Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil

Detalhes bibliográficos
Autor(a) principal: Mascarenhas, Mariana Bezerra
Data de Publicação: 2010
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/14264
Resumo: Com a finalidade de fornecer subsídios e discutir os problemas referentes ao diagnóstico e ao diagnóstico diferencial do tumor venéreo transmissível canino (TVTC), principalmente em sua forma extragenital, foi realizada a avaliação imuno-histoquímica e estabelecido termo de comparação com aspecto microscópico em 10 TVTCs genitais e em 13 exclusivamente extragenitais previamente diagnosticados através de histopatologia. Os TVTCs foram testados para reagentes específicos de antígenos de membrana (anti-macrófago e anti-cadeia leve lambda) e citoplasmáticos (anti-lisozima, anti-proteína S-100, anti-alfa-1-antitripsina, antivimentina e anti-CD68) com utilização da técnica complexo avidina-biotina-peroxidase. Adicionalmente, a reatividade aos anticorpos anti-CD3 e anti-CD-79a foi testada em um TVTC genital. Em 100% dos tumores testados (22/22) com anticorpo anti-vimentina houve forte imuno-reatividade. Não houve reatividade para os anticorpos anti-lisozima, antimacrófago, anti-proteína S-100, bem como aos anticorpos anti-CD3 e anti-CD79a. O clone do anticorpo anti-CD68 utilizado não apresentou reação cruzada com macrófagos de cão. Não houve diferença histopatológica e de imuno-reatividade entre os TVTCs genitais e extragenitais. Estes achados não corroboram com a hipótese da origem histiocítica do TVTC (ausência de reatividade dos anticorpos anti-lisozima e anti-macrófago). O painel de anticorpos utilizado é útil para o diagnóstico diferencial deste tumor com linfomas, plasmocitomas, tumores histiocíticos, melanomas amelanóticos e neoplasias de origem epitelial pobremente diferenciadas, entre outros.
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spelling Mascarenhas, Mariana BezerraFrança, Ticiana do Nascimentohttp://lattes.cnpq.br/3545873525091315Peixoto, Paulo de VargasRamadinha, Regina RuckertVaraschin, Mary Suzan055.187.017-64http://lattes.cnpq.br/51251358562047602023-12-22T02:58:30Z2023-12-22T02:58:30Z2010-07-30Mascarenhas, Mariana Bezerra. Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil. 2010. 67 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)) - Universidade Federal Rural do Rio de Janeiro, Seropédica.https://rima.ufrrj.br/jspui/handle/20.500.14407/14264Com a finalidade de fornecer subsídios e discutir os problemas referentes ao diagnóstico e ao diagnóstico diferencial do tumor venéreo transmissível canino (TVTC), principalmente em sua forma extragenital, foi realizada a avaliação imuno-histoquímica e estabelecido termo de comparação com aspecto microscópico em 10 TVTCs genitais e em 13 exclusivamente extragenitais previamente diagnosticados através de histopatologia. Os TVTCs foram testados para reagentes específicos de antígenos de membrana (anti-macrófago e anti-cadeia leve lambda) e citoplasmáticos (anti-lisozima, anti-proteína S-100, anti-alfa-1-antitripsina, antivimentina e anti-CD68) com utilização da técnica complexo avidina-biotina-peroxidase. Adicionalmente, a reatividade aos anticorpos anti-CD3 e anti-CD-79a foi testada em um TVTC genital. Em 100% dos tumores testados (22/22) com anticorpo anti-vimentina houve forte imuno-reatividade. Não houve reatividade para os anticorpos anti-lisozima, antimacrófago, anti-proteína S-100, bem como aos anticorpos anti-CD3 e anti-CD79a. O clone do anticorpo anti-CD68 utilizado não apresentou reação cruzada com macrófagos de cão. Não houve diferença histopatológica e de imuno-reatividade entre os TVTCs genitais e extragenitais. Estes achados não corroboram com a hipótese da origem histiocítica do TVTC (ausência de reatividade dos anticorpos anti-lisozima e anti-macrófago). O painel de anticorpos utilizado é útil para o diagnóstico diferencial deste tumor com linfomas, plasmocitomas, tumores histiocíticos, melanomas amelanóticos e neoplasias de origem epitelial pobremente diferenciadas, entre outros.Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, BrasilWith the aim of providing insight and discussing the problems related to the diagnosis and differential diagnosis of canine transmissible venereal tumor (CTVT), especially in its extragenital form, immunohistochemical evaluation was performed and a comparison was established by analysis of the microscopic appearance of 10 genital CTVTs and 13 exclusively extragenital CTVTs previously diagnosed by histopathology. CTVT samples were incubated with biotinylated antibodies raised against specific membrane (antimacrophage and anti- light lambda chains) and cytoplasmic antigens (anti-lysozyme, anti-S- 100 protein, anti-alpha-1-antitrypsin, anti-vimentin and anti-CD68) and subsequently developed using the avidin-biotin-peroxidase complex technique. Additionally, the reactivity with anti-CD3 and anti-CD79a antibodies was tested in one genital CTVT sample. A strong reactivity with the anti-vimentin antibody was found in 100% of the tumors tested (22/22). No reactivity was found for the anti-lysozyme, anti-macrophage, anti-S-100 protein, anti-CD3 and anti-CD79a antibodies. The clone of the antibody anti-CD68 does not seem to present any cross-reactivity with macrophages of dogs. No histopathological or immunoreactivity differences between genital and extragenital CTVTs were found. These findings do not corroborate the hypothesis of histiocytic origin of CTVT (no reactivity to anti-lysozyme and anti-macrophage antibodies). 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dc.title.por.fl_str_mv Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
dc.title.alternative.eng.fl_str_mv Immunohistochemical study and differential diagnosis of genital and extragenital forms of canine transmissible venereal tumor in Brazil
title Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
spellingShingle Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
Mascarenhas, Mariana Bezerra
TVTC
imuno-histoquímica
tumor de células redondas
cão
TVT
immunohistochemistry
round cell tumor
dog
Medicina Veterinária
title_short Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
title_full Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
title_fullStr Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
title_full_unstemmed Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
title_sort Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil
author Mascarenhas, Mariana Bezerra
author_facet Mascarenhas, Mariana Bezerra
author_role author
dc.contributor.author.fl_str_mv Mascarenhas, Mariana Bezerra
dc.contributor.advisor1.fl_str_mv França, Ticiana do Nascimento
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3545873525091315
dc.contributor.advisor-co1.fl_str_mv Peixoto, Paulo de Vargas
dc.contributor.referee1.fl_str_mv Ramadinha, Regina Ruckert
dc.contributor.referee2.fl_str_mv Varaschin, Mary Suzan
dc.contributor.authorID.fl_str_mv 055.187.017-64
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5125135856204760
contributor_str_mv França, Ticiana do Nascimento
Peixoto, Paulo de Vargas
Ramadinha, Regina Ruckert
Varaschin, Mary Suzan
dc.subject.por.fl_str_mv TVTC
imuno-histoquímica
tumor de células redondas
cão
topic TVTC
imuno-histoquímica
tumor de células redondas
cão
TVT
immunohistochemistry
round cell tumor
dog
Medicina Veterinária
dc.subject.eng.fl_str_mv TVT
immunohistochemistry
round cell tumor
dog
dc.subject.cnpq.fl_str_mv Medicina Veterinária
description Com a finalidade de fornecer subsídios e discutir os problemas referentes ao diagnóstico e ao diagnóstico diferencial do tumor venéreo transmissível canino (TVTC), principalmente em sua forma extragenital, foi realizada a avaliação imuno-histoquímica e estabelecido termo de comparação com aspecto microscópico em 10 TVTCs genitais e em 13 exclusivamente extragenitais previamente diagnosticados através de histopatologia. Os TVTCs foram testados para reagentes específicos de antígenos de membrana (anti-macrófago e anti-cadeia leve lambda) e citoplasmáticos (anti-lisozima, anti-proteína S-100, anti-alfa-1-antitripsina, antivimentina e anti-CD68) com utilização da técnica complexo avidina-biotina-peroxidase. Adicionalmente, a reatividade aos anticorpos anti-CD3 e anti-CD-79a foi testada em um TVTC genital. Em 100% dos tumores testados (22/22) com anticorpo anti-vimentina houve forte imuno-reatividade. Não houve reatividade para os anticorpos anti-lisozima, antimacrófago, anti-proteína S-100, bem como aos anticorpos anti-CD3 e anti-CD79a. O clone do anticorpo anti-CD68 utilizado não apresentou reação cruzada com macrófagos de cão. Não houve diferença histopatológica e de imuno-reatividade entre os TVTCs genitais e extragenitais. Estes achados não corroboram com a hipótese da origem histiocítica do TVTC (ausência de reatividade dos anticorpos anti-lisozima e anti-macrófago). O painel de anticorpos utilizado é útil para o diagnóstico diferencial deste tumor com linfomas, plasmocitomas, tumores histiocíticos, melanomas amelanóticos e neoplasias de origem epitelial pobremente diferenciadas, entre outros.
publishDate 2010
dc.date.issued.fl_str_mv 2010-07-30
dc.date.accessioned.fl_str_mv 2023-12-22T02:58:30Z
dc.date.available.fl_str_mv 2023-12-22T02:58:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv Mascarenhas, Mariana Bezerra. Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil. 2010. 67 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)) - Universidade Federal Rural do Rio de Janeiro, Seropédica.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/14264
identifier_str_mv Mascarenhas, Mariana Bezerra. Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil. 2010. 67 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)) - Universidade Federal Rural do Rio de Janeiro, Seropédica.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/14264
dc.language.iso.fl_str_mv por
language por
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