"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais"
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRRJ |
Texto Completo: | https://tede.ufrrj.br/jspui/handle/jspui/4176 |
Resumo: | This work describes the synthesis of four 1,3-Diarylpropanes: 1-(4'- hidroxy-5'-methyl-2'methoxyphenyl)-3-(2"-hidroxy-4",5"-methylenedioxyphenyl)- propane (IX-B) was synthesized with the purpose of confirming the proposed structures for the natural 1,3-diarylpropane extracted from Iryanthera laevis ; 1-(4'- hydroxy-2'-methoxyphenyl)-3-(4"-hydroxyphenyl)-propane (XV) (Broussonin B) and 1-(2'-hydroxy-4'-methoxyphenyl)-3-(4"-hydrixyphenyl)-propane (XlV) (Broussonin A) are phytoalexins isolated from Broussonetia papyrifera Vent., which show antifungic and antibacterian activities; 1-(2',4'-dimethoxyphenyl)-3-(4"-hydroxyphenyl)-propane (XVlII) is a synthetic product prepared by catalytic hydrogenation of 4-benzyloxy-2',4'- dimethoxychalcone. The synthetic pathway employed in this work involved the preparation of substituted acetophenones and benzaldehydes which, by aldol condensation, afforded the corresponding chalcones. These were submitted to catalytic hidrogenation (Pd-C 10%) and were characterized by I.R, Mass Spectrometry and MNR (1H, 13C, COSY & HETCOSY). |
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Fraiz Junior, Silas VarellaBraz Filho, Raimundohttp://lattes.cnpq.br/6747215104363265Fraiz Junior, Silas VarellaMorais, Anselmo AlpandeSouza, Maria Cec?lia Bastos Vieira deCarvalho, M?rio Geraldo dehttp://lattes.cnpq.br/4266221191908452Almeida, Paulo Afonso de2020-11-23T14:38:30Z1995-03-10Almeida, Paulo Afonso de. "S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais". 1995. 138 f. Disserta??o (Programa de P?s-Gradua??o em Qu?mica) - Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ.https://tede.ufrrj.br/jspui/handle/jspui/4176This work describes the synthesis of four 1,3-Diarylpropanes: 1-(4'- hidroxy-5'-methyl-2'methoxyphenyl)-3-(2"-hidroxy-4",5"-methylenedioxyphenyl)- propane (IX-B) was synthesized with the purpose of confirming the proposed structures for the natural 1,3-diarylpropane extracted from Iryanthera laevis ; 1-(4'- hydroxy-2'-methoxyphenyl)-3-(4"-hydroxyphenyl)-propane (XV) (Broussonin B) and 1-(2'-hydroxy-4'-methoxyphenyl)-3-(4"-hydrixyphenyl)-propane (XlV) (Broussonin A) are phytoalexins isolated from Broussonetia papyrifera Vent., which show antifungic and antibacterian activities; 1-(2',4'-dimethoxyphenyl)-3-(4"-hydroxyphenyl)-propane (XVlII) is a synthetic product prepared by catalytic hydrogenation of 4-benzyloxy-2',4'- dimethoxychalcone. The synthetic pathway employed in this work involved the preparation of substituted acetophenones and benzaldehydes which, by aldol condensation, afforded the corresponding chalcones. These were submitted to catalytic hidrogenation (Pd-C 10%) and were characterized by I.R, Mass Spectrometry and MNR (1H, 13C, COSY & HETCOSY).Este trabalho descreve a s?ntese de quatro 1,3-diarilpropanos. O 1-(4'- hidroxi-5'-metil-2'-metoxifenil)-3-(2"-hidroxi-4",5"-metilenodioxifenil)-propano IX-B, foi sintetizado para comprova??o inequ?voca do produto natural IX isolado da Iryanthera laevis (Myristicaceae). O 1-(4'-hidroxi-2'-metoxifenil)-3-(4"-hidroxifenil)- propano XV (Broussonina B) e o 1-(2'-hidroxi-4'-metoxifenil)-3-(4"-hidroxifenil)- propano XIV (Broussonina A), s?o fitoalexinas isoladas da Broussonetia papyrifera Vent (Moraceae) e que possuem atividades antif?ngica e antibacteriana. O 1-(2',4'- dimetoxifenil)-3-(4"-hidroxifenil)-propano XVIII ? um produto sint?tico oriundo da hidrogena??o catal?tica da 4-benziloxi-2',4'-dimetoxichalcona. A rota sint?tica utilizada envolveu a hidrogena??o catal?tica (Pd-C 10%) de chalconas obtidas por condensa??o ald?lica de acetofenonas e benzalde?dos devidamente substitu?dos. Os 1,3-diarilpropanos foram caracterizados por I.V, Espectrometria de massas e RMN (1H, 13C, COSY e HETCOSY).Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2020-11-23T14:38:30Z No. of bitstreams: 1 1995 - Paulo Afonso de Almeida.pdf: 2617146 bytes, checksum: 54d13d0288a0fa6c8a77571c1e135ffa (MD5)Made available in DSpace on 2020-11-23T14:38:30Z (GMT). No. of bitstreams: 1 1995 - Paulo Afonso de Almeida.pdf: 2617146 bytes, checksum: 54d13d0288a0fa6c8a77571c1e135ffa (MD5) Previous issue date: 1995-03-10Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESFunda??o de Amparo ? Pesquisa do Estado do Rio de Janeiro - FAPERJapplication/pdfhttps://tede.ufrrj.br/retrieve/63109/1995%20-%20Paulo%20Afonso%20de%20Almeida.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Qu?micaUFRRJBrasilInstituto de Ci?ncias ExatasQu?micaqu?mica org?nica"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais"info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL1995 - Paulo Afonso de Almeida.pdf.jpg1995 - Paulo Afonso de Almeida.pdf.jpgimage/jpeg1946http://localhost:8080/tede/bitstream/jspui/4176/4/1995+-+Paulo+Afonso+de+Almeida.pdf.jpg9c4c33fe1f23faf5f85e1f6ea6df4d21MD54TEXT1995 - Paulo Afonso de Almeida.pdf.txt1995 - Paulo Afonso de Almeida.pdf.txttext/plain78394http://localhost:8080/tede/bitstream/jspui/4176/3/1995+-+Paulo+Afonso+de+Almeida.pdf.txtc5aa2a9f4de20d6cbe16565329f4383bMD53ORIGINAL1995 - Paulo Afonso de Almeida.pdf1995 - Paulo Afonso de Almeida.pdfapplication/pdf2617146http://localhost:8080/tede/bitstream/jspui/4176/2/1995+-+Paulo+Afonso+de+Almeida.pdf54d13d0288a0fa6c8a77571c1e135ffaMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/jspui/4176/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51jspui/41762022-06-07 12:53:24.43oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttps://tede.ufrrj.br/PUBhttps://tede.ufrrj.br/oai/requestbibliot@ufrrj.br||bibliot@ufrrj.bropendoar:2022-06-07T15:53:24Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)false |
dc.title.por.fl_str_mv |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" |
title |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" |
spellingShingle |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" Almeida, Paulo Afonso de Qu?mica qu?mica org?nica |
title_short |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" |
title_full |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" |
title_fullStr |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" |
title_full_unstemmed |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" |
title_sort |
"S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais" |
author |
Almeida, Paulo Afonso de |
author_facet |
Almeida, Paulo Afonso de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Fraiz Junior, Silas Varella |
dc.contributor.advisor2.fl_str_mv |
Braz Filho, Raimundo |
dc.contributor.advisor2Lattes.fl_str_mv |
http://lattes.cnpq.br/6747215104363265 |
dc.contributor.referee1.fl_str_mv |
Fraiz Junior, Silas Varella |
dc.contributor.referee2.fl_str_mv |
Morais, Anselmo Alpande |
dc.contributor.referee3.fl_str_mv |
Souza, Maria Cec?lia Bastos Vieira de |
dc.contributor.referee4.fl_str_mv |
Carvalho, M?rio Geraldo de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4266221191908452 |
dc.contributor.author.fl_str_mv |
Almeida, Paulo Afonso de |
contributor_str_mv |
Fraiz Junior, Silas Varella Braz Filho, Raimundo Fraiz Junior, Silas Varella Morais, Anselmo Alpande Souza, Maria Cec?lia Bastos Vieira de Carvalho, M?rio Geraldo de |
dc.subject.por.fl_str_mv |
Qu?mica qu?mica org?nica |
topic |
Qu?mica qu?mica org?nica |
description |
This work describes the synthesis of four 1,3-Diarylpropanes: 1-(4'- hidroxy-5'-methyl-2'methoxyphenyl)-3-(2"-hidroxy-4",5"-methylenedioxyphenyl)- propane (IX-B) was synthesized with the purpose of confirming the proposed structures for the natural 1,3-diarylpropane extracted from Iryanthera laevis ; 1-(4'- hydroxy-2'-methoxyphenyl)-3-(4"-hydroxyphenyl)-propane (XV) (Broussonin B) and 1-(2'-hydroxy-4'-methoxyphenyl)-3-(4"-hydrixyphenyl)-propane (XlV) (Broussonin A) are phytoalexins isolated from Broussonetia papyrifera Vent., which show antifungic and antibacterian activities; 1-(2',4'-dimethoxyphenyl)-3-(4"-hydroxyphenyl)-propane (XVlII) is a synthetic product prepared by catalytic hydrogenation of 4-benzyloxy-2',4'- dimethoxychalcone. The synthetic pathway employed in this work involved the preparation of substituted acetophenones and benzaldehydes which, by aldol condensation, afforded the corresponding chalcones. These were submitted to catalytic hidrogenation (Pd-C 10%) and were characterized by I.R, Mass Spectrometry and MNR (1H, 13C, COSY & HETCOSY). |
publishDate |
1995 |
dc.date.issued.fl_str_mv |
1995-03-10 |
dc.date.accessioned.fl_str_mv |
2020-11-23T14:38:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Almeida, Paulo Afonso de. "S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais". 1995. 138 f. Disserta??o (Programa de P?s-Gradua??o em Qu?mica) - Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ. |
dc.identifier.uri.fl_str_mv |
https://tede.ufrrj.br/jspui/handle/jspui/4176 |
identifier_str_mv |
Almeida, Paulo Afonso de. "S?ntese e confirma??o estrutural de 1,3-Diarilpropanos naturais". 1995. 138 f. Disserta??o (Programa de P?s-Gradua??o em Qu?mica) - Universidade Federal Rural do Rio de Janeiro, Serop?dica-RJ. |
url |
https://tede.ufrrj.br/jspui/handle/jspui/4176 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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dc.publisher.none.fl_str_mv |
Universidade Federal Rural do Rio de Janeiro |
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Programa de P?s-Gradua??o em Qu?mica |
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UFRRJ |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Ci?ncias Exatas |
publisher.none.fl_str_mv |
Universidade Federal Rural do Rio de Janeiro |
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