Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica

Detalhes bibliográficos
Autor(a) principal: Cid, Gabriela de Carvalho
Data de Publicação: 2020
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/5940
Resumo: Chronic kidney disease (CKD) is characterized by irreversible morphostructural lesions, which may progressively progress to chronic renal failure (CKD) and renal failure. The heart and kidneys are known to be closely related, and communication between these organs occurs in a variety of ways; subtle physiological changes in one of these organs are offset by the other. On microscopic examination, routine histological staining is limited to identify specific or discrete lesions in cardiomyocytes. Many immunohistochemical techniques with high specificity and sensitivity have been developed in order to detect early lesions to cardiomyocytes. At time there are no studies evaluating immunohistochemistry with cardiac Troponin I (anti-cTnI) antibody in the detection of CKD-associated cardiac lesions in domestic cats. Thus, it aims to evaluate serum troponin levels in cats with CKD, associated with clinical-pathological findings, as well as correlated as morphostructural cardiac lesions, in order to determine the daily distribution through macroscopic, histological and immunological evaluation. anti-cTnI histochemistry. The objective of this study was to evaluate serum troponin levels in cats with CKD associated with clinical and pathological findings, as well as to correlate the morphostructural cardiac lesions, in order to determine their distribution through macroscopic, histological and anti-cTnI histochemistry evaluation. In this study, 20 cats (Felis catus) diagnosed with CKD were selected. As inclusion criteria, the patients presented stable azotemic biochemical profile examination, were in stage II or higher of International Renal Interest Society (IRIS) and also had clinical signs and complementary exams consistent with the diagnosis of CKD. Necropsies of the 20 animals and fragments of all macroscopically evaluated organs were performed, as well as eight fragments of different regions of the heart (apex, interventricular septum, left ventricle, right ventricle, left papillary muscle, right papillary muscle, left atrium and right atrium) were collected in 10% formalin solution for 24h and routinely processed for histopathology. To perform the human anti-troponin C immunohistochemistry technique, serial sections were obtained from the eight regions of the heart. Serum troponin examination showed data above reference values in 11 animals (55%). In immunohistochemical examination, decreased expression of anti-cTnC was observed in individual cardiomyocytes (affected areas) of nine cats (45%), of which six (66.7%) had only one affected region and three (33.3%) had two affected regions. Of the eight areas observed, the most frequently affected heart region was the apex (41.7%), followed by left ventricle (25%), right papillary muscle (16.7%), left papillary muscle (8.3%). and right ventricle (8.3%). The number of regions with decreased expression for cTnC antibody in cardiomyocytes was found to be strongly and significantly correlated with serum Troponin dosage.
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spelling Nogueira, Vivian de Assun??o089.375.877-93http://lattes.cnpq.br/6012855368365110Souza, Heloisa Justen Moreira dePeixoto, Tiago da CunhaNogueira, Vivian de Assun??oBaldani, Cristiane DivanNascimento, Aparecida Alves doCerqueira, Val?ria DuarteCastro, Maria Cristina Nobre124.460.277-92http://lattes.cnpq.br/1474541499986492Cid, Gabriela de Carvalho2022-08-26T20:02:10Z2020-02-04CID, Gabriela de Carvalho. Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica. 2020. 86 f. Tese (Doutorado em Medicina Veterin?ria) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2020.https://tede.ufrrj.br/jspui/handle/jspui/5940Chronic kidney disease (CKD) is characterized by irreversible morphostructural lesions, which may progressively progress to chronic renal failure (CKD) and renal failure. The heart and kidneys are known to be closely related, and communication between these organs occurs in a variety of ways; subtle physiological changes in one of these organs are offset by the other. On microscopic examination, routine histological staining is limited to identify specific or discrete lesions in cardiomyocytes. Many immunohistochemical techniques with high specificity and sensitivity have been developed in order to detect early lesions to cardiomyocytes. At time there are no studies evaluating immunohistochemistry with cardiac Troponin I (anti-cTnI) antibody in the detection of CKD-associated cardiac lesions in domestic cats. Thus, it aims to evaluate serum troponin levels in cats with CKD, associated with clinical-pathological findings, as well as correlated as morphostructural cardiac lesions, in order to determine the daily distribution through macroscopic, histological and immunological evaluation. anti-cTnI histochemistry. The objective of this study was to evaluate serum troponin levels in cats with CKD associated with clinical and pathological findings, as well as to correlate the morphostructural cardiac lesions, in order to determine their distribution through macroscopic, histological and anti-cTnI histochemistry evaluation. In this study, 20 cats (Felis catus) diagnosed with CKD were selected. As inclusion criteria, the patients presented stable azotemic biochemical profile examination, were in stage II or higher of International Renal Interest Society (IRIS) and also had clinical signs and complementary exams consistent with the diagnosis of CKD. Necropsies of the 20 animals and fragments of all macroscopically evaluated organs were performed, as well as eight fragments of different regions of the heart (apex, interventricular septum, left ventricle, right ventricle, left papillary muscle, right papillary muscle, left atrium and right atrium) were collected in 10% formalin solution for 24h and routinely processed for histopathology. To perform the human anti-troponin C immunohistochemistry technique, serial sections were obtained from the eight regions of the heart. Serum troponin examination showed data above reference values in 11 animals (55%). In immunohistochemical examination, decreased expression of anti-cTnC was observed in individual cardiomyocytes (affected areas) of nine cats (45%), of which six (66.7%) had only one affected region and three (33.3%) had two affected regions. Of the eight areas observed, the most frequently affected heart region was the apex (41.7%), followed by left ventricle (25%), right papillary muscle (16.7%), left papillary muscle (8.3%). and right ventricle (8.3%). The number of regions with decreased expression for cTnC antibody in cardiomyocytes was found to be strongly and significantly correlated with serum Troponin dosage.A doen?a renal cr?nica (DRC) ? caracterizada por les?es morfoestruturais irrevers?veis, que podem evoluir progressivamente para insufici?ncia renal cr?nica e fal?ncia renal. Sabe-se que o cora??o e os rins mant?m estreita rela??o e a comunica??o entre esses ?rg?os ocorre por uma variedade de vias; altera??es fisiol?gicas sutis em um desses ?rg?os nem sempre s?o compensadas pelo outro. A avalia??o histopatol?gica card?aca mediante a colora??es rotineiras s?o limitadas para identificar les?es espec?ficas ou discretas em cardiomi?citos. O presente trabalho teve como objetivos avaliar os n?veis s?ricos de troponina em gatos com DRC, associados aos achados cl?nico-patol?gicos, bem como correlacionar as les?es card?acas morfoestruturais, a fim de determinar a distribui??o destas, por meio da avalia??o macrosc?pica, histol?gica e imunohistoqu?mica com anti-cTnC. Neste estudo foram selecionados 20 gatos (18 diagnosticados com DRC e 2 animais controle). Para a aplica??o da t?cnica de imunohistoqu?mica anti-troponina C humana, necropsias foram realizadas e cada cora??o coletado separadamente em 8 regi?es. Fragmentos do cora??o de 2 gatos sem les?o card?aca foram utilizados como controle. Em 11/18 animais (61,11%) a troponina s?rica encontrava-se acima dos valores de refer?ncia e foram observadas diminui??o da express?o para anticorpo-cTnC em cardiomi?citos individuais em 9/18 (50%). Notou-se que o n?mero de regi?es com diminui??o da express?o para anticorpo-cTnC em cardiomi?citos est? significativamente correlacionado com a troponina s?rica. O anticorpo anti-TnC humano se mostrou eficaz para detectar les?es card?acas e demonstrou diminui??o da express?o nos cardiomi?citos de gatos com DRC. Houve correla??o entre o aumento da CTnI s?rica e perda da imunorretividade na avalia??o imunohistoqu?mica com anticorpo anti-TnC em gatos com DRC o que comprova danos em cardiomi?citos secund?rios a doen?a renal.Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2022-08-26T20:02:10Z No. of bitstreams: 1 2020 - Gabriela de Carvalho Cid.pdf: 1747808 bytes, checksum: 96aa3494acccae10d3eb2e394bb70d67 (MD5)Made available in DSpace on 2022-08-26T20:02:10Z (GMT). No. of bitstreams: 1 2020 - Gabriela de Carvalho Cid.pdf: 1747808 bytes, checksum: 96aa3494acccae10d3eb2e394bb70d67 (MD5) Previous issue date: 2020-02-04CAPES - Coordena??o de Aperfei?oamento de Pessoal de N?vel Superiorapplication/pdfhttps://tede.ufrrj.br/retrieve/70532/2020%20-%20Gabriela%20de%20Carvalho%20Cid.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riaACIERNO, M.J.; LABATO, A. Hypertension in renal disease: diagnosis and treatment. Clinical Techniques in Small Animal Practice. 20:23-30, 2005. ADAMS, J.E.; ABENDSCHEIN, D.R.; JAFFE, A. S. Biochemical markers of myocardial injury. Is MB creatine kinase the choice for the 1990s? Circulation, v. 88, p. 750-763, 1993. AIRES, M.M. Excre??o Renal de Solutos. In: AIRES, M.M. Fisiologia. 3? ed. Rio de Janeiro. Guanabara Koogan, sec. 7, cap. 51, p. 730-747, 2008. ALFREY, A.C. 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Human heart generates complement proteins that are upregulated and activated after myocardial infarction. Circulation Research, v. 83, n. 8, p. 860-869, 1998. ZOYSA, J.R.D. Cardiac troponins and renal disease. 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dc.title.por.fl_str_mv Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
dc.title.alternative.eng.fl_str_mv Clinical-pathological and immunohistochemical evaluations of cardiac lesions in cats (felis catus) with chronic renal disease
title Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
spellingShingle Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
Cid, Gabriela de Carvalho
Felino
Cardiologia
Nefrologia
Troponina
Feline
Cardiology
Nephrology,
Troponin
Medicina Veterin?ria
title_short Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
title_full Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
title_fullStr Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
title_full_unstemmed Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
title_sort Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica
author Cid, Gabriela de Carvalho
author_facet Cid, Gabriela de Carvalho
author_role author
dc.contributor.advisor1.fl_str_mv Nogueira, Vivian de Assun??o
dc.contributor.advisor1ID.fl_str_mv 089.375.877-93
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6012855368365110
dc.contributor.advisor-co1.fl_str_mv Souza, Heloisa Justen Moreira de
dc.contributor.advisor-co2.fl_str_mv Peixoto, Tiago da Cunha
dc.contributor.referee1.fl_str_mv Nogueira, Vivian de Assun??o
dc.contributor.referee2.fl_str_mv Baldani, Cristiane Divan
dc.contributor.referee3.fl_str_mv Nascimento, Aparecida Alves do
dc.contributor.referee4.fl_str_mv Cerqueira, Val?ria Duarte
dc.contributor.referee5.fl_str_mv Castro, Maria Cristina Nobre
dc.contributor.authorID.fl_str_mv 124.460.277-92
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1474541499986492
dc.contributor.author.fl_str_mv Cid, Gabriela de Carvalho
contributor_str_mv Nogueira, Vivian de Assun??o
Souza, Heloisa Justen Moreira de
Peixoto, Tiago da Cunha
Nogueira, Vivian de Assun??o
Baldani, Cristiane Divan
Nascimento, Aparecida Alves do
Cerqueira, Val?ria Duarte
Castro, Maria Cristina Nobre
dc.subject.por.fl_str_mv Felino
Cardiologia
Nefrologia
Troponina
topic Felino
Cardiologia
Nefrologia
Troponina
Feline
Cardiology
Nephrology,
Troponin
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Feline
Cardiology
Nephrology,
Troponin
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Chronic kidney disease (CKD) is characterized by irreversible morphostructural lesions, which may progressively progress to chronic renal failure (CKD) and renal failure. The heart and kidneys are known to be closely related, and communication between these organs occurs in a variety of ways; subtle physiological changes in one of these organs are offset by the other. On microscopic examination, routine histological staining is limited to identify specific or discrete lesions in cardiomyocytes. Many immunohistochemical techniques with high specificity and sensitivity have been developed in order to detect early lesions to cardiomyocytes. At time there are no studies evaluating immunohistochemistry with cardiac Troponin I (anti-cTnI) antibody in the detection of CKD-associated cardiac lesions in domestic cats. Thus, it aims to evaluate serum troponin levels in cats with CKD, associated with clinical-pathological findings, as well as correlated as morphostructural cardiac lesions, in order to determine the daily distribution through macroscopic, histological and immunological evaluation. anti-cTnI histochemistry. The objective of this study was to evaluate serum troponin levels in cats with CKD associated with clinical and pathological findings, as well as to correlate the morphostructural cardiac lesions, in order to determine their distribution through macroscopic, histological and anti-cTnI histochemistry evaluation. In this study, 20 cats (Felis catus) diagnosed with CKD were selected. As inclusion criteria, the patients presented stable azotemic biochemical profile examination, were in stage II or higher of International Renal Interest Society (IRIS) and also had clinical signs and complementary exams consistent with the diagnosis of CKD. Necropsies of the 20 animals and fragments of all macroscopically evaluated organs were performed, as well as eight fragments of different regions of the heart (apex, interventricular septum, left ventricle, right ventricle, left papillary muscle, right papillary muscle, left atrium and right atrium) were collected in 10% formalin solution for 24h and routinely processed for histopathology. To perform the human anti-troponin C immunohistochemistry technique, serial sections were obtained from the eight regions of the heart. Serum troponin examination showed data above reference values in 11 animals (55%). In immunohistochemical examination, decreased expression of anti-cTnC was observed in individual cardiomyocytes (affected areas) of nine cats (45%), of which six (66.7%) had only one affected region and three (33.3%) had two affected regions. Of the eight areas observed, the most frequently affected heart region was the apex (41.7%), followed by left ventricle (25%), right papillary muscle (16.7%), left papillary muscle (8.3%). and right ventricle (8.3%). The number of regions with decreased expression for cTnC antibody in cardiomyocytes was found to be strongly and significantly correlated with serum Troponin dosage.
publishDate 2020
dc.date.issued.fl_str_mv 2020-02-04
dc.date.accessioned.fl_str_mv 2022-08-26T20:02:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv CID, Gabriela de Carvalho. Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica. 2020. 86 f. Tese (Doutorado em Medicina Veterin?ria) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2020.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/5940
identifier_str_mv CID, Gabriela de Carvalho. Avalia??es cl?nico-patol?gica e imunohistoqu?mica de les?es card?acas em gatos (Felis catus) com doen?a renal cr?nica. 2020. 86 f. Tese (Doutorado em Medicina Veterin?ria) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2020.
url https://tede.ufrrj.br/jspui/handle/jspui/5940
dc.language.iso.fl_str_mv por
language por
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