Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador

Detalhes bibliográficos
Autor(a) principal: Mello, Erica Bertha Führich Raupp Bezerra de
Data de Publicação: 2016
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/10162
Resumo: O aumento das concentrações de indicadores do metabolismo de gorduras é bastante comum em casos diagnosticados de Síndrome Metabólica Equina (SME), mas apesar disto não entra no hall de fatores determinantes para diagnóstico da SME. Para avaliar a influência do escore corporal (EC) nas alterações secundárias associadas à SME, foram avaliados lipidograma, glicemia, concentração de insulina, sensibilidade à insulina (RISQI) e secreção β-pancreática de três grupos de de éguas Mangalarga Marchador não-getsantes/não-lactantes em três diferentes categorias de EC (Ideal, Sobrepeso e Obeso). Cada grupo contou com 6 animais. Foram coletadas amostras de sangue em jejum de concentrado para a determinação de concentração plasmática de triglicerídeos, colesterol total, glicose e insulina e a partir dos valores de glicemia e insulinemia foram calculados valores preditivos de sensibilidade à insulina (RISQI) e secreção β-pancreática (MIRG). Houve diferença estatística entre os grupos quando avaliado os níveis de triglicerídeos (p<0,01), sendo que o Grupo Obeso apesentou resultados significativamente superiores aos demais grupos. Foi observada diferença estatística entre os grupos quando avaliado as concentrações de colesterol total (p=0,01), sendo que o Grupo Obeso apresentou resultados significativamente superiores ao Grupo Ideal. Não foi observada diferença estatística entre os grupos nas concentrações plasmáticas de glicose (p=0,53) e insulina (p=0,10). Não foi observada diferença estatística nos valores obtidos de RISQI (p=0,46), mas houve diferença estatística entre os grupos nos valores obtidos de MIRG (p=0,05), sendo que o Grupo Obeso obteve resultados significativamente superiores quando comparado com o Grupo Ideal. O escore corporal influenciou de forma positiva nos resultados do lipidograma e valor preditivo de secreção β-pancreática, sendo encontrados maiores níveis em animais obesos.
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spelling Mello, Erica Bertha Führich Raupp Bezerra deBotteon, Paulo de Tarso Landgraf924.895.677-72http://lattes.cnpq.br/6104411705808124Hess, Tanja Maria922.139.107-82http://lattes.cnpq.br/5704085262962086Faleiros, Rafael ResendeLessa, Daniel Augusto BarrosoAlmeida, Norma Aparecida dosPaiva, Jonimar Pereira5418700866http://lattes.cnpq.br/26433336077810452023-12-21T18:58:05Z2023-12-21T18:58:05Z2016-10-25MELLO, Erica Bertha Führich Raupp Bezerra de Mello. Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador. 2016. 87 f. Tese (Doutorado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica-RJ, 2016.https://rima.ufrrj.br/jspui/handle/20.500.14407/10162O aumento das concentrações de indicadores do metabolismo de gorduras é bastante comum em casos diagnosticados de Síndrome Metabólica Equina (SME), mas apesar disto não entra no hall de fatores determinantes para diagnóstico da SME. Para avaliar a influência do escore corporal (EC) nas alterações secundárias associadas à SME, foram avaliados lipidograma, glicemia, concentração de insulina, sensibilidade à insulina (RISQI) e secreção β-pancreática de três grupos de de éguas Mangalarga Marchador não-getsantes/não-lactantes em três diferentes categorias de EC (Ideal, Sobrepeso e Obeso). Cada grupo contou com 6 animais. Foram coletadas amostras de sangue em jejum de concentrado para a determinação de concentração plasmática de triglicerídeos, colesterol total, glicose e insulina e a partir dos valores de glicemia e insulinemia foram calculados valores preditivos de sensibilidade à insulina (RISQI) e secreção β-pancreática (MIRG). Houve diferença estatística entre os grupos quando avaliado os níveis de triglicerídeos (p<0,01), sendo que o Grupo Obeso apesentou resultados significativamente superiores aos demais grupos. Foi observada diferença estatística entre os grupos quando avaliado as concentrações de colesterol total (p=0,01), sendo que o Grupo Obeso apresentou resultados significativamente superiores ao Grupo Ideal. Não foi observada diferença estatística entre os grupos nas concentrações plasmáticas de glicose (p=0,53) e insulina (p=0,10). Não foi observada diferença estatística nos valores obtidos de RISQI (p=0,46), mas houve diferença estatística entre os grupos nos valores obtidos de MIRG (p=0,05), sendo que o Grupo Obeso obteve resultados significativamente superiores quando comparado com o Grupo Ideal. O escore corporal influenciou de forma positiva nos resultados do lipidograma e valor preditivo de secreção β-pancreática, sendo encontrados maiores níveis em animais obesos.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorIncreased indicators of fat metabolism are found in Equine Metabolic Syndrome (EMS) subjects although these symptons are not included in the EMS definition described in the literature and in its diagnosis. 18 mares were allocated in three groups according to body condition status. In Group Ideal there were animals in fit condition (n=6), in Group Overweight, considered in overweight (n=6) and in Group Obese (n=6), animals considered obese. Fasting blood samples were taken to determine triglycerides, total cholesterol, glucose, and insulin concentrations in plasma. Insulin sensitivity proxy (RISQI) and β-pancreatic secretion proxy (MIRG) were calculated from glucose and insulin data. There was a difference between groups in triglycerides levels (p<0.01), where Group Obese had significantly higher concentrations than other groups. Total cholesterol was higher in Group Obese compared to Group Ideal (p=0.01). No differences in plasma glucose (p=0.53) nor insulin (p = 0.10) concentrations and insulin sensitivity (RISQI: p=0.46) were seen among groups. Group Obese had a higher β-pancreatic secretion (MIRG: p=0.05) compared to Group Ideal. 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dc.title.por.fl_str_mv Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
dc.title.alternative.eng.fl_str_mv Obesity, insulin deregulation and mixed lipidemia in horses of the mangalarga walker breed
title Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
spellingShingle Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
Mello, Erica Bertha Führich Raupp Bezerra de
horse
triglycerides
hypercholesterolemia
insulin dysfunction
obesity
equino
trigliceridemia
colesterolemia
disfunção insulínica
obesida
Medicina Veterinária
title_short Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
title_full Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
title_fullStr Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
title_full_unstemmed Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
title_sort Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador
author Mello, Erica Bertha Führich Raupp Bezerra de
author_facet Mello, Erica Bertha Führich Raupp Bezerra de
author_role author
dc.contributor.author.fl_str_mv Mello, Erica Bertha Führich Raupp Bezerra de
dc.contributor.advisor1.fl_str_mv Botteon, Paulo de Tarso Landgraf
dc.contributor.advisor1ID.fl_str_mv 924.895.677-72
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6104411705808124
dc.contributor.advisor-co1.fl_str_mv Hess, Tanja Maria
dc.contributor.advisor-co1ID.fl_str_mv 922.139.107-82
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/5704085262962086
dc.contributor.referee1.fl_str_mv Faleiros, Rafael Resende
dc.contributor.referee2.fl_str_mv Lessa, Daniel Augusto Barroso
dc.contributor.referee3.fl_str_mv Almeida, Norma Aparecida dos
dc.contributor.referee4.fl_str_mv Paiva, Jonimar Pereira
dc.contributor.authorID.fl_str_mv 5418700866
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2643333607781045
contributor_str_mv Botteon, Paulo de Tarso Landgraf
Hess, Tanja Maria
Faleiros, Rafael Resende
Lessa, Daniel Augusto Barroso
Almeida, Norma Aparecida dos
Paiva, Jonimar Pereira
dc.subject.eng.fl_str_mv horse
triglycerides
hypercholesterolemia
insulin dysfunction
obesity
topic horse
triglycerides
hypercholesterolemia
insulin dysfunction
obesity
equino
trigliceridemia
colesterolemia
disfunção insulínica
obesida
Medicina Veterinária
dc.subject.por.fl_str_mv equino
trigliceridemia
colesterolemia
disfunção insulínica
obesida
dc.subject.cnpq.fl_str_mv Medicina Veterinária
description O aumento das concentrações de indicadores do metabolismo de gorduras é bastante comum em casos diagnosticados de Síndrome Metabólica Equina (SME), mas apesar disto não entra no hall de fatores determinantes para diagnóstico da SME. Para avaliar a influência do escore corporal (EC) nas alterações secundárias associadas à SME, foram avaliados lipidograma, glicemia, concentração de insulina, sensibilidade à insulina (RISQI) e secreção β-pancreática de três grupos de de éguas Mangalarga Marchador não-getsantes/não-lactantes em três diferentes categorias de EC (Ideal, Sobrepeso e Obeso). Cada grupo contou com 6 animais. Foram coletadas amostras de sangue em jejum de concentrado para a determinação de concentração plasmática de triglicerídeos, colesterol total, glicose e insulina e a partir dos valores de glicemia e insulinemia foram calculados valores preditivos de sensibilidade à insulina (RISQI) e secreção β-pancreática (MIRG). Houve diferença estatística entre os grupos quando avaliado os níveis de triglicerídeos (p<0,01), sendo que o Grupo Obeso apesentou resultados significativamente superiores aos demais grupos. Foi observada diferença estatística entre os grupos quando avaliado as concentrações de colesterol total (p=0,01), sendo que o Grupo Obeso apresentou resultados significativamente superiores ao Grupo Ideal. Não foi observada diferença estatística entre os grupos nas concentrações plasmáticas de glicose (p=0,53) e insulina (p=0,10). Não foi observada diferença estatística nos valores obtidos de RISQI (p=0,46), mas houve diferença estatística entre os grupos nos valores obtidos de MIRG (p=0,05), sendo que o Grupo Obeso obteve resultados significativamente superiores quando comparado com o Grupo Ideal. O escore corporal influenciou de forma positiva nos resultados do lipidograma e valor preditivo de secreção β-pancreática, sendo encontrados maiores níveis em animais obesos.
publishDate 2016
dc.date.issued.fl_str_mv 2016-10-25
dc.date.accessioned.fl_str_mv 2023-12-21T18:58:05Z
dc.date.available.fl_str_mv 2023-12-21T18:58:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELLO, Erica Bertha Führich Raupp Bezerra de Mello. Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador. 2016. 87 f. Tese (Doutorado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica-RJ, 2016.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/10162
identifier_str_mv MELLO, Erica Bertha Führich Raupp Bezerra de Mello. Obesidade, desregulação insulínica e lipidemia mista em equinos da raça mangalarga marchador. 2016. 87 f. Tese (Doutorado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica-RJ, 2016.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/10162
dc.language.iso.fl_str_mv por
language por
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Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses Veterinary Clinical Pathology v.38, n. 2, p. 136–156, 2009 RATTIGAN, S.; BUSSEY, C. T.; ROSS, R. M.; RICHARDS, S. M. Obesity, insulin resistance, and capillary recruitment Microcirculation, v.14, p. 299–309, 2007 SZABO, C. Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction British Journal of Pharmacology v. 156, p. 713–727, 2009 64 TILG, H.; MOSCHEN, A. R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nature Reviews Immunology v. 6, p. 772-783, 2006 TREIBER, K. H.; KRONFELD, D. S.; HE
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