de Publicação: | 2020 |
| Tipo de documento: | Dissertação |
| Idioma: | por |
| Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRRJ |
| Texto Completo: | https://rima.ufrrj.br/jspui/handle/20.500.14407/14277 |
Resumo: | As lesões causadas por bernes são bastante desconfortáveis e dolorosas para os cães, podendo causar infecções bacterianas secundárias e predispor a outras miíases. Um tratamento eficaz deve eliminar ou matar as larvas existentes e promover a cicatrização da ferida o mais precoce possível. Entretanto, atualmente, o tratamento recomendado para esse parasito consiste na retirada manual das larvas, o que causa muito desconforto para o animal parasitado, tanto que, em alguns casos, há a necessidade de sedação para realização do procedimento. O objetivo deste estudo foi avaliar a eficácia bernicida do sarolaner para o tratamento de Dermatobia hominis em cães naturalmente infestados. Foram incluídos dez cães, sem raça definida, com idade variando entre dois e seis anos, independente da variável sexo, com peso entre 11,4 e 19,1 kg, com no mínimo três larvas. No total foram contabilizadas 75 larvas, com média de 7,5 larvas por animal. A maior parte do parasitismo (46 larvas) estava localizado na região lateral dos animais. Os animais foram medicados com sarolaner na dose de 2,0 mg/kg, administrado por via oral em dose única, seguindo as recomendações em bula para o tratamento de outras ectoparasitoses. Após o tratamento, os animais foram mantidos em seus domicílios e foram feitas observações para verificar a atividade de eliminação e o efeito bernicida do fármaco após 24 horas da administração da medicação. Foi considerada larva viva qualquer parasito que apresentasse motilidade após remoção mecânica. Como critérios de avaliação da eficácia do sarolaner, o efeito larvicida foi calculado para cada animal pela fórmula: [Número de larvas vivas após o tratamento – número de larvas vivas antes do tratamento) / Número de larvas vivas antes do tratamento] × 100. Após 24 horas da administração da medicação todas as larvas foram encontradas mortas, ainda que localizadas na derme dos animais. Nenhum animal apresentou efeito adverso ou alteração do comportamento após a utilização da isoxazolina. Conclui-se que o sarolaner administrado em dose única de 2,0mg/kg, por via oral, foi 100% eficaz em cães naturalmente infestados por D. hominis. |
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Andriotti, Paula AzevedoFernandes, Júlio Israel082.100.187-60http://lattes.cnpq.br/9221592908532393Fernandes, Júlio IsraelBalthazar, Daniel de AlmeidaCirne, Lilian Cristina de Souza Oliveira Batista140.711.147-70http://lattes.cnpq.br/94472550040029292023-12-22T02:58:44Z2023-12-22T02:58:44Z2020-02-20ANDRIOTTI, Paula Azevedo. Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae). 2020. 46 f. Dissertação (Mestrado em Medicina Veterinária, Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020.https://rima.ufrrj.br/jspui/handle/20.500.14407/14277As lesões causadas por bernes são bastante desconfortáveis e dolorosas para os cães, podendo causar infecções bacterianas secundárias e predispor a outras miíases. Um tratamento eficaz deve eliminar ou matar as larvas existentes e promover a cicatrização da ferida o mais precoce possível. Entretanto, atualmente, o tratamento recomendado para esse parasito consiste na retirada manual das larvas, o que causa muito desconforto para o animal parasitado, tanto que, em alguns casos, há a necessidade de sedação para realização do procedimento. O objetivo deste estudo foi avaliar a eficácia bernicida do sarolaner para o tratamento de Dermatobia hominis em cães naturalmente infestados. Foram incluídos dez cães, sem raça definida, com idade variando entre dois e seis anos, independente da variável sexo, com peso entre 11,4 e 19,1 kg, com no mínimo três larvas. No total foram contabilizadas 75 larvas, com média de 7,5 larvas por animal. A maior parte do parasitismo (46 larvas) estava localizado na região lateral dos animais. Os animais foram medicados com sarolaner na dose de 2,0 mg/kg, administrado por via oral em dose única, seguindo as recomendações em bula para o tratamento de outras ectoparasitoses. Após o tratamento, os animais foram mantidos em seus domicílios e foram feitas observações para verificar a atividade de eliminação e o efeito bernicida do fármaco após 24 horas da administração da medicação. Foi considerada larva viva qualquer parasito que apresentasse motilidade após remoção mecânica. Como critérios de avaliação da eficácia do sarolaner, o efeito larvicida foi calculado para cada animal pela fórmula: [Número de larvas vivas após o tratamento – número de larvas vivas antes do tratamento) / Número de larvas vivas antes do tratamento] × 100. Após 24 horas da administração da medicação todas as larvas foram encontradas mortas, ainda que localizadas na derme dos animais. Nenhum animal apresentou efeito adverso ou alteração do comportamento após a utilização da isoxazolina. Conclui-se que o sarolaner administrado em dose única de 2,0mg/kg, por via oral, foi 100% eficaz em cães naturalmente infestados por D. hominis.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorLesions caused by breeds are quite uncomfortable and painful for dogs, and can cause secondary bacterial infections and predispose to other myiasis. Effective treatment should eliminate or kill existing larvae and promote wound healing as early as possible. However, currently, the recommended treatment for this parasite consists of manual removal of the larvae, which causes a lot of discomfort for the parasitized animal, so much so that, in some cases, there is a need for sedation to perform the procedure. The aim of this study was to evaluate the bernicidal efficacy of sarolaner for the treatment of Dermatobia hominis in naturally infested dogs. Ten mongrel dogs were included, aged between one and ten years, regardless of the sex variable, weighing between 11.4 and 19.1 kg, with at least three larvae. In total 75 larvae were counted, with an average of 7.5 larvae per animal. Most of the parasitism (46 larvae) was located in the lateral region of the animals. The animals were medicated with sarolaner at a dose of 2.0 mg / kg, administered orally in a single dose, following the recommendations in the package insert for the treatment of other ectoparasitoses. After treatment, the animals were kept in their homes and observations were made to verify the elimination activity and the bernicidal effect of the drug after 24 hours of medication administration. Any parasite that showed motility after mechanical removal was considered a live larva. As criteria for assessing the efficacy of sarolaner, the larvicidal effect was calculated for each animal using the formula: [Number of live larvae after treatment - number of live larvae before treatment) / Number of live larvae before treatment] × 100. After 24 hours after medication administration, all larvae were found dead, although located in the animals' dermis. No animal had an adverse effect or behavior change after using isoxazoline. 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Rio de Janeiro: Guanabara, p. 175-176, 1990. VARLOUD, M.; FOURIE, J. J. Onset of efficacy and residual speed of kill over one month of a topical dinotefuran-permethrin-pyriproxyfen combination (Vectra® 3D) against the adult cat flea (Ctenocephalides felis felis) on dogs. Veterinary Parasitology, v.211, s.1-2, p.89-92, 2015. VATTA, A. F. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner for cats against adult Ctenocephalides felis, flea egg production and adult flea emergence. Veterinary parasitology, v.238, S22-S26, 2017. VATTA, A. F. et al. Comparative efficacy of topical treatments with Revolution Plus (selamectin and sarolaner) and Bravecto for cats (fluralaner) against Ixodes scapularis ticks on cats. Veterinary parasitology, v.270, S58-S63, 2019b. VILLALOBOS. G.; VEGA - MEMIJE. M, E.; MARAVILLA. P.; MARTINEZ- HERNANDEZ, F. Review: Myiasis caused by Dermatobia hominis: countries with increased risk for travelers going to neotropic areas. International Journal of Dermatology, v. 55, p. 1060-1068, 2016. VERANI, S.; TASSINARI, D.;ELLERI, D, et al. A case of furuncular myiasis associated with systemic inflammation. International Journal for Parasitology, v. 56:330-333, 2007. WALTHER, F.M. et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1 (-/-) Collies after oral administration. Parasites & Vectors, v.7, s.86, 2014a. WEBER, T.; SELZER, P.M. Isoxazolines: A novel chemotype higly effective on ectoparasites. Chemmedchem Minireviews, v. 11, p.270-276, 2016. WILLWMSE, T. Doenças Parasitárias. In: WILLEMSE, T. Dermatologia clínica de cães e gatos. São Paulo: Manole, p. 27-39, 1998. WISMER, T.; MEANS, C. Toxicology of newer insecticides in small animals. Veterinary of North America: Small Animal Practice, v.42, s.2, 2012. WOODS, D.J.; MCTIER T.L.; DEROSA, A.A. Comparison of the Anti-ectoparasite and Anti-endoparasite Therapies and Control Strategies. In: Ectoparasites – Drug Discovery Against Moving Targets, v.8, p.3-24, 2018. WOODS, D.J.; MCTIER, T.L. Discovery, development and commercialization of sarolaner (Simparica®), a novel oral isozaxoline ectoparasiticide for dogs. In: Ectoparasites – Drug Discovery Against Moving Targets, v.8, p. 295-318, 2018. ZAKSON-AIKEN, M. et al. Systemic activity of the avermectins against the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). Journal of the Medical Entomology, v.38, n.4, p.576-580, 2000.https://tede.ufrrj.br/retrieve/72140/2020%20-%20Paula%20Azevedo%20Andriotti.Pdf.jpghttps://tede.ufrrj.br/jspui/handle/jspui/6319Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2023-02-07T17:05:34Z No. of bitstreams: 1 2020 - Paula Azevedo Andriotti.Pdf: 2355562 bytes, checksum: f818e8478a2807e3bd8e4a2817234bc3 (MD5)Made available in DSpace on 2023-02-07T17:05:34Z (GMT). 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| dc.title.por.fl_str_mv |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) |
| dc.title.alternative.eng.fl_str_mv |
Efficacy of Sarolaner in the treatment of myiasis in dogs caused by Dermatobia hominis (Diptera: Cutebridae) |
| title |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) |
| spellingShingle |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) Andriotti, Paula Azevedo berne sarolaner larvicida larvicide Medicina Veterinária |
| title_short |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) |
| title_full |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) |
| title_fullStr |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) |
| title_full_unstemmed |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) |
| title_sort |
Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae) |
| author |
Andriotti, Paula Azevedo |
| author_facet |
Andriotti, Paula Azevedo |
| author_role |
author |
| dc.contributor.author.fl_str_mv |
Andriotti, Paula Azevedo |
| dc.contributor.advisor1.fl_str_mv |
Fernandes, Júlio Israel |
| dc.contributor.advisor1ID.fl_str_mv |
082.100.187-60 |
| dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9221592908532393 |
| dc.contributor.referee1.fl_str_mv |
Fernandes, Júlio Israel |
| dc.contributor.referee2.fl_str_mv |
Balthazar, Daniel de Almeida |
| dc.contributor.referee3.fl_str_mv |
Cirne, Lilian Cristina de Souza Oliveira Batista |
| dc.contributor.authorID.fl_str_mv |
140.711.147-70 |
| dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9447255004002929 |
| contributor_str_mv |
Fernandes, Júlio Israel Fernandes, Júlio Israel Balthazar, Daniel de Almeida Cirne, Lilian Cristina de Souza Oliveira Batista |
| dc.subject.por.fl_str_mv |
berne sarolaner larvicida |
| topic |
berne sarolaner larvicida larvicide Medicina Veterinária |
| dc.subject.eng.fl_str_mv |
larvicide |
| dc.subject.cnpq.fl_str_mv |
Medicina Veterinária |
| description |
As lesões causadas por bernes são bastante desconfortáveis e dolorosas para os cães, podendo causar infecções bacterianas secundárias e predispor a outras miíases. Um tratamento eficaz deve eliminar ou matar as larvas existentes e promover a cicatrização da ferida o mais precoce possível. Entretanto, atualmente, o tratamento recomendado para esse parasito consiste na retirada manual das larvas, o que causa muito desconforto para o animal parasitado, tanto que, em alguns casos, há a necessidade de sedação para realização do procedimento. O objetivo deste estudo foi avaliar a eficácia bernicida do sarolaner para o tratamento de Dermatobia hominis em cães naturalmente infestados. Foram incluídos dez cães, sem raça definida, com idade variando entre dois e seis anos, independente da variável sexo, com peso entre 11,4 e 19,1 kg, com no mínimo três larvas. No total foram contabilizadas 75 larvas, com média de 7,5 larvas por animal. A maior parte do parasitismo (46 larvas) estava localizado na região lateral dos animais. Os animais foram medicados com sarolaner na dose de 2,0 mg/kg, administrado por via oral em dose única, seguindo as recomendações em bula para o tratamento de outras ectoparasitoses. Após o tratamento, os animais foram mantidos em seus domicílios e foram feitas observações para verificar a atividade de eliminação e o efeito bernicida do fármaco após 24 horas da administração da medicação. Foi considerada larva viva qualquer parasito que apresentasse motilidade após remoção mecânica. Como critérios de avaliação da eficácia do sarolaner, o efeito larvicida foi calculado para cada animal pela fórmula: [Número de larvas vivas após o tratamento – número de larvas vivas antes do tratamento) / Número de larvas vivas antes do tratamento] × 100. Após 24 horas da administração da medicação todas as larvas foram encontradas mortas, ainda que localizadas na derme dos animais. Nenhum animal apresentou efeito adverso ou alteração do comportamento após a utilização da isoxazolina. Conclui-se que o sarolaner administrado em dose única de 2,0mg/kg, por via oral, foi 100% eficaz em cães naturalmente infestados por D. hominis. |
| publishDate |
2020 |
| dc.date.issued.fl_str_mv |
2020-02-20 |
| dc.date.accessioned.fl_str_mv |
2023-12-22T02:58:44Z |
| dc.date.available.fl_str_mv |
2023-12-22T02:58:44Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| format |
masterThesis |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ANDRIOTTI, Paula Azevedo. Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae). 2020. 46 f. Dissertação (Mestrado em Medicina Veterinária, Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020. |
| dc.identifier.uri.fl_str_mv |
https://rima.ufrrj.br/jspui/handle/20.500.14407/14277 |
| identifier_str_mv |
ANDRIOTTI, Paula Azevedo. Eficácia do Sarolaner no tratamento de miíases em cães causadas por Dermatobia hominis (Diptera: Cutebridae). 2020. 46 f. Dissertação (Mestrado em Medicina Veterinária, Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020. |
| url |
https://rima.ufrrj.br/jspui/handle/20.500.14407/14277 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.references.por.fl_str_mv |
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ZAKSON-AIKEN, M. et al. Systemic activity of the avermectins against the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). Journal of the Medical Entomology, v.38, n.4, p.576-580, 2000. |
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