Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)

Detalhes bibliográficos
Autor(a) principal: Teixeira, Felipe Marques
Data de Publicação: 2018
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/10309
Resumo: Cecropia hololeuca, popularmente conhecida como embaúba-prateada, pertence ao gênero Cecropia que consiste em cerca de 60 espécies, algumas delas amplamente utilizadas na medicina tradicional. Os flavonoides são amplamente distribuídos no reino vegetal e responsáveis por uma variedade de atividades farmacológicas. Este estudo investigou o potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato aquoso (EACH), frações aquosa (FAqCH), butanólica (FBuCH), enriquecida em flavonoides (FEFCH), flavonoídica (FFCH) e composto flavonoide da Cecropia hololeuca, bem como o possível mecanismo de ação. O pré-tratamento com EACH (30-1000 mg/kg, p.o) produziu inibição dose dependente das contorções induzidas pelo ácido acético (DI50 190 mg/kg) em camundongos machos albinos da linhagem Swiss. A administração oral de FAqCH (180 mg/kg) e FBuCH (120 mg/kg) reduziu as contorções induzidas por ácido acético em 80% e 37,9%, respectivamente. A administração oral de EACH (1 g/kg) não produziu efeito antinociceptivo enquanto o controle positivo fentanil (50 μg/kg, s.c) aumentou o limiar nociceptivo no teste de imersão da cauda. Adicionalmente, EACH não alterou a atividade motora no teste do rota-rod, ao contrário do diazepan (5 mg/kg, i.p). No teste de pleurisia induzida por carragenina, a avaliação do EACH (100, 300 e 1000 mg/kg, p.o) evidenciou que a maior dose inibiu significativamente a migração de leucócitos em 50%, em relação ao veículo (1,5±0,3x106 leucócitos/mL). Nos experimentos com FAqCH (60, 180 e 600 mg/kg, p.o) e FBuCH (400 mg/kg, p.o), observamos que FAqCH inibiu a migração de leucócitos de forma dose dependente em 35,7%, 67,7% e 85,4%, respectivamente, e FBuCH reduziu a migração de leucócitos em 68,8%, quando comparados ao veículo (2,9±0,4x106 leucócitos/mL). Os animais pré-tratados com FEFCH (2,5, 5 e 10 mg/kg, p.o) reduziram a migração de leucócitos em 43,6%, 42,3% e 53,9%, respectivamente, em relação ao veículo (1,8±0,3 x106 leucócitos/mL). No teste de pleurisia induzida por carragenina o controle positivo dexametasona (2 mg/kg, s.c) apresentou valores semelhantes para inibição da migração de leucócitos. No modelo de artrite induzida por zimosan EACH, FAqCH, FBuCH, FEFCH, FFCH e a rutina inibiram a formação do edema articular, a nocicepção e a migração de neutrófilos para o espaço articular em pelo menos uma das doses testadas. A administração da rutina (30 mg/kg, p.o.) promoveu diminuição do diâmetro da articulação fêmur-tibial, antinocicepção através do teste de Von Frey e inibiu a migração de leucócitos para a cavidade articular em 42,9%, 24,4% e 48,7%, respectivamente, em relação ao veículo e semelhante ao controle positivo dexametasona. Adicionalmente, os tratamento com EACH (1 g/kg, p.o), rutina (30 mg/kg, p.o) e dexametasona (2 mg/kg, s.c) reduziram a concentração de TNF-α no macerado articular, em 32,8%, 47% e 64%, respectivamente, quando comparados ao grupo veículo (146,5±21,5 pg/g de tecido). Estes resultados indicam que o EACH e as frações isoladas da Cecropia hololeuca produziram atividade anti-edematogênica, antinociceptiva e anti-inflamatória. A avaliação da rutina no modelo de artrite induzida por zimosan sugere que este importante flavonoide possa ser responsável pelas atividades promovidas pelo EACH através da inibição de TNF-α, justificando os relatos do uso etnomedicinal desta espécie em doenças inflamatórias.
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spelling Teixeira, Felipe MarquesVanderlinde, Frederico Argollo492958967-34http://lattes.cnpq.br/3183716703092107Malvar, David do CarmoVanderlinde, Frederico ArgolloMateus, Maria ElineRocha, Fábio Fagundes daSilva, Alba Cenélia Matos daCosta, Edson Alves078119707-40http://lattes.cnpq.br/28154213519648302023-12-21T19:00:44Z2023-12-21T19:00:44Z2018-02-27TEIXEIRA, Felipe Marques. Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae). 2018. 98 f. Tese (Doutorado em Ciências Fisiológicas) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2018.https://rima.ufrrj.br/jspui/handle/20.500.14407/10309Cecropia hololeuca, popularmente conhecida como embaúba-prateada, pertence ao gênero Cecropia que consiste em cerca de 60 espécies, algumas delas amplamente utilizadas na medicina tradicional. Os flavonoides são amplamente distribuídos no reino vegetal e responsáveis por uma variedade de atividades farmacológicas. Este estudo investigou o potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato aquoso (EACH), frações aquosa (FAqCH), butanólica (FBuCH), enriquecida em flavonoides (FEFCH), flavonoídica (FFCH) e composto flavonoide da Cecropia hololeuca, bem como o possível mecanismo de ação. O pré-tratamento com EACH (30-1000 mg/kg, p.o) produziu inibição dose dependente das contorções induzidas pelo ácido acético (DI50 190 mg/kg) em camundongos machos albinos da linhagem Swiss. A administração oral de FAqCH (180 mg/kg) e FBuCH (120 mg/kg) reduziu as contorções induzidas por ácido acético em 80% e 37,9%, respectivamente. A administração oral de EACH (1 g/kg) não produziu efeito antinociceptivo enquanto o controle positivo fentanil (50 μg/kg, s.c) aumentou o limiar nociceptivo no teste de imersão da cauda. Adicionalmente, EACH não alterou a atividade motora no teste do rota-rod, ao contrário do diazepan (5 mg/kg, i.p). No teste de pleurisia induzida por carragenina, a avaliação do EACH (100, 300 e 1000 mg/kg, p.o) evidenciou que a maior dose inibiu significativamente a migração de leucócitos em 50%, em relação ao veículo (1,5±0,3x106 leucócitos/mL). Nos experimentos com FAqCH (60, 180 e 600 mg/kg, p.o) e FBuCH (400 mg/kg, p.o), observamos que FAqCH inibiu a migração de leucócitos de forma dose dependente em 35,7%, 67,7% e 85,4%, respectivamente, e FBuCH reduziu a migração de leucócitos em 68,8%, quando comparados ao veículo (2,9±0,4x106 leucócitos/mL). Os animais pré-tratados com FEFCH (2,5, 5 e 10 mg/kg, p.o) reduziram a migração de leucócitos em 43,6%, 42,3% e 53,9%, respectivamente, em relação ao veículo (1,8±0,3 x106 leucócitos/mL). No teste de pleurisia induzida por carragenina o controle positivo dexametasona (2 mg/kg, s.c) apresentou valores semelhantes para inibição da migração de leucócitos. No modelo de artrite induzida por zimosan EACH, FAqCH, FBuCH, FEFCH, FFCH e a rutina inibiram a formação do edema articular, a nocicepção e a migração de neutrófilos para o espaço articular em pelo menos uma das doses testadas. A administração da rutina (30 mg/kg, p.o.) promoveu diminuição do diâmetro da articulação fêmur-tibial, antinocicepção através do teste de Von Frey e inibiu a migração de leucócitos para a cavidade articular em 42,9%, 24,4% e 48,7%, respectivamente, em relação ao veículo e semelhante ao controle positivo dexametasona. Adicionalmente, os tratamento com EACH (1 g/kg, p.o), rutina (30 mg/kg, p.o) e dexametasona (2 mg/kg, s.c) reduziram a concentração de TNF-α no macerado articular, em 32,8%, 47% e 64%, respectivamente, quando comparados ao grupo veículo (146,5±21,5 pg/g de tecido). Estes resultados indicam que o EACH e as frações isoladas da Cecropia hololeuca produziram atividade anti-edematogênica, antinociceptiva e anti-inflamatória. A avaliação da rutina no modelo de artrite induzida por zimosan sugere que este importante flavonoide possa ser responsável pelas atividades promovidas pelo EACH através da inibição de TNF-α, justificando os relatos do uso etnomedicinal desta espécie em doenças inflamatórias.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Brasil.Cecropia hololeuca, popularly known as embaúba-prateada, belongs to the genus Cecropia which consists of about 60 species, some of them widely used in traditional medicine. Flavonoids are widely distributed in the plant kingdom and responsible for the variety of pharmacological activities. This study investigated the anti-edematogenic, antinociceptive and anti-inflammatory potential of aqueous extract (EACH), aqueous (FAqCH), butanolic (FBuCH), enriched in flavonoids (FEFCH) and flavonoidic (FFCH) fractions and flavonoid compound of Cecropia hololeuca, as well as the possible mechanism of action. Were pretreated with EACH (30-1000 mg/kg, p.o) produces dose-related inhibition of acetic acid-induced writhing (ID50 190 mg/kg) in Swiss albino mice, male (25-35g) (CEUA/UFRRJ -nº 012/2014). Oral administration of FAqCH (180 mg/kg) e FBuCH (120 mg/kg), reduced the acetic acid-induced writhing at 80% e 37,9%, respectively. Oral administration of EACH (1 g/kg) did not produces antinociceptive effect while the positive control fentanyl (50 μg/kg, s.c.) increased the nociceptive threshold in the tail immersion test. Additionally, EACH did not change the motor activity in the rota-rod test, unlike diazepan (5 mg/kg, i.p). In the carrageenan-induced pleurisy test, the evaluation of the EACH (100-1000 mg/kg, p.o.) showed that the dose of 1000 mg/kg significantly inhibited leukocyte migration at 50%, relative to vehicle (1,5±0.3x106leukocytes/mL). In the experiments with FAqCH (60, 180 and 600 mg/kg, p.o) and FBuCH (400 mg/kg, p.o), we observed that FaqCH presented dose-related inhibition of the migration of leukocytes at 35.7%, 67.7% and 85.4%, respectively, and FBuCH reduced leukocyte migration at 68.8%, when compared to vehicle (2.9±0.4x106 leukocytes/mL). The animals pretreated with FEFCH (2.5; 5 and 10 mg/kg, p.o), reduced leukocyte migration at 43.6%, 42.3% and 53.9%, respectively, relative to vehicle (1.8±0.3x106 leukocytes/mL). In the carrageenan-induced pleurisy test, the positive control dexamethasone (2 mg/kg, s.c) presented similar values for inhibition of leukocyte migration. In the zymosan-induced arthritis model EACH, FAqCH, FBuCH, FEFCH, FFCH and rutin inhibited the formation of joint edema, nociception and migration of neutrophils into joint space in at least one of the doses tested. Administration of rutin (30 mg/kg, p.o) promoted a decrease in femur-tibial joint diameter, antinociception by the Von Frey test and inhibited the migration of leukocytes to the joint cavity, in 42.9%, 24.4% and 48.7%, respectively, relative to the vehicle and similar to the positive control dexamethasone. Additionally, the treatment with EACH (1 g/kg, p.o), rutin (30 mg/kg, p.o) and dexamethasone (2 mg/kg, s.c) reduced the concentration of TNF-α in the joint macerate, at 32,8%, 47% and 64%, respectively, when compared to the vehicle group (146.5±21.5 pg/g tissue). These results indicate that EACH and the isolated fractions of Cecropia hololeuca produced anti-edematogenic, antinociceptive and anti-inflammatory activity. The evaluation of the rutin in the zymosan-induced arthritis model suggests that this important flavonoid may be responsible by the activities promoted by EACH through of the inhibition of TNF-α, justifying the reports of the ethnomedicinal use of this species in inflammatory diseases.application/pdfporUniversidade Federal Rural do Rio de JaneiroPrograma Multicêntrico de Pós-Graduação em Ciências FisiológicasUFRRJBrasilInstituto de Ciências Biológicas e da SaúdeCecropia hololeucaflavonoidesrutinaCecropia hololeucaflavonoidsrutinFisiologiaAvaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)Evaluation of the anti-edematogenic, antinociceptive and anti-inflammatory potential of the extract, fractions and flavonoid compound of Cecropia hololeuca Miq. (Urticaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisABDEL-RAHEEM, I.T. 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dc.title.por.fl_str_mv Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
dc.title.alternative.eng.fl_str_mv Evaluation of the anti-edematogenic, antinociceptive and anti-inflammatory potential of the extract, fractions and flavonoid compound of Cecropia hololeuca Miq. (Urticaceae)
title Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
spellingShingle Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
Teixeira, Felipe Marques
Cecropia hololeuca
flavonoides
rutina
Cecropia hololeuca
flavonoids
rutin
Fisiologia
title_short Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
title_full Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
title_fullStr Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
title_full_unstemmed Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
title_sort Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae)
author Teixeira, Felipe Marques
author_facet Teixeira, Felipe Marques
author_role author
dc.contributor.author.fl_str_mv Teixeira, Felipe Marques
dc.contributor.advisor1.fl_str_mv Vanderlinde, Frederico Argollo
dc.contributor.advisor1ID.fl_str_mv 492958967-34
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3183716703092107
dc.contributor.advisor-co1.fl_str_mv Malvar, David do Carmo
dc.contributor.referee1.fl_str_mv Vanderlinde, Frederico Argollo
dc.contributor.referee2.fl_str_mv Mateus, Maria Eline
dc.contributor.referee3.fl_str_mv Rocha, Fábio Fagundes da
dc.contributor.referee4.fl_str_mv Silva, Alba Cenélia Matos da
dc.contributor.referee5.fl_str_mv Costa, Edson Alves
dc.contributor.authorID.fl_str_mv 078119707-40
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2815421351964830
contributor_str_mv Vanderlinde, Frederico Argollo
Malvar, David do Carmo
Vanderlinde, Frederico Argollo
Mateus, Maria Eline
Rocha, Fábio Fagundes da
Silva, Alba Cenélia Matos da
Costa, Edson Alves
dc.subject.por.fl_str_mv Cecropia hololeuca
flavonoides
rutina
topic Cecropia hololeuca
flavonoides
rutina
Cecropia hololeuca
flavonoids
rutin
Fisiologia
dc.subject.eng.fl_str_mv Cecropia hololeuca
flavonoids
rutin
dc.subject.cnpq.fl_str_mv Fisiologia
description Cecropia hololeuca, popularmente conhecida como embaúba-prateada, pertence ao gênero Cecropia que consiste em cerca de 60 espécies, algumas delas amplamente utilizadas na medicina tradicional. Os flavonoides são amplamente distribuídos no reino vegetal e responsáveis por uma variedade de atividades farmacológicas. Este estudo investigou o potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato aquoso (EACH), frações aquosa (FAqCH), butanólica (FBuCH), enriquecida em flavonoides (FEFCH), flavonoídica (FFCH) e composto flavonoide da Cecropia hololeuca, bem como o possível mecanismo de ação. O pré-tratamento com EACH (30-1000 mg/kg, p.o) produziu inibição dose dependente das contorções induzidas pelo ácido acético (DI50 190 mg/kg) em camundongos machos albinos da linhagem Swiss. A administração oral de FAqCH (180 mg/kg) e FBuCH (120 mg/kg) reduziu as contorções induzidas por ácido acético em 80% e 37,9%, respectivamente. A administração oral de EACH (1 g/kg) não produziu efeito antinociceptivo enquanto o controle positivo fentanil (50 μg/kg, s.c) aumentou o limiar nociceptivo no teste de imersão da cauda. Adicionalmente, EACH não alterou a atividade motora no teste do rota-rod, ao contrário do diazepan (5 mg/kg, i.p). No teste de pleurisia induzida por carragenina, a avaliação do EACH (100, 300 e 1000 mg/kg, p.o) evidenciou que a maior dose inibiu significativamente a migração de leucócitos em 50%, em relação ao veículo (1,5±0,3x106 leucócitos/mL). Nos experimentos com FAqCH (60, 180 e 600 mg/kg, p.o) e FBuCH (400 mg/kg, p.o), observamos que FAqCH inibiu a migração de leucócitos de forma dose dependente em 35,7%, 67,7% e 85,4%, respectivamente, e FBuCH reduziu a migração de leucócitos em 68,8%, quando comparados ao veículo (2,9±0,4x106 leucócitos/mL). Os animais pré-tratados com FEFCH (2,5, 5 e 10 mg/kg, p.o) reduziram a migração de leucócitos em 43,6%, 42,3% e 53,9%, respectivamente, em relação ao veículo (1,8±0,3 x106 leucócitos/mL). No teste de pleurisia induzida por carragenina o controle positivo dexametasona (2 mg/kg, s.c) apresentou valores semelhantes para inibição da migração de leucócitos. No modelo de artrite induzida por zimosan EACH, FAqCH, FBuCH, FEFCH, FFCH e a rutina inibiram a formação do edema articular, a nocicepção e a migração de neutrófilos para o espaço articular em pelo menos uma das doses testadas. A administração da rutina (30 mg/kg, p.o.) promoveu diminuição do diâmetro da articulação fêmur-tibial, antinocicepção através do teste de Von Frey e inibiu a migração de leucócitos para a cavidade articular em 42,9%, 24,4% e 48,7%, respectivamente, em relação ao veículo e semelhante ao controle positivo dexametasona. Adicionalmente, os tratamento com EACH (1 g/kg, p.o), rutina (30 mg/kg, p.o) e dexametasona (2 mg/kg, s.c) reduziram a concentração de TNF-α no macerado articular, em 32,8%, 47% e 64%, respectivamente, quando comparados ao grupo veículo (146,5±21,5 pg/g de tecido). Estes resultados indicam que o EACH e as frações isoladas da Cecropia hololeuca produziram atividade anti-edematogênica, antinociceptiva e anti-inflamatória. A avaliação da rutina no modelo de artrite induzida por zimosan sugere que este importante flavonoide possa ser responsável pelas atividades promovidas pelo EACH através da inibição de TNF-α, justificando os relatos do uso etnomedicinal desta espécie em doenças inflamatórias.
publishDate 2018
dc.date.issued.fl_str_mv 2018-02-27
dc.date.accessioned.fl_str_mv 2023-12-21T19:00:44Z
dc.date.available.fl_str_mv 2023-12-21T19:00:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv TEIXEIRA, Felipe Marques. Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae). 2018. 98 f. Tese (Doutorado em Ciências Fisiológicas) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2018.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/10309
identifier_str_mv TEIXEIRA, Felipe Marques. Avaliação do potencial anti-edematogênico, antinociceptivo e anti-inflamatório do extrato, frações e composto flavonoide de Cecropia hololeuca Miq. (Urticaceae). 2018. 98 f. Tese (Doutorado em Ciências Fisiológicas) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2018.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/10309
dc.language.iso.fl_str_mv por
language por
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