Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame

Detalhes bibliográficos
Autor(a) principal: Rangel, Natália D' Assumpção Lima
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/11399
Resumo: A obesidade tornou-se um problema de saúde pública no mundo. Mulheres grávidas com sobrepeso podem causar programação metabólica na linhagem, com o surgimento de diabetes tipo2, dislipidemias e doenças cardiovasculares na fase adulta da progênie. Nosso grupo de pesquisa demonstrou anteriormente que o consumo materno de dieta hiperlipídica promoveu aumento da massa corporal, adiposidade, hiperleptinemia na prole de ratas ao desmame, além de prejuízo na função sistólica aos 30 dias de idade. O sistema renina angiotensina (SRA) expresso no coração parece desencadear hipertrofia cardíaca (HC), através da super expressão de Angiotensina II (Ang II) e ativação do seu receptor, AT1. Este estudo teve como objetivo investigar se o consumo materno de dieta hiperlipídica promove HC, e correlacionar este fenótipo à alterações ao sistema SRA cardíaco em animais machos e fêmeas da prole ao desmame. Para isso, ratas Wistar receberam dieta controle (9% lipídeos, grupo C) ou hiperlipídica (29% lipídeos, grupo DH) durante 8 semanas antes do acasalamento, e durante a gestação e lactação. Ao desmame, 21 dias de vida, as proles foram pesadas e eutanasiadas. O coração e os tecidos adiposos branco (retroperitoneal, inguinal e perigonadal) foram pesados. Análises histológicas (cortes corados com HE e picrossírius) foram realizadas utilizando amostras dos ventrículos e análises bioquímicas e moleculares (RIA e qPCR) foram realizadas utilizando amostras do ventrículo esquerdo (VE) e a expressão do receptor AT1 foi avaliada através da técnica de Western Blotting. Fêmeas e machos da prole DH, apresentaram maior massa corporal, adiposidade, hipertrofia do VE, mas não apresentaram fibrose; maior expressão do RNAm de Nppn; e menor de β-MHC, SERCA2a e Ryr2. A expressão do RNAm de α-MHC estava reduzida somente nos machos da prole DH. Não houve diferença na dosagem de Ang II entre as proles. A expressão protéica de AT1 estava maior nas fêmeas da prole DH, mas não foi alterada nos machos. Estes resultados sugerem que o consumo materno de dieta hiperlipídica promove hipertrofia do VE em fêmeas e machos, no entanto verificamos alteração na expressão de AT1 somente nas fêmeas, o que sugere que o sistema RAS pode estar envolvido com a HC observada nas fêmeas mas não nos animais machos da prole.
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spelling Rangel, Natália D' Assumpção LimaOliveira, Norma Aparecida Almeida Figueiredo de072.340.197-74http://lattes.cnpq.br/8601494649709728Oliveira, Norma Aparecida Almeida Figueiredo de072.340.197-74http://lattes.cnpq.br/8601494649709728Silveira, Anderson Luiz Bezerra dahttp://lattes.cnpq.br/2389812933788850Souza, Luciane Claudia Barcellos dos Santos060.010.817-19http://lattes.cnpq.br/89288051417225202023-12-22T01:52:18Z2023-12-22T01:52:18Z2018-03-08RANGEL, Natália D’Assumpção Lima. Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame. 2018. 88 f. Dissertação (Mestrado em Ciências Fisiológicas) -Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2018.https://rima.ufrrj.br/jspui/handle/20.500.14407/11399A obesidade tornou-se um problema de saúde pública no mundo. Mulheres grávidas com sobrepeso podem causar programação metabólica na linhagem, com o surgimento de diabetes tipo2, dislipidemias e doenças cardiovasculares na fase adulta da progênie. Nosso grupo de pesquisa demonstrou anteriormente que o consumo materno de dieta hiperlipídica promoveu aumento da massa corporal, adiposidade, hiperleptinemia na prole de ratas ao desmame, além de prejuízo na função sistólica aos 30 dias de idade. O sistema renina angiotensina (SRA) expresso no coração parece desencadear hipertrofia cardíaca (HC), através da super expressão de Angiotensina II (Ang II) e ativação do seu receptor, AT1. Este estudo teve como objetivo investigar se o consumo materno de dieta hiperlipídica promove HC, e correlacionar este fenótipo à alterações ao sistema SRA cardíaco em animais machos e fêmeas da prole ao desmame. Para isso, ratas Wistar receberam dieta controle (9% lipídeos, grupo C) ou hiperlipídica (29% lipídeos, grupo DH) durante 8 semanas antes do acasalamento, e durante a gestação e lactação. Ao desmame, 21 dias de vida, as proles foram pesadas e eutanasiadas. O coração e os tecidos adiposos branco (retroperitoneal, inguinal e perigonadal) foram pesados. Análises histológicas (cortes corados com HE e picrossírius) foram realizadas utilizando amostras dos ventrículos e análises bioquímicas e moleculares (RIA e qPCR) foram realizadas utilizando amostras do ventrículo esquerdo (VE) e a expressão do receptor AT1 foi avaliada através da técnica de Western Blotting. Fêmeas e machos da prole DH, apresentaram maior massa corporal, adiposidade, hipertrofia do VE, mas não apresentaram fibrose; maior expressão do RNAm de Nppn; e menor de β-MHC, SERCA2a e Ryr2. A expressão do RNAm de α-MHC estava reduzida somente nos machos da prole DH. Não houve diferença na dosagem de Ang II entre as proles. A expressão protéica de AT1 estava maior nas fêmeas da prole DH, mas não foi alterada nos machos. Estes resultados sugerem que o consumo materno de dieta hiperlipídica promove hipertrofia do VE em fêmeas e machos, no entanto verificamos alteração na expressão de AT1 somente nas fêmeas, o que sugere que o sistema RAS pode estar envolvido com a HC observada nas fêmeas mas não nos animais machos da prole.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorCNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroObesity has become a public health problem in the world. Overweight pregnant women can cause metabolic programming in the lineage, with the emergence of type 2 diabetes, dyslipidemias and cardiovascular diseases in the adult progeny. Our research group has previously shown that maternal consumption of a high fat diet promoted increased body mass, adiposity, hyperleptinemia in the offspring of rats at weaning, as well as impairment of systolic function at 30 days of age. The renin angiotensin system (RAS) expressed in the heart appears to trigger cardiac hypertrophy (CH), through the overexpression of Angiotensin II (Ang II) and activation of it’s receptor, AT1. This study aimed to investigate whether the maternal consumption of a high fat diet promotes CH, and correlate such changes to the cardiac RAS system in male and female offspring. For this, Wistar rats received control diet (9% lipids, group C) or high fat (29% lipids, HF group) for 8 weeks before mating, and during gestation and lactation. At weaning, 21 days of life, the offspring were weighed and euthanized. The heart and adipose white tissue (retroperitoneal, inguinal and perigonadal) were weighed. Histological analyzes (sections stained with HE and picrosirius) were realized using samples from the ventricles and biochemical and molecular analyzes (RIA and qPCR) were performed using left ventricular (LV) samples and AT1 receptor expression was assessed by Western blotting. Females and males of the HF progeny presented higher body mass, adiposity, LV hypertrophy, but did not present fibrosis; higher mRNA expression of Nppn; and less expression of β-MHC, SERCA2a and Ryr2. mRNA expression of α-MHC was reduced only in males of the DH offspring. There was no difference in Ang II dosage among the offspring. Protein expression of AT1 was higher in females of the HF progeny, but was not altered in males. These results suggest that the maternal consumption of high fat diet promotes LV hypertrophy in females and males of the HF offspring, however we verified alteration in the AT1 protein expression only in females of HF progeny, which suggests that the RAS system may be involved with HC observed in the females and not in the male animals of the HF offspring.application/pdfporUniversidade Federal Rural do Rio de JaneiroPrograma de Pós-Graduação em Ciências FisiológicasUFRRJBrasilInstituto de Ciências Biológicas e da SaúdeDieta hiperlipídicaProgramação metabólicaHipertrofia cardíacaHigh fat dietMetabolic programmingCardiac hypertrophyFisiologiaConsumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmameMaternal high fat diet consumption: change in the angiotensina II receptor expression (AT1) and left ventricular hypertrophy in the offspring at weaninginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisADAMS TD, YANOWITZ FG, FISHER AG, RIDGES JD, LOVELL K, AND PRYOR TA. 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dc.title.por.fl_str_mv Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
dc.title.alternative.eng.fl_str_mv Maternal high fat diet consumption: change in the angiotensina II receptor expression (AT1) and left ventricular hypertrophy in the offspring at weaning
title Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
spellingShingle Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
Rangel, Natália D' Assumpção Lima
Dieta hiperlipídica
Programação metabólica
Hipertrofia cardíaca
High fat diet
Metabolic programming
Cardiac hypertrophy
Fisiologia
title_short Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
title_full Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
title_fullStr Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
title_full_unstemmed Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
title_sort Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame
author Rangel, Natália D' Assumpção Lima
author_facet Rangel, Natália D' Assumpção Lima
author_role author
dc.contributor.author.fl_str_mv Rangel, Natália D' Assumpção Lima
dc.contributor.advisor1.fl_str_mv Oliveira, Norma Aparecida Almeida Figueiredo de
dc.contributor.advisor1ID.fl_str_mv 072.340.197-74
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/8601494649709728
dc.contributor.referee1.fl_str_mv Oliveira, Norma Aparecida Almeida Figueiredo de
dc.contributor.referee1ID.fl_str_mv 072.340.197-74
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/8601494649709728
dc.contributor.referee2.fl_str_mv Silveira, Anderson Luiz Bezerra da
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/2389812933788850
dc.contributor.referee3.fl_str_mv Souza, Luciane Claudia Barcellos dos Santos
dc.contributor.authorID.fl_str_mv 060.010.817-19
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8928805141722520
contributor_str_mv Oliveira, Norma Aparecida Almeida Figueiredo de
Oliveira, Norma Aparecida Almeida Figueiredo de
Silveira, Anderson Luiz Bezerra da
Souza, Luciane Claudia Barcellos dos Santos
dc.subject.por.fl_str_mv Dieta hiperlipídica
Programação metabólica
Hipertrofia cardíaca
topic Dieta hiperlipídica
Programação metabólica
Hipertrofia cardíaca
High fat diet
Metabolic programming
Cardiac hypertrophy
Fisiologia
dc.subject.eng.fl_str_mv High fat diet
Metabolic programming
Cardiac hypertrophy
dc.subject.cnpq.fl_str_mv Fisiologia
description A obesidade tornou-se um problema de saúde pública no mundo. Mulheres grávidas com sobrepeso podem causar programação metabólica na linhagem, com o surgimento de diabetes tipo2, dislipidemias e doenças cardiovasculares na fase adulta da progênie. Nosso grupo de pesquisa demonstrou anteriormente que o consumo materno de dieta hiperlipídica promoveu aumento da massa corporal, adiposidade, hiperleptinemia na prole de ratas ao desmame, além de prejuízo na função sistólica aos 30 dias de idade. O sistema renina angiotensina (SRA) expresso no coração parece desencadear hipertrofia cardíaca (HC), através da super expressão de Angiotensina II (Ang II) e ativação do seu receptor, AT1. Este estudo teve como objetivo investigar se o consumo materno de dieta hiperlipídica promove HC, e correlacionar este fenótipo à alterações ao sistema SRA cardíaco em animais machos e fêmeas da prole ao desmame. Para isso, ratas Wistar receberam dieta controle (9% lipídeos, grupo C) ou hiperlipídica (29% lipídeos, grupo DH) durante 8 semanas antes do acasalamento, e durante a gestação e lactação. Ao desmame, 21 dias de vida, as proles foram pesadas e eutanasiadas. O coração e os tecidos adiposos branco (retroperitoneal, inguinal e perigonadal) foram pesados. Análises histológicas (cortes corados com HE e picrossírius) foram realizadas utilizando amostras dos ventrículos e análises bioquímicas e moleculares (RIA e qPCR) foram realizadas utilizando amostras do ventrículo esquerdo (VE) e a expressão do receptor AT1 foi avaliada através da técnica de Western Blotting. Fêmeas e machos da prole DH, apresentaram maior massa corporal, adiposidade, hipertrofia do VE, mas não apresentaram fibrose; maior expressão do RNAm de Nppn; e menor de β-MHC, SERCA2a e Ryr2. A expressão do RNAm de α-MHC estava reduzida somente nos machos da prole DH. Não houve diferença na dosagem de Ang II entre as proles. A expressão protéica de AT1 estava maior nas fêmeas da prole DH, mas não foi alterada nos machos. Estes resultados sugerem que o consumo materno de dieta hiperlipídica promove hipertrofia do VE em fêmeas e machos, no entanto verificamos alteração na expressão de AT1 somente nas fêmeas, o que sugere que o sistema RAS pode estar envolvido com a HC observada nas fêmeas mas não nos animais machos da prole.
publishDate 2018
dc.date.issued.fl_str_mv 2018-03-08
dc.date.accessioned.fl_str_mv 2023-12-22T01:52:18Z
dc.date.available.fl_str_mv 2023-12-22T01:52:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv RANGEL, Natália D’Assumpção Lima. Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame. 2018. 88 f. Dissertação (Mestrado em Ciências Fisiológicas) -Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2018.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/11399
identifier_str_mv RANGEL, Natália D’Assumpção Lima. Consumo materno de dieta hiperlipídica: alteração na expressão do receptor de angiotensina II (AT1) e hipertrofia no coração da prole ao desmame. 2018. 88 f. Dissertação (Mestrado em Ciências Fisiológicas) -Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2018.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/11399
dc.language.iso.fl_str_mv por
language por
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