Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico

Detalhes bibliográficos
Autor(a) principal: Silva, Amanda Couto
Data de Publicação: 2021
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/11722
Resumo: O Lúpus eritematoso sistêmico (LES) é uma doença autoimune crônica que acomete cães, gatos, cavalos, humanos e primatas. A patogênese é multifatorial, estando associado a fatores genéticos, hormonais e ambientais. O LES leva a deposição de complexos imunes em articulações e diversos órgãos resultando em manifestações clínicas. A participação dos linfócitos T e B é crucial para a patogênese da doença. Linfócitos B-1, uma subpopulação de células B, possuem características que podem contribuir com a patogênese de doenças autoimunes pois são capazes de secretar citocinas como IL-10 exercendo uma ação moduladora tanto da resposta inflamatória aguda como crônica, apresentam antígenos as células T, participam da imunidade inata e adaptativa e são as principais produtoras de anticorpos naturais. O entendimento do papel das células B-1 na imunopatogênese do LES pode abrir frentes de estudos sobre estratégias de imunoterapias que possibilitem o controle dessa doença complexa e multifatorial. O presente trabalho avaliou o papel das células B-1 na imunopatogênese do LES utilizando o modelo de indução pelo pristane. LES foi induzido em camundongos fêmeas BALB/c, XID (deficientes em B-1) e XID repopulados com B-1. Os animais foram avaliados por seis meses. Verificamos que, BALB/c pristane e XID repopulados com B-1 apresentaram sinais característicos da doença como, formação de lipogranulomas e esplenomegalia. Em destaque, BALB/c pristane também apresentou ascite, edema articular, artrite, lesão renal com deposição de imunocomplexo. No baço, os animais BALB/c tiveram maior porcentagem de células B (CD19+, IgM+), BALB/c pristane de T CD8 (CD3+,CD8+), enquanto XID pristane teve aumento T CD4 (CD3+,CD4+). No lavado peritoneal, após indução com pristane houve diminuição de células B (CD19+, IgM+) e aumento de B1a (CD19+ IgM+ CD5+) em BALB/c pristane. No sangue periférico, BALB/c apresentou maior quantidade de linfócitos, XID apresentou um perfil neutrofilico, e em todos os grupos com LES houve aumento de monócitos. As citocinas IL-10, IL-6 e IFN- foram aumentadas nos BALB/c e XID repopulados. Com base nesses resultados, sugerimos que a presença de células B-1 pode contribuir com o desenvolvimento do LES.
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spelling Silva, Amanda CoutoLima, Débora Decote Ricardo de875.362.007-06http://lattes.cnpq.br/3572066508469025Lima, Célio Freire Geraldo de002.031.157-59Lima, Débora Decote Ricardo deSilva, Lucia Helena Pinto daBizarro, Heloisa D’Avila da Silva442.399.278-70https://orcid.org/0000-0003-1878-1696http://lattes.cnpq.br/68607236294698552023-12-22T01:56:32Z2023-12-22T01:56:32Z2021-09-20SILVA, Amanda Couto. Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico. 2021. 70 f. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2021.https://rima.ufrrj.br/jspui/handle/20.500.14407/11722O Lúpus eritematoso sistêmico (LES) é uma doença autoimune crônica que acomete cães, gatos, cavalos, humanos e primatas. A patogênese é multifatorial, estando associado a fatores genéticos, hormonais e ambientais. O LES leva a deposição de complexos imunes em articulações e diversos órgãos resultando em manifestações clínicas. A participação dos linfócitos T e B é crucial para a patogênese da doença. Linfócitos B-1, uma subpopulação de células B, possuem características que podem contribuir com a patogênese de doenças autoimunes pois são capazes de secretar citocinas como IL-10 exercendo uma ação moduladora tanto da resposta inflamatória aguda como crônica, apresentam antígenos as células T, participam da imunidade inata e adaptativa e são as principais produtoras de anticorpos naturais. O entendimento do papel das células B-1 na imunopatogênese do LES pode abrir frentes de estudos sobre estratégias de imunoterapias que possibilitem o controle dessa doença complexa e multifatorial. O presente trabalho avaliou o papel das células B-1 na imunopatogênese do LES utilizando o modelo de indução pelo pristane. LES foi induzido em camundongos fêmeas BALB/c, XID (deficientes em B-1) e XID repopulados com B-1. Os animais foram avaliados por seis meses. Verificamos que, BALB/c pristane e XID repopulados com B-1 apresentaram sinais característicos da doença como, formação de lipogranulomas e esplenomegalia. Em destaque, BALB/c pristane também apresentou ascite, edema articular, artrite, lesão renal com deposição de imunocomplexo. No baço, os animais BALB/c tiveram maior porcentagem de células B (CD19+, IgM+), BALB/c pristane de T CD8 (CD3+,CD8+), enquanto XID pristane teve aumento T CD4 (CD3+,CD4+). No lavado peritoneal, após indução com pristane houve diminuição de células B (CD19+, IgM+) e aumento de B1a (CD19+ IgM+ CD5+) em BALB/c pristane. No sangue periférico, BALB/c apresentou maior quantidade de linfócitos, XID apresentou um perfil neutrofilico, e em todos os grupos com LES houve aumento de monócitos. As citocinas IL-10, IL-6 e IFN- foram aumentadas nos BALB/c e XID repopulados. Com base nesses resultados, sugerimos que a presença de células B-1 pode contribuir com o desenvolvimento do LES.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects dogs, cats, horses, humans and primates. The pathogenesis is multifactorial, being associated with genetic, hormonal and environmental factors. SLE leads to deposition of immune complexes in joints and various organs, resulting in clinical manifestations. The participation of T and B lymphocytes is crucial for the pathogenesis of the disease. B-1 lymphocytes, a subpopulation of B cells, have characteristics that may contribute to the pathogenesis of autoimmune diseases through the secretion of cytokines such as IL-10 exerting a modulating action on both the acute and chronic inflammatory response, presenting antigens to T cells, participating of innate and adaptive immunity and are the main producers of natural antibodies. Understanding the role of B-1 cells in SLE immunopathogenesis may open new fronts for studies on immunotherapeutic strategies to control this complex and multifactorial disease. The present work evaluated the role of B-1 cells in the immunopathogenesis of SLE using the pristane induction model. SLE was induced in BALB/c, XID (B-1 deficient) and XID mice repopulated with B-1. The animals were evaluated for six months. We found that BALB/c pristane and XID repopulated with B-1 showed characteristic signs of the disease, such as lipogranuloma formation and splenomegaly. Notably, BALB/c pristane also presented ascites, joint edema, arthritis, kidney damage with immune complex deposition. In the spleen, animals BALB/c had a higher percentage of B cells (CD19+, IgM+), BALB/c pristane T CD8 (CD3+, CD8+), while XID pristane had increased T CD4 (CD3+,CD4+). In the peritoneal lavage, after induction with pristane, there was a decrease in B cells (CD19+, IgM+) and an increase in B1a (CD19+, IgM CD5+) in BALB/c pristane. In peripheral blood, BALB/c had a higher number of lymphocytes, XID had a neutrophilic profile, and all groups with SLE showed an increase in monocytes. The cytokines IL-10, IL-6 and IFN-γ were increased in BALB/c and XID repopulated that developed SLE. 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dc.title.por.fl_str_mv Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
dc.title.alternative.eng.fl_str_mv Role of B1 cells in the immunopathogenesis of systemic lupus erythematosus
title Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
spellingShingle Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
Silva, Amanda Couto
Linfócitos B-1
Lúpus eritematoso sistêmico
Imunomodulação
Autoimunidade
B-1 lymphocytes
Systemic lupus erythematosus
Immunomodulation; autoimmunity
Medicina Veterinária
title_short Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
title_full Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
title_fullStr Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
title_full_unstemmed Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
title_sort Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico
author Silva, Amanda Couto
author_facet Silva, Amanda Couto
author_role author
dc.contributor.author.fl_str_mv Silva, Amanda Couto
dc.contributor.advisor1.fl_str_mv Lima, Débora Decote Ricardo de
dc.contributor.advisor1ID.fl_str_mv 875.362.007-06
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3572066508469025
dc.contributor.advisor-co1.fl_str_mv Lima, Célio Freire Geraldo de
dc.contributor.advisor-co1ID.fl_str_mv 002.031.157-59
dc.contributor.referee1.fl_str_mv Lima, Débora Decote Ricardo de
dc.contributor.referee2.fl_str_mv Silva, Lucia Helena Pinto da
dc.contributor.referee3.fl_str_mv Bizarro, Heloisa D’Avila da Silva
dc.contributor.authorID.fl_str_mv 442.399.278-70
https://orcid.org/0000-0003-1878-1696
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6860723629469855
contributor_str_mv Lima, Débora Decote Ricardo de
Lima, Célio Freire Geraldo de
Lima, Débora Decote Ricardo de
Silva, Lucia Helena Pinto da
Bizarro, Heloisa D’Avila da Silva
dc.subject.por.fl_str_mv Linfócitos B-1
Lúpus eritematoso sistêmico
Imunomodulação
Autoimunidade
topic Linfócitos B-1
Lúpus eritematoso sistêmico
Imunomodulação
Autoimunidade
B-1 lymphocytes
Systemic lupus erythematosus
Immunomodulation; autoimmunity
Medicina Veterinária
dc.subject.eng.fl_str_mv B-1 lymphocytes
Systemic lupus erythematosus
Immunomodulation; autoimmunity
dc.subject.cnpq.fl_str_mv Medicina Veterinária
description O Lúpus eritematoso sistêmico (LES) é uma doença autoimune crônica que acomete cães, gatos, cavalos, humanos e primatas. A patogênese é multifatorial, estando associado a fatores genéticos, hormonais e ambientais. O LES leva a deposição de complexos imunes em articulações e diversos órgãos resultando em manifestações clínicas. A participação dos linfócitos T e B é crucial para a patogênese da doença. Linfócitos B-1, uma subpopulação de células B, possuem características que podem contribuir com a patogênese de doenças autoimunes pois são capazes de secretar citocinas como IL-10 exercendo uma ação moduladora tanto da resposta inflamatória aguda como crônica, apresentam antígenos as células T, participam da imunidade inata e adaptativa e são as principais produtoras de anticorpos naturais. O entendimento do papel das células B-1 na imunopatogênese do LES pode abrir frentes de estudos sobre estratégias de imunoterapias que possibilitem o controle dessa doença complexa e multifatorial. O presente trabalho avaliou o papel das células B-1 na imunopatogênese do LES utilizando o modelo de indução pelo pristane. LES foi induzido em camundongos fêmeas BALB/c, XID (deficientes em B-1) e XID repopulados com B-1. Os animais foram avaliados por seis meses. Verificamos que, BALB/c pristane e XID repopulados com B-1 apresentaram sinais característicos da doença como, formação de lipogranulomas e esplenomegalia. Em destaque, BALB/c pristane também apresentou ascite, edema articular, artrite, lesão renal com deposição de imunocomplexo. No baço, os animais BALB/c tiveram maior porcentagem de células B (CD19+, IgM+), BALB/c pristane de T CD8 (CD3+,CD8+), enquanto XID pristane teve aumento T CD4 (CD3+,CD4+). No lavado peritoneal, após indução com pristane houve diminuição de células B (CD19+, IgM+) e aumento de B1a (CD19+ IgM+ CD5+) em BALB/c pristane. No sangue periférico, BALB/c apresentou maior quantidade de linfócitos, XID apresentou um perfil neutrofilico, e em todos os grupos com LES houve aumento de monócitos. As citocinas IL-10, IL-6 e IFN- foram aumentadas nos BALB/c e XID repopulados. Com base nesses resultados, sugerimos que a presença de células B-1 pode contribuir com o desenvolvimento do LES.
publishDate 2021
dc.date.issued.fl_str_mv 2021-09-20
dc.date.accessioned.fl_str_mv 2023-12-22T01:56:32Z
dc.date.available.fl_str_mv 2023-12-22T01:56:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Amanda Couto. Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico. 2021. 70 f. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2021.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/11722
identifier_str_mv SILVA, Amanda Couto. Papel dos linfócitos B-1 na imunopatogênese do Lúpus eritematoso sistêmico. 2021. 70 f. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2021.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/11722
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