Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)

Detalhes bibliográficos
Autor(a) principal: Polo, Patrícia de Almeida
Data de Publicação: 2009
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/9214
Resumo: Esse trabalho deu continuidade a um achado incidental do Laboratório de Fisiologia Animal da UFRRJ, no Departamento de Ciências Fisiológicas, no qual, codornas tratadas perifericamente com serotonina, em um estudo sobre comportamento alimentar, apresentaram comportamentos semelhantes ao sono. A partir dessa evidência, a idéia de que a serotonina permeia a barreira hematoencefálica de aves, diferentemente de mamíferos, incitou novas investigações neurofarmacológicas e comportamentais. Foi realizado, primeiramente, um estudo com antagonistas e agonistas de receptores serotoninérgicos, confirmando a permeabilidade da barreira hematoencefálica de codornas à essa amina biogênica e sua participação em mecanismos centrais envolvidos na regulação de comportamentos semelhantes aos do sono. Esse trabalho resultou em uma publicação na Brazilian Joumal of Biology, em 2007, intitulada "Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Gallifonnes: Aves)". Levando-se em consideração que a serotonina é precursora da melatonina, e que esta última está envolvida no controle do ritmo circadiano, continuou-se a investigação, em tomo das alterações séricas de melatonina, mediante administração do precursor da serotonina, L-5-hidróxi-triptofano. Esse estudo resultou na publicação do segundo artigo na Brazilian Journal of Biology, em 2007, "Nocturnal plasma leveis of melatonin in quails (Coturnix japonica) injected with L-5-hydroxy-tryptophan". Uma vez que os comportamentos relacionados ao sono envolvem uma série de inibições centrais e que o ácido y-amino-butírico (GABA) é o maior neurotransmissor central do sistema nervoso central, continuou-se a explorar neurofarmacológica e comportamentalmente, o sono em codornas, abordando-se um tipo de receptor gabaérgico, o complexo receptor GABAA. O estudo resultou na última publicação desse doutoramento, Study of GABAA receptors on the sleep-lik:e behavior in Coturnix japonica (Temminck Schlegel, 1849) (Galliformes: Aves), na Joumal of Comparative Physiology A, em 2008. O objetivo dessa tese não foi traçar um paralelo filogenético entre aves e mamíferos, entretanto, muitas evidências foram inevitáveis. Certamente, esse trabalho contribuiu para ampliar o conhecimento científico sobre os elementos estudados. Ainda há muito o que se investigar a respeito do sono, não só em aves, como também em mamíferos.
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spelling Polo, Patrícia de AlmeidaReis, Luis CarlosSilva, Hélio Ricardo daPiratelli, Augusto JoãoFerreira, IldemarMendes, Lys Angela FavaroniLuis Carlos Reishttp://lattes.cnpq.br/68884291219520122023-12-21T18:36:11Z2023-12-21T18:36:11Z2009-03-06POLO, Patrícia de Almeida. Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes). 2009. 78 f. Tese (Doutorado em Biologia Animal) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2009.https://rima.ufrrj.br/jspui/handle/20.500.14407/9214Esse trabalho deu continuidade a um achado incidental do Laboratório de Fisiologia Animal da UFRRJ, no Departamento de Ciências Fisiológicas, no qual, codornas tratadas perifericamente com serotonina, em um estudo sobre comportamento alimentar, apresentaram comportamentos semelhantes ao sono. A partir dessa evidência, a idéia de que a serotonina permeia a barreira hematoencefálica de aves, diferentemente de mamíferos, incitou novas investigações neurofarmacológicas e comportamentais. Foi realizado, primeiramente, um estudo com antagonistas e agonistas de receptores serotoninérgicos, confirmando a permeabilidade da barreira hematoencefálica de codornas à essa amina biogênica e sua participação em mecanismos centrais envolvidos na regulação de comportamentos semelhantes aos do sono. Esse trabalho resultou em uma publicação na Brazilian Joumal of Biology, em 2007, intitulada "Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Gallifonnes: Aves)". Levando-se em consideração que a serotonina é precursora da melatonina, e que esta última está envolvida no controle do ritmo circadiano, continuou-se a investigação, em tomo das alterações séricas de melatonina, mediante administração do precursor da serotonina, L-5-hidróxi-triptofano. Esse estudo resultou na publicação do segundo artigo na Brazilian Journal of Biology, em 2007, "Nocturnal plasma leveis of melatonin in quails (Coturnix japonica) injected with L-5-hydroxy-tryptophan". Uma vez que os comportamentos relacionados ao sono envolvem uma série de inibições centrais e que o ácido y-amino-butírico (GABA) é o maior neurotransmissor central do sistema nervoso central, continuou-se a explorar neurofarmacológica e comportamentalmente, o sono em codornas, abordando-se um tipo de receptor gabaérgico, o complexo receptor GABAA. O estudo resultou na última publicação desse doutoramento, Study of GABAA receptors on the sleep-lik:e behavior in Coturnix japonica (Temminck Schlegel, 1849) (Galliformes: Aves), na Joumal of Comparative Physiology A, em 2008. O objetivo dessa tese não foi traçar um paralelo filogenético entre aves e mamíferos, entretanto, muitas evidências foram inevitáveis. Certamente, esse trabalho contribuiu para ampliar o conhecimento científico sobre os elementos estudados. Ainda há muito o que se investigar a respeito do sono, não só em aves, como também em mamíferos.This work gives continuity to an incidental discovery from the Laboratory of Animal Plhysiology of UFRRJ, in the Department of Physiologic Science in which quails were treated periphericaly by serotonin, in a study of feeding behavior became sleep. From this evidence, the idea of which serotonin permeates the blood-brain barrier (BBB) of the birds, differently to mammals, incited new investigations about neuropharmacology and regarding this issue. Firstly, a study of antagonists e agonists of serotonergic receptors was held, confirming the permeability of the barrier of (BBB) of quails to serotonin and your participation in the central mechanisms involved in the regulation of the similar sleep-like behaviors. This research resulted in a publication of a first in the Brazilian Journal of Biology, in 2007, entitled "Behavioral and neuropharmacological evidence that serotonin crosses the bloodbrain barrier in Cortunix japonica (Galliformes: Aves). Taking into consideration that the serotonin is the precursor of melatonin and this last one is involved in the control of the circadian rhythm, we continued with the investigation about the plasma leveis of melatonin, by means of application of the serotonin precursor, L-5-hydroxy-tryptophan. This study resulted in the publication of a second article in the Brazilian Journal of Biology, in 2007, "Nocturnal plasma levels of melatonin in quails (Cortunix japonica) injected with L-5-hydroxy-tryptophan". Once the behaviors related to sleep involves a series of central inhibition and the y-aminobutyric acid (GABA) is the biggest central inhibitory neurotransmitter of the central nervous system, we continued exploring behavioral and neuropharmacologically broaching the one type of gabaergic receptor, aiming the sleep of quails, the complex receptor GABAA. This work resulted in the third and last publication of this doctorate work, "Study of GABAA receptors on the sleep-like behavior in Cortunix japonica (Temminck Schlegel, 1849) (Galliformes: Aves)", in the Journal of Comparative Physiology A, in 2008. Toe aim of this thesis was not to draw a parallel between birds and mammals. However, many evidences were inevitable. Certainly, this research contributed to increase the scientific knowledge of the analysed elements. There is still too much to investigate concerning sleep, not only in birds, but also in mammals.application/pdfporUniversidade Federal Rural do Rio de JaneiroPrograma de Pós-Graduação em Biologia AnimalUFRRJBrasilInstituto de Ciências Biológicas e da SaúdeSonocodornascomportamentoSleepquailsbehaviorFisiologiaEstudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)Study of neurobiologic components of the sleep in quails (Coturnix japonica) (Temminck Schlegel, 1849) (Birds: Galliformes)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisADACHI, N.; TOMONAGA, N.; TACHIBANA, T.; DENBOW, D.M.; FURUSE, M. Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain. Eur J Pharmacol v. 631, p.171–175, 2006. ADELL, A.; ARTIGAS, F. Regulation of the Release of 5-hydroxytryptamine in the Median raphe nucleus of the rat by Catecholaminergic Afferents. 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V. 9, p. 51-65, 2005. ZDANOVA, I.V.; WURTMAN, R.J. Efficacy of melatonin as a sleep-promoting agent. Journal of Biological Rhythms., v. 12, n. 6, p. 644-650, 1997.https://tede.ufrrj.br/retrieve/69064/2009%20-%20Patricia%20de%20Almeida%20Polo.pdf.jpghttps://tede.ufrrj.br/jspui/handle/jspui/5595Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2022-05-02T18:33:09Z No. of bitstreams: 1 2009 - Patricia de Almeida Polo.pdf: 1032409 bytes, checksum: 53b4b0668b4466242679b8e4b98eefb7 (MD5)Made available in DSpace on 2022-05-02T18:33:09Z (GMT). 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dc.title.por.fl_str_mv Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
dc.title.alternative.eng.fl_str_mv Study of neurobiologic components of the sleep in quails (Coturnix japonica) (Temminck Schlegel, 1849) (Birds: Galliformes)
title Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
spellingShingle Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
Polo, Patrícia de Almeida
Sono
codornas
comportamento
Sleep
quails
behavior
Fisiologia
title_short Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
title_full Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
title_fullStr Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
title_full_unstemmed Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
title_sort Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes)
author Polo, Patrícia de Almeida
author_facet Polo, Patrícia de Almeida
author_role author
dc.contributor.author.fl_str_mv Polo, Patrícia de Almeida
dc.contributor.advisor1.fl_str_mv Reis, Luis Carlos
dc.contributor.referee1.fl_str_mv Silva, Hélio Ricardo da
dc.contributor.referee2.fl_str_mv Piratelli, Augusto João
dc.contributor.referee3.fl_str_mv Ferreira, Ildemar
dc.contributor.referee4.fl_str_mv Mendes, Lys Angela Favaroni
dc.contributor.referee5.fl_str_mv Luis Carlos Reis
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6888429121952012
contributor_str_mv Reis, Luis Carlos
Silva, Hélio Ricardo da
Piratelli, Augusto João
Ferreira, Ildemar
Mendes, Lys Angela Favaroni
Luis Carlos Reis
dc.subject.por.fl_str_mv Sono
codornas
comportamento
topic Sono
codornas
comportamento
Sleep
quails
behavior
Fisiologia
dc.subject.eng.fl_str_mv Sleep
quails
behavior
dc.subject.cnpq.fl_str_mv Fisiologia
description Esse trabalho deu continuidade a um achado incidental do Laboratório de Fisiologia Animal da UFRRJ, no Departamento de Ciências Fisiológicas, no qual, codornas tratadas perifericamente com serotonina, em um estudo sobre comportamento alimentar, apresentaram comportamentos semelhantes ao sono. A partir dessa evidência, a idéia de que a serotonina permeia a barreira hematoencefálica de aves, diferentemente de mamíferos, incitou novas investigações neurofarmacológicas e comportamentais. Foi realizado, primeiramente, um estudo com antagonistas e agonistas de receptores serotoninérgicos, confirmando a permeabilidade da barreira hematoencefálica de codornas à essa amina biogênica e sua participação em mecanismos centrais envolvidos na regulação de comportamentos semelhantes aos do sono. Esse trabalho resultou em uma publicação na Brazilian Joumal of Biology, em 2007, intitulada "Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Gallifonnes: Aves)". Levando-se em consideração que a serotonina é precursora da melatonina, e que esta última está envolvida no controle do ritmo circadiano, continuou-se a investigação, em tomo das alterações séricas de melatonina, mediante administração do precursor da serotonina, L-5-hidróxi-triptofano. Esse estudo resultou na publicação do segundo artigo na Brazilian Journal of Biology, em 2007, "Nocturnal plasma leveis of melatonin in quails (Coturnix japonica) injected with L-5-hydroxy-tryptophan". Uma vez que os comportamentos relacionados ao sono envolvem uma série de inibições centrais e que o ácido y-amino-butírico (GABA) é o maior neurotransmissor central do sistema nervoso central, continuou-se a explorar neurofarmacológica e comportamentalmente, o sono em codornas, abordando-se um tipo de receptor gabaérgico, o complexo receptor GABAA. O estudo resultou na última publicação desse doutoramento, Study of GABAA receptors on the sleep-lik:e behavior in Coturnix japonica (Temminck Schlegel, 1849) (Galliformes: Aves), na Joumal of Comparative Physiology A, em 2008. O objetivo dessa tese não foi traçar um paralelo filogenético entre aves e mamíferos, entretanto, muitas evidências foram inevitáveis. Certamente, esse trabalho contribuiu para ampliar o conhecimento científico sobre os elementos estudados. Ainda há muito o que se investigar a respeito do sono, não só em aves, como também em mamíferos.
publishDate 2009
dc.date.issued.fl_str_mv 2009-03-06
dc.date.accessioned.fl_str_mv 2023-12-21T18:36:11Z
dc.date.available.fl_str_mv 2023-12-21T18:36:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv POLO, Patrícia de Almeida. Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes). 2009. 78 f. Tese (Doutorado em Biologia Animal) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2009.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/9214
identifier_str_mv POLO, Patrícia de Almeida. Estudo neurobiológico de componentes do sono em codornas (Coturnix japonica) (Temminck Schlegel, 1849) (Aves: Galliformes). 2009. 78 f. Tese (Doutorado em Biologia Animal) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2009.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/9214
dc.language.iso.fl_str_mv por
language por
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TAKAGI, T.; BUNGO, T.; TACHIBANA, T.; SAITO
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